A Plasma Proteomic Approach in Rett Syndrome: Classical versus Preserved Speech Variant by Alessio Cortelazzo, Roberto Guerranti, Claudio De Felice, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Claudia Landi, Luca Bini, Barbara Montomoli, Claudia Sticozzi, Lucia Ciccoli, Giuseppe Valacchi, Joussef Hayek

“…Rett syndrome (RTT) is a progressive neurodevelopmental disorder mainly caused by mutations in the gene encoding the methyl-CpG-binding protein 2 (MeCP2). …”
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Optimization Study on the Freshwater Production Ratio from the Freezing and Thawing Process of Saline Water with Varied Qualities by Xinyu Feng, Xue Ding, Jiale Yuan, Wanli Xu, Jiao Liu

“…The results indicated the following: (1) Within the range of the set experimental factor levels, the freshwater production ratio after the freezing of saline water ranged from 23.34% to 81.11%. (2) The significant negative effect of the main factor on the freshwater production ratio was descending order: initial salinity > freezing temperature. …”
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Fatigue fracture mechanism of Ni-base superalloy GH4065A at elevated temperatures by LI Linhan, ZHANG Ji, ZHANG Wenyun, TIAN Qiang, QIN Heyong, ZHANG Beijiang

“…The results show that the alloy’s inclusions of the alloy are mainly nitrides. For the fine-grained samples， discrete nitride particles and clustered nitrides both with a critical size larger than the average grain size are responsible for the fatigue crack initiation. …”
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Quantitative Analysis of the Proteome and the Succinylome in the Thyroid Tissue of High-Fat Diet-Induced Hypothyroxinemia in Rats by Baoxiang Hu, Meng Zhao, Dandan Luo, Chunxiao Yu, Shanshan Shao, Lifang Zhao, Yashuang Yang, Xiaohan Zhang, Jiajun Zhao, Ling Gao

“…Downregulated proteins were enriched in the thyroid hormone synthesis and thyroid hormone signaling pathways and were mainly localized in the mitochondria. In addition, 172 lysine succinylation sites on 104 proteins were obviously changed. …”
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Radical decomposition of hydrogen peroxide catalyzed by iodide for degradation of organic dyes by Naiara Miotto Menino, Paloma Truccolo Reato, Carolina Elisa Demaman Oro, Luciana Dornelles Venquiaruto, Rogério Marcos Dallago, Marcelo Luis Mignoni

“… The decomposition of hydrogen peroxide into hydroxyl radical, a powerful oxidizing agent, has aroused the interest of the scientific community due to the numerous possible applications, mainly in the treatment of effluents. In this work, the potential of using iodide ions as precursors of the hydroxyl radical was evaluated. …”
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Attribution Identification of Runoff Changes Based on the Budyko Elasticity Coefficient Method: A Case Study of the Middle and Upper Reaches of the Jinghe River in the Yellow River... by Xueliang Wang, Haolin Li, Weidong Huang, Lemin Wei, Junfeng Liu, Rensheng Chen

“…., construction of water conservancy projects), precipitation, and potential evapotranspiration are the main factors contributing to the change in runoff.…”
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Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway by Huili Jiang, Xuhui Zhang, Yu Wang, Huimin Zhang, Jing Li, Xinjing Yang, Bingcong Zhao, Chuntao Zhang, Miao Yu, Mingmin Xu, Qiuyun Yu, Xingchen Liang, Xiang Li, Peng Shi, Tuya Bao

“…Conclusively, our findings further support the hypothesis that acupuncture could ameliorate depressive-like behaviors by regulating PKA/CREB signaling pathway, which might be mainly mediated by regulating the phosphorylation level of CREB.…”
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Stability Analysis and Monitoring Method for the Key Block Structure of the Basic Roof of Noncoal Pillar Mining with Automatically Formed Gob-Side Entry by Jianning Liu, Manchao He, Yajun Wang, Ruifeng Huang, Jun Yang, Xichun Tian, Can Ming, Shan Guo

“…The key block of the basic roof is the main contributor to the structural stability of a roadway. …”
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Analysis and optimization of LN2 two-phase flow in CRAFT NNBI cryopump by Qianxu Wang, Yuanlai Xie, Huihui Hong, Yang Zhu, Fang Wang, Kun Tian, Bin Li

“…As an important component of Negative ion based Neutral Beam Injector (NNBI), the cryopump mainly provides a suitable vacuum environment for beam generation and transmission. …”
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Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation by Yu Huang, Yu Huang, Yu Huang, Lu Li, Lu Li, Ran Chen, Ran Chen, Lang Yu, Lang Yu, Shunkai Zhao, Yanjun Jia, Yanjun Jia, Ying Dou, Ying Dou, Ying Dou, Zhiyong Zhang, Zhiyong Zhang, Yunfei An, Yunfei An, Xuemei Tang, Xuemei Tang, Xiaodong Zhao, Xiaodong Zhao, Lina Zhou

