Massive pulmonary thromboembolism in a pediatric patient with eosinophilic granulomatosis with polyangiitis: a case-based review emphasizing management by Batuhan Küçükali, Merve Yazol, Çisem Yıldız, Büşra Acun, Nuran Belder, Nihal Karaçayır, Merve Kutlar, Pelin Esmeray Şenol, Zühre Kaya, Deniz Gezgin Yıldırım, Sevcan A. Bakkaloğlu

“…Although the exact mechanisms underlying AVTE remain unclear, eosinophils play a pivotal role in AVTE. Main body Current guidelines lack evidence-based recommendations, particularly concerning anticoagulant and antiplatelet treatments for this condition. …”
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UHPLC-UV method validation for simultaneous quantification of vitexin and isovitexin from Santalum album L. leaves by Thi Kim Phung Phan, Minh Quan Le, Kien Duc Ngo

“…Studies have revealed that the leaves contain two main active ingredients vitexin and isovitexin, which have demonstrated significant potential in treating diabetes, cancer, and inflammation. …”
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Pharmacological evidence supporting a role for IL-1, IL-2 and serotonin in the inflammation induced by Schistosoma mansoni Soluble Egg Antigen (SEA) in rat paws by C. M. F. Pacheco, C. A. P. Tavares, P. M. Z. Coelho, O. A. Rocha, J. M. M. Santos, F. R. M. Prado, J. N. Francischi

“…This study intended to characterize pharmacologically the mediator(s ) released in the inflammation induced by Soluble Egg Antigen (SEA), the main antigen released from eggs of Schistosoma mansoni, in rat hindpaws . …”
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Quality Assessment of Some Essential Children’s Medicines Sold in Licensed Outlets in Ashanti Region, Ghana by Grace Frimpong, Kwabena Ofori-Kwakye, Noble Kuntworbe, Kwame Ohene Buabeng, Yaa Asantewaa Osei, Mariam El Boakye-Gyasi, Ofosua Adi-Dako

“…Thirty-two (47.1%) of the medicines were imported, mainly from India (65.6%) and the United Kingdom (28.1%), while 36 (52.9%) were locally manufactured. …”
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Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice by Ziyi Xiong, Qiling Kong, Juan Hua, Qi Chen, Dandan Wang

“…They can be accumulated through the food webs and enter the human body through dietary intake, posing health risks. The main target organs of NP accumulation are the lungs, liver, heart, and kidneys. …”
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Knowledge and awareness of asbestos risk among General Practitioners: Validation of a questionnaire in an area with a high incidence of asbestos-related diseases by Marinella Bertolotti, Manuela Tamburro, Angelo Salzo, Antonella Cassinari, Stefania Crivellari, Carlotta Bertolina, Marianna Farotto, Carmen Adesso, Michela Anna Di Palma, Anna Natale, Federico Torregiani, Guglielmo Pacileo, Antonio Maconi, Giancarlo Ripabelli

“…It contained 29 questions covering three main areas: ‘knowledge and awareness’, ‘competence and experience’, ‘sociodemographic characteristics and workload’. …”
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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Increased amyloid-β (Aβ) plaque deposition is thought to be the main cause of Alzheimer’s disease (AD). β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is the key protein involved in Aβ peptide generation. …”
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Analysis of the Internal Radial Gradient of Chemical Abundances in Spiral Galaxies from CALIFA by A. F. S. Cardoso, O. Cavichia, M. Mollá, L. Sánchez-Menguiano

“…We observe that DIG, concentrated mainly in the central regions of galaxies, can modify oxygen abundance gradient profiles if left unaddressed.…”
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Action plan proposal to obtain triple certification in a natural gas transportation company by Cintia Guerra Bueno, Jorge Lucas Costa Pinheiro, Wagner da Silveira Marques, Telma Fidelis Fragoso da Silva, Alberto Eduardo Besser Freitag

“…Limitations of the investigation: The main one is the generalization limit of the conclusions, models or theories developed from a single case study, used in this work. …”
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The burden of Alagille syndrome: uncovering the potential of emerging therapeutics – a comprehensive systematic literature review by Philip Bufler, Robin Howard, Lucia Quadrado, Guy Lacey, Jolan Terner-Rosenthal, Andrea Goldstein, Pamela Vig, Deirdre Kelly

“…Clinical symptoms of cholestasis include debilitating pruritus, xanthomas, fatsoluble vitamin deficiencies, growth failure, renal disease and impaired health-related quality of life (HRQoL). The main objective was to review the current literature on the epidemiological, clinical, psychosocial and economic burden of ALGS in view of the development of ileal bile acid transporter (IBAT) inhibitors. …”

The Icing Characteristics of Post Insulators in a Natural Icing Environment by Zhijin Zhang, Jiahui Tu, Yuanpeng Zhang, Xingliang Jiang, Zhenbing Zhu

