Projected background and sensitivity of AMoRE-II by A. Agrawal, V. V. Alenkov, P. Aryal, J. Beyer, B. Bhandari, R. S. Boiko, K. Boonin, O. Buzanov, C. R. Byeon, N. Chanthima, M. K. Cheoun, J. S. Choe, Seonho Choi, S. Choudhury, J. S. Chung, F. A. Danevich, M. Djamal, D. Drung, C. Enss, A. Fleischmann, A. M. Gangapshev, L. Gastaldo, Y. M. Gavrilyuk, A. M. Gezhaev, O. Gileva, V. D. Grigorieva, V. I. Gurentsov, C. Ha, D. H. Ha, E. J. Ha, D. H. Hwnag, E. J. Jeon, J. A. Jeon, H. S. Jo, J. Kaewkhao, C. S. Kang, W. G. Kang, V. V. Kazalov, S. Kempf, A. Khan, S. Khan, D. Y. Kim, G. W. Kim, H. B. Kim, Ho-Jong Kim, H. J. Kim, H. L. Kim, H. S. Kim, M. B. Kim, S. C. Kim, S. K. Kim, S. R. Kim, W. T. Kim, Y. D. Kim, Y. H. Kim, K. Kirdsiri, Y. J. Ko, V. V. Kobychev, V. Kornoukhov, V. V. Kuzminov, D. H. Kwon, C. H. Lee, DongYeup Lee, E. K. Lee, H. J. Lee, H. S. Lee, J. Lee, J. Y. Lee, K. B. Lee, M. H. Lee, M. K. Lee, S. W. Lee, Y. C. Lee, D. S. Leonard, H. S. Lim, B. Mailyan, E. P. Makarov, P. Nyanda, Y. Oh, S. L. Olsen, S. I. Panasenko, H. K. Park, H. S. Park, K. S. Park, S. Y. Park, O. G. Polischuk, H. Prihtiadi, S. Ra, S. S. Ratkevich, G. Rooh, E. Sala, M. B. Sari, J. Seo, K. M. Seo, B. Sharma, K. A. Shin, V. N. Shlegel, K. Siyeon, J. So, N. V. Sokur, J. K. Son, J. W. Song, N. Srisittipokakun, V. I. Tretyak, R. Wirawan, K. R. Woo, H. J. Yeon, Y. S. Yoon, Q. Yue, The AMoRE Collaboration

“…Abstract AMoRE-II aims to search for neutrinoless double beta decay ( $$0\nu \beta \beta $$ 0 ν β β ) with an array of 423 $$\hbox {Li}_2^{100}\hbox {MoO}_4$$ Li 2 100 MoO 4 crystals operating in the cryogenic system as the main phase of the Advanced Molybdenum-based Rare process Experiment (AMoRE). …”
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Infection with Toxoplasma gondii triggers coagulation at the blood-brain barrier and a reduction in cerebral blood flow by Evelyn M. Hoover, Christine A. Schneider, Christian Crouzet, Tatiane S. Lima, Dario X. Figueroa Velez, Cuong J. Tran, Dritan Agalliu, Sunil P. Gandhi, Bernard Choi, Melissa B. Lodoen

“…However, little is known about the effect of T. gondii infection on the BBB and the functional consequences of infection on cerebral blood flow (CBF) during the different stages of infection. Main body We demonstrate that brain endothelial cells upregulate the adhesion molecules ICAM-1 and VCAM-1 and become morphologically more tortuous during acute T. gondii infection of mice. …”
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Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing by Youliang Shen, Yuelei Wang, Yidan Xu, Jie Wang, Chuqiang Yin, Zengshuai Han, Feng Shen, Ting Wang

“…Traditional treatments such as surgery and physical therapy can provide temporary relief, but it is difficult to achieve complete healing of the tendon, mainly because of the limited repair capacity of the tendon cells. …”
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Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

