Etoposide targets 2A protease to inhibit enterovirus 71 replication by Qinqin Liang, Sai Shi, Qingjie Zhang, Yaxin Wang, Sheng Ye, Binghong Xu

“…Furthermore, both molecular dynamics simulations and site-directed mutagenesis assays revealed that Etoposide inhibited the activity of the EV71 2A protease by mainly binding to two residues, Y89 and P107. The findings indicate that Etoposide serves as a promising inhibitor of the EV71 2Apro, demonstrating strong antiviral properties and positioning itself as a formidable candidate for clinical trials against EV71.IMPORTANCEWe first used a drug screening approach focused on monomeric compounds and their derivatives from traditional Chinese medicine to identify an EV71 2Apro inhibitor—Etoposide. …”
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Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism by Rui Yang, Dan Chen, Yanling Chen, Yage Ma, Chaoyin Chen, Shenglan Zhao

“…Metabonomics analysis identified that a total of 19 potential biomarkers were screened out from the differential metabolites with |log2FC| > 1, VIP > 1 and p < 0.05.ConclusionWalnut oil can significantly prevent hyperlipidemia caused by high-fat diet. The mechanism is mainly through significantly reducing the content of MDA and the activities of ALT and AST, significantly increasing the activity of GSH-PX, and improving intestinal flora and liver metabolism.…”
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Response of Tree Seedlings to a Combined Treatment of Particulate Matter, Ground-Level Ozone, and Carbon Dioxide: Primary Effects by Valentinas Černiauskas, Iveta Varnagirytė-Kabašinskienė, Ieva Čėsnienė, Emilis Armoška, Valda Araminienė

“….); and Norway maple (<i>Acer platanoides</i> L.). The main objectives of this paper were to evaluate the seedling stem growth response and the biochemical response of seedling foliage to pollutant exposure. …”
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Factors and Reasons Associated with Hesitating to Seek Care for Migraine: Results of the OVERCOME (US) Study by Robert E. Shapiro, Eva Jolanda Muenzel, Robert A. Nicholson, Anthony J. Zagar, Michael L. Reed, Dawn C. Buse, Susan Hutchinson, Sait Ashina, Eric M. Pearlman, Richard B. Lipton

“…The most common reasons participants stated for hesitating included (1) 44.2% wanting to try and take care of migraine on their own, (2) 33.8% feeling that their migraine or headache would not be taken seriously, (3) 29.2% thinking that their migraine was not serious/painful enough, and (4) 27.4% not being able to afford it or not wanting to spend the money. The main limitation of the study includes the requirement for respondents to have internet, access which may have reflected cohort bias, and the quota sampling rather than random sampling to create a demographically representative sample. …”
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Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

“…To date, no comprehensive review regarding both the benefits and risks of marathon running on different organ systems has been published. Main Body The aim of this review was to provide a comprehensive review of the benefits and risks of marathon training and racing on different organ systems. …”
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The Mechanisms of Guaranteeing the Right to Clean Air in Iran and International Documents by Fatemeh Hamidi, Maryam Afshari, Ali Mashhadi

“…Therefore, taking measures to reform the existing structures based on scientific principles and applying the laws and experiences of other countries in the world to deal with air pollution are among the main priorities. The distinction of this research is to investigate the role of international guarantees and documents and Iranian laws in dealing with air pollution, so this research seeks to bridge the gap between domestic laws and documents in comparison with international laws.Materials and Methods: The present study is in the group of applied research in terms of objectives and nature, and an analytical-descriptive method has been used in its conduct. …”
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Defining Nocturnal Polyuria in Adolescents by Tasmia Promi, Anthony Brooks, Gulzhan Tologonova, Marie-Claire Roberts, Sarita Dhuper, Meseret Tena, Oluwatoyin Bamgbola, Monique Hanono, Jeffrey P. Weiss, Karel Everaert, Tine DeBacker, Thomas F. Monaghan, Louis Salciccioli, Stephen Wadowski, Elka Jacobson-Dickman, Jason M. Lazar

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KATALIKYBĖ IR VISUOMENĖ TARPUKARIO LIETUVOJE by Valdas Pruskus

“…In this way it would more widely open itself to the world and because of an acceptance of believers and unbelievers would really become the Mother for everybody. A priest is a main worker of the Church on the Earth, and the image of the Church in the society depends on his actions and the example set by his style of life. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Artificial viral mimetic Ag43β 700_RBD OMVs were fabricated by self-assembly through membrane disruption of the Ag43β 700_RBD E. coli using a chemical detergent mainly containing lysozyme. Through serial centrifugation to purify fabricated OMVs, spherical Ag43β 700_RBD OMVs with an average diameter of 218 nm were obtained. …”
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Establishment and maturation of gut microbiota in White King pigeon squabs: role of pigeon milk by Xiaoqin Xu, Xiaoqin Xu, Zihan Wang, Zihan Wang, Yi Jian, Long Zhang, Long Zhang, Caiquan Zhou, Caiquan Zhou, Li Liu, Hui Liu

“…At the genus level, the main dominant bacterial groups included Lactobacillus, Limosilactobacillus, and Turicibacter. …”
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Role of Sling Tuina Exercise Technique in Improving Paraspinal Muscle Asymmetry in Patients with Adolescent Idiopathic Scoliosis by LIU Min, MA Zhaoshui, XU Qiangqiang, LI Li

