Therapeutic proteins immunogenicity: a peptide point of view by Feliciana Real-Fernandez, Fosca Errante, Andrea Di Santo, Anna Maria Papini, Paolo Rovero

“…Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset of patients appears to be refractory to these treatments, mainly due to the development of an immune response to the drug. …”
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Clinical characteristics and removal of broken burs retained in the lower jaw by Xin Xing, Chao Gong, Zhi-Yi Ye, Kun Lv, Zhi Li

“…The localization of the broken burs in types 2 and 3 was based on the preoperative radiographs, and the removal of the broken burs in the two types was mainly dependent on the surgeons’ experience. All the broken burs were successfully removed, and all patients displayed uneventful healing. …”
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Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia by Nourchène Toukabri, Cyrine Dhieb, Dalenda El Euch, Mustapha Rouissi, Mourad Mokni, Najla Sadfi-Zouaoui

“…Non-dermatophyte molds (NDMs) were observed in 8.02% cases and Fusarium sp. was the frequent genus (29.1%). The main predisposing factors of fungal foot infections were practicing ritual washing (56.6%) and frequentation of communal showers (50.5%). …”
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Black Hole Supernovae, Their Equation of State Dependence, and Ejecta Composition by Oliver Eggenberger Andersen, Evan O’Connor, Haakon Andresen, André da Silva Schneider, Sean M. Couch

“…We simulate these events self-consistently from core collapse until 20–50 days after collapse using three axisymmetric models of a 60 M _⊙ zero-age main-sequence progenitor star and investigate how the composition of the ejecta is impacted by the BH formation. …”
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Assistive Devices Analysis for Visually Impaired Persons: A Review on Taxonomy by Sadia Zafar, Muhammad Asif, Maaz Bin Ahmad, Taher M. Ghazal, Tauqeer Faiz, Munir Ahmad, Muhammad Adnan Khan

“…These techniques are categorized based on their functionality and working principles. The main attributes, challenges, and limitations of these techniques have also been highlighted. …”
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The Architectural Layout and Degree of Preservation of the Sanctuary of Pachacamac Archaeological Complex (2nd to 16th Centuries AD, Peru) from the Morphometric Analysis of Orthoph... by Luigi Magnini, Pierdomenico Del Gaudio, Maria Ilaria Pannaccione Apa, Denise Pozzi-Escot, Janet Oshiro, Rommel Angeles, Guido Ventura

“…This is due to buildings constructed along the two main NW-SE and NE-SW striking roads of the Qhapac–Ñan road network. …”
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Associations of Atopic Dermatitis in Late Adolescence with Occupation, Mental Health, Income from Work and Marital Status: A National Longitudinal Study by Grigorios Theodosiou, Therese Sterner, Ayako Hiyoshi, Michael Carlberg, Åke Svensson, Scott Montgomery, Laura von Kobyletzki

“…The main aim of this study was to evaluate longitudinal associations between atopic dermatitis (AD) in late adolescence and occupational socioeconomic group, labour market participation, income from work, and marital status later in adult life. …”
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Development of Natural Fiber Hybrid Composites Using Sugarcane Bagasse and Bamboo Charcoal for Automotive Thermal Insulation Materials by Fasika Abedom, S. Sakthivel, Daniel Asfaw, Bahiru Melese, Eshetu Solomon, S. Senthil Kumar

“…The effective utilization of fibers from natural sources is the main objective of this research work, but natural fibers alone are not meeting the required strength properties. …”
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New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

“…However, their physiological functions in bacterial and host physiologies are still controversial and not clear. In this review, we mainly discuss the current evidence related to the physiological roles that BSHs played in gut microbiota and human health, and the possible underlying mechanisms. …”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…Dysregulated epigenetic mechanisms are implicated in various diseases, including cardiovascular disorders, neurodegenerative diseases, obesity, and mainly cancer. Therefore, to develop innovative therapeutic strategies, research for compounds able to modulate the complex epigenetic landscape of cancer is rapidly surging. …”
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The Opposite Effects of High-Sucrose and High-Fat Diet on Fatty Acid Oxidation and Very Low Density Lipoprotein Secretion in Rat Model of Metabolic Syndrome by Monika Cahova, Helena Dankova, Eliska Palenickova, Zuzana Papackova, Ludmila Kazdova

“…To determine the effect of two different diets (high-sucrose (HS) and high-fat (HF)) on the main metabolic pathways potentially contributing to the development of steatosis: (1) activity of the liver lysosomal and heparin-releasable lipases; (2) fatty acid (FFA) oxidation; (3) FFA synthesis de novo; (4) VLDL output in vivo in a rat model of metabolic syndrome (MetS), hereditary hypertriglyceridemic (HHTg) rats fed HS or HF diets. …”
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Post-Traumatic Segmental Tibial Defects Management: A Systematic Review of the Literature by Giovanni Marrara, Biagio Zampogna, Viktor Dietrich Schick, Leone Larizza, Paolo Rizzo, Ilaria Sanzarello, Matteo Nanni, Danilo Leonetti

