Genotypic and ecological variability of zinc content in the grain of spring bread wheat varieties in the international nursery KASIB by V. P. Shamanin, P. Flis, T. V. Savin, S. S. Shepelev, O. G. Kuzmin, A. S. Chursin, I. V. Pototskaya, I. E. Likhenko, I. Yu. Kushnirenko, A. A. Kazak, V. A. Chudinov, T. V. Shelaeva, A. I. Morgounov

“…The analysis of variance showed that the main contribution into the general phenotypic variation of the studied trait, 38.7 %, was made by the factor ‘location’ due to different contents of zinc and moisture in the soil of trial sites; the effect of the factor ‘year’ was 13.5 %, and the effect of the factor ‘genotype’ was 8.0 %. …”
Get full text

Effectiveness of multicomponent interventions in primary healthcare settings to promote continuous smoking cessation in adults: a systematic review by Carlos Martín Cantera, Elisa Puigdomènech, Jose Luis Ballvé, Olga Lucía Arias, Lourdes Clemente, Ramon Casas, Lydia Roig, Santiago Pérez-Tortosa, Laura Díaz-Gete, Sílvia Granollers

“…Methodologies used were mainly individual or group sessions, telephone conversations, brochures or quit-smoking kits, medications and economic incentives for doctors and no-cost medications for smokers. …”
Get full text

Perspectives of nurses and patient representatives on the morally competent nurse: An international focus group study by Chris Gastmans, Evelyne Mertens, Alvisa Palese, Brian Keogh, Francesca Apolloni, Johanna Wiisak, Catherine Mc Cabe, Maria Dimitriadou, Alessandro Galazzi, Michael Igoumenidis, Nikos Stefanopoulos, Paraskevi Charitou, Evridiki Papastavrou, Riitta Suhonen, Stefania Chiappinotto

“…This person-centred quality is expressed on intrapersonal and interpersonal levels. The theme ‘main components of moral competence in nurses’ can be divided into three subthemes: knowledge, skills, and attitudes. …”
Get full text

Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…The visualization zones of the pathological process in the brain in case of toxic damage are mainly basal ganglia and/or thalamus and dentate nucleus, cortical zone of grey matter, periventricular zone of white matter, corticospinal tract and corpus callosum; asymmetric white matter damage as a sign of demyelination; parietal-occipital subcortical vasogenic edema and lesions of the central pons are characteristic. …”
Get full text

Durvalumab as consolidation therapy in patients who received chemoradiotherapy for unresectable stage III NSCLC: Real-world data from an expanded access program in Brazil (LACOG 01... by Mauro Zukin, Victor Gondim, Andrea Kazumi Shimada, Ellias Magalhães e Abreu Lima, Clarissa Mathias, Williams Fernandes Barra, William Nassib William Junior, Mônica Padoan, Yuri Bittencourt, Rosely Yamamura, Carlos Eduardo Baston Silva, Letícia de Jesus Rossato, Caio de Almeida Monteiro, Rafaela Gomes de Jesus, Gustavo Gössling, Ana Caroline Zimmer Gelatti

“…Durvalumab was administered for a median of 17 cycles (10 to 24), with 45.2% of patients completing the planned therapy. The main reason for discontinuation was disease progression. …”
Get full text

Prostate cancer cells elevate glycolysis and G6PD in response to caffeic acid phenethyl ester-induced growth inhibition by Tzu-Ping Lin, Pei-Chun Chen, Ching-Yu Lin, Bi-Juan Wang, Ying-Yu Kuo, Chien-Chih Yeh, Jen-Chih Tseng, Chieh Huo, Cheng-Li Kao, Li-Jane Shih, Jen-Kun Chen, Chia-Yang Li, Tzyh-Chyuan Hour, Chih-Pin Chuu

“…Abstract Background Caffeic acid phenethyl ester (CAPE) is the main bioactive component of poplar type propolis. …”
Get full text

Systematic Review of Surgical Care in the Incarcerated Population: Identifying Knowledge Gaps for Future Research by Totadri Dhimal, MD, Paula Cupertino, PhD, Aqsa Ghaffar, BS, Yue Li, PhD, Xueya Cai, PhD, Cristopher Soto, BS, Megha Ramaswamy, PhD, MPH, Bruce W. Herdman, PhD, Fergal J. Fleming, MD, MPH, Anthony Loria, MD, MSCI

