Akt/p27kip1 Pathway Is Not Involved in Human Insulinoma Tumorigenesis by Adriana Graciela Díaz, Andrea Paes de Lima, Paula Garibaldi, Maria de los Milagros Rubio, Florencia García, Marta Kral, Oscar D. Bruno

“…Staining was performed on embedded paraffin tissue using polyclonal antibodies against total Akt, p-Akt, p27kip1, and pp27kip1. p-Akt was the predominant form in insulinomas; they presented lower Akt and p-Akt expression than normal islets in 83.3% and 87.5% of tumors, respectively. p27kip1 and pp27kip1 were mainly cytoplasmic in both insulinomas and normal tissue. …”
Get full text

U–Pb Dating and Hf Isotopes Analysis of Detrital Zircons of the Shanxi Formation in the Otuokeqi Area, Northwestern Ordos Basin by Jiaxuan Song, Hujun Gong, Jingli Yao, Huitao Zhao, Xiaohui Zhao, Yunxiang Zhang, Biao Chen

“…The third and fourth groups of detrital zircons mainly come from Paleozoic magmatic rocks formed by the subduction and collision of the Siberian plate and the North China plate. …”
Get full text

Child Injury in Israel: Emergency Room Visits to a Children's Medical Center by Michal Hemmo-Lotem, Claudia Jinich-Aronowitz, Liri Endy-Findling, Michal Molcho, Michal Klein, Yehezkel Waisman, Yehuda L. Danon, Joav Merrick

“…Despite this low rate of non-Jewish patients, however, they constituted 20% of later hospitalizations. The main injuries recorded were bruises and wounds from blunt objects, falls, motor vehicle–related accidents, and sport injuries. …”
Get full text

The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women by Marina Yazigi Solis, Guilherme Giannini Artioli, Eduardo Montag, Vitor de Salles Painelli, Fábio Lopes Saito, Fernanda Rodrigues Lima, Hamilton Roschel, Bruno Gualano, Antonio Herbert Lancha Junior, Fabiana Braga Benatti

“…In contrast, TNF-α, IL-6, and IL-10 mRNA levels in scAT were increased, whereas adiponectin scAT mRNA and serum levels were decreased at POST6 (P<0.05, main effect for time). No changes were observed in mRNA levels of MCP-1, CD14, and CD68 in any of the groups. …”
Get full text

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy by Naizhen Zheng, Kun Li, Jing Cao, Zijie Wang, Liang Zhang, Zihao Zhao, Jiawei He, Yong Wang, Xiang Zhu, Yiqing Chen, Jian Meng, Dongdong Zhao, Mengxi Niu, Hong Luo, Xian Zhang, Hao Sun, Yun-wu Zhang

“…Among them, we found that HtrA serine peptidase 2 (HTRA2) was mainly expressed in neurons and that HTRA2 levels were increased in both the LTP and the LTD processes in C57BL/6 mice. …”
Get full text

Chemical Constituents and Combined Larvicidal Effects of Selected Essential Oils against Anopheles cracens (Diptera: Culicidae) by Jitrawadee Intirach, Anuluck Junkum, Benjawan Tuetun, Wej Choochote, Udom Chaithong, Atchariya Jitpakdi, Doungrat Riyong, Daruna Champakaew, Benjawan Pitasawat

“…Chemical compositions analyzed by gas chromatography coupled to mass spectrometry demonstrated that the main component in the oil derived from P. sarmentosum, F. vulgare, C. longa, M. fragrans, and Z. piperitum was croweacin (71.01%), anethole (63.00%), ar-turmerone (30.19%), safrole (46.60%), and 1,8-cineole (21.27%), respectively. …”
Get full text

Estimating Seafloor Topography of the South China Sea Using SWOT Wide-Swath Altimetry Data by Fengshun Zhu, Jinbo Li, Yang Li, Jianqiao Xu, Jinyun Guo, Jiangcun Zhou, Heping Sun

