Impact of Deep Brain Stimulation on Daily Routine Driving Practice in Patients with Parkinson’s Disease by Carsten Buhmann, Eik Vettorazzi, Christian Oehlwein, Fred Rikkers, Monika Poetter-Nerger, Alessandro Gulberti, Christian Gerloff, Christian K. Moll, Wolfgang Hamel

“…Inactive drivers had quit driving mainly due to disease burden (90.9%). Active drivers were younger, more often males, and less impaired according to H&Y and MMSE, had surgery more recently, and reported more often overall benefit from DBS. …”
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Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats by Yonglin Zhao, Yahui Zhao, Ming Zhang, Junjie Zhao, Xudong Ma, Tingqin Huang, Honggang Pang, Jiaxi Li, Jinning Song

“…The purpose of this study was to investigate the role of the TLR4 signalling pathway in secondary axonal injury in the cortices of DAI rats. TLR4 was mainly localized in microglial cells and neurons, and the levels of TLR4 downstream signalling molecules, including TLR4, myeloid differentiation primary response gene 88, toll/IR-1-(TIR-) domain-containing adaptor protein inducing interferon-beta, interferon regulatory factor 3, interferon β, nuclear factor κB (NF-κB) p65, and phospho-NF-κB p65, significantly increased and peaked at 1 d after DAI. …”
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The Alteration and Clinical Significance of Th22/Th17/Th1 Cells in Patients with Chronic Myeloid Leukemia by Ping Chen, Min Wang, Daqi Li, Yan Jia, Na He, Wei Li, Daoxin Ma, Chunyan Ji

“…In the present study, we mainly investigated the role of Th22, Th17, and Th1 cell and their related cytokines (IL-22, IL-17, and IFN-r) in the pathophysiology of CML. …”
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Oxidation of Styrene to Benzaldehyde Using Environmentally Friendly Calcium Sulfate Hemihydrate-Supported Titania Catalysts by Soerja Koesnarpadi, Teguh Wirawan, Mukhamad Nurhadi, Wirhanuddin Wirhanuddin, Yuniar Ponco Prananto, Nazarudin Nazarudin, Volkan Degirmenci, Sin Yuan Lai, Hadi Nur

“…The catalysts exhibited high selectivity for benzaldehyde, achieving up to 49.45% conversion of styrene, with benzaldehyde as being the main product. The research highlights that the catalyst’s performance decreased after calcination due to a reduced surface area and pore volume, yet it maintained recyclability across three cycles with minimal  lose  in selectivity loss. …”
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CDR-Detector: a chronic disease risk prediction model combining pre-training with deep reinforcement learning by Shaofu Lin, Shiwei Zhou, Han Jiao, Mengzhen Wang, Haokang Yan, Peng Dou, Jianhui Chen

“…Abstract Chronic disease risk prediction based on electronic health record (EHR) is an important research direction of Internet healthcare. Current studies mainly focused on developing well-designed deep learning models to predict the disease risk based on large-scale and high-quality longitudinal EHR data. …”
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Glucose Required for Tissue Formation and Its Effects on Cane Yield, Recoverable Sugar, and Sugar Yield by Nunik Eka Diana, Supriyadi, Djumali, Budi Santoso, Anik Herwati, Sri Yulaikah, Supriyono, Ruly Hamida, Aprilia Ridhawati, Abdurrakhman

“…A split plot design with two factors and three replications was utilized. The main factor was the growth phases, namely, the vegetative phase and maturity phase, while the other factor was sugarcane varieties, namely, PS-881 (early mature), JR-01 (early-middle mature), Kenthung (early-middle mature), and Bululawang (middle-late mature). …”
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Investigation of the Use of the Thermo-Biological Method in the Return Sludge Line on the Biokinetics of the Activated Sludge Process and the Amount of Excess Sludge Produced by Naeim Banisaeid, Afshin Takdastan, Mahboobeh Cheraghi, Ali Afrous, Reaz Jalilzadeh Yengejeh

“…Relatively high production of excess biological sludge is considered one of the main drawbacks of aerobic processes used in biological wastewater treatment. …”
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Definition of minimum clearance height of railway bridges in a windblown sand area based on numerical simulation by Xian Zhang, Shengbo Xie, Yingjun Pang

“…With higher wind speeds, the main position of wind speed deceleration moved further from the bridge. …”
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Small-scale land use effects on plant communities in Mediterranean urban ecosystems by Vincenzo Baldi, Alessandro Bellino, Daniela Baldantoni

“…Overall, results indicate a remarkable heterogeneity of plant communities, even at scales in the order of few meters, with land use and margin effect differentially affecting their structural and functional biodiversity. The main drivers of biodiversity appear to be a combination of anthropogenic pressures (e.g. trampling/soil sealing) and the presence/absence of canopy shading, determining higher abundances of therophytes (especially Asteraceae and Poaceae) in open and trampled spaces and a proportional increase in hemichryptophytes under canopies. …”
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Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment by Peixian Chen, Kaifeng Liang, Xiaofan Mao, Qiuyuan Wu, Zhiyan Chen, Yabin Jin, Kairong Lin, Tiancheng He, Shuqing Yang, Huiqi Huang, Guolin Ye, Juntao Gao, Dan Zhou, Zhihao Zeng

