Retrospective Comparison of 27-Gauge and 25-Gauge Microincision Vitrectomy Surgery with Silicone Oil for the Treatment of Primary Rhegmatogenous Retinal Detachment by Jie Li, Bo Zhao, Sanmei Liu, Fang Li, Wentao Dong, Jie Zhong

“…We analyzed the characteristics of the patients, surgical time, main clinical outcomes, and rate of complications. …”
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Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction: a systematic review and meta-analysis by Kyle White, Ian Scott, Mansey Kinarivala

“…All review stages were conducted by two reviewers.Main outcomes and measures Risk factors, presenting symptoms, cardiac investigations such as troponin and angiogram, management and outcomes such as mortality.Results 40 cohort studies comprising 98 930 patients with T1MI and 13 803 patients with T2MI were included. …”
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Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes by Chloe Wong, Jun Yan Ng, Yang Yie Sio, Fook Tim Chew

“…There did not appear to be any significant publication bias observed across the all phenotypes. Main body A total of 48 studies were included, revealing 30 loci that were confirmed to be associated with skin ageing by multiple studies (e.g., AFG3L1P: odds ratio 1.133 95% confidence interval [1.044, 1.222]; BPIFA3: 1.859 [1.567, 2.151]; CLPTML1: 1.164 [1.0.99, 1.229]; CPNE7: 0.905 [0.852–0.958]; DEF8: 1.186 [1.042, 1.331]; IRF4: 1.260 [1.025, 1.495]; MYO16: 2.303 [1.697, 2.908]; PRDM16: 1.105 [1.084, 1.127]; RORA: 1.391 [1.206, 1.577]; SPG7: 0.922 [0.897, 0.947]; SPON1: 2.214 [1.204, 3.225]; SPTLC1: 1.464 [1.432, 1.495]; TYR: 1.175 [1.007, 1.343]). …”
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Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases by Longyu Zhu, Miaomiao Liu, Yuguang Shang, Jingge Cheng, Hongye Zhao, Jun Zhang, Dongxing Shen

“…Abstract Breast cancer is the most common malignant tumor in the world, and its metastasis is the main cause of death in breast cancer patients. However, the differences between primary breast cancer tissue and lymphatic node, bone, and brain metastases at the single-cell level are not fully understood. …”
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Prediction model study focusing on eHealth in the management of urinary incontinence: the Personalised Advantage Index as a decision-making aid by Huibert Burger, Henk van der Worp, Marco H Blanker, Marjolein Y Berger, Anne Martina Maria Loohuis, Nienke Wessels, Janny Dekker, Alec GGA Malmberg

“…Of the 350 screened women, 262 were eligible and randomised to app-based treatment or care as usual; 195 (74%) attended follow-up.Predictors Literature review and expert opinion identified 13 candidate predictors, categorised into two groups: Prognostic factors (independent of treatment type), such as UI severity, postmenopausal state, vaginal births, general physical health status, pelvic floor muscle function and body mass index; and modifiers (dependent on treatment type), such as age, UI type and duration, impact on quality of life, previous physical therapy, recruitment method and educational level.Main outcome measure Primary outcome was symptom severity after a 4-month follow-up period, measured by the International Consultation on Incontinence Questionnaire the Urinary Incontinence Short Form. …”
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Population Pharmacokinetics of Pegcetacoplan in Patients with Geographic Atrophy or Neovascular Age-related Macular Degeneration by Ryan L. Crass, PharmD, Komal Prem, MD, Francois Gauderault, PhD, Ramiro Ribeiro, MD, PhD, Caroline R. Baumal, MD, Brandon Smith, PhD, Daniel Epling, PhD, Sunny Chapel, PhD

“…Predicted PK parameters and exposure metrics were generated via simulation in serum and vitreous humor. Main Outcome Measures: Pharmacokinetic parameters. …”
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Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial by Scott A. Shikora, Bruce M. Wolfe, Caroline M. Apovian, Mehran Anvari, David B. Sarwer, Robert D. Gibbons, Sayeed Ikramuddin, Christopher J. Miller, Mark B. Knudson, Katherine S. Tweden, Michael G. Sarr, Charles J. Billington