“…BackgroundWHIM syndrome is a rare, autosomal dominant inborn error of immunity characterized by warts, hypogammaglobulinemia, infection, and myelokathexis. It is caused mainly by heterozygous mutations at the C-terminus of the C-X-C chemokine receptor type 4 (CXCR4) gene.MethodsWe described the detailed clinical, genetic, immunological and treatment characteristic of four WHIM patients from a single Chinese family.ResultsHere, we report four patients from a family carrying a variant of CXCR4 (c.1016_1017dupCT), which introduces a frameshift at codon V340, resulting in an extension of 14 amino acids (p.V340L fs*27). …”
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Paget’s disease of the breast: a contemporary perspective by O. O. Yemelyanova, A. D. Zikiryakhodzhaev, N. N. Volchenko, V. V. Efanov

“…Determining clear indications for organ‑p reserving operations is the main opportunity to improve the quality of life of patients and their further rehabilitation.…”
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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Cancer affects 9 million people every year constituting one of the main causes of death. However, current treatments are frequently associated with adverse effects and can exhibit limitations in therapeutic efficacy. …”
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Epidemiological Survey of Toxoplasma gondii and Associated Risk Factors in Ruminant Species of the Khyber Pakhtunkhwa Province of Pakistan by Abid Ali, Talha Omer, Asad Ullah, Abdul Haleem, Maryam Naseem, Mujeeb Ullah, Seemab, Fahad Shamim, Amna Tehreem, Muhammad Bilal, Muhammad Numan Khan

“…Infection with T. gondii seems mainly associated with different geographic features and the presence of cats in the environment, low hygiene water systems and livestock that are mostly dependent on outdoor drinking and grazing. …”
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Fully Covered Metallic Stents for the Treatment of Benign Airway Stenosis by Caroline Dahlqvist, Sebahat Ocak, Maximilien Gourdin, Anne Sophie Dincq, Laurie Putz, Jean-Paul d’Odémont

“…Twenty-one stents were inserted: 13 for posttransplant left main bronchus anastomotic stricture, seven for postintubation tracheal stenosis, and one for postlobectomy anastomotic stricture. …”
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Comparative transcriptomics analysis of Zygosaccharomyces mellis under high-glucose stress by Gongliang Liu, Xinyu Bi, Changli Tao, Yongtao Fei, Sujuan Gao, Jinglong Liang, Weidong Bai

“…The high-glucose tolerance of yeast is the main factor determining the efficiency of high-density alcohol fermentation. …”
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Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway by Dacheng Wu, Keyan Wu, Qingtian Zhu, Weiming Xiao, Qing Shan, Zhigang Yan, Jian Wu, Bin Deng, Yan Xue, Weijuan Gong, Guotao Lu, Yanbing Ding

“…By intraperitoneal injection of formononetin in mice, the disease severity of colitis was attenuated in a dose-dependent manner, mainly manifesting as relieved clinical symptoms of colitis, mitigated colonic epithelial cell injury, and upregulations of colonic tight junction proteins levels (ZO-1, claudin-1, and occludin). …”
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Three-dimensional phase field simulation for rafting of multiparticle precipitate in elastic inhomogeneous alloy under external stress by Mao H., Kong Y., Shuai X., Tang S., Du Y.

“…Nickel-based super alloys are the main candidate materials for aero-engines, gas turbine blades etc. …”
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Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Endometriosis is a chronic, estrogen-dependent disorder associated with the presence of endometrial cells mainly in the pelvic cavity, causing systemic immune inflammation, infertility, epigenetic dysregulation of differential DNA methylation, coelomic metaplasia, and pain. …”
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A Network Investigation on Idiopathic Hypogonadotropic Hypogonadism in China by Weiwei Zhao, Hongying Ye, Xiaolong Zhao, Zhaoyun Zhang, Shouyue Sun, Yiran Jiang, Min He, Cheng Xu, Renming Hu, Yiming Li

“…The clinical symptoms before treatment mainly included small testis, underdeveloped secondary sexual characteristics, and sexual dysfunction. …”
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Comprehensive Study on Endocrine Disruptor Removal from Wastewater Using Different Microalgae Species by Noelia García, Rosalía Rodríguez, Gemma Vicente, Juan J. Espada, Luis Fernando Bautista

“…BP degradation was predominantly abiotic, accomplishing 95% removal in 7 days. E degradation was mainly abiotic, achieving approximately 40% within 7 days, with a notable contribution from a biodegradation mechanism in the later stages, accounting for 27% and 40% of the final total removal in the presence of <i>Scenedesmus</i> sp. and <i>C. vulgaris</i>, respectively. …”
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