“…Hematological toxicity, mainly attributable to gemcitabine, was the predominant grade 3 or 4 adverse event, with additional occurrences of loss of appetite, rash, and interstitial lung disease. …”
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Shifting Paradigms: A Deep Dive Into Public Perceptions of Gender-affirming Surgery by Justin M. Camacho, MBA, Michael Alfertshofer, MD, Heli S. Patel, MBA, Daniel Najafali, BS, Noelle Thompson, BS, Victoria Stoffel, MS, Chris M. Reid, MD, Michael Alperovich, MD, Samuel Knoedler, BS, Leonard Knoedler, MD

“…The majority of participants (78%) did not personally know anyone who underwent GAS, and 74% believed that plastic surgeons mainly perform GAS. Only 22% felt healthcare professionals were well qualified to provide gender-affirming care. …”
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Negative heterosis for meiotic recombination rate in spermatocytes of the domestic chicken Gallus gallus by L. P. Malinovskaya, K. V. Tishakova, T. I. Bikchurina, A. Yu. Slobodchikova, N. Yu. Torgunakov, A. A. Torgasheva, Y. A. Tsepilov, N. A. Volkova, P. M. Borodin

“…The differences in overall recombination rate between the breeds, hybrids and backcrosses were mainly determined by the differences in the crossing over number in the seven largest macrochromosomes. …”
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“Lung-on-a-chip” as an instrument for studying the pathophysiology of human respiration by Oksana A. Zhukova, Iuliia V. Ozerskaya, Dmitry V. Basmanov, Vsevolod Yu. Stolyarov, Vladimir G. Bogush, Vladimir V. Kolesov, Kirill A. Zykov, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev

“…In the present review, we have analyzed the existing types of LoC, the biomaterials used, the methods of detecting molecular processes within the microfluidic devices and the main directions of research to be conducted using the “lung-on-a-chip”.…”
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Executive function deficit in patients with long COVID syndrome: A systematic review by Siti Maisarah Nasir, Noorazrul Yahya, Kah Hui Yap, Hanani Abdul Manan

“…Results: A total of 31 out of 3268 articles were included in the present study. The main outcome is the proportion of individuals with cognitive deficits, particularly in the EF domain, as detected by neuropsychological assessments. …”
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Causal relationship between blood lipids and diabetic kidney disease：a Mendelian randomization study by Wang Hao-hao, Liu Hao-fei, Miao Shao-bo, Jia Run-ke, Ma Ji-wei

“…Steiger test was used to test directionality， and leave-one-out analysis was used to determine whether there was potential single nucleotide polymorphism.ResultsThe IVW method was used as the main analysis method. The analysis results showed that the genetic prediction of TG （OR=1.428， 95%CI： 1.150-1.774， P=0.001） and TC （OR=0.683， 95%CI： 0.486-0.960， P=0.028） had a causal relationship with DKD. …”
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Distal protein-protein interactions contribute to nirmatrelvir resistance by Eric M. Lewandowski, Xiujun Zhang, Haozhou Tan, Aiden Jaskolka-Brown, Navita Kohaal, Aliaksandra Frazier, Jesper J. Madsen, Lian M. C. Jacobs, Jun Wang, Yu Chen

“…Abstract SARS-CoV-2 main protease, Mpro, is responsible for processing the viral polyproteins into individual proteins, including the protease itself. …”
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LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis, Helen Gika

“…An extraction solvent optimization study was first performed on the three devices before the main study, which compared the global metabolic profiles of the four extracts (three BµS devices and plasma). …”
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Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells by Charles Elias Assmann, Vitor Bastianello Mostardeiro, Grazielle Castagna Cezimbra Weis, Karine Paula Reichert, Audrei de Oliveira Alves, Vanessa Valéria Miron, Margarete Dulce Bagatini, Taís Vidal Palma, Cinthia Melazzo de Andrade, Micheli Mainardi Pillat, Fabiano Barbosa Carvalho, Cristina Ruedell Reschke, Ivana Beatrice Mânica da Cruz, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch

