Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review by Shizhong Liu, Zuyu Du, Le Song, Haoyue Liu, Clarence Augustine T. H. Tee, Huanyu Liu, Yuan Liu

“…Conclusion In patients with moderate KOA, changes in MAP are mainly related to symptoms and the difficulty of tasks. …”
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Relationship between Tai Chi and clinical outcomes in elderly patients with COVID-19: a protocol for systematic review and dose–response meta-analysis by Yang Wang, Na Li, Xiao Peng, Chun Wang, Sheng He, Jinfeng Yang, Yuanpeng Liao

“…The secondary outcomes are the time of main symptoms disappearance, length of hospital stay, serum levels of interleukin (IL)-6, IL-1b and tumour necrosis factor-α, and adverse event rate. …”
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Role of Vigilin and RACK1 in dengue virus-Aedes aegypti-Wolbachia interactions by Guijie Wang, Mazhar Hussain, Zhi Qi, Sassan Asgari

“…Overall, our results support the involvement and significance of AeVigilin and AeRACK1 in DENV replication in Ae. aegypti.IMPORTANCEDengue virus (DENV), transmitted mainly by Aedes aegypti mosquitoes, poses significant health risks. …”
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Effect of SKT-b Vibrio probiotic bacteria addition at different developmental stages on tiger shrimp Penaeus monodon larvae survival rate by . Widanarni, M.S. Arifin, . Sukenda

“… This experiment was conducted to study the effect of probiotic bacteria SKT-b Vibrio addition at different developmental stages on survival rates of tiger shrimp Penaeus monodon larva.  Main activity of this experiment consisted of tiger shrimp rearing started from nauplius stage until Pl10 and addition of 106 CFU/ml SKT-b Vibrio probiotic bacteria at various developmental stages namely at early nauplius stage, early zoea zoea stage, early mysis stage, early postlarva (Pl) stage, every developmental stage changes, everyday, and control (without probiotic bacteria addition). …”
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Differences in Metabolites of Different Varieties from Xinjiang Large-fruit Sea Buckthorn as Analyzed by Non-targeted Metabolomics by Rong HAN, Yan MA, Shengjie LI, Xintao MENG, Mingqiang XU, Ting ZHANG, Yan PAN

“…The metabolic pathway enrichment analysis showed that the differential metabolites of different large-fruit sea buckthorns were mainly enriched in the pathways of unsaturated fatty acid biosynthesis, fatty acid biosynthesis, tryptophan metabolism, and flavonoid and flavonol biosynthesis. …”
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One-year experience with latanoprostene bunod ophthalmic solution 0.024% in clinical practice: A retrospective observational study. by Chun-Mei Hsueh, Chen-Hsin Tsai, Jou-Chen Huang, Si-Huei Lee, Tsung-Jen Wang, Siao-Pei Guo

“…All included patients received LBN 0.024% as a replacement for a PGA, with examinations at 1-, 3-, 6-and 12-months follow-up. Main outcome measures were IOP, retinal nerve fiber layer thickness, visual fields before/after LBN use and adverse effects. …”
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Mechanism of Electroacupuncture on Neuropathic Pain via Regulation of CD137L in Hippocampal Glia by ZHENG Changyue, LAN Yanyan, HUANG Qiuling, JIANG Menghong, WANG Zhifu