“…Moreover, we revealed the profound cellular heterogeneity of myeloid cell lineages in breast cancer. In macrophages, two mainly tumor associated macrophages (TAMs), TAM1 and TAM2, were also detected and the highly variable genes in TAM2 were strongly enriched in IFN-α and IFN-γ. …”
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Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report by Christian Koch, Patrick Roth, Juliane Fleischer, Todor Popov, Karl Frontzek, Bettina Schreiner, Markus G. Manz, Simone Unseld, Antonia M. S. Müller, Norman F. Russkamp

“…Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited.Main body We here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement. …”
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Comparative Analysis of Chemical Composition and Antibacterial Activity of Essential Oils from Five Varieties of <i>Lavender</i> Extracted via Supercritical Fluid Extraction by Lijing Lin, Zhencheng Lv, Meiyu Wang, Ankang Kan, Songling Zou, Bin Wu, Limin Guo, Salamet Edirs, Jiameng Liu, Lin Zhu

“…The compounds of LEOs from different varieties of <i>Lavender</i> were similar and mainly comprised linalool, linalyl acetate, eucalyptol, and isoborneol. …”
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Person-centred eHealth intervention for patients on sick leave due to common mental disorders: study protocol of a randomised controlled trial and process evaluation (PROMISE) by Ingibjörg H Jonsdottir, Hanna Gyllensten, Lilas Ali, Andreas Fors, Karl Swedberg, Inger Ekman, Matilda Cederberg, Kristina Glise

“…Participants will include 220 primary care patients on sick leave due to CMDs and data will mainly be collected through questionnaires at baseline and 3, 6, 12 and 24 months from the inclusion date. …”
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The Outcomes of Gestational Diabetes Mellitus after a Telecare Approach Are Not Inferior to Traditional Outpatient Clinic Visits by Natalia Pérez-Ferre, Mercedes Galindo, M. Dolores Fernández, Victoria Velasco, Isabelle Runkle, M. José de la Cruz, Patricia Martín Rojas-Marcos, Laura del Valle, Alfonso L. Calle-Pascual

“…Methods. 100 women diagnosed of GDM were randomized into two parallel groups, a control group based on traditional face-to-face outpatient clinic visits and an intervention group, which was provided with a Telemedicine system for the transmission of capillary glucose data and short text messages with weekly professional feedback. 97 women completed the study (48/49, resp.). Main Outcomes Measured. The percentage of women achieving HbA1c values <5.8%, normal vaginal delivery and having a large for-gestational-age newborn were evaluated. …”
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Tobacco use patterns and attitudes in Singapore young male adults serving military national service: a qualitative study by Mee-Lian Wong, Jeong Kyu Lee, Clive Tan, Lavinia Lin, Mervyn Lim, Seeu Kun Ong

“…At the individual level, the two main contributing factors to tobacco use were smoking as a coping mechanism, and physical or psychological addiction. …”
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A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos by Phimpha Paboriboune, Thomas Vial, François Chassagne, Philavanh Sitbounlang, Sengaloun Soundala, Stéphane Bertani, Davone Sengmanothong, Francois-Xavier Babin, Nicolas Steenkeste, Paul Dény, Pascal Pineau, Eric Deharo

“…Globally 20% of patients received treatment (mainly immunostimulant and reverse-transcriptase inhibitors); 11% had high levels of VL and liver enzymes, but only 2% of them were treated. …”
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Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis by Louisane Desbiens, Catherine Lapointe, Marjan Gharagozloo, Shaimaa Mahmoud, Gunnar Pejler, Denis Gris, Pedro D’Orléans-Juste

“…Mast cells are suggested to be involved in the main inflammatory phases occurring during EAE development, possibly by secreting several autacoids and proteases. …”
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Transforming education with AI: A systematic review of ChatGPT's role in learning, academic practices, and institutional adoption by Sayeed Salih, Omayma Husain, Mosab Hamdan, Samah Abdelsalam, Hashim Elshafie, Abdelwahed Motwakel

“…The methodology involved a systematic search across academic databases with a structured analysis of key studies in AI-supported education. The main contributions include identifying the comparative advantages and limitations of AI in enhancing student learning, offering best practices for incorporating AI tools into teaching, and examining prompt engineering as a crucial factor in optimizing AI usage. …”
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Forsythia suspensa leaf fermented tea extracts attenuated oxidative stress in mice via the Ref-1/HIF-1α signal pathway and modulation of gut microbiota by Lijuan Li, Yating zhao, Yuxin Ding, Lanze Guo, Ruiyao Dai, Aixiang Chen, Guofeng Duan

“…Abstract Forsythia suspensa leaf fermented tea (FSLFT) is made from tender buds of Forsythia suspensa collected in spring. The main active components of FSLFT include forsythiaside, forsythia ester glycoside, rutin, and forsythia flavonoids, which have antibacterial, antioxidant, liver-protective, and immune-regulatory effects. …”
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Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI3K/mTOR Signaling Pathway by Dandan Chai, Guoyu Wang, Ziyu Zhou, Hanyan Yang, Zhiwen Yu

“…Furthermore, the proteasomal inhibitor, MG132, dramatically increased SESN2 protein and its ubiquitination level while in the presence of MG132 insulin did not further increase SESN2 content, suggesting that insulin increases SESN2 content mainly via inhibiting its proteasomal degradation. …”
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