Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…This study revealed neoadjuvant‐chemotherapy‐induced changes in metabolic pathways in PDAC, mainly amino acid and nucleotide metabolism, and these correlated with reduced CA 19‐9 following neoadjuvant FOLFIRINOX treatment.…”
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Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis by Xuening Wang, Dan Cheng, Guanglei Hu, Lili Liang, Fei Tan, Tong Xiao, Shengxiang Xiao, Yumin Xia

“…Normal keratinocytes (mainly expressing TNFR1) and TNFR2-overexpressing keratinocytes were stimulated with TWEAK. …”
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Amniotic fluid microbiota and metabolism with non-syndromic congenital heart defects: a multi-omics analysis by Wenli Xu, Lu Li, Hong Kang, Meixian Wang, Yanqun Liu, Guicun Wang, Ping Yu, Juan Liang, Zhen Liu

“…The nine differential metabolites were mainly associated with pathways involving steroid hormone biosynthesis, bile secretion, glycolysis, tricarboxylic acid (TCA) cycle, NADPH metabolism, and acyl transfer pathways. …”
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Enrichment of Cancer‐Associated Fibroblasts, Macrophages, and Up‐Regulated TNF‐α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis by Eirik Høye, Chakravarthi Kanduri, Annette Torgunrud, Susanne Lorenz, Bjørn Edwin, Stein G. Larsen, Åsmund A. Fretland, Vegar J. Dagenborg, Kjersti Flatmark, Christin Lund‐Andersen

“…ABSTRACT Background Metastatic colorectal cancer (mCRC) is the main cause of CRC mortality, with limited treatment options. …”
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High nature value farming systems in Europe: A dataset encompassing the environmental impact assessment of farms and extensive ruminant food productsFigshare by M. Torres-Miralles, P. Jeanneret, M. Lamminen, F. Joly, B. Dumont, H. Tuomisto, I. Herzon

“…Additionally, we utilised the LCA inventory Agribalyse 3.0 database to estimate the environmental footprint of four pivotal HNV products: goat cheese, cow milk, lamb, and beef. The main outcome is a unique and novel dataset for HNV farming systems, addressing critical gaps in available information. …”
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Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection [version 2; peer review: 2 approved] by Raasti Naseem, Sara Pretorius, Nicola Howe, Clare Lendrem, Cameron Williams, Enitan D Carrol, Philip Pallmann

“…Facilitators to the adoption of infection diagnostic tests is their clinical need, and the main potential barrier is poor change management and behavioural change. …”
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GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses by Lei Sun, Jinwen Luan, Jinbiao Wang, Xiaoli Li, Wenqian Zhang, Xiaohui Ji, Longhua Liu, Ru Wang, Bingxiang Xu

“…There were also samples across 9 mice tissues with skeletal muscle (359, 35.7 %) and brain (280, 27.8 %) accounting for the main fractions. Metadata—including subject, exercise interventions, sampling sites, and post-processing methods—are also included. …”
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Dietary Beliefs and Their Association with Overweight and Obesity in the Spanish Child Population by María Teresa Murillo-Llorente, Alma María Palau-Ferrè, María Ester Legidos-García, Javier Pérez-Murillo, Francisco Tomás-Aguirre, Blanca Lafuente-Sarabia, Adalberto Asins-Cubells, Miriam Martínez-Peris, Ignacio Ventura, Jorge Casaña-Mohedo, Marcelino Pérez-Bermejo

“…Background/Objectives: Childhood obesity is a multifactorial chronic disease that represents one of the main preventable causes of morbidity and mortality. …”
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Floristic Diversity and Potential of Site of Biological and Ecological Interest Brikcha, Prérif (North-West Morocco) by Ahmed Chriqui, Ouafae Benkhnigue, Issam El Khadir, Yassine Mouniane, Sidi Mohamed Hachimi Alaoui, Lahcen Zidane, Driss Hmouni

“…The spring season is the preferred flowering time for 56.77% of the flora. Life forms are mainly represented by therophytes (46.01%), followed by geophytes (17.49%) and phanerophytes (14.11%). …”
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Geothermal Fluid Variation Recorded by Banded Ca-Carbonate Veins in a Fault-Related, Fissure Ridge-Type Travertine Depositional System (Iano, southern Tuscany, Italy) by Paola Francesca Matera, Gennaro Ventruti, Martina Zucchi, Andrea Brogi, Enrico Capezzuoli, Domenico Liotta, Tsai-Luen Yu, Chuan-Chou Shen, Katharine W. Huntington, László Rinyu, Sándor Kele

“…Interpreted in the context of the tectonic setting, the data show that the NW-trending faults have mainly controlled travertine deposition. Their intersection with NE-trending faults, interpreted as transfer faults, highlights the important role of transfer zones in channeling the geothermal fluids.…”
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Alleviating small sample problem in continuous forest monitoring with remote sensing-assisted Copulas by Xinjie Cheng, Zhengyang Hou, Annika Kangas, Jean-Pierre Renaud, Hao Tang, Weisheng Zeng, Qing Xu

