Chondroitin Sulphate-Chitosan Based Nanogels Loaded with Naringenin-β-Cyclodextrin Complex as Potential Tool for the Treatment of Diabetic Retinopathy: A Formulation Study by Zucca G, Vigani B, Valentino C, Ruggeri M, Marchesi N, Pascale A, Giovilli G, Malavasi L, Sandri G, Rossi S

“…Gaia Zucca,1 Barbara Vigani,1 Caterina Valentino,1 Marco Ruggeri,1 Nicoletta Marchesi,1 Alessia Pascale,1 Giulia Giovilli,2 Lorenzo Malavasi,2 Giuseppina Sandri,1 Silvia Rossi1 1Department of Drug Sciences, University of Pavia, Pavia, 27100, Italy; 2Department of Chemistry and INSTM, University of Pavia, Pavia, 27100, ItalyCorrespondence: Silvia Rossi; Barbara Vigani, Department of Drug Sciences, University of Pavia, Via Taramelli 12, Pavia, 27100, Italy, Email silvia.rossi@unipv.it; barbara.vigani@unipv.itPurpose: The main purpose of the study was the formulation development of nanogels (NHs) composed of chondroitin sulfate (CS) and low molecular weight chitosan (lCH), loaded with a naringenin-β-cyclodextrin complex (NAR/β-CD), as a potential treatment for early-stage diabetic retinopathy.Methods: Different formulations of NHs were prepared by varying polymer concentration, lCH ratio, and pH and, then, characterized for particle size, zeta potential, particle concentration (particles/mL) and morphology. …”
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Perancangan User Experience Aplikasi E-Business Pasar Tradisional Dengan Metode Human Centered Design (Studi Kasus: Pasar Oro-Oro Dowo) by Indrihana Kharismaning Larasati, Widhy Hayuhardhika Nugraha Putra, Retno Indah Rokhmawati

“…However, the solution has not been able to provide an easy user experience, and several functions that are still separated from the main platform make this solution less effective. …”
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¿La combinación dolutegravir y rifampicina en los pacientes no incluidos en los ensayos clínicos es también eficaz y segura en el binomio VIH-infección micobacteriana? Casos de la... by Sara Fontserè Recuenco, Rafael Luque-Márquez

“…Results: Thirteen from 18 were men, 46 years (interquartile range [IQR]: 38–49), diagnosed of HIV or treated since 1.8 years (IQR: 0.1–12), presenting mainly disseminated mycobacterial infections (11 of 18 cases). …”
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Perbandingan Metode Simple Additive Weighting dan Analytic Hierarchy Process Untuk Pemilihan Supplier pada Restoran by Yulaikha Maratullatifah, Catur Edi Widodo, Kusworo Adi

“…Abstract Kedai Susu Its Milk is a restaurant in the culinary field with a characteristic menu of milk processing, the main ingredient of pure cow's milk is located on Jalan Taman Siswa Unnes Gunungpati Semarang. …”
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Danggui-Shaoyao-San Can Ameliorate Alzheimer’s Disease by Inhibiting Hippocampal Neuron Apoptosis: Findings from Serum Pharmacology by Zhang KX, Zhang JW, Jiang YH, Wang YR, Liu ZL, Ding PL, Wang XY, Cui WQ, Xu XQ, Wang YH

“…DSS serum can increase the cell viability of HT-22 and reduce apoptosis mainly by alleviating mitochondrial calcium overloading.Conclusion: DSS can modulate the calcium signaling pathway and enhance the cAMP/PKA/CREB signaling pathway to ameliorate Tau aberrant phosphorylation, cognitive deficits and neuronal apoptosis after AD. …”
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Spatiotemporal analysis of oil palm land clearing by M.K. Rosyidy, E. Frimawaty

