Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…Qualitative findings revealed that favorable perceptions of self-administered 5FU were driven by its ease of use, the discrete nature of the treatment, and the comfort of home application. The main challenges included correctly measuring the study drug, finding a private place at home to self-administer, and the need to use condoms during treatment. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…CD8+ T cells and natural killer cells were the main effector cells for NDCs to function. NDCs can promote PD-L1 expression on intratumoral APCs and tumor cells, and subsequently achieve targeted enrichment in tumors. …”
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RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…Introduction: Asparagus (Asparagus officinalis) is a perennial flowering plant species. Its main components have tumor-prevention, immune system-enhancement, and anti-inflammation effects. …”
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Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

“…Results We identified the expansion of CD56dim natural killer (NK) cells in ALS (fold change = 2; adj. p-value = 0.0051), mainly driven by a specific subpopulation, NK_2 cells (fold change = 3.12; adj. p-value = 0.0001), which represent a mature and cytotoxic CD56dim NK subset. …”
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Deep-Reticular Pseudodrusen-Net: A 3-Dimensional Deep Network for Detection of Reticular Pseudodrusen on OCT Scans by Amr Elsawy, PhD, Tiarnan D.L. Keenan, PhD, MD, Alisa T. Thavikulwat, MD, Amy Lu, MD, Sunil Bellur, MD, Souvick Mukherjee, PhD, Elvira Agron, MS, Qingyu Chen, PhD, Emily Y. Chew, MD, Zhiyong Lu, PhD

“…En face and B-scan heatmaps of all networks were visualized and graded on 25 OCT scans with positive labels, using a scale of 1 to 4, to explore the models' decision-making. Main Outcome Measures: Accuracy and area under the receiver-operating characteristic curve (AUROC). …”
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Productivity of water and heat resources and cotton yield response to cropping pattern and planting density in cotton fields in arid area by Zhenlin Dong, Sumei Wan, Yunzhen Ma, Jinbin Wang, Lu Feng, Yunlong Zhai, Tiantian Li, Zhengjun Cui, Jian Wang, Beifang Yang, Ze Yang, Zhan Zhao, Fei Yan, Shiwu Xiong, Yabing Li, Guodong Chen

“…To test this, a two-year field experiment (2022–2023) employed a split-plot design with two main planting patterns (four rows per film and six rows per film) and three planting densities (low, medium, and high) as subplots. …”
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Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study by Hussein Okasha, Eyad Gadour, Ghias Un Nabi Tayyab, Andrada Seicean, Elbacha Hicham, Emad Emad, Turki Alamri, Nadeem Tehami, Heero Ismael Faraj, Ahmed Alzamzamy, Hiwa Hussein, Mohammed Tag-Adeen, Mohamed Elbasiony, Abed Al-Lehibi, Shereen Saleh, Zaher Houmani, Mohamed Abdelghani, Khaled Ragab, Zahi Ismaili, Othmane Drir, Elsayed Ghoneem, Omar Abdallah, Souad Rebiai, Nonthalee Pausawasdi, Fedoua Rouibaa, Mohamed Borahma, Hassan Atalla, Mahmoud Farouk, Ahmed Altonbary

“…Abstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. …”
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Effects of nitrogen fertilizer basal-to-top-dressing ratios on maize straw decomposition, soil carbon and nitrogen, and bacterial community structure in different soil textures on... by Jingyu Li, Jingyu Li, Xiaonan Yang, Rui Hou, Yujie Ma, Yanqun Wang, Yang Ma, Wenchao Zhen, Yuanyuan Huang, Xin Fu, Zhengping Peng, Zhengping Peng, Mingxin Men

“…Structural equation modeling indicated that different N application treatments in loam influenced maize straw decomposition by altering the soil C/N ratio and bacterial community diversity, while in clay loam, N application treatments influenced maize straw decomposition mainly by altering the soil C/N ratio. Overall, the N4:6 treatment in loam and the N5:5 treatment in clay loam accelerated the decomposition and nutrient release of maize straw, enhanced SOC, TN, and bacterial community abundance, and provided a scientific basis for efficient straw utilization and sustainable agricultural development in the North China Plain region.…”
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Health literacy assessment and analysis of influencing factors in pregnant women with gestational diabetes mellitus in Southwest China by Fangmei Tang, Fangmei Tang, Li Gu, Li Gu, Xiujing Guo, Xiujing Guo, Wenjing Fu, Wenjing Fu, Benyi He, Yuqing Song, Yuqing Song, Dehua Li, Dehua Li

