The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach by Jianqing Qiu, Ting Zhu, Ke Qin, Wei Zhang

“…Therefore, we employed unsupervised learning to translate five domains of eRDoC scores derived from electronic medical records (EMR) of patients diagnosed with Major Depressive Disorder (MDD), Schizophrenia (SCZ), and Bipolar Disorder (BD) at West China Hospital between 2008 and 2021. …”
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RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study by Andrea Miranda-Mendizabal, Diana Vetter, Juan Zambrano, Jeff Zarp, Victor Chavarría, Anna Giménez-Palomo, Meritxell Gonzalez-Campos, Marc Valenti, Lara Walczer Baldinazzo, Sara Siddi, Maurizio Ferrari, Dinah Weissmann, Chantal Henry, Josep Maria Haro, Lars Vedel Kessing, Eduard Vieta

“…Objective diagnostic tests or precise tools to diagnose BD and distinguish it from major depressive disorder (MDD) in depressed patients are lacking. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…These subjects are characterized by reduced naïve T cells and a premature T cell senescence similar to that of patients with major depressive disorder (MDD). It is known that T cells are essential for limbic system development/function. …”
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Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study by Yong Zhou, Jiayue Duan, Jiayi Zhu, Yunying Huang, Tao Tu, Keke Wu, Qiuzhen Lin, Yingxu Ma, Qiming Liu

“…Results Genetically determined frailty was significantly associated with increased risk of major depressive disorder (MDD) (odds ratio 1.86, 95% CI 1.36–2.53, P = 8.1 × 10−5), anxiety (odds ratio 2.76, 95% CI 1.56–4.90, P = 5.0 × 10−4), post-traumatic stress disorder (PTSD) (odds ratio 2.56, 95% CI 1.69–3.87, P = 9.9 × 10−6), neuroticism (β = 0.25, 95% CI 0.11–0.38, P = 3.3 × 10−4) and insomnia (β = 0.50, 95% CI 0.25–0.75, P = 1.1 × 10−4). …”
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Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis by Mengqi Liu, Mengqi Liu, Jie Tang, Jie Tang, Gaoyang Xu, Gaoyang Xu, Xu Chen, Xu Chen, Kun Fang, Fan He, Fan He, Yi Zheng, Yi Zheng

“…BackgroundMajor depressive disorder (MDD) in adolescents poses a significant threat to physical health. …”
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Gambaran Peningkatan Angka Kejadian Gangguan Afektif dengan Gejala Psikotik pada Pasien Rawat Inap di RSJ Prof. Dr. HB. Sa’anin Padang pada Tahun 2010 - 2011 by Aisyah Fithri Syafwan, Kurniawan Sedjahtera, Asterina .

“…<br />Keywords:manic disorder, psychotic symptoms, major depressive disorder, affective disorder mixed type</p>…”
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Dynamic functional connectivity patterns predict early antidepressant treatment response in drug-naïve, first-episode adolescent MDD by Maojia Ran, Hang Zhang, Meijiang Jin, Yuanmei Tao, Hanmei Xu, Shoukang Zou, Zhujun Wang, Fang Deng, Lijuan Huang, Hong Zhang, Xiaowei Tang, Yanping Wang, Xia Fu, Li Yin, Li Yin, Li Yin

“…ObjectiveAdolescents with major depressive disorder (MDD) exhibit abnormal dynamic functional connectivity (dFC) patterns, but it remains unclear whether these aberrant dFC patterns are linked to antidepressant treatment. …”
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Development and predictors of bipolar disorder in children and adolescents with depressive disorders: a systematic review, meta-analysis, and meta-regression by Gonzalo Salazar de Pablo, Violeta Perez-Rodriguez, Javier de Otazu Olivares, Javier Camacho-Rubio, Aditya Sharma, Ana Catalán, Josefien Breedvelt, Claudia Aymerich, Mihai Pop, Carmen Moreno, Ian Kelleher, Jane Anderson, Paolo Fusar-Poli, Christoph U Correll, Allan H. Young

“…Studies using the DSM (21.6%, 95% CI=20.2% to 23.1%) and studies evaluating C&A with a major depressive disorder only (19.8%, 95% CI=16.8% to 23.1%) found higher rates of development of BD. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Additionally, there is no consensus of what constitutes harm when withholding treatment; placebos are often used in trials for major depressive disorder, yet this population has statistically higher rates of self-harm and suicide without treatment compared to the general population.[14] Serious risks can be incurred due to a placebo intervention by not offering experimental treatment, without excusing the psychological harm withholding a treatment may have on a patient should it be unblinded. …”
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Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress by Phillip W. Gold, Rodrigo Machado-Vieira, Maria G. Pavlatou

“…Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder with high mortality and medical comorbidities. …”
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Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations by Peter Rotheneichner, Simona Lange, Anna O’Sullivan, Julia Marschallinger, Pia Zaunmair, Christian Geretsegger, Ludwig Aigner, Sebastien Couillard-Despres

“…This review revisits recent findings on the close relation between the mode(s) of action of electroconvulsive therapy (ECT), a powerful intervention used as second-line treatment of major depression disorders, and the neurogenic response to ECT. …”
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Mental health and substance use among rehabilitation sciences students during the COVID-19 pandemic by Itumeleng Ntatamala, Saajida Khan, Zenzo Chakara

“…Diagnoses included major depressive disorders (13.27%) and anxiety disorders (11.50%). …”
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