Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…Whole-cortex general linear modeling of cortical atrophy was applied as an MRI-based validation of these distinct clinical phenotypes. …”
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BRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center’s experience by S. S. McThenia, S. S. McThenia, S. S. McThenia, K. M. Reddy, K. M. Reddy, E. Damaraju, E. Castellino, Z. He, R. Beer, F. Chien, F. Chien, F. Chien, R. C. Castellino, R. C. Castellino, R. C. Castellino, A. E. Goldman-Yassen, A. E. Goldman-Yassen, J. R. Fangusaro, J. R. Fangusaro, J. R. Fangusaro, T. MacDonald, T. MacDonald, T. MacDonald

“…All toxicities possibly associated with BRAF inhibition therapy were evaluated and described according to Common Terminology Criteria for Adverse Events version 5 (CTCAEv5). MRI brain imaging data at baseline and best response was evaluated to identify patterns that may predict response to BRAF inhibition monotherapy.ResultsFifteen patients diagnosed with BRAFV600E mutated pLGG, treated with monotherapy BRAF inhibition, were identified. …”
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T₁灰阶反转图评估中轴型脊柱关节炎骶髂关节结构性病变的价值 by 李禧萌, 李文娟, 张珂, 刘超然, 祝云飞, 占颖莺, 梁明柱, 洪国斌

“…方法回顾性搜集我院 2020 年 2 月至 2022 年 12 月在 1 周内行骶髂关节MRI 及 CT 检查并符合 ax-SpA 诊断标准的患者52例， 共计104 个骶髂关节。两名放射科医师基于常规T₁WI、rT₁、T₁WI + rT₁三组图像，分别评估ax-SpA骶髂关节结构病变：骨侵蚀、骨质硬化、关节间隙改变，在斜冠状位图像上将骶髂关节分为前、中、后 3 部分，每部分分骶面、髂面，共6个区域，并按拟定评分规则对上述 3 种结构性病变进行评分，其中1名医师间隔1月后再次进行评分。…”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…Clinical measures included: MRI activity, annualized relapse rate (ARR), 6-month confirmed disability progression (6mCDP), timed 25-foot walk (T25FW), and 9-hole peg test (9HPT).ResultsAll B, T and NK cells were reduced at month (M)3 after CladT administration, except regulatory B cells which increased above BL from M3 to M24. …”
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Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, m... by Prithwish Banerjee, Guy A MacGowan, Frans H Rutten, Iacopo Olivotto, Petar M Seferović, Jonathan Mant, Djordje G Jakovljevic, Oscar Fernandez, Josep Darbà, Nduka C Okwose, Jose Zamorano, Duncan Edwards, David Sinclair, Lazar Velicki, Amy Groenewegen, Lars S Maier, Dimitris Fotiadis, Sarah Jane Charman, Annamaria Del Franco, Maria Tafelmeier, Andrej Preveden, Cristina Garcia Sebastian, Amy S Fuller, Anne Pauline Nelissen, Petros Malitas, Aikaterini Zisaki, Zoran Bosnic, Petar Vracar, Fausto Barlocco, Marta Jiménez-Blanco Bravo, Nenad Filipovic, Bano Fatima, Williams Kate, Fornaro Alessandra, Milovancev Aleksandra, Ascanio Meritxell, Aguera Ainoa, Pičulin Matej, Flis Borut, Boucharas Dimitrios, Manousos Dimitris, Tsiknakis Manolis, Kassiotis Thomas, Sustersic Tijana, Milicevic Bogdan, Hobbs FD Richard, Kaagman Onno

“…All measurements will be recorded at baseline and at 12-month follow-up, with medical history and hospitalisation also recorded at 24-month follow-up. Cardiovascular MRI assessment will be completed in a subset of participants (n=20–40) from eligible clinical centres only at baseline. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Furthermore, it exhibited effective T2-weighted MRI enhancement for tumor imaging, making them valuable for clinical diagnosis. …”
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A phase II double-blind multicentre, placebo-controlled trial to assess the efficacy and safety of alpelisib (BYL719) in paediatric and adult patients with Megalencephaly-CApillary... by Jean-Marc Treluyer, Benedicte Demeer, Laurence Faivre, Marc Bardou, Nathalie Boddaert, Paul Kuentz, Florence Petit, Christine Francannet, Pierre Vabres, Nadia Bahi-Buisson, Estelle Colin, Laurent Guibaud, Romaric Loffroy, Maxime Luu, Caroline Racine, Aurore Garde, Philippe Khau Van Kien, Aurore Curie, Nawale Hadouiri, Aurélie Espitalier, Agnès Maurer, Maud Carpentier, Adélaide Rega, Mouna Chebbi, Julie Charligny, Guillaume Canaud, Camille Fleck, Amelie Cransac, Elise Boucher-Brischoux, Adélaïde Brosseau-Beauvir, Florian Cherik, Alice Phan, Michaela Semeraro, Marion Nys, Charles Joris Roux, Alinoë Lavillaureix, Isabelle Maruani

“…Patients will be evaluated by volumetric MRI at baseline and at 24 months. An optional lumbar puncture will be performed to investigate blood-brain barrier crossing. …”
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بررسی روند بارش و دماهای کمینه و بیشینه استان آذربایجان شرقی با استفاده از مدل‌‌های جفت شده گزارش ششم (CMIP6)... by نازلی زنوزی علمداری, بهروز سبحانی, مهدی اصلاحی, مسیح اله محمدی

“…برای ارزیابی روند بارش، دما بیشینه و کمینه استان تا پایان قرن 21، از داده‌‌های 12 مدل (ACCESS-CM2، BCC-CSM2-MR، CESM2، CNRM-CM6-1، CanESM5، MIROC6، MRI-EMS2-0، IPSL-CM6A-LR، GISS-E2-1-G، HadGEM3-GC31- LL، NESM3 و NOR-ESM2-MM) از مجموعه مدل‌‌های در دسترس CMIP6 با سه سناریوی (SSP1-2.6، SSP2-4.5 و SSP5-8.5) استفاده شد. …”
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Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system by Xueqian Yang, Meiqi Wu, Menglin Liang, Haiqiong Zhang, Bo Li, Chenhui Mao, Liling Dong, Yuan Wang, Haiqun Xing, Chao Ren, Zhenghai Huang, Qingxiang Wen, Qi Ge, Zhengqing Yu, Feng Feng, Jing Gao, Li Huo

“…Methods Thirty-eight participants (29 Aβ positive and 9 Aβ negative) from a prospective dementia cohort at Peking Union Medical University Hospital underwent routine [18F]florbetapir PET scans using the uMI Panorama PET/CT scanner and a T1-weighted brain MRI scan. List-mode PET data were reconstructed into durations of 10 min, 2 min, 1 min, 45 s, and 30 s (G10min, G2min, G1min, G45s, G30s). …”
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پیش‌نگری تغییرات نمایه‌های حدی دما در پهنه استان مازندران تحت سناریوهای CMIP6 by رضا نوروز ولاشدی, صدیقه برارخانپور احمدی, حدیقه بهرامی پیچاقچی, سارا مطلوم باب اناری

“…مواد و روش‌‏ها در این پژوهش، از داده‎‌های دمای مدل MRI-ESM-2 تحت سه سناریو خوش‏بینانه SSP1-2-6، حد متوسط SSP2-4-5 و بدبینانه SSP5-8-5 برای دو دوره‏ آینده‏ نزدیک (۲۰۶۰-۲۰۲۱) و آینده‏ دور (۲۱۰۰-۲۰۶۱) استفاده شد. …”
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