Prevalence of thyroid diffuse goiter and its association with body mass index and the presence of cysts and nodules in children and adolescents: the Fukushima Health Management Sur... by Nana Nakahata, Mahiro Asano, Norikazu Abe, Haruka Ejiri, Hisashi Ota, Satoshi Suzuki, Ayako Sato, Rina Tazaki, Natsuki Nagamine, Chisato Takahashi, Yukie Yamaya, Manabu Iwadate, Takashi Matsuzuka, Tetsuya Ohira, Seiji Yasumura, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Hitoshi Ohto, Kenji Kamiya

“…The main cause of diffuse thyroid goiter is autoimmune chronic thyroiditis, otherwise known as Hashimoto’s thyroiditis. …”
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Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway by Zhitao Hou, Ruijin Qiu, Qingshuang Wei, Yitian Liu, Meng Wang, Tingting Mei, Yue Zhang, Liying Song, Xianming Shao, Hongcai Shang, Jing Chen, Zhongren Sun

“…The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the NLRP3/caspase-1 signaling pathway. Main Methods. Thirty male SAMP8 mice were randomly divided into the model, the 2 Hz EA and 10 Hz EA groups. …”
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Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain. …”
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Sources analysis and risk assessment of heavy metals in soil in a polymetallic mining area in southeastern Hubei based on Monte Carlo simulation by Jing Wang, Bo Wang, Qibin Zhao, Jinnan Cao, Xiao Xiao, Di Zhao, Zhenya Chen, Di Wu

“…This study investigates the pollution characteristics, spatial patterns, causes, and ecological risks of heavy metals in the soils of the southeastern Hubei polymetallic mining areas, specifically the Jilongshan (JLS) and Tonglushan (TLS) regions, located in the middle and lower reaches of the Yangtze River. The main findings are as follows: (1) Among the heavy metals present in the soil, copper (Cu) has the highest average concentration at 278.54 mg/kg, followed by zinc (Zn) at 161.16 mg/kg, chromium (Cr) at 75.23 mg/kg, nickel (Ni) at 30.38 mg/kg, arsenic (As) at 22.53 mg/kg, cadmium (Cd) at 0.76 mg/kg, and mercury (Hg) at 0.14 mg/kg; (2) The distribution of heavy metal concentrations exhibits significant regional variations, with the spatial pattern of pollution indicating that TLS is more affected than JLS, as evidenced by the Pollution Load Index (PLI) values; (3) Three potential sources of heavy metals were identified: natural sources, anthropogenic activities (including industrial production and agricultural practices), and atmospheric deposition (both dry and wet); (4) While severe contamination levels of specific metals such as copper and cadmium are observed in JLS and TLS soils, the overall contamination is mild, suggesting complex contamination dynamics; (5) Cadmium poses a moderate to high ecological risk, being the most sensitive factor in the comprehensive ecological risk assessment with a contribution rate of 65.2 %; (6) The concentrations of heavy metals in the soil present certain health risks, with children being more vulnerable than adults. …”
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Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…Conclusion: The present study provides an animal model of immunological liver injury induced by Hm infection that exhibits main characteristics similar to those observed in AIH-1 patients. …”
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Daily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients by Hidetaka Matsuda, Takuto Nosaka, Yu Akazawa, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto

“…We retrospectively examined the relationship between daily proton pump inhibitor (PPI) use and severity of upper gastrointestinal bleeding (UGIB), mainly in the elderly. Methods. We included 97 patients with nonvariceal UGIB diagnosed at our hospital from January 2012 to October 2017. …”
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Antibacterial Effect of Luma apiculata (DC.) Burret Extracts in Clinically Important Bacteria by Tiare Araya-Contreras, Rhonda Veas, Carlos A. Escobar, Pamela Machuca, Mauricio Bittner

“…Nosocomial infections caused by bacteria are one of the main public health problems. Moreover, the resistance to antibiotics by these bacteria makes it necessary to find new treatments to fight them. …”
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Comparative safety and effectiveness of cryoballoon versus radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis by Muhammad Furqan, Ifrah Inbisat Raza, Shaheera Younus, Hareer Fatima, Hiba Azhar, Sania Kaneez Fatima, Laiba Ali, Sara Khan, Aayat Ellahi