“…We find that the control point number barely affects strategy A/C but significantly affects strategy B, while the priori bathymetry model mainly affects strategy C. Then, the three strategies are applied to the traditional radar altimetry gravity anomaly, and the results are compared with the SWOT-derived seafloor topography. …”
Get full text

Non-Destructive Testing of Concrete Materials from Piers: Evaluating Durability Through a Case Study by Abraham Lopez-Miguel, Jose A. Cabello-Mendez, Alejandro Moreno-Valdes, Jose T. Perez-Quiroz, Jose M. Machorro-Lopez

“…Concrete is currently the most used construction material, mainly due to its mechanical strength, chemical stability, and low cost. …”
Get full text

Increasing incidences and changes in treatment trends of clavicle fractures in adults during 2 decades in Denmark: a nationwide study on data from the Danish National Patient Regis... by Ida Tryggedsson, Bjarke Viberg, Per Hviid Gundtoft, Ilija Ban, Søren Overgaard, Tazio Maleitzke, Arvind von Keudell

“…The incidence was more than 50% higher in males (113) than females (53). 6,096 cases (7.5%) were treated surgically, mainly with plate osteosynthesis (94%). The surgical rate increased from 1% in 1996 to 14% in 2011, whereafter it decreased again. …”
Get full text

Comparison of In Vitro Biotransformation of Olive Polyphenols Between Healthy Young and Elderly by Stef Lauwers, Anne-Sophie Weyns, Annelies Breynaert, Tim Van Rillaer, Valerie Van Huynegem, Erik Fransen, Wout Bittremieux, Sarah Lebeer, Emmy Tuenter, Nina Hermans

“…Most biotransformation reactions took place within the first 24 h of colon incubation, and mainly, deglycosylation, hydrolysis, flavonoid ring cleavage, and demethylation reactions were observed. …”
Get full text

Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in HCV-Positive Egyptian Patients Treated with Sofosbuvir by Ali Nada, Mohamed Abbasy, Aliaa Sabry, Azza Mohamed Abdu Allah, Somaia Shehab-Eldeen, Nada Elnaidany, Hanan Elimam, Kawthar Ibraheem Mohamed Ibraheem, Abdallah Essa

“…Sofosbuvir is one of the highly potent DAAs, eliminated mainly through the kidney. But concerns about renal safety during treatment may limit its use. …”
Get full text

Anthropometric, aerobic and muscle power profile of young costa rican basketball players by Randall Gutiérrez-Vargas, José Alexis Ugalde-Ramírez, José Pino-Ortega, José Andrés Trejos-Montoya, Luis Blanco-Romero, Braulio Sánchez-Ureña, Juan Carlos Gutiérrez-Vargas, Daniel Rojas-Valverde

“…The following parameters were assessed: height, weight, body mass index, skeletal muscle mass and body fat percentage, countermovement test (CMJ) and Yo-Yo Intermittent Recovery Test Level I. The main results showed significantly higher values in men than in women in terms of weight, height, skeletal muscle mass, distance covered in the yo-yo test, VO2max, height in CMJ and in flight time. …”
Get full text

Understanding co-production of injury research in Australian Aboriginal and Torres Strait Islander communities: a comprehensive scoping review by Genevieve Westacott, Victoria McCreanor, Susanna Cramb, Silvia Manzanero, Kim Vuong, Michelle Allen, Shannon Dias, Geoffrey Binge, Arpita Das

“…A scoping review was undertaken to investigate the use of co-production methodologies in research within the unintentional injuries space for Australian Aboriginal and Torres Strait Islander communities over time. Main body A systematic search was conducted using PubMed, ProQuest, Embase and Indigenous Health Infonet databases. …”
Get full text

Correlation between follicle diameter and pre-ovulatory metabolic profile in Bos grunniens by Jiuru Yan, Jiuru Yan, Jiuru Yan, Yuxin Fu, Yuxin Fu, Yuxin Fu, Lan Lan, Huizhu Zhang, Huizhu Zhang, Huizhu Zhang, Ling Huang, Ling Huang, Yaying Wang, Yaying Wang, Xianrong Xiong, Xianrong Xiong, Xianrong Xiong, Shi Yin, Shi Yin, Shi Yin, Jian Li, Jian Li, Jian Li, Honghong He, Honghong He, Honghong He