“…Conclusions: D.O. and the Masquelet technique are the main treatment options for post-traumatic segmental tibial defects. …”
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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities by Piero Ruscitti, Paola Di Benedetto, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Cipriani, Roberto Giacomelli

“…Adipocytokines are pleiotropic molecules, mainly released by white adipose tissue and immune cells. …”
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Do pregnant women living in higher well-being populations in the USA experience lower risk of preterm delivery? A cross-sectional study by Jeph Herrin, Harlan M Krumholz, Carley Riley, Brita Roy, Erica Spatz, Mark T Silvestri, Anita Arora, Kenneth P Kell, Elizabeth Y Rula

“…Objective To determine if preterm birth, defined as gestational age <37 weeks, is lower for women living in counties with higher well-being, after accounting for known individual risk factors.Design Cross-sectional study of all US births in 2011.Participants We obtained birth data from the National Center for Health Statistics which included 3 938 985 individuals.Main outcomes measures Primary outcome measure was maternal risk of preterm delivery by county; primary independent variable was county-level well-being as measured by the Gallup-Sharecare Well-Being Index (WBI).Results Women living in counties with higher population well-being had a lower rate of preterm delivery. …”
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Chemical Composition and Antioxidant and Antimicrobial Activities of Wormwood (Artemisia absinthium L.) Essential Oils and Phenolics by Kamel Msaada, Nidhal Salem, Olfa Bachrouch, Slim Bousselmi, Sonia Tammar, Abdulkhaleg Alfaify, Khaldoun Al Sane, Wided Ben Ammar, Sana Azeiz, Adel Haj Brahim, Majdi Hammami, Sawsen Selmi, Ferid Limam, Brahim Marzouk

“…Chromatographic analysis of wormwood essential oils showed the predominance of monoterpene hydrocarbons represented mainly by chamazulene. RP-HPLC analysis of wormwood methanolic extract revealed the predominance of phenolic acids. …”
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Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity by Chiara Macchi, Andrea Giachi, Isabella Fichtner, Silvia Pedretti, Piercarlo Sarzi-Puttini, Nico Mitro, Alberto Corsini, Massimiliano Ruscica, Roberta Gualtierotti

“…Since mitochondria are the main source of cellular energy, we hypothesized that fibromyalgia syndrome (FMS) could be linked to mitochondrial impairment. …”
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The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class? by Ricardo Godinho, Cristina Mega, Edite Teixeira-de-Lemos, Eugénia Carvalho, Frederico Teixeira, Rosa Fernandes, Flávio Reis

“…This review outlines the therapeutic potential of DPP-4 inhibitors for the treatment of T2DM, focusing on their main features, clinical applications, and risks, and discusses the major challenges for the future, in particular the possibility of becoming the preferred therapy for T2DM due to their ability to modify the natural history of the disease and ameliorate nephropathy, retinopathy, and cardiovascular complications.…”
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Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival by Xiangjun Liu, Yikun Ju, Pu Yang, Naisi Shen, Yunyuan Shao, Anqi Yang, Rui Wu, Lanjie Lei, Bairong Fang

“…Ischemia-reperfusion and oxidative stress-induced injuries are the main causes of flap failure. Oxidative stress exacerbates cell damage through the accumulation of reactive oxygen species (ROS), thereby affecting flap function and survival. …”
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Effect and Safety of Mycophenolate Mofetil or Sodium in Systemic Sclerosis-Associated Interstitial Lung Disease: A Meta-Analysis by Argyris Tzouvelekis, Nikolaos Galanopoulos, Evangelos Bouros, George Kolios, George Zacharis, Paschalis Ntolios, Andreas Koulelidis, Anastasia Oikonomou, Demosthenes Bouros

“…All studies were reviewed systematically. The main end-points were safety and efficacy profile as estimated by forced vital capacity (FVC)% and diffusion capacity of the lung for carbon monoxide (DLCO)% of the predicted normal value (%pred.) before and after treatment in patients with SSc-ILD. …”
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Efficacy of 2‐Mercaptoethane Sulfonate Sodium (MESNA) in the Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography: A Randomized Open Label Trial by Amir Sadeghi, Hesamoddin Samar, Mohammad Abbasinazari, Parvaneh Mohammadi, Ali Abazarikia, Shadi Ziaie

“…The PEP incidence and degree were measured in the patients as the main outcome. Results The total rate of PEP was equal to 13.7%. …”
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