Relativistic Electron Acceleration and the “Ankle” Spectral Feature in Earth’s Magnetotail Reconnection by Weijie Sun, Mitsuo Oka, Marit Øieroset, Drew L. Turner, Tai Phan, Ian J. Cohen, Xiaocan Li, Jia Huang, Andy W. Smith, James A. Slavin, Gangkai Poh, Kevin J. Genestreti, Dan Gershman, Kyunghwan Dokgo, Guan Le, Rumi Nakamura, James L. Burch

“…Spectral analysis showed that these relativistic electrons deviated from the main plasma sheet population and exhibited an “ankle” feature similar to that observed in galactic cosmic rays. …”
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Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and me... by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

“…Polygenic risk scores (PRS) can be effective in predicting adverse coronary events in younger and middle-aged patients. Our main aim is to assess the utility of a new PRS created for the Polish population in predicting mortality during an 8-year follow-up in the nationwide LIPIDOGEN2015 population. …”
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GYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation by Pengyu Duan, Xiaoyan Li, Yonghong Bi, Weiyu Feng, Zhehao Jin, Xiaoqian Zhang, Guanghui He, Da An, Zhibin Wen, Bing Zhang

“…The detection of autophagy flow and protein degradation pathways showed the inhibition of occludin reduction by GYY4137 was mainly achieved by suppressing autophagy mediated degradation. …”
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Urban green infrastructure index: Assessing supply of regulating and cultural ecosystem services at a megacity scale by Yury Dvornikov, Valentina Grigorieva, Vyacheslav Vasenev, Mikhail Varentsov, Olga Romzaykina, Olga Maximova, Anastasia Konstantinova, Victor Matasov, Ekaterina Kozlova

“…The proposed UGI index has several important advantages: 1) it considers multiple scales; 2) it relies on CICES classification of ES, including regulating and cultural services; and 3) it is mainly based on open data sources. The developed approach allowed to explore spatial variation in UGI ES and to identify hotspots on the city map where these ES were undersupplied. …”
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Impact of land use changes on waterlogging disasters in the small urban watershed of Hangzhou by Rikun Wen, Liu Yang, Hexian Jin, Hao Tao, Chingaipe N’tani

“…New hydrological insights for the region: 1) Using the GSSHA model to simulate waterlogging disasters at the small urban watershed scale was effective. 2) The waterlogging points in a small watershed were mainly distributed in areas with high building density, low forest area, low elevation, and low surface permeability. …”
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Pseudomonas azotoformans and Pseudomonas putida: Novel kiwifruit-native biological control agents against Pseudomonas syringae pv. actinidiae by Cristiana Correia, Antonio Cellini, Irene Donati, Panagiotis Voulgaris, Adebayo Ebenezer Obafemi, Elia Soriato, Elodie Vandelle, Conceição Santos, Francesco Spinelli

“…Pseudomonas syringae pv. actinidiae (Psa), the etiological agent of the bacterial canker in Actinidia plants, remains the main threat to kiwifruit orchards worldwide. Though environment-friendly disease control methods based on biological control agents (BCAs) represent a promising alternative to xenobiotic pesticides, their efficacy in field conditions has often resulted erratic. …”
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A study on the differences in the gut microbiota and metabolism between male and female mice in different stress periods by Yajun Qiao, Yajun Qiao, Yajun Qiao, Juan Guo, Qi Xiao, Jianv Wang, Jianv Wang, Xingfang Zhang, Xingfang Zhang, Xinxin Liang, Xinxin Liang, Lixin Wei, Lixin Wei, Hongtao Bi, Tingting Gao, Tingting Gao

“…There is a lack of studies linking sex differences in depression to microbiota, and the specific mechanisms of this process have not been explained in detail. The main purpose of this study was to explore the gender differences in the intestinal tract of male and female depressed mice. …”
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Assessing the declining trend in soil erodibility across China: A comparison of conventional and digital K-factor maps by Zhiyuan Tian, Yan Zhao, Longxi Cao, Yuan Zhao, Yin Liang

“…The K value decrease was mainly attributed to the update of soil survey data (the mean K value changed from 0.03193 t ha·h/(MJ·mm·ha) in the soil species database to 0.02988 t ha·h/(MJ·mm·ha) in the soil series) and was less influenced by the replacement of the mapping methods (the mean K value changed from 0.03197 t ha·h/(MJ·mm·ha) in the soil polygon linkage method to 0.03193 t ha·h/(MJ·mm·ha) in the random forest). …”
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Difficult choledocholithiasis – result of overdue surgical treatment of gallstone disease by S. G. Shapovalyants, T. B. Ardasenov, A. G. Pankov, S. A. Budzinsky, V. S. Veselova

“…Complex anatomical conditions in patients with choledocholithiasis basically develop as a result of overdue surgical treatment of gallstone disease. The main cause of delay in cholecystectomy is unjustified long-term and ineffective conservative treatment.…”
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Nuclear Intron Sequence Variation of the <i>Bulinus globosus</i> Complex (Mollusca: Planorbidae): Implications for Molecular Systematic Analyses by Chairat Tantrawatpan, Kotchaphon Vaisusuk, Chrysantus M. Tanga, Warayutt Pilap, Naruemon Bunchom, Ross H. Andrews, Tongjit Thanchomnang, Wanchai Maleewong, Weerachai Saijuntha

“…The freshwater snail <i>Bulinus globosus</i> is its main intermediate host. The species that make up the <i>B. globosus</i> group are genetically complex, and their taxonomic status remains controversial. …”
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Integrated analysis of transcriptome, sRNAome, and degradome involved in the drought-response of maize Zhengdan958 by Yang Shuqiong, Liu Jiafei, Cao Lingling, Chen Jibao, Duan Pengfei