“…This condition has led to oil palm plantation intensification, which has been extensive to deforestation in Indonesia, including Jambi province. The main aim of this investigation is to evaluate deforestation and land change affected by oil palm expansion conducted by smallholders, which influences environmental change using remote sensing combined with a geographic information system approach. …”
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Randomised controlled trial of topical kanuka honey for the treatment of rosacea by James Fingleton, Mark Weatherall, Richard Beasley, Irene Braithwaite, Janwillem Kocks, Mark Holliday, Andrew Corin, Colin Helm, Davitt Sheahan, Barney Montgomery, Judith Riley, Anna Hunt, Christopher Tofield

“…Objective To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.Design Randomised controlled trial with blinded assessment of primary outcome variable.Setting Outpatient primary healthcare population from 5 New Zealand sites.Participants 138 adults aged ≥16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.Interventions Participants were randomly allocated 1:1 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks.Main outcome measures The primary outcome measure was the proportion of participants who had a ≥2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. …”
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Efficacy and Safety of Transcranial Magnetic Stimulation for Attention‐Deficit Hyperactivity Disorder: A Systematic Review and Meta‐Analysis by Binbin Fu, Xiangyue Zhou, Xuan Zhou, Xin Li, Zhengquan Chen, Yanbin Zhang, Qing Du

“…Extracted data from the included studies involved patient characteristics, intervention protocols, and main outcomes. The effect size of the TMS treatment was evaluated using the standardized mean difference (SMD) with a 95% confidence interval (CI), calculated with either a random effects model or fixed effects model depending on the level of heterogeneity. …”
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Explainable artificial intelligence in web phishing classification on secure IoT with cloud-based cyber-physical systems by Sultan Refa Alotaibi, Hend Khalid Alkahtani, Mohammed Aljebreen, Asma Alshuhail, Muhammad Kashif Saeed, Shouki A. Ebad, Wafa Sulaiman Almukadi, Moneerah Alotaibi

“…The developed XAIAOA-WPC approach mainly emphasizes the effectual classification and recognition of web phishing based on CPS. …”
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Designing a Multimodal and Culturally Relevant Alzheimer Disease and Related Dementia Generative Artificial Intelligence Tool for Black American Informal Caregivers: Cognitive Walk... by Cristina Bosco, Ege Otenen, John Osorio Torres, Vivian Nguyen, Darshil Chheda, Xinran Peng, Nenette M Jessup, Anna K Himes, Bianca Cureton, Yvonne Lu, Carl V Hill, Hugh C Hendrie, Priscilla A Barnes, Patrick C Shih

“…We asked them to perform 3 tasks on the mobile app (ie, searching for an article on brain health, searching for local events, and finally, searching for opportunities to participate in scientific research in their area), then we recorded their opinions and impressions. The main aspects to be evaluated were the mobile app’s usability, accessibility, cultural relevance, and adoption. …”
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Are Saudi Radiological Sciences Students Prepared for Emergencies? Exploring Knowledge, and Attitudes Towards Basic Life Support and Cardiopulmonary Resuscitation by Alshamrani KM, Alkhayyat AA, Arif RN, Alahmadi AAS, Aldahery ST, Alsharif WM, Qurashi AA

“…Hesitation to perform CPR was mainly due to fear of mistakes (53.6%) and harm concerns (31.1%).Conclusion: Our findings reveal significant gaps in knowledge, confidence, and preparedness for cardiac emergencies among Saudi radiological sciences students, with only 41.4% having completed BLS training. …”
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Study on sedimentary organic facies of coal-measure source rocks in Shuixigou Group, Taibei Sag, Tuha Basin by Hao LIANG, Tanguang FAN, Zhiyong WANG, Shu TAO, Yijie WEN, Haitian ZHENG, Zijian ZHANG

“…The coal-measure source rocks in the Jurassic Shuixigou Group are the main hydrocarbon source layers in the area, with significant hydrocarbon generation potential. …”
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Short Term Outcome of High Dose Dexamethasone Versus Prednisone In Children With Acute Immune Thrombocytopenic Purpura: A Single Center Trial by Ahmed Osama Kaddah, Niveen Salama, Doaa Maged Ahmed, Mariam Saad Nassim

