Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis by Julia Vullings, Juliana P. Vago, Claire E. J. Waterborg, Rogier M. Thurlings, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Flavio A. Amaral, Fons A. J. van de Loo

“…These findings suggest that the reduced negative control of cell activation by TAM receptors due to their shedding in the synovial fluid, mainly sTyro3, favoring joint inflammation in RA patients.…”
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Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodi... by Zhiliang Guo, Rula Sa, Daqiang Zhao, Songxia Li, Hui Guo, Lan Zhu, Gang Chen

“…Phase 1 consisted of an intensive treatment period (Dara plus PP/IVIG) and a maintenance treatment period (Dara alone). The main clinical indicators were DSA, Banff scores and renal function. …”
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Individual mobility prediction by considering current traveling features and historical activity chain by Xiaotong Zhang, Zhipeng Gui, Yuhang Liu, Dehua Peng, Qianxi Lan, Zhangxiao Shen, Huan Chen, Yuhui Zuo, Yao Yao, Huayi Wu, Kai Li, Kun Qin

“…Whereas, it remains challenging due to the complexity and uncertainty of human mobility. Existing methods mainly consider spatiotemporal contexts in current traveling, but overlook those in historical trips, as well as relationships between traversed road intersections. …”
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Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery? by Elizabeth Cho, MD, Hanna House, MD, Andrew Marten, BS, Marina Feffer, MPH, Julie Agel, MA, John Scolaro, MD, Meir Marmor, MD, Ashley E. Levack, MD, MAS, OTA Classification & Outcomes Committee, James Kellam, MD, Gillian Soles, MD, Jarrod Dumpe, MD, Kyle Schweser, MD, Geoffrey Maracek, MD

“…Adult patients with operatively treated fractures of the leg, ankle, and hindfoot between 2007 and 2022. Intervention:. N/A. Main Outcome Measurements:. Presence of SSI was determined by selective chart review of patients who met the screening variables for repeated procedures, open fracture, abscess or wound debridement, intraoperative cultures, or infectious disease consultation (n = 551). …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

“…Mediation analysis applied to examine potential direct and indirect effects of sleep duration on ToM tasks indicated that total sleep time had significant indirect effects through cognitive planning—mainly as rule violation total score—on specific ToM aspects. …”
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A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

“…The high expression of most HOX genes is mainly related to immune subtypes C1-C4 and C6. Potential anti-tumor compounds for down-regulating HOX gene expression were identified, such as HDAC inhibitors and tubulin inhibitors. …”
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Potential epidemiological impact of the 2017 American College of Cardiology/American Heart Association high blood pressure guideline on the Chinese population: a cross-sectional st... by Zhao Li, Guozhe Sun, Yingxian Sun, Zhaoqing Sun, Yue Dai, Jia Zheng, Yuanyuan Dong, Xiaofan Guo, Yanxia Xie, Yali Wang, Rongrong Guo, Liqiang Zheng

“…Objectives The present study estimated the percentage of rural Chinese adults with hypertension and recommended pharmacological antihypertensive treatment according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline compared with the 2010 Chinese Guideline for the Management of Hypertension.Design Cross-sectional study.Setting Three counties in rural areas of northeastern China.Participants A total of 11 747 eligible individuals aged ≥35 years from rural areas of northeastern China were selected for the present analysis.Main outcome measures The percentage of rural Chinese adults with hypertension and recommended pharmacological antihypertensive treatment according to the 2017 ACC/AHA guideline and the 2010 Chinese Guideline for the Management of Hypertension, and the proportion of rural Chinese adults taking antihypertensive medication with blood pressure (BP) above the 2017 ACC/AHA guideline and the 2010 Chinese guideline treatment goal.Results The mean age of the study population was 53.9±10.8 years and 53.7% of the participants were women. …”
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Evidence-based exercise recommendations to improve functional mobility in older adults - A study protocol for living systematic review and meta-analysis [version 2; peer review: 2... by Claudia Volecker-Rehage, Uros Marusic, Bettina Wollesen, Antoine Langeard, Tamar Yellon, Anna Wunderlich, Vera Belkin, Guoping Qian, Eleftheria Giannouli, Zbigniew Ossowski, Rafael A. Bernades, Yael Netz, Rajesh Sighdel