“…Immunofluorescence was used for the cellular localization of CD137L and receptor CD137, and to measure the Iba-1 and GFAP expression in hippocampal CA1 region.Results1) Compared with the sham operation group, mechanical pain threshold and new object recognition index in the model group significantly decreased (<italic>P</italic>&lt;0.01); compared with the model group, mechanical pain threshold and new object recognition index in the electroacupuncture group significantly increased (<italic>P</italic>&lt;0.01). 2) Compared with the sham operation group, the concentrations of CD137L, Iba-1, GFAP and TNF-α in hippocampus of rats in the model group significantly increased (<italic>P</italic>&lt;0.01), and the number of positive Iba-1 and GFAP immune reactions significantly increased (<italic>P</italic>&lt;0.01); compared with the model group, the concentrations of CD137L, Iba-1, GFAP and TNF-α in hippocampus of rats in the electroacupuncture group significantly decreased (all <italic>P</italic>&lt;0.05), and the number of positive immune reactions of Iba-1 and GFAP significantly decreased (all <italic>P</italic>&lt;0.01). 3) Immunofluorescence detection showed that CD137L and its receptor CD137 were significantly co-expressed with microglia marker (Iba-1) and astrocyte marker (GFAP) in hippocampal CA1 region, suggesting that CD137L and CD137 were mainly expressed in microglia and astrocytes, but not in neurons.ConclusionElectroacupuncture may play an analgesic role by reducing the expression of glial CD137L, the amount of activated glial cells and the concentrations of TNF-α.…”
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The Shiism Dimension in Iran's Relations with Europe: The Example of Germany-France-United Kingdom by Orhan Karaoğlu

“…In this context, Iranian Shiism, which creates a socio-cultural system different from other civilizations around it, has become the main determinant on the security and foreign policy of today's Iran by intertwining with Persian nationalism since the reign of Shah Ismail. …”
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Advancements, Trends and Future Prospects of Lower Limb Prosthesis by Muhammad Asif, Mohsin Islam Tiwana, Umar Shahbaz Khan, Waqar Shahid Qureshi, Javaid Iqbal, Nasir Rashid, Noman Naseer

“…No such work exists covering the main aspects from causes of amputation to the psycho-social impact of the amputees after using the prosthetic device. …”
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Optimizing boron application methods and dosages to enhance jute (Corchorus olitorius) seed yield and quality under sub-tropical climate by Tapan Kumar, Pritthee Mallick Tama, Syed Aflatun Kabir Hemel, Ranjit Kumar Ghosh, Md Imran Ali, Abdullah Al-Bakky, Abdul Alim

“…Principal component analysis indicated that the number of seeds per capsule, capsule length, and seed yield were the main contributors. So, 3.0 kg/ha foliar boron treatment, applied half at 20–25 days after sowing and the remainder at the first flowering stage is recommended for late jute seed production to achieve optimum seed yield and net profit.…”
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Design and Experimental Research on a Chisel-Type Variable Hierarchical Deep Fertilization Device Suitable for Saline–Alkali Soil by Nan Xu, Zhenbo Xin, Jin Yuan, Zenghui Gao, Yu Tian, Chao Xia, Xuemei Liu, Dongwei Wang

“…Simultaneously, this research mainly focuses on analyzing the impact of the forward speed on the operational effect of layered and variable-rate fertilization. …”
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Perspectives on which health settings geriatricians should staff: a qualitative study of patients, care providers and health administrators by Eric Kai-Chung Wong, Andrea C. Tricco, Wanrudee Isaranuwatchai, David M. J. Naimark, Sharon E. Straus, Joanna E. M. Sale

“…Conclusions Overall, participants found CGAs acceptable yet had different preferences of which setting to prioritise staffing if there was a shortage of geriatricians. The main barriers to implementing the geriatrician-led CGA related to lack of resources. …”
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Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation by Cao R, Jing J, Ma Y, Qi W, Huang X, Zhang C, Lu Z, He J, Wang G, Ma Y, Zhang H

“…Met could also block macrophage infiltration and subsequently reduced the level of IL-1β, NLRP3, and Caspase-1 in the colorectal tissue, which were mainly expressed by macrophages. In addition, the level of IL-1β in serum was remarkedly down-regulated by Met. …”
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Association of individual-based morphological brain network alterations with cognitive impairment in type 2 diabetes mellitus by Die Shen, Xuan Huang, Ziyu Diao, Jiahe Wang, Kun Wang, Weiye Lu, Shijun Qiu, Shijun Qiu

“…Subsequently, partial correlation analyses were performed to explore the relationship between clinical biochemical indices, neuropsychological test scores, and altered cortical morphology and network indices.ResultsBrain regions with reduced gray matter volume and cortical thickness in T2DM patients were mainly concentrated in the frontal lobe, temporal lobe, parietal lobe, anterior cingulate gyrus, insula, lingual gyrus, and cerebellar hemispheres. …”
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Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study by Guan R, Zheng Z, Deng M, Mei J, Lin Y

