Deficit irrigation enhances yield and water productivity of apples by inhibiting excessive vegetative growth and improving photosynthetic performance by Shenglin Wen, Ningbo Cui, Yaosheng Wang, Daozhi Gong, Liwen Xing, Zongjun Wu, Yixuan Zhang, Zhihui Wang

“…The indirect negative effect of leaf area index (LAI) on WP was mainly through its positive effect on water consumption (ET) and ET's subsequent negative effect on WP. …”
Get full text

Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…The dimensionality reduction techniques Principal Component Analysis (PCA) and Multidimensional Scaling (MDS) were employed to explore data patterns. Main outcome measures: Reproducibility of TRT measurements, image quality, and the degree of agreement between the two OCT models. …”
Get full text

Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection by Aya Ishizaka, Azumi Tamura, Michiko Koga, Taketoshi Mizutani, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Atsuhiro Yasuhara, Shinya Yamamoto, Hiroyuki Nagai, Eisuke Adachi, Yutaka Suzuki, Yoshihiro Kawaoka, Hiroshi Yotsuyanagi

“…In classifying phages based on host bacteria, a decreased number of phages infecting mainly the Clostridia class was observed immediately after the onset of COVID-19 and recovered over time. …”
Get full text

Behavioral factors associated with SARS-CoV-2 infection. Results from a web-based case-control survey in the Capital Region of Denmark by Mikkel Porsborg Andersen, Christian Torp-Pedersen, Helle Collatz Christensen, Ulrik Pedersen-Bjergaard, Thomas Alexander Gerds, Amalie Lykkemark Moeller, Birgitte Lindegaard, Mille Dybdal Cajar, Florence Chia Chin Tan, Mogens Karsboel Boisen, Sebastian Moretto Krog, Rúna Nolsoee, Peter Lommer Kristensen, Thomas Broe Christensen, Maria Elisabeth Lendorf

“…Controls were matched on sex, age, test date and municipality.Exposure Activities during the 14 days prior to being tested positive for SARS-CoV-2 or during the same period for matched controls and precautions taken during the entire pandemic.Main outcomes and measures SARS-CoV-2 infection incidence rate ratios (IRR).Results Response rate was 41.4% (n=93 121). …”
Get full text

Virtual reality-based cognitive–behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction: a randomised clinical trial by Jiajun Weng, Junbo Ge, Jiajia Liu, Juying Qian, Xiao Huang, Yuanyuan Li, Juan Peng, Yan'e Lu, Dong Huang, Pingyuan Yang, Shikun Xu, Lihua Guan, Qibing Wang, Zexin Zhao, Yabin Wei

“…Cybersickness was the main reported adverse event (n=5).Conclusions Our results indicate that VR-CBT can significantly reduce post-AMI anxiety at the acute stage of the illness; the improvement was maintained at the 3-month follow-up.Trial registration number The trial was registered at www.chictr.org.cn with the identifier: ChiCTR2200066435.…”
Get full text

The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation by Ke Yuan, Chunyou Lai, Lingling Wei, Tianhang Feng, Qinyan Yang, Tianying Zhang, Tao Lan, Yutong Yao, Guangming Xiang, Xiaolun Huang

“…In addition, the analysis of CM-DiI-labeled BMSCs showed that the BMSC+VEGF group exhibited better cell engraftment and that the engrafted cells were mainly distributed in the hepatic parenchyma. Furthermore, compared with the other situation, it is best to reconstitute the liver secretion and regeneration function of rats after combined application of VEGF and BMSC. …”
Get full text

Case Report: Efficacy and safety of recombinant growth hormone therapy in a girl with Loeys–Dietz syndrome by Kamil Dyrka, Aleksander Jamsheer, Michal Bartecki, Waldemar Bobkowski, Malgorzata Pawelec-Wojtalik, Justyna Rajewska-Tabor, Andzelika Tomaszewska, Justyna Balcerzak, Zuzanna Aniol, Marek Niedziela, Monika Obara-Moszynska

“…However, whether IGF-1, the main biochemical marker of GH activity, can be independently associated with increased aortic diameter has not been determined. …”
Get full text

Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ by Yong-Jik Lee, Hyun Soo Kim, Hong Seog Seo, Jin Oh Na, You-Na Jang, Yoon-Mi Han, Hyun-Min Kim

“…In addition, the action mechanism of α1-adrenergic receptor may be mainly exerted via PPARδ.…”
Get full text

Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Regarding its role in cancer development/progression, paradoxical results exist in the literature and it is still unclear whether HMGB1 mainly acts as an oncogene or a tumor suppressor.Methods HMGB1 expression was first assessed in tissue specimens (n=359) of invasive breast, lung and cervical cancer and the two distinct staining patterns detected (nuclear vs cytoplasmic) were correlated to the secretion profile of malignant cells, patient outcomes and the presence of infiltrating immune cells within tumor microenvironment. …”
Get full text

Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…River-borne populations of SRP were composed mainly of Pectobacterium versatile and P. aquaticum that have little known epidemiological importance. …”
Get full text

Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts by Feng Ding, Wanfei Liu, Chi Wu, Chi Wu, Wensi Zhang, Shuyan Chen, Shuyan Chen, Wenjie Lai, Wenjie Lai, Jiayao Qu, Jiayao Qu, Qiang Lin, Shuihua Lu, Jiuxin Qu, Jiuxin Qu