“…Therefore, after identifying all potential interventions, we will use the F.I.T.T. principles (frequency, intensity, time, type) as well as the physical and health status of the participants as moderators to analyse the mechanisms for the positive benefits of exercise interventions. The main research questions are: Which exercise types are most beneficial for improving functional mobility in various populations of older adults? …”
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Care Complexity Factors and Discharge Destination in an Emergency Department: A Retrospective Cohort Study by Andrea Urbina, Jordi Adamuz, Maria-Eulàlia Juvé-Udina, Judith Peñafiel-Muñoz, Virginia Munoa-Urruticoechea, Maribel González-Samartino, Pilar Delgado-Hito, Javier Jacob, Marta Romero-García

“…Data were collected from electronic health records. The main study outcomes were discharge destinations (mortality, intensive care unit admission, hospitalization, left without being seen/discharge against medical advice, and home discharge) and 26 CCIFs. …”
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Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults by Yaoyao Wu, Zesheng Chen, Zongxue Cheng, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu

“…Abstract Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms. Therefore, the main objective of this study was to explore how sleep difficulty mediates the impact of chronic diseases on the HRQoL of middle-aged and older adults. …”
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Clinical and microbiological analysis of risk factors for breakthrough bloodstream infection during Tigecycline Therapy by Sol Jin, So Yun Lim, Yun Woo Lee, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Eun Hee Song, Yong Pil Chong

“…Intraabdominal (33.9%), catheter-related (30.4%), and hepatobiliary (19.1%) infections were the main sources of breakthrough BSI. In multivariable analysis, independent risk factors for breakthrough BSI during tigecycline therapy were liver cirrhosis (adjusted odds ratio [aOR], 3.09), indwelling catheter (aOR, 3.42), previous Candida colonization (aOR, 14.95), and previous multi-drug resistant bacteria colonization (aOR, 10.30). …”
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Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry by Gyu Chul Oh, Kyung Woo Park, Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon Kwon Koo, Hyo-Soo Kim

“…SB treatment for LAD bifurcation lesions showed favorable long-term outcomes compared with main-branch-only intervention, especially in patients with low pretreatment risk.…”
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Clinical features of cystic neutrophil granulomatous mastitis in 62 cases by Mengjie Wang, Dongxiao Zhang, Na Fu, Min Liu, Hongkai Zhang, Shuo Feng, Yifei Zeng, Wenjie Zhao, Jianchun Cui, Khattak Mazher Mansoor

“…Some patients have a history of NPM, hyperprolactinemia and breast trauma. The main symptoms of CNGM include breast lumps, redness, pain, and ulceration. …”
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From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi by Asanka Madhushan, Dulan Bhanuka Weerasingha, Evgeny Ilyukhin, Paul W. J. Taylor, Amila Sandaruwan Ratnayake, Jian-Kui Liu, Sajeewa S. N. Maharachchikumbura

“…While sexual recombination is rare and mainly occurs at the center of origin of the pathogen, asexual mechanisms such as mutations, parasexual recombination, horizontal gene or chromosome transfer, and chromosomal structural variations are predominant. …”
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Erectile Function and Sexual Activity Are Declining in the Younger Generation: Results from a National Survey in Japan by Akira Tsujimura, Shinichiro Fukuhara, Koji Chiba, Tsuyoshi Yoshizawa, Hikaru Tomoe, Masato Shirai, Kazunori Kimura, Eiji Kikuchi, Eri Maeda, Yoshikazu Sato, Atsushi Nagai, Koichi Nagao, Haruaki Sasaki