“…Abstract Background Over the past fifty years, the incidence of atrial fibrillation (AF) has tripled. Traditionally, the main treatment for this condition has been pulmonary vein isolation (PVI) performed using radiofrequency catheter ablation (RFCA). …”
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Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study by Marieke Bierhoff, Chaisiri Angkurawaranon, Aung Myat Min, Mary Ellen Gilder, Nay Win Tun, Arunrot Keereevijitt, Aye Kyi Win, Elsi Win, Verena Ilona Carrara, Tobias Brummaier, Cindy S. Chu, Laurence Thielemans, Kanlaya Sriprawat, Borimas Hanboonkunupakarn, Marcus Rijken, François Nosten, Michele van Vugt, Rose McGready

“…The inclusion criteria were not met for 4,089/15,046 (27.2%) women due mainly to unavailability of pregnancy outcome and nonconfirmation of HBsAg+. …”
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Safety, feasibility and initial efficacy of an app-facilitated telerehabilitation (AFTER) programme for COVID-19 survivors: a pilot randomised study by Kristine M Erlandson, Jacob John Capin, Amy Nordon-Craft, Sarah E Jolley, Jennifer E Stevens-Lapsley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha MaWhinney, Michelle Rauzi, Sheryl Flynn

“…The 30 s chair stand test was the main secondary (efficacy) outcome.Results No adverse events (AEs) occurred during testing or in telerehabilitation sessions; 38% (11/29) of the intervention group compared with 60% (9/15) of the control group experienced an AE (p=0.21), most of which were minor, over the course of the 12-week study. 27 of 29 participants (93%; 95% CI 77% to 99%) receiving the intervention attended ≥75% of sessions. …”
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A study on sexual violence among women in Northern Ethiopia's 2022 conflict: mixed methods by Atitegeb Abera Kidie, Seteamlak Adane Masresha, Birtukan Gizachew Ayal, Kindie Mekuria, Tsion Kokeb Kodo, Abayneh Tunta Boye, Misganaw Guadie Tiruneh, Fassikaw Kebede Bizuneh, Eneyew Talie Fenta

“…Factors such as being a prostitute, having a lower income, and living in attacked villages were significant predictors of this violence. The main impacts included psychosocial effects, external blame, and stigma, fear of humiliation, divorce, and displacement.…”
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Effects of Different Nitrogen Fertilizer Application Rates on Soil Microbial Structure in Paddy Soil When Combined with Rice Straw Return by Xiannan Zeng, Qi Wang, Qiulai Song, Quanxi Liang, Yu Sun, Fuqiang Song

“…Redundancy analysis showed that the main physicochemical drivers behind these differences were total nitrogen, total potassium, ammonium nitrogen, total phosphorus, and available potassium. …”
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Breeding Performances of the European Blackbird (Turdus merula) in Morocco: Habitat Selection, Breeding Phenology, and Breeding Success by Abderahim El Hassani, Ismail Mansouri, Wafae Squalli, Abdelbari El Agy, Amine Assouguem, Kenza Bouayad, Abdellah Markou, Mohamed Mounir, Hamid Achiban, Mohamed Dakki, Lahsen El Ghadraoui

“…Results showed that the European Blackbird nests mainly in apple orchards, on Golden Delicious and Starkrimson Delicious trees. …”
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A clinical decision model for failed adrenal vein sampling in primary aldosteronism by Sophie N. M. ter Haar, Sofie J. van Goor, Eleonora P. M. Corssmit, Arian R. van Erkel, Bartholomeus E. P. B. Ballieux, Olaf M. Dekkers, Olaf M. Dekkers, Michiel F. Nijhoff

“…This study aimed to develop a clinical decision model using only measurements from the left adrenal vein (LAV) and peripheral blood (IVC) to differentiate between PA subtypes.MethodsThe retrospective cohort study included 54 PA patients who underwent bilaterally successful AVS. The main objective was to determine optimal cut-off values for the LAV/IVC index, using ROC analysis for subtype prediction. …”
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Preventive Effects of Intrauterine Injection of Bone Marrow-Derived Mesenchymal Stromal Cell-Conditioned Media on Uterine Fibrosis Immediately after Endometrial Curettage in Rabbit by Sanaz Bazoobandi, Nader Tanideh, Farhad Rahmanifar, Shahrokh Zare, Omid Koohi-Hosseinabadi, Iman Razeghian-Jahromi, Mehdi Dianatpour, Masoumeh Ahmadi, Arezoo Khoradmehr, Iraj Nabipour, Zahra Khodabandeh, Amin Tamadon

“…MSC-conditioned media (MSC-CM) contain paracrine components—exosomes—with a great potential for repairing damaged tissue or preventing fibrosis. The main goal of this study was to evaluate the preventive effects of bone marrow-derived MSC-CM (BM-MSC-CM) on uterine fibrosis after uterine curettage in rabbits. …”
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Study on Roof-Coal Caving Characteristics with Complicated Structure by Fully Mechanized Caving Mining by Yunpei Liang, Lei Li, Xuelong Li, Kequan Wang, Jinhua Chen, Zhongguang Sun, Xuelin Yang