“…ObjectiveThe main objectives of our study are evaluating the health literacy level among women with gestational diabetes mellitus (GDM) in Southwest China and explore the influencing factors, using a multidimensional health literacy assessment scale (Chinese version of the HLS-14). …”
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Maintenance of patient-reported health-related quality of life post neoadjuvant relugolix prior to the initiation of prostate radiation therapy by Min Jung Koh, Min Ji Koh, Jessica Y. Hsueh, Lindsey Gallagher, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Michael Carrasquilla, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…Relugolix is a newly available oral GnRH receptor antagonist that achieves swift and profound castration (total testosterone <20 ng/dl) at high rates, which may shape patients’ health-related quality of life. The main objective of this prospective study was to explore the effects of neoadjuvant relugolix on health-related quality of life in prostate cancer patients immediately prior to stereotactic body radiation therapy (SBRT).MethodsPatients treated at Georgetown between January 2021 and September 2023 with neoadjuvant relugolix per an institutional protocol were included in the study (IRB 12-1775). …”
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Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…After inclusion in the trial and genotyping has been performed, subjects will be randomly allocated to experimental group (pharmacogenetic genotype-guided statin prescription) or standard-of-care statin prescription (as deemed by attending physician). The main objective is to assess the efficacy of a statin pre-emptive genotyping strategy in reducing the incidence of SAMS. …”
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Spatial and temporal changes of breast-conserving surgery rates and its influential factors among Chinese patients with breast cancer from 2013 to 2019: a registry-based study by Pengpeng Ye, Yuan Yang, Wei Hu, Lingyan Dai, Erwei Song, Shunrong Li, Liling Zhu, Kai Chen, Yanjie Xu, Xiaoyu Wang, Jianli Zhao, Jianrong He, Queran Lin, Tongrui Shang, Xiujuan Gui, Ziliang Zhong, Qianru Chen, Qing Yan, Xiaoliang Huang, Zijian Liang

“…Patients with non-metastatic breast cancer, who underwent breast surgery between 2013 and 2019, were included.Main outcomes and measures We analysed the BCS rate in Guangdong Province between 2013 and 2019. …”
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Resilience Based on Community-Oriented Capacities in Crisis Conditions by Mohammad Jalali, Mahdi Mahmoodzadeh Vashan, Nour Mohammad Yaghoubi, Mohammad Mohammadi

“…Therefore, nowadays, mainly the view that exists towards crisis management is to increase "resilience" in the face of various crises (Rafieiyan et al., 2011). …”
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WUJUD ARSITEKTUR RUMAH TRADISIONAL DI DELTA LAKKANG KOTA MAKASSAR by Marwati Marwati, A. Eka Oktawati

“…The layout in the traditional Lakkang house consisted of three front zones (terrace), center (living room) and back (bedroom and kitchen. The main circulation area was on the left side of the house (function: connecting the terrace and the kitchen). …”
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Clinical analysis of microscopic modified ostium obstruction surgery for symptomatic sacral Tarlov cysts by HUANG Qin‐guo, WU Yan‐yu, LI Hong, ZHOU Qiang, PENG Lin, LU Yun‐tao

“…Results A total of 74 cysts were detected in 35 patients, among which 49 (66.26%) were large cysts (diameter > 1.50 cm), and cysts mainly compressed S1 nerve roots (22 cysts, 29.73%) and S2 nerve roots (36 cysts, 48.65%), all of which had fistulas and nerve roots passing through them. …”
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Application of lacrimal gland ultrasonography in the evaluation of chronic ocular graft-versus-host-disease by Mingxia Zhong, Siyuan Liu, Jinghan Luo, Qin Zhang, Zhou Yang, Shanshan Zhang

“…Homogeneity and parenchymal vascularization were not found to be significantly correlated with ocular surface status.ConclusionThe ocular surface condition in oGVHD patients is worse than that observed in non-GVHD patients. The main manifestations include keratoconjunctival injury and a reduction in tear secretion and tear film stability. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Major population studies were mainly conducted in developed countries: the prevalence of self-reported olfactory dysfunction was 27% in Australia, 24.5% in USA, 19.4% in Spain, 19.1% in Sweden, and 4.5% in South Corea [3]. …”

A Study on the Yield Stability of Oilseed Sunflower Genotypes under Drought Stress by Nasrin Akbari, Reza Darvishzadeh

“…Stability indices are divided into two main groups: parametric and non-parametric stability indices. …”
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Evaluation of Dynamic Visual Perception of Riverside Interface in Mountainous Cities from the Perspective of Boating by Dan LUO, Ruhong WEI

“…By sorting out the space types, it is found that among the five types of visual units, namely the multi-level unit, characteristic unit, concave unit, filling unit and natural unit, the filling unit gets a lower score in the evaluation of interface perception, which is mainly affected by the less change of building level. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…We found no consistent evidence of differences in growth or physical function outcomes. The main limitation of our study was the restriction to one of two previous study districts, with possible survivor and selection bias.…”
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