Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects by Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama

“…IntroductionThe brain uses ketones, mainly 3-hydroxybutyrate (3-HB), as an alternative energy source. …”
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Altered Topological Properties of Grey Matter Structural Covariance Networks in Complete Thoracic Spinal Cord Injury Patients: A Graph Theoretical Network Analysis by Wen-Li Wang, Yu-Lin Li, Mou-Xiong Zheng, Xu-Yun Hua, Jia-Jia Wu, Fei-Fei Yang, Nan Yang, Xia He, Li-Juan Ao, Jian-Guang Xu

“…SCI patients would experience depressive and/or anxious feelings at the early stage. Their GMV reduction mainly involved psychology-cognition related rather than sensorimotor brain regions. …”
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Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…Hence, identifying the main contributors of these disparities will help health policy makers, program designers and implementers for the reduction of composite index of anthropometric failures in children under-5 years old in the study areas. …”
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Visual analysis of Traditional Chinese Medicine nursing for lung cancer patients with chemotherapy induced nausea and vomiting based on CiteSpace (基于CiteSpace的肺癌患者化疗相关性恶心呕吐中医护理研究热点... by LIN Haiqing (林海青), CHEN Yang (陈扬), LIU Jie (刘杰), HOU Yanli (侯燕丽), BAI Xue (白雪), CHEN Mengna (陈梦娜), TANG Xinyu (唐新宇)

“…The keywords were acupoint application and acupoint injection, and researches focused mainly on the effect of TCM nursing on patients’ quality of life. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…The problems found in the current healthcare model were grouped into ten main areas: (1) the healthcare model for RDs; (2) coordination with primary healthcare providers and other tertiary and secondary hospitals; (3) access to and coordination with non-medical services; (4) the role of case manager in the XUEC; (5) genetic diagnosis; (6) undiagnosed patients; (7) treatments; (8) referring process, continuous follow-up, and transition from pediatric to adult centers; (9) research and education for professionals; and (10) associations of PLWRD and their families (patients’ advocacy). …”
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Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover tr... by Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

“…Participants and researchers were blinded. The main outcomes were the reduction of blood pressure and safety outcomes. …”
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Correlation between nursing dependence and discharge readiness in middle-aged and elderly patients undergoing coronary artery bypass grafting (中老年冠状动脉旁路移植术后患者护理依赖与出院准备度的相关性研究)... by JI Yanxia (纪延霞), ZHENG Donglian (金亚楠), MA Xiaoying (郑栋莲), MA Fuzhen (马晓莹), JIN Yanan (马富珍), GUO Shuping (郭淑萍)

“…Conclusion Age and medical payment ratio were the main factors affecting the degree of nursing dependence of patients. …”
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'Which treatment do you believe you received?' A randomised blinding feasibility trial of spinal manual therapy by Javier Muñoz Laguna, Astrid Kurmann, Léonie Hofstetter, Emanuela Nyantakyi, Julia Braun, Lauren Clack, Heejung Bang, Mazda Farshad, Nadine E. Foster, Milo A. Puhan, Cesar A. Hincapié, the SALuBRITY Blinding Clinician Group

“…Abstract Background Blinding is essential for mitigating biases in trials of low back pain (LBP). Our main objectives were to assess the feasibility of blinding: (1) participants randomly allocated to active or placebo spinal manual therapy (SMT), and (2) outcome assessors. …”
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MaxEnt-Based Predictions of Suitable Potential Distribution of <i>Leymus secalinus</i> Under Current and Future Climate Change by Shimeng Zhao, Zongxian Zhang, Changyu Gao, Yiding Dong, Zeyao Jing, Lixia Du, Xiangyang Hou

“…The results showed the following: (1) Mean diurnal temperature range, annual mean temperature, precipitation of the wettest quarter, and elevation are the major factors impacting the distribution of <i>L. secalinus</i>. (2) Under the current climatic conditions, <i>L. secalinus</i> is mainly distributed in the farming–pastoral ecotone of northern China; in addition, certain suitable areas also exist in parts of Xinjiang, Tibet, Sichuan, Heilongjiang, and Jilin. (3) Under future climate change scenarios, the suitable areas for <i>L. secalinus</i> are generally the same as at present, with slight changes in area under different scenarios, with the largest expansion of 97,222 km² of suitable area in 2021–2040 under the SSP1-26 scenario and the largest shrinkage of potential suitable area in 2061–2080 under the SSP2-45 scenario, with 87,983 km². …”
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Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia by Muazzam Sheriff Maqbul, Reem Saleh Alzaki, Reema Sami Meeralam, Norah Abdulmajeed Alqutami, Bayan Mohammed Alturki, Lina Sultan Alhazmi, Reem Mamdouh Alaseeri, Lama Saad Alghamdi, Reem Khalid bin Brik, Shaima Tariq Mansoor Beig, Muath Saeed Alamri, Wjood Abdullah A. Alshehri, Turki Ayed Almutairi, Maha Abdullah Alqurashi, Ahmed Jamal Nasef

“…The study revealed a high PUD prevalence, with 463 respondents (82.53 ​%) reporting a history of the disease, primarily gastric ulcers (256 cases, 45.63 ​%) and duodenal ulcers (207 cases, 36.89 ​%). Treatment mainly involved outpatient antibiotic use (419 respondents, 74.68 ​%), while 44 respondents (7.84 ​%) required hospitalization. …”
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Spatio-temporal dynamics of speleothem growth and glaciation in the British Isles by S. Panitz, S. Panitz, M. Rogerson, J. Longman, N. Scroxton, T. J. Lawson, T. C. Atkinson, V. Ersek, J. Baldini, L. Baldini, S. Umbo, M. A. Lone, G. M. Henderson, S. F. M. Breitenbach

