Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor by Melissa V. Gammons, Elsa Franco-Echevarría, Tie-Mei Li, Trevor J. Rutherford, Miha Renko, Christopher Batters, Mariann Bienz

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The intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility by Giulia Manigrasso, Kittirat Saharat, Panjaporn Chaichana, Chitrasak Kullapanich, Sharanjeet Atwal, Jerome Boulanger, Tomos E. Morgan, Holger Kramer, Jeanne Salje, Andrew P. Carter

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Foam film vitrification for cryo-EM by Yue Zhang, Biplob Nandy, Kasim Sader, Christopher J. Russo, Jan Löwe

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Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation by Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, Stephen H. McLaughlin, Geoffrey W. Grime, Elspeth F. Garman, Andreas Boland, David Barford

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Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis by Charlotte Maserumule, Charlotte Passemar, Olivia S.H. Oh, Kriztina Hegyi, Karen Brown, Aaron Weimann, Adam Dinan, Sonia Davila, Catherine Klapholz, Josephine Bryant, Deepshikha Verma, Jacob Gadwa, Shivankari Krishnananthasivam, Kridakorn Vongtongsalee, Edward Kendall, Andres Trelles, Martin L. Hibberd, Joaquín Sanz, Jorge Bertol, Lucia Vázquez-Iniesta, Kaliappan Andi, S. Siva Kumar, Diane Ordway, Rafael Prados-Rosales, Paul A. MacAry, R. Andres Floto

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Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex by Luojia Zhang, Christopher Batters, Shintaro Aibara, Yuliya Gordiyenko, Kristina Žumer, Jana Schmitzová, Kerstin Maier, Patrick Cramer, Suyang Zhang

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Molecular basis of autoimmune disease protection by MDA5 variants by Rahul Singh, Joe D. Joiner, Alba Herrero del Valle, Marleen Zwaagstra, Ida Jobe, Brian J. Ferguson, Frank J.M. van Kuppeveld, Yorgo Modis

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Revealing and mitigating the inhibitory effect of serotonin on HRP-mediated protein labelling by Zora Chui-Kuen Chan, Cheng Qi, Yuanhong Cai, Xin Li, Jing Ren

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Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture by Raja Jothi, S Balaji, Arthur Wuster, Joshua A Grochow, Jörg Gsponer, Teresa M Przytycka, L Aravind, M Madan Babu

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ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes by Jonathon Nixon-Abell, Francesco S. Ruggeri, Seema Qamar, Therese W. Herling, Magdalena A. Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S. Fernandopulle, Tomas Sneideris, Joseph L. Watson, Visakh V. S. Pillai, William Meadows, James W. Henderson, Joseph E. Chambers, Jane L. Wagstaff, Sioned H. Williams, Helena Coyle, Greta Šneiderienė, Yuqian Lu, Shuyuan Zhang, Stefan J. Marciniak, Stefan M. V. Freund, Emmanuel Derivery, Michael E. Ward, Michele Vendruscolo, Tuomas P. J. Knowles, Peter St George-Hyslop

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Structural basis of anticancer drug recognition and amino acid transport by LAT1 by Yongchan Lee, Chunhuan Jin, Ryuichi Ohgaki, Minhui Xu, Satoshi Ogasawara, Rangana Warshamanage, Keitaro Yamashita, Garib Murshudov, Osamu Nureki, Takeshi Murata, Yoshikatsu Kanai

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Editorial: Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches by Ilenio Servettini, Luca Guglielmi, Luigi Sforna, Luigi Catacuzzeno

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Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP by Tanja Fuchsberger, Imogen Stockwell, Matty Woods, Zuzanna Brzosko, Ingo H Greger, Ole Paulsen

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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

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How HIV-1 Uses the Metabolite Inositol Hexakisphosphate to Build Its Capsid by Leo C. James

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DNA as a Double-Coding Device for Information Conversion and Organization of a Self-Referential Unity by Georgi Muskhelishvili, William Nasser, Sylvie Reverchon, Andrew Travers

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Cross‐species chemogenomic profiling reveals evolutionarily conserved drug mode of action by Laura Kapitzky, Pedro Beltrao, Theresa J Berens, Nadine Gassner, Chunshui Zhou, Arthur Wüster, Julie Wu, M Madan Babu, Stephen J Elledge, David Toczyski, R Scott Lokey, Nevan J Krogan

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Propylene glycol inactivates respiratory viruses and prevents airborne transmission by Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O'Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar

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Neural substrates of cold nociception in Drosophila larva by Atit A Patel, Albert Cardona, Daniel N Cox

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Control of 3′ splice site selection by the yeast splicing factor Fyv6 by Katherine A Senn, Karli A Lipinski, Natalie J Zeps, Amory F Griffin, Max E Wilkinson, Aaron A Hoskins

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