Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…Abstract Background Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) are chronic inflammatory diseases mainly affecting joints. RA primarily targets the synovial joints and is characterized by cartilage and bone erosion, whereas PsA is associated with skin and nail psoriasis and is characterized by erosive bone damage with an exuberant bone formation and soft tissue involvement. …”
Get full text

Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…Together, our study indicates that the reconstitution of antibodies in response to lymphopenia-induced homeostatic B cell proliferation is mainly elicited by innate MZB-like B cell responses via antigen- and T cell-independent pathways resulting in the selection of autoreactive IgA antibodies. …”
Get full text

Investigating the implementation of infection prevention and control practices in neonatal care across country income levels: a systematic review by Emanuela Nyantakyi, Julia Baenziger, Laura Caci, Kathrin Blum, Aline Wolfensberger, Angela Dramowski, Bianca Albers, Marta Castro, Marie-Therese Schultes, Lauren Clack

“…Neonatal units in LMICs and HICs showed general commonalities in reported implementation determinants, which were mainly reported at the organizational level. While educational as well as evaluative and iterative strategies were most frequently employed to support the implementation of IPC practices in both LMICs and HICs, other strategies employed showed variance across country income levels. …”
Get full text

Allelic variants for Waxy genes in common wheat lines bred at the Lukyanenko National Grain Center by E. R. Davoyan, L. A. Bespalova, R. O. Davoyan, E. V. Agaeva, G. I. Bukreeva, Yu. S. Zubanova, D. S. Mikov, D. M. Boldakov

“…The study was carried out as part of the work on the transfer of null alleles of the genes Wx-A1, Wx-B1, and Wx-D1 to the varieties of soft wheat and creation of breeding material with modified activities of the main enzymes involved in amylose biosynthesis. The lines were obtained at the Department of Breeding and Seed Production of Wheat and Triticale, National Center of Grain named after P.P. …”
Get full text

Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor by Guohui Lu, Linfeng Luo, Maolin Liu, Zijian Zheng, Bohan Zhang, Xiaosi Chen, Xing Hua, Houyou Fan, Guoheng Mo, Jian Duan, MeiHua Li, Tao Hong, Dongwei Zhou

“…An extensive search of articles published to date in 2019 was conducted, and two main aspects were analyzed. Improvement was calculated as a percentage of change in any objective tremor rating scale (TRS) and analyzed by subgroup analyses of patients’ tremor characteristics, laterality, and stimulation parameters. …”
Get full text

The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…We can conclude that our nanocomplex is a potent effector that prevents tumoral progression by activating three main immunological strategies: switching the surface expression profile of the activated macrophages into a proinflammatory M1-like phenotype, downregulating the expression of proinflammatory cytokines, and upregulating the expression level of anti-inflammatory cytokines.…”
Get full text

Does an increase in physiological indexes predict better cognitive performance: the PhyCog randomised cross-over protocol in type 2 diabetes by Frederic Dutheil, Guillaume T Vallet, Igor Tauveron, Julien S Baker, Valentin Magnon, Jordan Mille, Valentin Brusseau, Laetitia Silvert, Marie Izaute

“…The study will include a total of 81 patients with T2D.Cognitive performance and physiological variables will be assessed at baseline (week 0—W0), during the washout (W5, 72–96 hours after week 4), at the end of the intervention (W10), and at the end of the follow-up (W22). The main variables of interest will be executive function, memory and attention. …”
Get full text

Association of per- and polyfluoroalkyl substances with gout risk: a cross-sectional analysis of NHANES 2007–2018 data emphasizing mixture effects by Haixin Feng, Siran Li, Shiqing Huang, Linxi He, Ruihao Huang, Renhuizi Wei, Xin Peng, Haiyi Yan, Chongxiang Xiong, Bingsong Zhang

“…PFOA is highly persistent in the body, mainly accumulating in the kidneys and liver through enterohepatic circulation, posing risks due to its difficulty in metabolism and excretion. …”
Get full text

Enhancing home-based physical activity for neurodivergent children: adapting the InPACT at Home program with AI and universal design by Tania Sapre, Haylie L. Miller, Anna Schwartz, Leah R. Ketcheson, Alanna Price, Kerry Winkelseth, Jeanne M. Barcelona, Ronald F. Zernicke, Ronald F. Zernicke, Rebecca E. Hasson

“…The refinements were guided by the Universal Design for Learning (UDL) principle of “Representation,” which acknowledges that learners perceive and understand information in diverse ways.ResultsFrom the 132 InPACT at Home videos, over 500 activities were identified and categorized into main skill groups: jumping, core, lateral, sport, upper body, lower body, and compound movements. …”
Get full text

Is joint hypermobility linked to self-reported non-recovery from COVID-19? Case–control evidence from the British COVID Symptom Study Biobank by Hugo D Critchley, Dorina Cadar, Claire J Steves, Kevin A Davies, Alan J Hakim, Nicholas Gall, Jessica A Eccles, Vicky Bowyer, Lisa Quadt, Nathan Cheetham

