Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration by Salvador Cervin Serrano, Dalia González Villareal, Maribel Aguilar-Medina, Jose Guillermo Romero-Navarro, Jose Geovanni Romero Quintana, Eliakym Arámbula Meraz, Ignacio Osuna Ramírez, Veronica Picos-Cárdenas, Julio Granados, Iris Estrada-García, Guzman Sánchez-Schmitz, Rosalío Ramos-Payán

“…Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD n=100 and subjects with normal lumbar-spine MRI-scans n=100. Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% P=0.455 for T of rs1800587 (IL1A); 53.0% versus 58.0% P=0.183 for V of rs2228570 (VDR); and 18.0% versus 21.0% P=0.262 for C of rs731236 (VDR). …”
Get full text

Metal ion-crosslinking multifunctional hydrogel microspheres with inflammatory immune regulation for cartilage regeneration by Zhuoming Xu, Zhuoming Xu, Jun Ma, Hanyin Hu, Hanyin Hu, Jintao Liu, Jintao Liu, Haiyang Yang, Haiyang Yang, Jiayi Chen, Hongwei Xu, Xinyu Wang, Huanhuan Luo, Gang Chen

“…Moreover, the enhanced release of DIC and polydopamine (PDA) effectively downregulated inflammatory factors, and finally achieved OA therapy. In addition, in vivo MRI and tissue section staining of OA model proved the significant efficacy of the hydrogel microspheres on OA. …”
Get full text

Clinical analysis and case series report on autoimmune glial fibrillary acidic protein astrocytopathy presenting with autonomic dysfunction by Xiao Ke Wu, Guojie Zhai, Jin Ru Zhang, Hua Ping Du, Lan Hu, Shu Ye Yu, Hai Lun Hang, Sirui Han, Yanlin Zhang, Yuan Xu

“…Gastrointestinal disorders have associations with gender, sleep disturbances, protein content in the cerebrospinal fluid, and brain MRI lesions. The prognosis of autonomic nerve dysfunction is associated to sleep disorder and cerebrospinal fluid protein content. …”
Get full text

Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model by Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei

“…Methods: We established a rat model of SHR via 2-vessel gradual occlusion (SHR-2VGO) to mimic the CSVD. Subsequently, the MRI, pathomorphism, as well as Morriss water maze test were conducted to determine CSVD-related indicators. 8 weeks post-surgery, animals were randomly administered SAL, DAPT, ATN161 or saline.The aim was to explore the protective effects of SAL in CSVD as well as its possible mechanism. …”
Get full text

Brain radiotherapy and dorsal vagal complex irradiation: A new organ at risk to decrease radiation-induced nausea and vomiting? by Valentine Caspar, Nicolas Giraud, Thomas Charleux, Arnaud Beddok, Brieuc Bernard, Maelle Martin, Juliette Thariat, Aymeri Huchet, Véronique Vendrely, Charles Dupin

“…DVC delineation was performed on MRI T1 sequences with gadolinium injection using a reference atlas. …”
Get full text

Transcranial vibration stimulation at 40 Hz induced neural activity and promoted the coupling of global brain activity and cerebrospinal fluid flow by Linghan Kong, Wei Jin, Yue Jiang, Fuhua Yan, Jun Liu, Eric C. Leuthardt, Guang-Zhong Yang, Yuan Feng

“…Functional magnetic resonance imaging (fMRI) were performed before and after 5 mins TVS to explore the changes in ALFF and fALFF and the coupling of global brain activity with cerebrospinal fluid flow (CSF), which is related to the glymphatic clearance. …”
Get full text

Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study by Samuel Suárez-Suárez, Fernando Cadaveira, Alfonso Barrós-Loscertales, José Manuel Pérez-García, Socorro Rodríguez Holguín, Javier Blanco-Ramos, Sonia Doallo

“…In this two-year follow-up study, the impact of sustained BD on RS-FC was investigated in 44 college students (16 binge-drinkers) via two fMRI sessions at ages 18–19 and 20–21. Using a seed-to-voxel approach, RS-FC differences were examined in nodes of the main brain functional networks vulnerable to alcohol misuse, according to previous studies. …”
Get full text

Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures by Carol M. Stephens, Jacopo Proietti, Sean R. Mathieson, Vicki Livingstone, Brian McNamara, Niamh McSweeney, Olivia O'Mahony, Brian H. Walsh, Deirdre M. Murray, Geraldine B. Boylan

“…Several potential predictors for the development of later epilepsy were identified including infants delivered vaginally, low Apgar scores at 1 and 5 min, severe HIE diagnosis, presence of ENS, a severely abnormal EEG background and an abnormal brain MRI. Significance Following NE, term infants are at risk of epilepsy with a significantly higher incidence rate in infants who experience ENS compared to those who did not. …”
Get full text

The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction by Yang Wang, Yun Qin, Hui Li, Dezhong Yao, Bo Sun, Zhiliang Li, Xin Li, Yu Dai, Chao Wen, Lingrui Zhang, Chenchen Zhang, Tianmin Zhu, Cheng Luo

“…We acquired the functional magnetic resonance imaging (fMRI) data in IA subjects before and after 40 days of acupuncture treatment. …”
Get full text

Anti-NMDAR-Positive Small-Cell Lung Cancer Paraneoplastic Limbic Encephalitis: A Case Report and Literature Review by Raman Sohal, Steven H. Adams, Vishal Phogat, Abha Harish, Carlos Ynigo D. Lopez, Michael P. A. Williams, Kamal K. Khurana, Basel Abuzuaiter, Nia Jagroop, Bhavya Narapureddy

“…Initial EEG was unremarkable, though a repeat EEG showed mild slowing of the posterior dominant rhythm consistent with mild encephalopathy. MRI showed equivocal increased FLAIR on T2-weighted images in the bilateral temporal lobes, left greater than right. …”
Get full text