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Bayesian joint-regression analysis of unbalanced series of on-farm trials by Turbet Delof, Michel, Rivière, Pierre, Dawson, Julie C, Gauffreteau, Arnaud, Goldringer, Isabelle, van Frank, Gaëlle, David, Olivier

“…We compared various Bayesian Finlay-Wilkinson models and found that placing hierarchical distributions on model parameters and modelling residuals using a Student's t distribution jointly improved the estimates of main effects and interactions. Environment effects were the most important and explained more than 50% of the variance of observations. …”
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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…The sialic acid of the glycans attached to Asn298 in the engineered antibody was selectively conjugated to bisM6P without chemoenzymatic modification, which is often used for site-specific antibody conjugation through glycans. The conjugate is mainly homogeneous by analysis using mass spectrometry, typically with one or two glycans coupled. …”
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Spectrum and Clinical Characteristics of Renal Diseases in Ghanaian Adults: A 13-Year Retrospective Study by Perditer Okyere, Isaac Okyere, Richard Kobina Dadzie Ephraim, Joseph Attakorah, Charlotte Osafo, Bernard Arhin, Sarah Bachelle, Albert Abaka-Yawson

“…This study revealed that patients at the nephrology unit of KATH, Ghana, are mainly adults between ages 46–55. The clinical pattern of renal diseases is dominated by CKD and ESRD. …”
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Network meta-analysis of cadmium toxicity against Chlorella vulgaris and the role of growth stimulants and macronutrients by M. Iqhrammullah, S. Saudah, M. Monalisa, F. Fahrurrozi, S.A. Akbar, S.S. Lubis

“…Among the various microalgae species, Chlorella vulgaris stands out as a suitable candidate due to its potential for biodiesel production and its capacity to effectively absorb cadmium. Therefore, the main objective of this study is to assess the toxicity of cadmium on Chlorella vulgaris cells using network meta-analysis as a methodology.METHODS: A comprehensive search was conducted on Scopus, Scilit, Google Scholar, and Web of Science to identify relevant studies published from 1 January 1990 to 16 January 2024. …”
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Impact of pandemic service changes on ethnic inequalities in maternal and perinatal outcomes in England: a population-based study by Andrew Judge, Erik Lenguerrand, Tim Draycott, Stamatina Iliodromiti, Asma Khalil, Buthaina Ibrahim, Jennifer Elizabeth Jardine

“…Self-reported ethnicity was grouped into White, South-Asian, Black, Mixed and Other.Main outcome measures Composite and component measures of maternal (emergency caesarean section, obstetric anal sphincter injury, hysterectomy, sepsis, anaesthetic complications and prolonged hospital stay) and perinatal (stillbirth, neonatal death, preterm birth, brain injury, small for gestational age and prolonged hospital stay). …”
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Comparative Results of “Epi-Off” Conventional versus “Epi-Off” Accelerated Cross-Linking Procedure at 5-year Follow-Up by Cristina Ariadna Nicula, Dorin Nicula, Anca Maria Rednik, Adriana Elena Bulboacă

“…Cases with different stages of keratoconus and topographic evidence of progression were included. Main outcomes comprised refraction, keratometry measurements, uncorrected (UCVA) and best-corrected visual acuity (BCVA), and topographical indices. …”
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Characteristics of Soil Active Carbon Fractions and Carbon Pool Stability in Major Forest Types in Northern Daxing’an Mountains by LIU Beibei, CAI Tijiu

