Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR4... by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…In addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism have been considered to be important factors affecting central nervous system (CNS) homeostasis. Among the main mediators of host-microbe interactions, volatile fatty acids play a crucial role. …”
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Exploring the capacity of microorganism treatment for fermentation and glycosidic aroma bioconversion from rose oil distillation wastewater by Mohammad Karami, Mohsen Bagheri, Alireza Abbasi-Baharanchi, Kamahladin Haghbeen, Abdolrahim Nouri, Ali Asghar Karkhane, Mansour Ghorbanpour, Mohsen Farhadpour

“…Abstract Background One of the main concerns for ecological sustainability is finding ways to convert byproducts from medicinal aroma plants into high-value ingredients. …”
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Non-thermal atmospheric plasma treatments enhance the growth, photosynthesis, metabolite accumulation, and nutritional value of geranium (Pelargonium graveolens L’Herit) leaves by Hussein S. Mohamed, Dalia Shehata, Ahmed M. Mahmoud, Maha H. Khalaf, Mohammad K. Okla, Mohamed A. El-Tayeb, Yasmeen A. Alwasel, Ibrahim A. Alaraidh, Ali El-Keblawy, Izabela Josko, Mohamed S. Sheteiwy

“…Improved photosynthesis led to enhanced accumulation of primary metabolites, such as amino acids, organic acids, and fatty acids. NTAP treatments, mainly T3, significantly increased levels of essential and non-essential amino acids, oxalic, isobutyric, and fumaric acids. …”
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Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation by Leeanne Carey, Alistair Walsh, Achini Adikari, Peter Goodin, Damminda Alahakoon, Daswin De Silva, Kok-Leong Ong, Michael Nilsson, Lara Boyd

“…The methodology involved three main phases: data collection and filtering, development of a clinical vocabulary, and the development of an automatic clinical text processing engine to aid the process and identify the unique and common topics. …”
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Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk by Xiaoye Liu, Kaiyang Liu, Jie Yang, Hui Qiao, Lai-Yu Kwok, Wenyi Zhang

“…Functional metabolites like syringaldehyde, leucic acid, and gentianose accumulated toward the end of fermentation, whereas peptides emerged as the main differential metabolites after the 28-d storage period. …”
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Soil porosity as a key factor of soil aggregate stability: insights from restricted grazing by Yi Yang, Yi Yang, Yi Yang, Zhongju Meng, Zhongju Meng, Zhongju Meng, Haonian Li, Haonian Li, Haonian Li, Yue Gao, Yue Gao, Yue Gao, Tianyang Li, Tianyang Li, Tianyang Li, Lei Qin

“…Additionally, a preliminary exploration was conducted to identify the main factors affecting the soil aggregate stability. …”
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Symptoms of anxiety and depression among health and social science students: A multicenter study by Lara Guedes Pinho, Maria Engström, Brooke C. Schneider, Cesar Fonseca, Magnus Lindberg, Johanna Schröder, Anabela Afonso, Lena Jelinek, Johanna Börsting, Gonçalo Jacinto, Annika Nilsson

“…Our results, which are in line with international trends, underline the need for policy reforms that target the main determinants of mental health, in particular by improving socio-economic conditions. …”
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Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 201... by Zhen Junhai, Meng Yang, Tan Zongbiao, Yan Wenxuan, Li Tiange, Wu Yanrui, Liu Chuan, Dong Weiguo

“…Diet low in milk, diet low in calcium, alcohol use, and high body-mass index were the main contributors to deaths and DALYs. Conclusions: The increase in CRC burden among populations younger than 35 years globally requires vigilance from policy makers, physicians, and young individuals themselves, especially those regions experiencing faster growth burden of very EOCRC.…”
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Estimation and mapping of the contribution of nitric acid to atmospheric corrosion of zinc by J. Castillo-Miranda, F. Rodríguez-Gómez, J. Genescá-Llongueras, L. Ruiz-Suárez, J. García-Reynoso

“…BACKGROUND AND OBJECTIVES: Atmospheric zinc corrosion in the Mexico City Metropolitan area has long been attributed mainly to the effect of pollutants such as sulfur dipxide. …”
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Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development by Narmine Slimani, Soumaya Arraouadi, Hafedh Hajlaoui, Antonio Cid-Samamed, Mohamed Ali Borgi, Mejdi Snoussi

“…HPLC-DAD-ESI-MS/MS analysis corroborated these findings, showing that the main compounds also increased with higher NaCl concentrations. …”
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<i>In vitro</i> and <i>in vivo</i> tropism and biodistribution of recombinant simian adenovirus type 25 by Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…In vivo experiments have shown that recombinant adenoviruses are mainly localized at the injection site, and transgene expression persists for 21 days. …”
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Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor by Guoliang Yang, Hui Li, Jiabei Yin, Lei Yao, Jun Yang, Jiawei Tang, You Wu, Meng Zhou, TingTing Luo, Yi Zhang, Jing Zhang, Xuezhi Yang, XiaoXiao Dong, Zheng Liu, Ningshan Li

