Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease by Ziqing Feng, MD, Kang Yu, MD, Yupei Chen, MS, Gengyuan Wang, MS, Yuqing Deng, MD, Wei Wang, MD, Ruiwen Xu, MD, Yimin Zhang, MD, Peng Xiao, PhD, Jin Yuan, MD, PhD

“…The structure of the corneal nerve was extracted and characterized using the fractal dimension (CNDf), multifractal dimension (CND0), tortuosity (CNTor), fiber length (CNFL), and numbers of branching points. Main Outcome Measures: The characteristics of quantified whorl-like corneal nerve metrics in different groups of severity and subtype defined by symptoms and signs of DED. …”
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Bariatric surgery in elderly patients by Alexander V. Smirnov, Vladimir R. Stankevich, Ekaterina S. Danilina, Vladislav I. Sychev, Evgeniya M. Voronets, Vladimir I. Sharobaro, Nikolay A. Solovyev, Yury V. Ivanov, Robert I. Khabazov

“…The weight loss was found to be significantly less in the older age group (61 and older) comparing to the main group of patients (18–60 years): for laparoscopic longitudinal resection — 55.5% versus 73%, respectively (р=0.01), for laparoscopic Roux gastric bypass surgery — 58% versus 77.5% (р=0.0008). …”
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Emergency medicine pharmacists’ interventions in the tertiary hospitals’ emergency departments in Malaysia by Hock Peng Koh, Haliza Ab Jalal, Yee Ping Koo, Mary Siew Yng Chen, Manimegahlai Selvaratanam, Anaanthan Bhuvanendran Pillai, Wai Kit Wong, Xin Nee Guee, Sherene Su Ann Tan, Shirlyn Tan, Lih Jiuan Teh, Rosalind Guen Lin Sia

“…Inappropriate regimens (n = 1117, 67.3%) and incomplete prescriptions (n = 339, 20.4%) were the main categories of accepted interventions in ED. …”
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Study on stress corrosion behavior and failure mechanism of galvanized bolts in complex coal mine environments by Zhe He, Nong Zhang, Zhengzheng Xie, Chao Ma, Changliang Han, Fan Zhang, Huiqing Wang, Saad S. Alarifi

“…In short, the instantaneous fracture of galvanized bolts was mainly caused by the interaction of stress concentration cracking due to the geometry of the bolts and HIC under stress corrosion failure. …”
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Dietary supplementation of lysozyme can improve growth rate, laying performance, blood biochemistry, and mRNA levels of some related genes in different plumage-colored quails by Ibrahim Elkhaiat, Seham El-Kassas, Karima El-Naggar, Safaa Abdo, Haitham K. Shalaby, Mahmoud M. Azzam, Alessandro Di Cerbo, Mahmoud Alagawany, Reyad Y. Nofal

“…Whereas the 2nd, 3rd, and 4th received the BD supplemented with commercial LZ (CLZ) at 100 mg/kg diet, and natural LZ (NLZ) at 100 and 200 mg/kg diet, respectively. The main findings included significant increases in body weights and gains in the white-feathered quails supplemented with NLZ1 compared to the control and NLZ2. …”
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Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease by Zhongquan Xin, Zhenya Zhai, Hongrong Long, Fan Zhang, Xiaojun Ni, Jinping Deng, Lunzhao Yi, Baichuan Deng

“…Metabolism network and pathway analyses demonstrated that the metabolic disturbance of the liver in IBD mice was mainly enriched in bile acid metabolism, arachidonic acid metabolism, amino acid metabolism, and steroid hormone biosynthesis, while those disturbances were regulated or reversed through cecropin A and antibiotic treatment. …”
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Phytochemical, Cytotoxic, and Antimicrobial Evaluation of the Fruits of Miswak Plant, Salvadora persica L. by Mohammed Al Bratty, Hafiz A. Makeen, Hassan A. Alhazmi, Sohier M. Syame, Ashraf N. Abdalla, Husham E. Homeida, Shahnaz Sultana, Waquar Ahsan, Asaad Khalid