“…Differential metabolites enriched KEGG pathways to screen the pathways that might be related to follicle development.ResultsWe found that most of the metabolites were mainly enriched in amino acid metabolism pathways, energy metabolism pathways and other pathways of cofactor synthesis, and that during the development of the small follicle to the large follicle, 2-Lysophosphatidylcholine, PC (17:0/0:0), PC (16:0/0:0), and LysoPC (18:0/0:0) were down-regulated; Dioctyl succinate, P-Coumaraldehyde, ISOPRENE, L-Isoleucine, Dioctyl succinate up-regulated.ConclusionThese results suggest that amino acid metabolism, the production of steroid hormones and their metabolites, and the metabolic activity of granulosa cells play important roles in follicle development. …”
Get full text

Does candidate race influence simulated patient ratings in standardised assessments of clinical practice? A single-blinded randomised study in UK medical schools by Celia Brown, Amir H Sam, Rachel Westacott, Mark Gurnell, Sarah Khavandi, Malcolm Reed, Ann Sebastian, Kerry Badger

“…Therefore, each simulated patient assessor observed one white and one non-white candidate at each grade and scored communication and professionalism domains.Main outcome measure The median and interquartile range of the difference between total scores for the white and non-white candidates were compared at all three performance grades.Results The black fail candidate scored statistically significantly lower than their white fail counterpart. …”
Get full text

Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy by Dongming Li, Donghui Cao, Yangyu Zhang, Xinyi Yu, Yanhua Wu, Zhifang Jia, Jing Jiang, Xueyuan Cao

“…Spatial transcriptomic analysis found GLS expression was mainly derived from tumor cells, which implies tumor cells may have a stronger ability to utilize glutamine than antitumor immune cells in the tumor microenvironment (TME). …”
Get full text

Arthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry dat... by Anne Lübbeke, Lotje A Hoogervorst, Perla J Marang-van de Mheen, Heather A Prentice, Ola Rolfson, Rob G H H Nelissen, Arnd Steinbrück, Gearoid McGauran, Christophe Barea, Kajsa Erikson, Alma B Pedersen, Martyn Porter

“…Data was accessible in all but 2 registries, mainly as aggregated data. Important items relevant to registry quality for researchers to consistently indicate in scientific papers include scope, inclusion criteria, outcomes definitions, coverage/completeness, and validation processes. …”
Get full text

Hospital utilization and telemedicine preferences in patients with late-stage Parkinson’s disease and caregivers by Seo Hyun Hong, Seoyeon Kim, Seungmin Lee, Bora Jin, Jung Hwan Shin, Kyung Ah Woo, Han-Joon Kim

“…Over three-quarters of patients did not receive rehabilitation therapy, mainly due to mobility issues and the lack of nearby facilities. …”
Get full text

Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim of review: A thorough understanding of TAM lipid metabolism and its value in tumorigenesis may provide new ideas for TAM-based anti-tumor therapy.Key scientific concepts of review: TAMs can be divided into two main types, M1-like TAMs and M2-like TAMs, which play anti-tumor and pro-tumor functions in tumor occurrence and development, respectively. …”
Get full text

Molecular modeling to elucidate the dynamic interaction process and aggregation mechanism between natural organic matters and nanoplastics by Chi Zhang, Zhiyu Zhou, Mengning Xi, Haozhe Ma, Junhao Qin, Hanzhong Jia

“…The results showed that pristine NPs initially tend to aggregate homogeneously due to their hydrophobic nature, and then NOM fragments are bound to the formed NP aggregates mainly by vdW interaction. Homo- and hetero-aggregation between NOMs and aged NPs occur simultaneously through various mechanisms, including intermolecular forces and Ca2+ bridging effect, eventually resulting in a mixture of supramolecular structures. …”
Get full text