“…Consequently, this study aims to (1) develop and demonstrate estimation using Copulas modeling; (2) propose a sample size optimization procedure for MA estimators in the context of continuous forest monitoring; and (3) compare survey precisions of the estimators using Copulas and Weighted Least Squares regression (WLS) as a function of sample sizes. Four main conclusions are relevant: for both Burkina Faso (BF) and Genhe (GH) study area, (1) Copulas outperforms WLS in modeling and prediction, both in terms of mean values and maximum/minimum values; (2) Copulas consistently demonstrates superior performance and precision across varying sample sizes compared to the WLS with MA estimators; (3) a straightforward sample size optimization approach reveals that variance estimates of Copulas remain lower than those of WLS as the sample size decreases in monitoring surveys; (4) Copulas requires about 20% smaller sample size than WLS does when achieving a specified precision, suggesting enhanced efficiency. …”
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The interprovincial green water flow in China and its teleconnected effects on the social economy by S. Sang, S. Sang, Y. Li, Y. Li, C. Hou, C. Hou, S. Zi, S. Zi, H. Lin, H. Lin

“…Despite self-recycling (ranging from 0.6 % to 35 %), green water mainly forms precipitation in neighboring provinces, with average interprovincial flow directions from west to east and south to north. …”
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Enhancing Tropical Cyclone Risk Assessments: A Multi-Hazard Approach for Queensland, Australia and Viti Levu, Fiji by Jane Nguyen, Michael Kaspi, Kade Berman, Cameron Do, Andrew B. Watkins, Yuriy Kuleshov

“…To evaluate the methodology, the regions affected by TC Debbie (2017) for Queensland and TC Winston (2016) for Fiji’s main island of Viti Levu were used as proof-of-concept case studies. …”
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An evaluation of financial losses due to lumpy skin disease outbreaks in dairy farms of northern Thailand by Wittawat Modethed, Khwanchai Kreausukon, Tawatchai Singhla, Kittikorn Boonsri, Kidsadagon Pringproa, Nattawooti Sthitmatee, Nattawooti Sthitmatee, Paramintra Vinitchaikul, Supitchaya Srisawang, Roderick Salvador, Simon Gubbins, Georgina Limon, Veerasak Punyapornwithaya, Veerasak Punyapornwithaya

“…On farms without LSD outbreaks, the main expenses were related to vaccination and disease prevention, amounting to 130.66 USD and 218.53 USD per farm, respectively. …”
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Oncology Clinicians' Perspectives of a Remote Patient Monitoring Program: Multi-Modal Case Study Approach by Ann Marie Mazzella-Ebstein, Robert Daly, Jennie Huang, Camila Bernal, Clare Wilhelm, Katherine S Panageas, Jessie Holland, Rori Salvaggio, Jill Ackerman, Jennifer Cracchiolo, Gilad Kuperman, Jun Mao, Aaron Begue, Margaret Barton-Burke

“…Interview sessions revealed 3 main themes: clinician understanding and usability constraints, patient constraints, and suggestions for improving the program. …”
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Study on Viscosity Reducer Flooding Technology for Deep Low Permeability Extra Heavy Oil Reservoirs by Xiaopeng Cao, Zupeng Liu, Yong Yang, Shiming Zhang, Yahui Bu, Sen Wang, Yipu Liang, Qihong Feng

“…The results show that compared with waterflooding, the oil displacement efficiency of water-soluble viscosity reducer is increased by 12.7%; water-soluble viscosity reducer can effectively reduce the viscosity of extra heavy oil, under the same temperature and permeability, the higher the concentration of viscosity reducer, the better the viscosity reduction effect, and the smaller the pressure gradient required at the same injection rate; the main mechanism of water-soluble viscosity reducer for enhancing oil recovery is to form oil in water emulsion, which can reduce the viscosity and interfacial tension of crude oil and reduce the residual oil saturation; in the pilot well group, the optimized injection concentration of water-soluble viscosity reducer is 3%, and the optimal injection amount of water-soluble viscosity reducer solution is 50 t/d; water-soluble viscosity reducer displacement was implemented in the pilot well group, the average daily oil of well group was increased from 1.8 t/d to 7.34 t/d, and the pilot well group has achieved good development performance.…”
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Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study by Samuel Suárez-Suárez, Fernando Cadaveira, Alfonso Barrós-Loscertales, José Manuel Pérez-García, Socorro Rodríguez Holguín, Javier Blanco-Ramos, Sonia Doallo

“…Using a seed-to-voxel approach, RS-FC differences were examined in nodes of the main brain functional networks vulnerable to alcohol misuse, according to previous studies. …”
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The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction by Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Irina Zaitseva, Elmira Omirtaeva, Adolat Manakbayeva, Yergali Moldakhanov, Elmira Anarkulova, Anar Imangazy, Kuralay Akanova, Zhumagali Koshemetov, Nurkul Orazymbetova, Bakyt Umuraliyev

“…These proteins include ACE2 protein, HRV 3C Protease, and Mpro (Main Protease). It was shown that the plant-based complex effectively inhibited the activity of these viral proteins. …”
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…Overall, several of the six tested chemotherapeutic drugs mainly affected the expression levels of phosphatidylcholine (PtdC)-specific phospholipases and lysophospholipases, leading to the observed GPC/PC and tCho changes following treatment with the chemotherapeutic agents that altered choline phospholipid metabolism. …”
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Assessing Electricity Supply Reliability by Detection of Anomalies in Daily Nighttime Light by Miaoying Chen, Yang Hu, Xin Cao, Shijie Li, Luling Liu

“…Moreover, the electricity anomaly rate in Johannesburg increased from 36% to 51% between 2020 and 2023, with elevated areas mainly in densely residential areas and commercial centers. …”
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