“…Renguo Guan,1– 4,&ast; Zehao Zheng,2– 4,&ast; Min Deng,5,&ast; Jie Mei,2– 4 Ye Lin1 1Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 3State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 4Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, People’s Republic of China; 5Department of General Surgery, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ye Lin, Email linye@gdph.org.cn; Jie Mei, Email meijie@sysucc.org.cnBackground: Maximum diameter and number are the main parameters of tumor burden in hepatocellular carcinoma (HCC). …”
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Changes over a decade in psychotropic prescribing for people with intellectual disabilities: prospective cohort study by Paula McSkimming, Angela Henderson, Sally-Ann Cooper, Deborah Kinnear, Colin McCowan, Linda Allan, Alasdair McIntosh

“…Longitudinal cohort study with detailed health assessments at T1 and record linkage to T2 prescribing data.Setting General community.Participants 1190 adults with intellectual disabilities in T1 compared with 3906 adults with intellectual disabilities in T2. 545/1190 adults with intellectual disabilities in T1 were alive and their records linked to T2 prescribing data.Main outcome measures Encashed regular and as-required psychotropic prescriptions.Results 50.7% (603/1190) of adults in T1 and 48.2% (1881/3906) in T2 were prescribed at least one psychotropic; antipsychotics: 24.5% (292/1190) in T1 and 16.7% (653/3906) in T2; antidepressants: 11.2% (133/1190) in T1 and 19.1% (746/3906) in T2. 21.2% (62/292) prescribed antipsychotics in T1 had psychosis or bipolar disorder, 33.2% (97/292) had no mental ill health or problem behaviours, 20.6% (60/292) had problem behaviours but no psychosis or bipolar disorder. …”
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Determination of the Contents of Antioxidants and Their Degradation Products in Sodium Chloride Injection for Blood Transfusion by Bo Tao, Gang Wang, Zongning Yin, Xiaocong Pu, Yan Jiang, Luohong Zhang, Jie Cheng, Yong Li, Jiayu Zhang

“…The infusion bag is mainly made up of polyolefin polymer. Antioxidants are usually added to these polymer materials in the production process to prevent the materials from aging and enhance the stability of the materials. …”
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Body composition is associated with changes in health-related quality of life in patients with knee and/or hip osteoarthritis by Jérémie Sellam, Francis Guillemin, Bernard Mazières, Anne-Christine Rat, Patrice Fardellone, Willy Ngueyon Sime

“…Objective The objective of this study was to analyse the association between body composition and changes in health-related quality of life (HRQoL) of patients followed for hip and knee osteoarthritis (OA).Methods Longitudinal data from the Knee and Hip OsteoArthritis Long-term Assessments (KHOALA) cohort, a multicentre cohort of 878 patients with symptomatic knee and/or hip OA, were used. The main outcome criteria were changes in patient-reported outcomes measures, the Study Short Form-36 (physical functioning, pain, mental health and vitality) and the OsteoArthritis Knee and Hip Quality Of Life (OAKHQOL)(physical activity, pain and mental health). …”
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Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…Numerous potential pathophysiological mechanisms have been discussed, including (1) an indirect role of infectious agents (i.e. a role of infections located distant from the eye, mainly through their interactions with the immune system) and (2) a direct role of some infectious agents implying potential infection of various cells types within AMD-related tissues. …”
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Economics and cost effectiveness of a rain garden for flood-resistant urban design by D. Rinchumphu, N. Suriyanon, N. Phichetkunbodee, S. Munlikawong, C. Wanitchayapaisit, S. Sitthikankun

“…The need for more information on design and cost effectiveness can make designers and decision makers hesitate to implement such a new strategy. The main objective of the present study is to create a design approach and simultaneously specify the cost of the infiltration rate of the rain garden in urban areas.METHODS: This study focuses on the ability of rain garden design to determine accurately the cost of materials used for construction. …”
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