“…Whilst undersampling is currently the main limitation for speleothem-based ice and permafrost reconstruction even in relatively well-sampled parts of the British Isles, we show that speleothem dates obtained using modern mass spectrometry techniques reveal a higher spatio-temporal resolution of glacial–interglacial cycles and glacial extent than previously possible. …”
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Optimization and characterization studies of poultry waste valorization for peptone production using a newly Egyptian Bacillus subtilis strain by Hajar Saeed, Anthony Ragaey, Ziad Samy, Viola Ashraf, Aly ElMostafa, Norhan Ahmad, Enjy Bebawy, Nour ElHoda M. Sorour, Salwa M. El-Sayed, Ashraf Bakry, Naglaa Ebeed, Hesham Elhariry, Thanaa El-Noby, Samah H. Abu-Hussien

“…For screening the most significant factors for peptone production, the Plackett–Burman design identified meat and bone meal concentration as the main significant factor influencing total amino acid reaching 420 mg/mL. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Eligible individuals were diagnosed with HIV, ≥40 years of age, naïve to antiretroviral therapy (ART), had no dementia at the index date and were followed for ≥1 year during 2002–2016. Our main outcome was incident dementia. We examined the effect of sociodemographic and clinical covariates on the incidence of dementia using a cause-specific hazard (CSH) model, with all-cause mortality as a competing risk event.Results Among 5121 eligible PLWH, 108 (2%) developed dementia. …”
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Long-term Impact of Carotid Endarterectomy on Choroidal and Choriocapillaris Perfusion: The INFLATE Study by Alessandro Berni, MD, Yi Zhang, PhD, Sandy Zhou Wenting, MD, Natalie Noam, MD, David Rabinovitch, BSc, Basheer Sheick Yousif, MD, Gissel Herrera, MD, Mengxi Shen, MD, PhD, Robert O’Brien, PhD, Giovanni Gregori, PhD, Ruikang K. Wang, PhD, Philip J. Rosenfeld, MD, PhD, Omer Trivizki, MD

“…Multivariable regression analysis was conducted to evaluate the impact of baseline demographic and clinical factors on the changes in choroidal and CC parameters. Main Outcome Measures: Both the short- and long-term changes in MCT, CVI, CVV, CC FD%, and CC thickness. …”
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Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of athe... by Yifeng Zhang, Yifeng Zhang, Shuxian Lu, Shuxian Lu, Liang Qiu, Liang Qiu, Manman Qin, Manman Qin, Dan Shan, Lianhua Xie, Yao Yi, Yao Yi, Jun Yu

“…The five transcription factors (TEFC, IRF8, ZNF267, KLF2, and JUNB), identified as key targets associated with the function and the number of Tregs driving the progression of AS, primarily regulate immune response, ubiquitination, cytokine production, and T-cell differentiation pathways. ZNF267 may mainly involve in regulating ubiquitination, TGF-beta, and MAPK pathways of Tregs to regulate the function and the number of Tregs during the progress of AS. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Moreover, energy metabolism and amino acid metabolism were the main signaling pathways in response to cold stress for <i>P. sinensis</i>.…”
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Identification of Three Significant Genes Associated with Immune Cells Infiltration in Dysfunctional Adipose Tissue-Induced Insulin-Resistance of Obese Patients via Comprehensive B... by Ming Zhai, Peipei Luan, Yefei Shi, Bo Li, Jianhua Kang, Fan Hu, Mingjie Li, Lei Du, Donglei Zhou, Weixia Jian, Wenhui Peng

“…Thirty DEGs were commonly expressed across three datasets, most of which were upregulated. DEGs mainly participated in the process of multiple immune cells’ infiltration. …”
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Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <em>Vibrio cholerae</em> from Seventh Pandemic by Xiaorui Li, Yu Han, Wenxuan Zhao, Yue Xiao, Siyu Huang, Zhenpeng Li, Fenxia Fan, Weili Liang, Biao Kan

“…CTXΦ is a lysogenic filamentous phage that carries the genes encoding cholera toxin (<i>ctxAB</i>), the main virulence factor of <i>Vibrio cholerae</i>. …”
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Evaluation of the Residues of Rice (Oryza sativa L.), Black-Eyed Pea (Vigna unguiculata L.), Dill (Anethum graveolens L.), and Aubergine (Solanum melongena L.) on Characteristics o... by Einollah Hesami, Mohsen Jahan

“…Due to the fact that in dry areas such as North Khuzestan, the role of pre-cultivated plants and the effect of their residues on growth and performance have been studied less, this research can be done in different humidity conditions before planting the main plant, and the effects of plant residues and their role on the qualitative characteristics and organic matter of the soil and the performance of plants such as corn are promising and help farmers and researchers. …”
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Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study by Janey Sewell, Carole Kelly, Adamma Aghaizu, Hannah Kitt, Annegret Pelchen-Matthews, Veronique Martin, Amal Farah, Colette Smith, Alison Brown, Clare Humphreys, Alex Sparrowhawk, Valerie Delpech, Alison Rodger, Fiona Lampe, Meaghan Kall

“…At the start of 2023, the study was underrecruiting, mainly due to the mpox outbreak, and a separate sequential recruitment strategy was initiated in 14 of the largest and most demographically diverse clinics to increase participant numbers. …”
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