“…Mechanically, the enhanced efficacy of combination therapy was mainly based on promoting the infiltration and function of CD8+ T cells within tumors. …”
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MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…It consisted of three main components: (1) LLAVA data enhancement, which introduced a multimodal macromodel to improve the understanding of node attributes; (2) agricultural product association relationship fusion, which constructed and improved the complex association network structure among products to ensure that the system can better understand the substitution relationship, complementary relationship, and implied consumption logic among products; (3) user modal preference feature extraction block, which deeply mined the interaction data between consumers and products, and advanced the effective user feature information from the correspondence between global user representations and local modal user representations.Results and DiscussionWe conduct experiments on a real dataset from Amazon's large-scale e-commerce platform to verify the effectiveness of MP-LLAVRec. …”
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Western disturbances and climate variability: a review of recent developments by K. M. R. Hunt, K. M. R. Hunt, J.-P. Baudouin, A. G. Turner, A. G. Turner, A. P. Dimri, A. P. Dimri, G. Jeelani, Pooja, R. Chattopadhyay, R. Chattopadhyay, F. Cannon, T. Arulalan, T. Arulalan, M. S. Shekhar, T. P. Sabin, E. Palazzi

“…This review is separated into six main sections – structure and thermodynamics, precipitation and impacts, teleconnections, modelling experiments, forecasting at a range of scales, and paleoclimate and climate change – each motivated with a brief discussion of the accomplishments and limitations of previous research.…”
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Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B1 by Donghua Su, Jing Peng, Jingjing Hao, Xi Wang, Peiqiang Yu, Shengli Li, Haitao Shi

“…The DEG annotated were mainly involved in the cell part, cell, single-organism process, cellular process, binding, and other functional categories. …”
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Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…Theoretical sampling was used to recruit 35 participants from three main study sites across two western Canadian provinces. …”
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COVID-19 morbidity in Afghanistan: a nationwide, population-based seroepidemiological study by Siyu Chen, Fatima Arifi, Mohammad Nadir Sahak, Sayed Ataullah Saeedzai, Lisa J White, Amal Barakat, Eman Abdelkreem Aly, Margo van Gurp, Giti Azim, Bahara Rasoly, Soraya Safi, Jennifer A Flegg, Nasar Ahmed, Mohmmad Jamaluddin Ahadi, Niaz M Achakzai, Alaa AbouZeid

“…To adjust the seroprevalence for test sensitivity and specificity, and seroreversion, Bernoulli’s model methodology was used to infer the population exposure in Afghanistan.Outcome measures The main outcome was to determine the prevalence of current or past COVID-19 infection.Results The survey revealed that, to July 2020, around 10 million people in Afghanistan (31.5% of the population) had either current or previous COVID-19 infection. …”
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Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey by Chen Zhao, Liang Tang, Ting Chen, Hui Yang, Xiong Chen, Xiaobo Cui, Li Shi, Xiangping Li, Jian He, Xiaoxia Peng, Shuifang Xiao, Jinrang Li, Hongliang Zheng, Junbo Zhang, Shuihong Zhou, Donghui Chen, Xuping Xiao, Hui Huangfu, Zhenfeng Tao, Yehai Liu, Shenhong Qu, Guangke Wang, Linli Tian, Wensheng Zhou, Hongyan Fang, Yongwang Huang, Guodong Yu, Zhenqun Lin, Ruixia Ma, Zhaoyan Yu

“…Objectives This study aimed to investigate the status of the current knowledge about laryngopharyngeal reflux disease (LPRD) among Chinese otolaryngologists.Design Multi-centre cross-sectional survey.Setting 220 medical centres in different regions of China.Participants A total of 2254 otolaryngologists from 220 medical centres in China who were successfully on-site surveyed between November 2019 and December 2020.Main outcome measures Awareness about LPRD included knowledge about risk factors, symptoms, laryngoscope signs, related diseases, current diagnostic methods and treatments.Results The percentage of participants who had heard of LPRD was 96.4%, with academic conferences as the most common source of information (73.3%). …”
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Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease by Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo

“…Results: Our findings indicate that EuEO is mainly composed of 1,8-cineole (81.8 %) and that, in the parkinsonian rats, it improved impairments in spatial memory, motor performance, and strength; increased TH and DAT protein content; decreased TNF-α expression; diminished liver lipid content and body weight gain without changes in the rats’ food/water consumption or their serum lipid levels; diminished transaminase and alkaline phosphatase activity, and the albumin/globulin ratio. …”
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MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer by Milica Jaksic Karisik, Milos Lazarevic, Dijana Mitic, Maja Milosevic Markovic, Nicole Riberti, Drago Jelovac, Jelena Milasin

“…Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with poor prognosis, mainly due to the presence of cancer stem cells (CSCs), a small subpopulation of cells that contribute to therapy resistance and tumor progression. …”
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