“…Six of 12 patients had mixed and pure samples together, and major strains of mixed samples were closer to corresponding pure strains than minor strains.ConclusionsThis retrospective study, conducted at the only municipal hospital specializing in infectious diseases in Shenzhen, provides the opportunity to understand drug resistance of TB patients, which mainly are refractory patients. The study revealed transmission patterns of MTB, analyzed mixed infections, and tracked changes in MTB strains during short/long-term treatment.…”
Get full text

Comparison of the effects of production and processing parameters on the eating quality of lamb by L.J. Farmer, A.W. Gordon, D.W. Sanderson, J.S. Speers, T.D.J. Hagan, E.L. Swancott, J.L. Evans, D.J. Richards, E.M. Thomas

“…There was no significant effect of lamb finishing diet, abattoir, preslaughter daily liveweight gain or transportation time on any of the consumer sensory scores. The main factors tested that provide practical scope for improving the eating quality of lamb were ageing of the meat, carcase hanging and meat packaging. …”
Get full text

Anesthesia for pregnant patients with symptomatic neurological disease: 13 years’ experience from a tertiary care center by Stefano Catarci, Bruno Antonio Zanfini, Marco Scorzoni, Salvatore De Martino, Pietro Paolo Giuri, Luciano Frassanito, Gian Luigi Gonnella, Emanuele Capone, Francesco Vitale Di Maio, Giovanni Maddaloni, Antonio Lanzone, Gaetano Draisci

“…Results Data from 49,202 pregnant women were assessed over 13 years; 239 pregnant women with a diagnosis of preexisting neurological disease and who reported significant neurological symptoms during pregnancy were identified (prevalence 0.49%). The main neurological disorders that affected pregnant women included vascular abnormalities and intracranial bleeding (N = 42, 17.6%), central nervous system tumors (N = 35, 14.6%), epilepsy and episodic and paroxysmal disorders of the central nervous system (N = 34, 14.2%), diseases of the neuromuscular junction and muscles (N = 26, 10.9%), demyelinating central nervous system diseases (N = 24, 10%). …”
Get full text

HOTSED: A new integrated model for assessing potential hotspots of sediment sources and related sediment dynamics at watershed scale by Manuel La Licata, Alberto Bosino, Seyed Hamidreza Sadeghi, Mattia De Amicis, Andrea Mandarino, Andrea Terret, Michael Maerker

“…HOTSED revealed hotspots with a very high hazard potential located near main channels or upstream of the reservoir. These areas are often linked with active landslides highly connected to the drainage system and frequently associated with other processes like bank erosion or surficial soil erosion. …”
Get full text

Effects of time-of-day on the noradrenaline, adrenaline, cortisol and blood lipidome response to an ice bath by Alexander Braunsperger, Maximilian Bauer, Chaima Ben Brahim, Lea Seep, Dominik Tischer, Mirko Peitzsch, Jan Hasenauer, Sieglinde Hechenbichler Figueroa, Anna Worthmann, Joerg Heeren, Kenneth A. Dyar, Karsten Koehler, Ana Soriano-Arroquia, Martin Schönfelder, Henning Wackerhage

“…There was no difference in the hormonal and lipidome response to an ice bath between women and men. The main finding of the study was that noradrenaline, adrenaline, cortisol and plasma lipidome responses are similar after an ice bath in the morning and evening. …”
Get full text

Multispecies pasture diet and cow breed affect the functional lipid profile of milk across lactation in a spring-calving dairy system by Renata Kostovska, Gaetan Drouin, Joaquín J. Salas, Mónica Venegas-Calerón, Brendan Horan, John T. Tobin, Tom F. O'Callaghan, Sean A. Hogan, Alan L. Kelly, Laura G. Gómez-Mascaraque

“…The triglyceride and PL profiles were mainly affected by stage of lactation. Overall, these results show the effects of cow diet, breed, and stage of lactation on milk lipid profile, with important implications for the nutritional and techno-functional characteristics of dairy products.…”
Get full text

β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease by Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong

“…Abstract Background β-synuclein (β-syn), mainly expressed in central nerve system, is one of the biomarkers in cerebrospinal fluid (CSF) and blood for synaptic damage, which has been reported to be elevated in CSF and blood of the patients of prion diseases (PrDs). …”
Get full text

The microbiota of cork and yellow stain as a model for a new route for the synthesis of chlorophenols and chloroanisoles from the microbial degradation of suberin and/or lignin by Marina Ruiz-Muñoz, Ignacio Ontañón, Rebeca Cobos, Carla Calvo-Peña, Rebeca Otero-Suárez, Vicente Ferreira, Jordi Roselló, Juan José R. Coque

“…Abstract Background The main application of cork is the production of stoppers for wine bottles. …”
Get full text

Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-in... by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…Finally, human protein chips and molecular docking were carried out to confirm the binding of the main component of XYP injection, andrographolide, with SERPINB2/PAI-2 protein. …”
Get full text

Shining light on knee osteoarthritis: an overview of vitamin D supplementation studies by Di Zhang, Miaoyu Ye, Yao Xu, Luyu Jiang, Yanmei Hu, Qi Zhang, Xiao Han, Qian Dai, Junhui Qian, Jian Luo, Qiang Yuan

“…Bias risk and imprecision were the main factors for downgrading. The calculation of RCT overlap between SR/MA using CCA showed a high degree of overlap.ConclusionVitamin D supplementation may show potential efficacy in ameliorating symptoms of KOA. …”
Get full text