“…The petroleum ether extract of the fruits contained mainly eicosamethyl-cyclodecasiloxane (23.81%), 1-monolinoleoylglycerol (11.78%), (Z,Z,Z)-9,12,15-octadecatrienoic acid ethyl ester derivative (10.56%), and tetracosamethyl-cyclododecasiloxane (9.91%). …”
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FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…BackgroundDiabetic nephropathy (DN) is a prevalent global renal illness and one of the main causes of end-stage renal disease (ESRD). FGF21 has been shown to ameliorate diabetic nephropathy, and in addition FGF-21-treated mice impeded mitogenicity, whereas it is unclear whether FGF21 can influence DN progression by regulating the cell cycle in diabetic nephropathy.MethodsIn order to create a diabetic model, STZ injections were given to C57BL/6J mice for this investigation. …”
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Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets by Wenyu ZHANG, Xianshu FU, Xue BAI, Shiwen WU, Jiabin LI, Xiaoping YU, Mingzhou ZHANG, Zihong YE

“…Results showed that the optimal compound ratio of the main ingredients of D. officinale chewable tablets (mass fraction) was D. officinale:P. sibiricum:Z. jujuba=35%:10%:5%, and the corresponding total mass fractions of polysaccharides, flavonoids, and polyphenols were 159.64±0.14, 79.44±0.35, and 78.10±0.28 mg/g, respectively. …”
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Multiple Gene Deletion Mutants of Equine Herpesvirus 1 Exhibit Strong Protective Efficacy Against Wild Virus Challenge in a Murine Model by Stephanie S. Pradhan, Vekataramireddy Balena, Bidhan Chandra Bera, Taruna Anand, Rhushikesh Khetmalis, Aashwina Madhwal, Supriya Kandasamy, Selvaraj Pavulraj, Manju Bernela, Priya Mor, Bhupendra Nath Tripathi, Nitin Virmani

“…Conclusions: These studies are suggestive of vToH-QMV EHV1 being a potential vaccine candidate against EHV1 infection, which needs to be finally tested in the main host, i.e., horses.…”
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Reproductive modes in populations of late-acting self-incompatible and self-compatible polyploid Ludwigia grandiflora subsp. hexapetala in western Europe by Stoeckel, Solenn, Becheler, Ronan, Portillo-Lemus, Luis, Harang, Marilyne, Besnard, Anne-Laure, Lassalle, Gilles, Causse-Védrines, Romain, Michon-Coudouel, Sophie, Park, Daniel J., Pope, Bernard J., Petit, Eric J., Barloy, Dominique

“…We found that populations reproduced mainly clonally but with a high diversity of genotypes along with rates of sexuality ranging from 10% up to 40%. …”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…These CpGs have been previously associated with health outcomes such as carcinomas, and the related genes are mainly involved in pathways related to thyroid hormones and liver function. …”
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Post‐Glacial Vegetation Trajectories on the Eastern Tibetan Plateau Reflect Millennial‐Scale Migration Lags in Complex Mountain Terrain Based on Sedimentary Ancient DNA and Dynamic... by Wei Shen, Stefan Kruse, Sisi Liu, Kathleen Stoof‐Leichsenring, Ingolf Kühn, Wenjia Li, Xianyong Cao, Zhi‐Rong Zhang, Chun‐Xia Zeng, Jun‐Bo Yang, De‐Zhu Li, Ulrike Herzschuh

“…Our consistent proxy‐ and model‐based results, for the first time, indicate that dispersal related migration lags in complex mountain terrain lead to uneven vegetation trajectories at sites with similar climatic conditions mainly because of differences in connectivity to refugia. …”
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A fuzzy logic approach within the DPSIR framework to address the inherent uncertainty and complexity of water security assessments by Liang Yuan, Zhijie Zhou, Weijun He, Xia Wu, Dagmawi Mulugeta Degefu, Juan Cheng, Lin Chai, Thomas Stephen Ramsey