“…These individuals self-reported on recovery and completed a self-report questionnaire to detect GJH (Hakim and Grahame 5-part questionnaire, 5PQ).Main outcome measures The primary outcome was the presence of self-reported non-recovery from COVID-19 infection at the time of the survey. …”
Get full text

Auricular Acupuncture for Perioperative Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhou Y, Bao Q, Yang C, Li S, Yin Z, Xiong J, Sun M, Yang J, Liu F, Liang F

“…The results of the sensitivity analysis demonstrated the stability of the results of the meta-analysis. AA-related AEs were mainly nausea, vomiting, and drowsiness. None of the patients in the experimental group dropped out of the trial due to AA-related AEs.Conclusion: Current evidence suggests that AA may be a promising treatment option for improving perioperative pain with few AEs. …”
Get full text

Perbandingan Fungsi Extremitas Atas pada Fraktur Metafise Distal Radius Intraartikuler Usia Muda Antara Tindakan Operatif Dan Non Operatif dengan Penilaian Klinis Quickdash Score by Edi Burhan, Menker Manjas, Ardian Riza, Erkadius .

“…Djamil Hospital found 122 from 612 cases fracture of radius from january 2011 to june 2012. The main purpose therapy is restore the joint in the surface position anatomically by fixation a stable and restore the function upper extremitas over their best. …”
Get full text

Pembangunan Aplikasi Virtual Reality Tur Perumahan Pada Balimbingan Permai Regency (PT. Karya Propertindo Utama) by Komang Candra Brata, Reinhard Jonathan Silalahi, Adam Hendra Brata

“…Based on these problems, an interactive virtual reality-based tour application for Balimbingan Permai housing was developed. The main feature of the proposed app is to manage and display all types and details of the house unit catalog in Virtual Reality so that it can be used as an alternative solution for prospective buyers who cannot conduct direct site surveys due to limited time and distance issue. …”
Get full text

Prediction of growth and feed efficiency in mink using machine learning algorithms by A. Shirzadifar, G. Manafiazar, P. Davoudi, D. Do, G. Hu, Y. Miar

“…Measuring individual daily feed intake and BW is time-consuming, labor-intensive, and stressful for the animals and mink producers. The main objectives of this study were to (1) evaluate the application of machine learning (ML) algorithms to predict the average daily gain (ADG), feed conversion ratio (FCR), and residual feed intake (RFI) values during the whole growing and furring period (15 weeks from August 1st to November 14th) using less expensive features such as sex, color type, age, BW and length; (2) find the most significant contributing feature within the growth and furring period to predict the ADG, FCR and RFI. …”
Get full text

Role of various fishmeal ingredients on sangkuriang catfish Clarias sp. growth by Nur Bambang Priyo Utomo, , Susan, Mia Setiawati

“…It was indicated that the trash-fish meal might be used as the main protein source of sangkuriang catfish feed.   …”
Get full text

Assessment of the magnitude, economic impact, and factors associated with expired veterinary pharmaceuticals in animal health facilities in South Wollo, Ethiopia by Yesuneh Tefera Mekasha, Ermias Belay Mekonnen, Abebe Tesfaye Gessese, Kassahun Berrie, Achenef Melaku Beyene, Bereket Dessalegn

“…The existence of veterinary pharmaceutical expiration can be mainly associated with inadequate inventory control, store management, and a lack of effective pharmaceutical regulatory policies and guidelines. …”
Get full text

Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…., to include antiviral or other anti-inflammatory drugs.<h4>Main outcomes and measures</h4>The primary outcome was intubation or death within 14 days of randomization. …”
Get full text

Blanching-Induced Changes in Polyphenol Oxidase, Antioxidants and Phenolic Profile of Mangosteen Pericarp by Giroon Ijod, Nur Izzati Mohamed Nawawi, Rabiha Sulaiman, Noranizan Mohd Adzahan, Farooq Anwar, Ezzat Mohamad Azman

“…This is the first study to report the effects of blanching on the anthocyanins mainly present in mangosteen pericarp, in particular cyanidin-3-O-sophoroside (C3S) and cyanidin-3-O-glucoside (C3G), using high-performance liquid chromatography (HPLC) and LC-MS. …”
Get full text

Hubungan Perdarahan Postpartum dengan Paritas di RSUP Dr. M. Djamil Periode 1 Januari 2010 - 31 Desember 2012 by Nola Eriza, Defrin , Yuniar Lestari

“…<br />Kata kunci: perdarahan postpartum, paritas, kematian ibu</p><p> </p><p>Abstract <br />The main causes of maternal mortality in Indonesia are hemorrhage (28%), eclampsia (24%) and infection (11%). …”
Get full text

The prognostic role of vasculoendothelial growth factor A in patients with ST-segment elevation acute myocardial infarction during 6-months follow-up period by N.P. Kopytsya, I.M. Кutya, I.V. Rodionova, Ya.V. Hilova

“…The level of VEGF-A in the main group was 247.94 [107.22–486.50] pg/ml. In the control group, the level of VEGF-A was 80.76 [56.20–149.51] pg/ml (p = 0.011). …”
Get full text