“…Purinergic signaling has been shown to play a role in several neurological conditions as it can modulate the functioning of several cell types, such as microglial cells, the main resident immune cells of the CNS. However, Al effects on microglial cells and the role of the purinergic system remain elusive. …”
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Assisted Parkinsonism Diagnosis Using Multimodal MRI—The Role of Clinical Insights by Tobias Meindl, Alexander Hapfelmeier, Tobias Mantel, Angela Jochim, Jonas Deppe, Silke Zwirner, Jan S. Kirschke, Yong Li, Bernhard Haslinger

“…We provide a visual method that aids the interpretation of neuroimaging‐based classification results of the three main parkinsonian syndromes, improving clinical interpretability.…”
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Assessing the dynamics of  Mycobacterium bovis infection in three French badger populations by Calenge, Clément, Payne, Ariane, Réveillaud, Édouard, Richomme, Céline, Girard, Sébastien, Desvaux, Stéphanie

“…The Sylvatub system is a national surveillance program established in 2011 in France to monitor infections caused by Mycobacterium bovis, the main etiologic agent of bovine tuberculosis, in wild species. …”
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Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights by Bantayehu Addis Tegegne, Tesfa Begashaw, Wubetu Yihunie Belay, Mengistie Kassahun Tariku, Tirsit Ketsela Zeleke, Mohammed Jemal, Mamaru Getinet, Agumas Alemu Alehegn, Abebe Dagne

“…Phytochemical analysis identifies 77 secondary metabolites, mainly alkaloids, flavonoids, saponins, terpenes, and terpenoids and other miscellaneous metabolites. …”
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Oleuropein in olive leaf, branch, and stem extracts: stability and biological activity in human cervical carcinoma and melanoma cells by Benčić Đani, Barbarić Monika, Mornar Ana, Klarić Daniela Amidžić, Brozovic Anamaria, Dabelić Sanja, Fadljević Mihaela, Marković Ana Karković

“…Olive leaves as a main byproduct of olive oil and fruit industry are a valuable source of phytochemicals such as polyphenols, with multiple biomedical effects. …”
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Evaluation and Optimization Research on the Spatial Distribution of Automated External Defibrillators Based on a Genetic Algorithm: A Case Study of Central Urban District of Nanjin... by Ge Shi, Jiahang Liu, Chuang Chen, Jingran Zhang, Jinghai Xu, Yu Chen, Jiaming Na, Wei Chen

“…It enhances the efficiency of current AED deployment in the main urban areas of Nanjing and offers significant insights for the optimization of urban emergency resource allocation.…”
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Solar Flares Triggered by a Filament Peeling Process Revealed by High-resolution GST Hα Observations by Mia Mancuso, Ju Jing, Haimin Wang, Wenda Cao

“…High-resolution H α observations reveal details of the flares and some striking features, such as a filament peeling process: individual strands of thin flux tubes are separated from the main filament, followed shortly thereafter by a flare. …”
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Exploring the general practitioners’ perception of the inter-professional care of rheumatoid arthritis patients (GEPRA—II): a qualitative interview study by Anne-Laure Yailian, Audrey Janoly-Dumenil, Emmanuelle Vignot, Aurélie Fontana, Charline Estublier, Cyrille Confavreux, Roland Chapurlat, Claude Dussart, Humbert de Freminville

“…Five themes were identified in the care of their patients with RA. GPs reported being mainly involved in diagnosis and orientation, and frequently asked for pain management and explanation/reformulation of previously given information. …”
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Failure mechanics mechanisms and permeability stage evolution of limestone considering wave velocity and failure surface characteristics by Genshui Wu, Weijian Yu, Bao Pan, Chuangfeng Fang, Hanxiao Guo, Chao Zhang

“…Macroscopically, under the action of stress and seepage in different types of rocks, fissures provide the main seepage channels. Due to the confining pressure, the pores are compressed and the permeability decreases significantly. …”
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