“…Females and males were 16 (53.3%) and 14 (46.7%) in HD-DXM and 13 (43.3%) and 17 (56.7%) PDN groups (p=0.795). The main symptom was epistaxis in 30(50%) of cases, followed by purpura in 18(30%), gum bleeding in 10(16.6%), and subconjunctival hemorrhage in 2(3.4%). …”
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Hard and soft tissue alterations after the application of different soft tissue grafting materials during immediate dental implant placement: a systematic review and Bayesian netwo... by Ali Azadi, Fatemeh Rezaei, Atoosa Yazdani, Kimia Hejazi, Aryousha Moallem Savasari, Reza Amid, Mahdi Kadkhodazadeh

“…Methods Through an electronic search regarding the study’s main question (“In patients with non-restorable teeth, who receive immediate dental implants (P), what is the best adjunctive soft tissue grafting approach among different autogenous, allogenous, and xenogenous grafts (I), to achieve the desired hard and soft tissue structure (O), compared to sites without grafting (C)?”) …”
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Plastid genome comparison and phylogenetic analyses of the Chinese group of medicinal species and related taxa within Asparagus genus by Pingxuan Xie, Tinglu Wang, Jiawei Tan, Linyuan Fan, Changkun Liu, Hanjing Yan

“…Notably, medicinal Asparagus species were mainly found in Clade III. Although the phylogenetic relationships of most Asparagus species aligned with previous study findings, the phylogenetic positions of A. munitus, A. subscandens, A. gobicus, and A. dauricus were newly determined.ConclusionsThe plastomes of Asparagus are largely conserved in terms of genome structure, size, gene content, and arrangement. …”
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Diagnostic performance of CT for extrarenal fat invasion in renal cell carcinoma: a meta-analysis and systematic review by Junchao Ma, Enyu Yuan, Shijian Feng, Jin Yao, Chunlei He, Yuntian Chen, Bin Song

“…Abstract Objectives Renal cell carcinoma (RCC) with extrarenal fat (perinephric or renal sinus fat) invasion is the main evidence for the T3a stage. Currently, computed tomography (CT) is still the primary modality for staging RCC. …”
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Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study by Huaxing Meng, Bo Liu, Xiaoting Lu, Yan Tan, Shanshan Wang, Baolong Pan, Hui Zhang, Qiao Niu

“…Significant alterations in hippocampal FC were observed in certain brain areas, mainly in the left cerebellar vermis, left middle frontal gyrus (BA9), and right superior frontal gyrus relative to the supplementary motor area (BA6). …”
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Using mechanical and thermodynamic methods to evaluate the effects of nanomaterials on thermal cracking mechanisms of asphalt mixtures under the influence of different moisture con... by Amir Hossein Asadi, Gholam Hossein Hamedi, Alireza Azarhoosh

“…Water in the bitumen-aggregate system leads to various HMA damages in the form of adhesive (failure at the bitumen-aggregate contact surface) and cohesive (failure in the mastic phase). The main part of the moisture entering the HMA is the runoff containing dust, soot, and other surface contaminations, which affect the acidity or basicity of runoff and failure severity. …”
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Analisis Performa Ekstraksi Konten GPT-3 Dengan Matrik Bertscore Dan Rouge by Yetti Yuniati, Kaira Milani Fitria, Melvi, Sri Purwiyanti, Emir Nasrullah, Meizano A Muhammad

“…These features include information extraction, summarising paragraphs, identifying main topics, and interpreting text for optimal terminology presentation. …”
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CHANNELING: SEARCH OF THE METAANTHROPOLOGIC MEAS-UREMENTS OF MIND BEING IN THE UNIVERSE (based on the World Wide Web) by Anatoly T. Tshedrin

“…Channeling as an object of research, its network of representation – as a matter of methods involve the use of analytical hermeneutics and archaeographic commenting text fractal logic cluster analysis. The main body. The features of channeling as cultural practices aimed at solving the problem of finding meta an-thropological dimensions of existence in the universe of the mind, as an attempt to resolve the contradiction between the theoretical ideas about extraterrestrial civilizations and the lack of empirically observable, the expected signs of their activities. …”
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