“…The icing morphology and characteristics of these insulators were examined. The main conclusions are as follows: (1) the icing type and morphology of post insulators are influenced by meteorological conditions, with more severe icing observed on the windward side. (2) The icing mass and icicle length of the insulator increase nonlinearly with icing time. …”
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Quantifying the Spatiotemporal Evolution of Radiation Belt Electrons Scattered by Lower Band Chorus Waves: An Integrated Model by Weixin Chen, Song Fu, Xin Ma, Binbin Ni, Deyu Guo, Qiongyue Zhang, Xiangyuan Tong, Yibo Zhao, Xing Cao, Zheng Xiang, Yuan Lei

“…Incorporating the effect of radiation electron drift, we further use the 2‐D Fokker‐Planck equation to simulate the variations of electron phase space density in different MLT sectors at a fixed L, and find that the integrated model replicates reasonably the multi‐MeV electron acceleration at L = 4.5 during the period from the main phase to the early recovery phase of the storm. …”
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Spatial mapping of the localized corrosion behavior of a magnesium alloy AZ31B tungsten inert gas weld by Leslie G. (Bland) Miller, Corey M. Efaw, Rebecca F. Schaller, Kari Higginbotham, Steve D. Johns, Paul H. Davis, Elton Graugnard, John R. Scully, Michael F. Hurley

“…These microstructures were mapped with SKPFM before and after brief exposure to a salt solution, revealing micro-galvanic couples as the main driving force to corrosion initiation and propagation within each zone. …”
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Percutaneous Compression Plate versus Dynamic Hip Screw for Treatment of Intertrochanteric Hip Fractures: A Meta-Analyse of Five Randomized Controlled Trials by Lei Zhang, Jie Shen, Shengpeng Yu, Qiang Huang, Zhao Xie

“…All randomized controlled trials (RCT) that compared PCCP with DHS in treating adult patients with intertrochanteric fractures were included. Main outcomes were collected and analysed using the RevMan 5.1 version. …”
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3-Epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma by Mengjie Liu, Xuqiang Liu, Kaiyue He, Yongping Jian, Yujia Li, Jinrong Guo, Jingyu Yang, Zhixiang Xu, Wenyi Kang

“…3-Epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) is a pentacyclic triterpene mainly distributed in food and medicinal plants, which exhibits various pharmacological properties. …”
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Future Extreme Climate Events Threaten Alpine and Subalpine Woody Plants in China by Yongru Wu, Jian Shen, David C. Deane, Haibin Yu, Fangyuan Yu, Xuerong Wang, Zheng Cao, Rong Yu, Fuan Xiao, Tiejun Wang, Zhifeng Wu

“…We found fewer than 18% of high‐risk areas of diversity loss were currently protected, with priority conservation areas mainly located in the Daxue, Daliang, Wumeng, and Jade Dragon Snow Mountains, as well as in the Nyingchi. …”
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Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies by Elisa Monti, Clara Vianello, Ilaria Leoni, Giuseppe Galvani, Annalisa Lippolis, Federica D’Amico, Sara Roggiani, Claudio Stefanelli, Silvia Turroni, Francesca Fornari

“…In this review, we summarize the main changes in the GM and derived metabolites (e.g., short-chain fatty acids and bile acids) occurring in HCC patients and influencing NAFLD progression, emphasizing their potential as early diagnostic biomarkers and prognostic tools. …”
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Valorization of Olive Pruning Residues through Bioconversion into Edible Mushroom Pleurotus ostreatus (Jacq. Ex Fr.) P. Kumm. (1871) of Improved Nutritional Value by Sami Abou Fayssal, Mohammed A. Alsanad, Zeina El Sebaaly, Ahmed I. H. Ismail, Youssef N. Sassine

“…Polyunsaturated fatty acids, mainly linoleic acid, were the most abundant in mushrooms. …”
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The molecular prevalence of Theileria equi in the Arabian stallion in Egypt with special reference to biochemical parameters by Noora F. Thabet, Omaima M. Kandil, Omnia M. Kandil, Khalid M. Fararh

“…Theileria equi, a blood parasite spread by ticks, is thought to be a severe infectious disease that impacts the health of horses. The study's main goal was to determine the prevalence of T. equi in Arabian stallions in Egypt by comparing microscopic examination (ME) and conventional polymerase chain reaction (cPCR) and compare them. …”
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Impact on the  incorporation  of  metals  in  physicochemical  and antimicrobial  properties  in  films  based  on  arrowroot  starcha by Antonio Carlos Pereira de Menezes Filho, Matheus Vinicius Abadia Ventura, Carlos Frederico de Souza Castro, Rogério Favareto, Marconi Batista Teixeira, Frederico Antônio Loureiro Soares

“… New biodegradable packaging has been developed from renewable sources, mainly of vegetable origin. Arrowroot starch has been recently used to produce high-quality biodegradable films capable of behaving well when incorporating oils, extracts, metal, and metal nanocomposites. …”
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