“…[Results] (1) From May to September, soil total organic carbon (TOC), highly active organic carbon (LOC-H) and moderately active organic carbon (LOC-M) of the four forest types showed a “single-peak” trend of change, and reached a peak in August, and the contents were higher in broad-leaved forests than in coniferous forests. (2) The utilisation rate of soil stability organic carbon (ER4) fluctuated between 72.33% and 85.11% from May to September, it was significantly higher than the utilisation rates of the other three types of active carbon, and dominated the soil carbon pool. (3) Soil carbon pool activity (CPA) fluctuated between 0.20 and 0.38, with P. davidiana forests>B. platyphylla forests>P. sylvestris var. mongolica forests >L. gmelinii forests; that of coniferous forests peaked in August, while that of broad-leaved forests were highest in May. (4) Soil active organic carbon content and carbon pool stability were subject to the combined effects of climatic factors and soil factors. Sucrase was the main influence of soil factors, while rainfall and photosynthetically active radiation were more influential among climatic factors. …”
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Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…In terms of cell components (CC), it involved the composition of enzyme regulated complex, cystic cavity, membrane microregion and membrane region. ③ Components-target-pathway network analysis showed that, the main potential active ingredients of <italic>Coptis chinensis</italic> in the treatment of type 2 diabetes mellitus were quercetin, berberine, etc. …”
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Validity, Agreement and Reliability of the ForceFrame Dynamometer in Patients with Anterior Cruciate Ligament Injury by Kamilla Arp, Thomas Frydendal, Troels Kjeldsen, Ulrik Dalgas, Signe Timm, Bjarke Viberg, Kim Ingwersen, Claus Varnum

“…Day two included reliability assessments with FF performed by two assessors. Main outcome measures were day-to-day test-retest reliability and agreement and inter-tester reliability of FF, and concurrent validity (FF vs. an ID and a HHD). …”
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Sex-specific differences in children attending the emergency department: prospective observational study by Joany M Zachariasse, Henriette A Moll, Ian K Maconochie, Ewout W Steyerberg, Daan Nieboer, Dorine M Borensztajn, Claudio F Alves, Frank J Smit, Susanne Greber-Platzer, Claudia M G Keyzer-Dekker

“…Objective To assess the role of sex in the presentation and management of children attending the emergency department (ED).Design The TrIAGE project (TRiage Improvements Across General Emergency departments), a prospective observational study based on curated electronic health record data.Setting Five diverse European hospitals in four countries (Austria, The Netherlands, Portugal, UK).Participants All consecutive paediatric ED visits of children under the age of 16 during the study period (8–36 months between 2012 and 2015).Main outcome measures The association between sex (male of female) and diagnostic tests and disease management in general paediatric ED visits and in subgroups presenting with trauma or musculoskeletal, gastrointestinal and respiratory problems and fever. …”
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Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China. by Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin

“…Moreover, Mendelian randomization evidenced a positive association between a genetically instrumented ceramide (d18:1/20:1) and T2D (odds ratio: 1.15 [95% CI 1.05-1.26]; P = 0.002). Main limitations in the current study included potential undiagnosed cases and lack of an independent population for replication.…”
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Anti-thermal-quenching and colour-tuneable Tb3+/Ce3+-doped phosphor from natural wollastonite by Yu Xinhong, Chen Feng, Yang Ming, Ruan Min, Feng Wei

“…Series of doped natural wollastonite phosphors (xTb3+/xLi+, yCe3+/yLi+ and xTb3+/0.06Ce3+/xLi+ co-doped wollastonite) were synthesized by high temperature solid state thermal diffusion method in vacuum furnace. The powders mainly consisted of low temperature α-CaSiO3 phase corresponding to the triclinic crystal structure, and according to ionic radii differences it was proposed that Tb3+ and Ce3+ had tendency to be incorporated at the Ca2+ position. …”
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Cardiac Myosin-binding Protein-C as a Biomarker in the Early Diagnosis of Acute Coronary Syndrome and Differentiation of Its Types by Ali Abdul Rasool Hussein, Abdulkareem Hamadi Issa, Abbas Naji Muslem Al Shareeifi

“…Background: Coronary heart disease (CHD) is primarily caused by atherosclerotic lesions within the intima of coronary arteries and acute coronary syndrome (ACS) is the main acute clinical manifestation of CHD. The ACS is manifested in one of three subtypes and it is the leading cause of mortality worldwide. …”
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