“…The US prison system detains around 2 million individuals, mainly young, indigent males from ethnic and racial minorities. …”
Get full text

Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland by David Nanchen, Stephan Windecker, Isabella Locatelli, Nicolas Rodondi, Lorenz Räber, David Carballo, Francois Mach, Olivier Muller, Baris Gencer, Christian M Matter, Roland Klingenberg, Thomas Lüscher, Alex Boudon

“…Objectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS).Design Prospective cohort study from the Special Program University Medicine-Acute Coronary Syndromes.Setting Four university hospital centres in Switzerland.Participants 2274 patients with a main diagnosis of ACS between 2009 and 2017 who were available for a 1-year follow-up visit 1 year after hospital discharge.Outcome measures Self-reported physical activity was assessed with the International Physical Activity Questionnaire. …”
Get full text

Children’s emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children by Aisling Murray, Dominie Mahala Smith Scott, Milena Nikolajeva, Daniele Porricelli, Francois van Loggerenberg, Dennis Ougrin, Jennifer Y. F. Lau

“…We also identified socioecological factors that contributed to resilience, mainly at the individual and interpersonal levels. …”
Get full text

Cancer Burden Disease Attributable to PM2.5 and Health Risk by PM2.5-bound Toxic Species in Two Urban Chilean Municipalities by Ye Li, Franz Muñoz-lbañéz, Ana Maldonado-Alcaíno, Darby Jack, Beizhan Yan, Li Xu, Marco Acuña, Manuel Leiva-Guzman, Ana Valdés, Dante D. Cáceres

“…These results deserve further study to help guide policy in different environments, mainly carcinogenic PM2.5-bound toxic species from other emission sources, particularly firewood burning.…”
Get full text

Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles by Basit Yousuf, Walid Mottawea, Galal Ali Esmail, Nazila Nazemof, Nour Elhouda Bouhlel, Emmanuel Njoku, Yingxi Li, Xu Zhang, Zoran Minic, Riadh Hammami

“…Additionally, extracellular vesicles (EVs) produced by Bacteroides harbor multiple neuroactive metabolites, mainly GABA, and related key enzymes. We used CRISPR/Cas12a-based gene engineering to create a knockout mutant lacking the glutamate decarboxylase gene (gadB) to demonstrate the specific contribution of Bacteroides finegoldii-derived GABA in modulating intestinal homeostasis. …”
Get full text

Cost of introducing and delivering malaria vaccine (RTS,S/AS01E) in areas of seasonal malaria transmission, Mali and Burkina Faso by Jean Bosco Ouédraogo, Alassane Dicko, Ranju Baral, Clint Pecenka, Halimatou Diawara, Fadima Yaya Bocoum, Ann Levin, Cynthia Lee, Fatoumata Koita, Rosemonde Guissou, Seydou Yabré, Seydou Traoré, Winthrop Morgan

“…Excluding commodity costs, service delivery is the main cost driver under the mass campaign scenario, accounting for 36% to 55% of the financial cost. …”
Get full text

Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of <i>Crotalus durissus ruruima</i> Venom and Antivenom Efficacy by Poliana J. Demico, Isabele N. Oliveira, Vitória S. Proença-Hirata, Samuel R. Dias, Hugo A. Ghirotti, Elisangela O. Silva, Inês C. Giometti, Francis L. Pacagnelli, Kristian A. Torres-Bonilla, Stephen Hyslop, Nathália C. Galizio, Karen de Morais-Zani, Manuela B. Pucca, Anderson M. Rocha, Jéssica B. Maciel, Marco A. Sartim, Wuelton M. Monteiro, Rafael S. Floriano

“…<b>Results:</b> SDS-PAGE showed that the venoms had similar electrophoretic profiles, with the main bands being phospholipase A₂ (PLA₂), serine proteinases, L-amino acid oxidase (LAAO), and phosphodiesterase. …”
Get full text

Niche and interspecific association of dominant arbor species in Quercus communities in the Qinling Mountains, China by Ruizhi Huang, Qi Wang, Jingyi Sun, Yipei Zhao, Shaowei Yang, Wenfa Xiao, Jianfeng Liu