“…The experimental group was treated with sling Tuina exercise technique which mainly included adjusting the position of the spine to restore the neutral position, the methods of plucking, pressing and pushing and other techniques to act back and forth on the Governor vessel, bladder meridian and the convex-concave side of the paravertebral muscle dialectical tonifying and reducing therapy, neutral position control training in supine, prone and lateral position, trunk flexion, extension, rotation and lateral flexion closed chain movement training with the assistance of sling equipment. …”
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Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression by Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F

“…Tianxing Fang,1– 4 Liyu Hu,5 Tianshun Chen,4 Fei Li,6 Liu Yang,4 Bin Liang,7 Wenjun Wang,8 Fancai Zeng4 1Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of China; 3Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 4Laboratory of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 5Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 6Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 7Department of General Surgery (Breast Surgery), the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 8Institute for Cancer Medicine and School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence: Fancai Zeng; Wenjun Wang, Email zfcai@swmu.edu.cn; wenjunwang1213@126.comBackground: Breast cancer (BC) has become the main malignant tumor threatening the health of women worldwide. …”
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Kinerja Metode Rank Sum, Rank Reciprocal dan Rank Order Centroid Menggunakan Referensi Poin Moora (Studi Kasus: Bantuan Kuota Data Internet untuk Mahasiswa) by Ummul Hairah, Edy Budiman

“…Differences in criterion weights, even the slightest change in weight, can drastically change the final decision. The main objective of this research is to offer an implementation multi-criteria decision-making (MCDM) method in distributing internet data quota assistance for students' learning online from home to be right on target based on the needs. …”
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DepITCM: an audio-visual method for detecting depression by Lishan Zhang, Lishan Zhang, Zhenhua Liu, Yumei Wan, Yunli Fan, Diancai Chen, Qingxiang Wang, Kaihong Zhang, Yunshao Zheng

“…The resolution of these issues is crucial for constructing models of depression detection.MethodsIn this paper, we propose a multi-task representation learning based on vision and audio for depression detection model (DepITCM).The model comprises three main modules: a data preprocessing module, the Inception-Temporal-Channel Principal Component Analysis Module(ITCM Encoder), and a multi-task learning module. …”
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Une double discordance cardiaque complexe décompensée, à propos d’un cas et revue de la littérature by Nabila Soufi Taleb Bendiab, Rachid Djaziri, Fouad Sekkal, Nesrine Khedim, Abderrahim Meziane-Tani

“…Its prognosis depends mainly on other associated congenital heart defects, arrhythmias and disorders of the conduction, as well as systolic function of the right ventricle in the systemic position. …”
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Characteristics and outcomes of women using emergency medical services for third-trimester pregnancy-related problems in India: a prospective observational study by Jennifer A Newberry, Corey B Bills, Elizabeth A Pirrotta, Matthew C Strehlow, G V Ramana Rao, Hyeyoun (Elise) Min, Ann E Evensen, Lawrence Leeman, S V Mahadevan

“…Interfacility transfers, patients absent on ambulance arrival and patients refusing care were excluded.Main outcome measures Emergency medical technician (EMT) interventions, method of delivery and death.Results The median age enrolled was 23 years (IQR 21–25). …”
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Energy management education for persons living with long COVID-related fatigue (EMERGE): protocol of a two-parallel arms target trial emulation study in a multicentre outpatient in... by Emilia Riggi, Marco Barbero, Gian Luca Di Tanna, Ruth Hersche, Andrea Weise

“…Four self-reported questionnaires (fatigue impact, self-efficacy in performing energy management strategies, competency in performing daily activities, health-related quality of life) will be administered at baseline (T0; week 0), after lesson 7 (T1; week 6), post-intervention (T2; week 14) and follow-up (T3, week 24). Our main assessment will be at T2. Disease-related and productivity cost data will be collected, and a cost-effectiveness profile of the EME intervention will be compared with standard care.Ethics and dissemination Ethical approval has been obtained from the competent Swiss ethics commission.Findings will be reported (1) to the study participants; (2) to patient organisations and hospitals supporting EMERGE; (3) to funding bodies; (4) to the national and international occupational therapy community and healthcare policy; (5) will be presented at local, national, and international conferences and (6) will be disseminated by peer-review publications.…”
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Assessing the potential of germplasm collections for the management of genetic diversity: the case of the French National Cryobank by Jacques, Alicia, Duclos, Delphine, Danchin-Burge, Coralie, Mercat, Marie-José, Tixier-Boichard, Michèle, Restoux, Gwendal

“…Overall, breeds with a large commercial distribution had more donors in the collection than local breeds, while the number of doses available was mainly determined by the physiology of the species. …”
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Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…AREG and TGFBI were pDC marker genes, CXCR3 and CD27 were significantly expressed in T cell-related cells, while MS4A1 and CD19 were mainly expressed in B naïve cells. Conclusions. This study revealed dynamic changes in cell percentage and heterogeneity of cell subtypes of HNSCC. …”
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Predictors and prognosis of elderly hip fracture patients with perioperative atrial fibrillation: a nested case–control study by Wei Li, Aoying Min, Wei Zhao, Weining Li, Shuhan Li, Saidi Ran, Mingming Fu, Qili Yu, Junkai Kou, Zhiqian Wang, Zhiyong Hou

“…Based on COX regression analysis, we found that the main risk factors for all-cause death in elderly hip fracture patients with AF were concomitant pulmonary infection(HR 2.006,95%CI 1.019–3.949, P = 0.044), hyponatremia(HR 2.417,95%CI 1.177–4.961, P = 0.016), permanent AF(HR 2.806, 95%CI 1.036–4.198, P = 0.039). …”
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