En plaque meningioma of the temporal bone: A systematic review on the imaging and management of a rare tumor by Arianna Burato, Giuseppe Maruccio, Livio Presutti, Ignacio Javier Fernandez, Gabriele Molteni, Giulia Molinari

“…Magnetic Resonance Imaging (MRI) revealed dural enhancement (28 %), temporal hyperostosis (20 %), a clearly enhancing extra-axial mass (28 %), compression of the surrounding vasculo-nervous structures (8 %) and the possible involvement of the temporal lobe (8 %). …”
Get full text

Can screening for degenerative cervical myelopathy (SCREEN-DCM) be effectively undertaken based on signs, symptoms and known risk factors? Rationale and research protocol for a pro... by Benjamin Davies, Mark Kotter, Granit Molliqaj, Enrico Tessitore, Karl Schaller, Teresa Somma, Aria Nouri, Renato Gondar, Joseph S Cheng, Paolo Cappabianca, Alexandre Lavé, Gianpaolo Jannelli, Allan Martin, Justin Virojanapa, Carmen L A Vleggeert-Lankamp, Valerie ter Wengel, Torstein Meling

“…Patients with ≥3 points undergo cervical MRI examination. Patients with positive MRIs will be consulted and receive assessment via modified Japanese Orthopedic Association and Neck Disability Index scores, and subsequent clinical management will be based on practice guidelines. …”
Get full text

Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients by Bo Zhao, Nobuyuki Kanematsu, Shuri Aoki, Shinichiro Mori, Hideyuki Mizuno, Takamitsu Masuda, Hideyuki Takei, Hitoshi Ishikawa

“…The DILs were identified on multiparametric MRI and used to define the boost target (PTVboost). …”
Get full text

Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex by Eva A. Krijnen, Maureen vanDam, Albulena Bajrami, Piet M. Bouman, Samantha Noteboom, Frederik Barkhof, Bernard M.J. Uitdehaag, Martijn D. Steenwijk, Eric C. Klawiter, Ismail Koubiyr, Menno M. Schoonheim

“…Methods In this longitudinal study, 230 people with multiple sclerosis and 60 healthy controls underwent 3 Tesla MRI at baseline and neuropsychological assessment at baseline and 5‐year follow‐up. …”
Get full text

Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization by Luchen Chang, Jiamei Liu, Jialin Zhu, Shuyue Guo, Yao Wang, Zhiwei Zhou, Xi Wei

“…In radiomics, AI can analyze high-dimensional features from computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) images to discover imaging biomarkers associated with tumor heterogeneity, treatment response, and disease progression, thereby enabling non-invasive, real-time assessments for personalized therapy. …”
Get full text

Growth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats by Sepide Nateghi, Ameneh Rezayof, Fatemeh Kouhkan, Ladan Delphi, Yavar Bagheri Davisaraei, Fatemeh Rostami, Fatemeh Tirgar, Houri Sepehri

“…The implantation of C6 cells into the mPFC induced GBM in this brain region (referred to as the mPFC-GBM) in male Wistar rats via stereotaxic surgery, as confirmed by Magnetic Resonance Imaging (MRI), and Hematoxylin and Eosin (H&E) staining. …”
Get full text

The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space by Liwei Tan, Yidan Qiu, Lixin Qiu, Shuting Lin, Jinhui Li, Jiajun Liao, Yuting Zhang, Wei Zou, Ruiwang Huang

“…By performing a multi-step sequential task and multivariate analyses of functional magnetic resonance imaging (fMRI) data, we found that the mOFC and lOFC play complementary but dissociable roles in this process. …”
Get full text

Combined morphology and radiomics of intravoxel incoherent movement as a predictive model for the pathologic complete response before neoadjuvant chemotherapy in patients with brea... by Yunyan Zheng, Hui Zhang, Huijian Chen, Yang Song, Ping Lu, Mingping Ma, Mengbo Lin, Muzhen He

“…BackgroundTo develop a predictive model using baseline imaging of morphology and radiomics derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) to determine the pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer patients.MethodsA total of 265 patients who underwent 3.0 T MRI scans before NACT were examined. Among them, 113 female patients with stage II–III breast cancer were included. …”
Get full text

Decidualized ovarian and rectouterine deep endometriosis disguised as malignancy in the second-trimester of pregnancy: A case report by Lingjie Bao, Ting Wang, Yinping Xiao, Shouxin Gu, Xiaoyu Zhou, Yunxi Zheng, Yun Chen, Xiaofang Yi

“…Serial nuclear magnetic resonance imaging (MRI) without contrast media for further evaluation indicated that these newly found pelvic masses were suspected to be ovarian endometrioid carcinoma with a metastasized lesion at rectouterine pouch. …”
Get full text

Feasibility and preliminary efficacy of a physical activity intervention in adults with lymphoma undergoing treatment by Juliana V. Costa, Alexander R. Lucas, Shannon L. Mihalko, Peter H. Brubaker, Alexandra Marshall, Brianna Leitzelar, Brianna R. Wolle, Samuel Norton, R. Lee Franco, Jeremy Via, Victor Yazbeck, Rakhee Vaidya, Mary Beth Seegars, Ralph D’Agostino, Lynne Wagner, W. Gregory Hundley

“…Participants completed assessments of exercise capacity (VO2 peak and 6-min walk distance (6MWD)), objective and self-reported levels of physical activity, MRI-derived cardiovascular functioning (Left Ventricular Ejection Fraction [LVEF], stroke volume, and cardiac output), and self-reported health-related and disease-specific quality of life and self-efficacy for exercise at baseline, 3, and 6 months. …”
Get full text