“…The richness of tree layer in the vicarious distribution of Quercus communities was relatively low, with Pinus (Pinus armandii and Pinus tabuliformis) being the main associate species. The χ² test and Spearman analysis demonstrated a significant negative correlation between Pinus and Quercus. …”
Get full text

Effect of Exogenous of Transforming Growth Factor-β1 on Pregnancy Outcome in Mice with Recurrent Pregnancy Loss by Persistent Enhancement of Placental Tissue Indoleamine 2,3-Dioxyg... by Xinghui Wen, Xiaojuan Chen, Mei Li, Jinnian Zhou, Shouli Dao, Shixiang Li, Hui Cheng, Shuyun Zhao, Guanyou Huang

“…Background: The immunologic factors are the chief reason for recurrent pregnancy loss (RPL) and induction ofmaternal-fetal tolerance is the main treatment for this cause of RPL, but the effect of this method is uncertainly andneeds multiple doses and/or interventions. …”
Get full text

Evidence Graph Analysis of Postoperative Pain Sensitization Induced by Perioperative Sleep Deprivation by XUE Jianjun, WANG Caihong, GUO Lingling, LI Xiuxia, ZHANG Jie, XU Ziqing, HOU Huaijing, YANG Kehu

“…The number of publications increased rapidly after 2018 and peaked in 2022, and clinical studies in this field mainly focused on cohort studies, with fewer randomized controlled trials and systematic reviews/Meta-analysis studies. …”
Get full text

Assessment approach for conservation effectiveness and gaps for endangered species based on habitat suitability: A case study of alpine musk deer in western China by Feng Jiang, Pengfei Song, Jingjie Zhang, Dongwu Wang, Renhong Li, Chengbo Liang, Tongzuo Zhang

“…The suitable habitats were mainly distributed in central and southern Gansu, northeastern and scattered southern regions of Qinghai, central and western Sichuan, and central and eastern Xizang, with Xizang having the largest area of highly suitable habitat, Qinghai having the largest area of moderately suitable habitat, and Sichuan having the highest proportion of highly suitable habitat, while overall, Qinghai had the highest proportion of priority conservation areas. …”
Get full text

Analysis of Nucleotide Alterations in the E6 Genomic Region of Human Papillomavirus Types 6 and 11 in Condyloma Acuminatum Samples from Brazil by Marina Carrara Dias, Bruna Stuqui, Paola Jocelan Scarin Provazzi, Cíntia Bittar, Natália Maria Candido, Renata Prandini Adum de Matos, Rodolfo Miglioli Badial, Caroline Measso do Bonfim, Patricia Pereira dos Santos Melli, Silvana Maria Quintana, José Antônio Cordeiro, Paula Rahal, Marilia de Freitas Calmon

“…Condyloma acuminata (CA), or genital warts, are benign proliferative epidermal or mucous lesions that are caused by infection with human papillomavirus (HPV), mainly the low-risk types 6 and 11. HPV variants are defined as viral sequences that share identity in the nucleotide sequence of the L1 gene greater than 98%. …”
Get full text

Bayesian Estimation of the True Bovine Brucellosis Prevalence in Vaccinated and Non-Vaccinated Ecuadorian Cattle Populations, and the Sensitivity and Specificity of a Competitive a... by Ana Dolores Garrido Haro, Margoth Yolanda Barrionuevo Samaniego, Paola Moreno-Caballeros, Alexandra Burbano-Enríquez, Verónica Alexandra Salas Torres, María Cristina Galante Mulki, Constance Wielick, Jorge Ron-Román, Claude Saegerman

“…Bovine brucellosis (bB) is a zoonosis mainly caused by the <i>Brucella abortus</i> species in cattle. …”
Get full text

Changes on the Development of Rigor Mortis in Cultured Tilapia (Oreochromis niloticus) Fed with a Mixture of Plant Proteins by Nathaly Montoya Camacho, Enrique Márquez Ríos, Francisco Javier Castillo Yáñez, Saúl Ruíz Cruz, Aldo Alejandro Arvizu Flores, Wilfrido Torres Arreola, Jose Luis Cárdenas López, Santiago Valdéz Hurtado, Víctor Manuel Ocaño Higuera

“…A reference diet (DC) containing FM as the main protein source was used as a control. The fish were divided into triplicate groups per dietary treatment. …”
Get full text