“…With mining technology and mechanization degree being improving, fully mechanized caving mining technology (FCM) has become a main method for thick coal seam extraction in China. …”
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General practitioner-centered rural obesity management: Design, protocol and baseline data of the German HAPpEN pragmatic trial by Marika Haderer, Reiner Hofmann, Tina Bartelmeß, Laura König, Constanze Betz, Mirna Al Masri, Alisa Bader, Natascha von Schau

“…Chronic joint paint, mainly in the knees and hips, affected up to 82.4 %. …”
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Donkey milk supplementation alleviates renal fibrosis of chronic kidney disease by enhancing anti-inflammatory ability by Cui Huimin, Wang Peng, Chen Man, Lin Hong, Zhao Yuxin, Pu Zhiyu, Yang Jianjun

“…ABSTRACT: Donkey milk, rich in essential nutrients, is not only able to meet the nutritional needs of patients with chronic kidney disease (CKD) according to the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline for Nutrition in CKD, but also has strong anti-inflammatory properties. Inflammation is the main driving force of renal fibrosis, which directly determines renal function in CKD. …”
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Factors associated with failure of humerus nonunion surgery in patients with initial nonoperative management by Alexander Hysong, MD, Noah Harrison, MD, Samuel Posey, MD, Ziqing Yu, MS, Andrew T. Chen, MD, Patrick Pallitto, MD, Joseph R. Hsu, MD, William Obremskey, MD, Evidence-Based Musculoskeletal Injury and Trauma Collaborative (EMIT), Hassan Mir, MD, Roman M. Natoli, MD, PhD, Ishani Sharma, MD, MBA, Jenna Jones, Med, Luke A. Lopas, MD, Hassan Farooq, MD, Robert D. Zura, MD, Alexander Padovano, MD, Nathaniel Koutlas, MD, Steve Hemmerly, BS, Elsa Rodriguez, MD, Daniel E. Pereira, MD, Sharon Babcock, MD, Gabriel James Sowards, BS, Martha Holden, AAS, AA, Anna N. Miller, MD, Marc Schatz, MD, Jessica Rivera, MD, PhD, Katrina Bang, MD, Kamryn King, BS, Zachery Hong, BA, Jarrod Dumpe, MD, Gabriella Lea Stribling, BS, Merritt John Thompson, MD, Tracy Johns, MSN, RN-BC, Rachel Seymour, PhD, Susan Odum, PhD, Stephen Sims, MD, Olivia Rice, MD, Ainsley Bloomer, MD, Katheryn Peterson, BSPH, Amber Stanley, BSPH, Mario Cuadra, MD, Gisele Bailey, MS, Matthew Braswell, MD, Landon Bulloch, MD, William Haynes, MD, Josef Jolissaint, MD, Julia Mastracci, MD, Andrew Wohler, MD, Eddie Komie Afetse, BS, BA, Cara Girardi, Juliette Sweeney, BS, Benjamin Averkamp, MD, Meghan Wally, PhD, Madhav Karunakar, MD, Kevin Phelps, MD, Laurence Kempton, MD, Christine Churchill, MA, CCRP, David Macknet, MD, Hannah Pollock, BS, Rodney Arthur, MS, Samuel Cohen-Tanugi, Isaac Boateng, James Michael Ruth, BS, Joseph Michalski, MD, Anna Hemminger, BS, Kathryn Leighty, Mir Ibrahim Sajid, MD, Thea Lance, BA, William Hunter Waddell, MD, Andres Fidel Moreno Diaz, MD, Joseph Gutbrod, BS, Christopher G. Herbosa, BS

“…Operative treatment of humerus nonunions. Main Outcome Measurements:. Rate of recalcitrant nonunion after humerus nonunion surgery. …”
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Automatic Segmentation of Asphalt Cracks on Highways After Large-Scale and Severe Earthquakes Using Deep Learning-Based Approaches by Mehmet Yilmaz, Erkut Yalcin, Fatih Demir, Ahmet Munir Ozdemir, Muhammed Atar, Aysegul Gunes, Beyza Furtana Yalcin, Ertugrul Cambay

“…Unlike traditional manual inspections, which are time-consuming and error-prone, our approach leverages advanced segmentation techniques to ensure accurate, pixel-level classification of various crack types. The main challenge of this study was determining the damage caused to highways by earthquakes with magnitudes greater than 7.0, which occur approximately once every 200 years. …”
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