“…Furthermore, the sensitivity of the evaluation method is reported and ways for water security improvement are proposed. The main findings are: (1) The water security score of MRB is 65.034 which is considered to be a safe status. …”
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Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions by Vilde Øverlien Dåstøl, Vilde Øverlien Dåstøl, Kristine Løkås Haftorn, Hamid Khoshfekr Rudsari, Piotr Pawel Jaholkowski, Piotr Pawel Jaholkowski, Ketil Størdal, Ketil Størdal, Siri Eldevik Håberg, Siri Eldevik Håberg, Clarice R. Weinberg, Lisa G. Rider, Ole A. Andreassen, Ole A. Andreassen, Ole A. Andreassen, Anne Lise Brantsæter, Ida Henriette Caspersen, Ida Henriette Caspersen, Helga Sanner, Helga Sanner

“…We assessed maternal seafood intake and dietary contaminants typically found in seafood using a food frequency questionnaire completed during pregnancy, mainly comparing high (≥90th percentile, P90) vs low (<P90) intake. …”
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A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Target-site modification and increased insecticide detoxification are the two main mechanisms underlying insecticide resistance in mosquitoes. …”
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Hierarchizing multi-scale environmental effects on agricultural pest population dynamics: a case study on the annual onset of Bactrocera dorsalis population growth in Senegalese or... by Caumette, Cécile, Diatta, Paterne, Piry, Sylvain, Chapuis, Marie-Pierre, Faye, Emile, Sigrist, Fabio, Martin, Olivier, Papaïx, Julien, Brévault, Thierry, Berthier, Karine

“…We found that physical factors (humidity, temperature), and to some extent landscape variables, were the main drivers of the spatio-temporal variability of the onset of population growth in orchards. …”
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Physiological changes induced by green fodder expansion into grasslands and croplands enhance water-use efficiency in the Northeastern Tibetan Plateau by Xu Wang, Jilin Yang, Jie Wang, Tong Yang, Chuchen Chang, Yanbo Zhao, Xiaocui Wu, Geli Zhang, Xiangming Xiao

“…Green fodder expansion enhanced ecosystem-level water-use efficiency by increasing gross primary productivity and reducing evapotranspiration, while improvements in plant-level water-use efficiency were mainly driven by gross primary productivity increases. …”
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Global burden of ischemic heart disease in older adult populations linked to non-optimal temperatures: past (1990–2021) and future (2022–2050) analysis by Lihui Liu, Lihui Liu, Yisong He, Yisong He, Gang Huang, Yangxi Zeng, Yangxi Zeng, Jiaan Lu, Ru He, Haiqing Chen, Yuheng Gu, Qingwen Hu, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan

“…Additionally, the geographic differences in IHD burden were analyzed using World Bank regions.ResultsFrom 1990 to 2021, the IHD burden in the older adult population was mainly attributed to low temperatures. However, it has increased the burden of IHD due to high temperatures, especially in tropical and low-income regions. …”
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Pearl Millet Cover Crop Extract Inhibits the Development of the Weed <i>Ipomoea grandifolia</i> by Inducing Oxidative Stress in Primary Roots and Affecting Photosynthesis Efficienc... by Gislaine Cristiane Mantovanelli, Adriano Antônio Silva, Letycia Lopes Ricardo, Fernanda Lima Kagami, Jéssica Dario de Almeida, Mauro Cezar Barbosa, Márcio Shigueaki Mito, Isabela de Carvalho Contesoto, Paulo Vinicius Moreira da Costa Menezes, Gabriel Felipe Stulp, Beatriz Pereira Moreno, Francielli Alana Pereira Valeze, Rubem Silvério de Oliveira Junior, Debora Cristina Baldoqui, Emy Luiza Ishii Iwamoto

“…The stilbenoid pallidol was identified as the main compound in EAF. The allelopathic activity of pearl millet may be attributed, at least in part, to the impairment of energy metabolism and the induction of oxidative stress in weed seedlings, with pallidol possibly involved in this action. …”
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