“…Prevalence and frequencies were calculated for each 5-year age group. Main outcomes were the prevalence and number of patients with ED and simultaneous evaluation of age-related variations. …”

Response of the germinable soil seed bank of temperate Leymus chinensis meadows to mowing regimes by Zhitao Zhang, Zhitao Zhang, Tianqi Yu, Xiaoping Xin, Hongmei Liu, Shijie Lv, Zhijun Wei, Guodong Han, Ruirui Yan

“…In this study, we conducted germination experiments on 135 soil samples from various depths to comprehensively analyze the germinable seed bank under different mowing regimes. The main results were as follows: (1) the germinable soil seed bank density decreased significantly with a mowing event per year (C1), and the number of perennial grass seeds and upper grass seeds also decreased under the mowing event per year; (2) the size of the germinable soil seed bank increased under the other mowing regimes (control area without mowing or grazing, CK; mowing event every 2 years, C2; mowing event every 3 years, C3; and mowing event every six years, C6) relative to that under once-a-year mowing. …”
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Identification of alterations in the nucleotide sequence of the chromatin remodeling gene PBRM1 in clear cell renal cell carcinoma patients by E. A. Klimentova, I. R. Gilyazova, A. A. Izmailov, I. M. Sultanov, M. A. Bermisheva, V. N. Pavlov, E. K. Khusnutdinova

“…The PBRM1 gene is located on the short arm of the third chromosome in the 3p21 region near the von Hippel-Lindau gene (VHL), the mutation in which is the main event in the occurrence of ccRCC. The aim of our investigation is identification of changes in the nucleotide sequence of the PBRM1 tumor suppressor gene in patients with ccRCC. 210 pairs of DNA samples isolated from ccRCC tissue were studied. …”
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Multiple eco-regions contribute to the seasonal cycle of Antarctic aerosol size distributions by J. Brean, D. C. S. Beddows, E. Asmi, A. Virkkula, A. Virkkula, L. L. J. Quéléver, M. Sipilä, F. Van Den Heuvel, T. Lachlan-Cope, A. Jones, M. Frey, A. Lupi, J. Park, Y. J. Yoon, R. Weller, G. L. Marincovich, G. L. Marincovich, G. C. Mulena, G. C. Mulena, R. M. Harrison, R. M. Harrison, M. Dall'Osto

“…We utilise <span class="inline-formula"><i>k</i></span>-means cluster analysis to separate the PNSD data into six main categories. “Nucleation” and “bursting” PNSDs occur 28 %–48 % of the time between sites, most commonly at the coastal sites of Marambio and King Sejong where air masses mostly come from the west and travel over extensive regions of sea ice, marginal ice and open ocean and likely arise from new particle formation. …”
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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

“…The analytic sample consisted of n=4598 participants, median age 26 and 73% female.Interventions At each site, participants were randomly assigned to either immediate receipt of a self-directed forgiveness workbook intervention, or to receipt after a 2 week delay.Main outcomes measures The primary outcomes were unforgiveness (Transgression-Related Interpersonal Motivations Inventory-18), depression symptoms, and anxiety symptoms (Brief Symptom Inventory-18) measured at 2 weeks following intervention assignment.Results At 2 weeks follow-up, unforgiveness was lower among the immediate-treatment group compared with the delayed-treatment group (standardised mean difference=−0.53 (95% CI=−0.58 to –0.47)); similar patterns were found for depression (standardised mean difference=−0.22 (95% CI=−0.28 to –0.16)) and anxiety symptoms (standardised mean difference=−0.21 (95% CI=−0.27 to –0.15)).Conclusions A brief workbook intervention promoted forgiveness and reduced depression and anxiety symptoms. …”
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Exploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validat... by Yannan Zhang, Shuai Zhang, Yimeng Fan, Sijuan Huang, Shimin Wang, Zhihui Hao, Jianzhong Shen

“…Molecular docking revealed strong binding affinities between the main components of WLD and key targets within these pathways. …”
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