“…These target genes were mainly involved in the plant hormone signal transduction and phenylpropanoid biosynthesis pathways. …”
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Current molecular understanding of central nervous system schwannomas by Takahiro Tsuchiya, Satoru Miyawaki, Yu Teranishi, Kenta Ohara, Yudai Hirano, Shotaro Ogawa, Seiei Torazawa, Yu Sakai, Hiroki Hongo, Hideaki Ono, Nobuhito Saito

“…Merlin, the protein encoded by NF2, is integral to several signaling pathways, including Ras/Raf/MEK/ERK, PI3K/Akt/mTORC1, Wnt/β-catenin, and the Hippo pathway. Main body Recent research has also uncovered novel genetic alterations, such as the SH3PXD2A::HTRA1 fusion gene, VGLL-fusions in intraparenchymal CNS schwannomas, and the SOX10 mutation particularly in non-vestibular cranial nerve schwannomas. …”
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Ten-Year Persistence of Biologic Drugs in Psoriasis and Its Relationship with Pharmacogenetic Biomarkers by Andrea Rodríguez-Lopez, María Martínez-Sendino, Rocío Prieto-Pérez, Paula Soria-Chacartegui, Eva González-Iglesias, Mario Aparicio-Domínguez, Sonsoles Berenguer-Ruiz, Esteban Daudén, Francisco Abad-Santos

“…Adalimumab was the most persistent drug (41.5%), followed by ustekinumab (34.8%), infliximab (28%) and etanercept (9.3%). The main reason for discontinuation was insufficient efficacy (51%). …”
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The ENaC taste receptor’s perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis by Wen Li, Wanchao Chen, Di Wu, Zhong Zhang, Peng Liu, Zhengpeng Li, Yan Yang

“…The salty peptide-ENaC receptor binding complex was stable around 0.3 nm, and the tight and multisite binding was the main reason the ENaC receptor sensed the salty peptide, enabling it to exert its taste effect. …”
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Ethnic disparities in rapid tranquillisation use and justifications in adult mental health inpatient settings: a systematic review and meta-analysis by Alessio Bricca, John Baker, Trine Munk-Olsen, Martin Locht Pedersen, Ole Schjerning, Frederik Alkier Gildberg

“…PROSPERO: CRD42024423831.Findings Fifteen studies with 38 622 individuals were included, mainly using white or native as the ethnic majority group compared with other ethnic groups. …”
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Inhibition of Anti-Reflection Film Cracks on Plastic Substrates Using Nanolaminate Layer Deposition in Plasma-Enhanced Atomic Layer Deposition by Chi-Chieh Wang, Cheng-Fu Wang, Meng-Chi Li, Li-Chen Su, Chien-Cheng Kuo

“…In this research, we mainly increase the adhesion of PMMA substrate and film, which is reflected in the environmental test. …”
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Nonylphenol exposure increases the risk of Hirschsprung’s disease by inducing macrophage M1 polarization by Xuefeng Yang, Chengyan Tang, Daiwei Zhu, Xingrong Xia, Qing Du, Lu Huang, Jianguo Liu, Yuanmei Liu

“…Hirschsprung’s disease (HSCR), one of the most frequently observed congenital malformations of the digestive system, arises mainly due to the failure of enteric neural crest cells to migrate to the distal colon during embryonic development. …”
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Phenotypic plasticity vs. local genetic adaptation: essential oil diversity of natural immortelle (Helichrysum italicum (Roth.) G.Don) populations along eastern Adriatic coast by Tonka Ninčević Runjić, Dejan Pljevljakušić, Marko Runjić, Martina Grdiša, Martina Grdiša, Zlatko Šatović, Zlatko Šatović

“…Correlations between the 18 main compounds and the bioclimatic variables of the populations’ native environment revealed that BIO14 Precipitation of driest month and BIO15 Precipitation seasonality, were the most informative. …”
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Instability mechanism of coal pillar in steeply dipping ultra-thick coal seam “segmented and stratified” combined mining by Yong LIU, Yao YANG, Xiao WANG, Wenqiang WANG, Xuesong WU, Anye CAO, Zujun LU, Tao YANG, Zhanquan WEI

“…The simulation results show that under the influence of pre-abutment pressure in inclined stratified mining, the section coal pillar is in a state of high stress, and the stress change rate is the most significant. The main cause of pillar instability is the local stress concentration in the combined mining of “segmented and stratified” coal seam with large dip angle; based on the instability mechanism of coal pillar in the composite mining area with large dip angle and ultra-thick coal seam, the prevention and control idea of rock burst of working face and key areas, the plan of the deep hole pre-splitting blasting in the roof and the combining of near and far blasting in the coal body, pressure relief in batches and shock absorption and shock prevention is formulated, which effectively reduces the stress and energy level of the gob side and significantly reduces the “segmented and stratified” composite mining of large dip angle and ultra-thick coal seam.…”
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Regeneration of Rabbit Auricular Cartilage After the Intravenous Stem Cell Injection by Pavlo Virych, Nadiia Shuvalova, Anton Karas, Galina Karas, Svitlana Chaika, Tetiana Kucherenko, Ganna Minina, Marina Timchenko, Oleg Melnykov, Yurii Minin

“…In addition, the amount of interleukin-6 (IL-6) and the transforming growth factor β1 (TGF-β1) in the blood serum were determined. Results. The main method of healing is the formation of a connective tissue scar. …”
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