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Assessment of MGMT and TERT Subtypes and Prognosis of Glioblastoma by Whole Tumor Apparent Diffusion Coefficient Histogram Analysis
Published 2025-01-01Subjects: Get full text
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The relationship between IDH, P53 mutations, MGMT methylation with characteristics in high grade glioma patients
Published 2022-07-01Subjects: Get full text
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Radiomics prediction of MGMT promoter methylation in adult diffuse gliomas: a combination of structural MRI, DCE, and DTI
Published 2025-01-01Subjects: “…MGMT…”
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胰腺神经内分泌肿瘤CT征象与SSTR2、VEGFR2及MGMT表达的关系
Published 2021-11-01“…目的探讨胰腺神经内分泌肿瘤(pNENs)的CT征象与生长抑素2型受体(SSTR2)、血管内皮生长因子2型受体(VEGFR2)及O<sup>6</sup>-甲基鸟嘌呤-DNA甲基转移酶(O<sup>6</sup>-methylguanine-DNA-methyltransferse,MGMT)表达的关系。方法收集2010年1月至2020年11月本机构经术后病理证实为pNENs 86例,所有患者术前均行增强CT检查,术后行SSTR2、VEGFR2、MGMT免疫组化检查。…”
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Deep learning classification of MGMT status of glioblastomas using multiparametric MRI with a novel domain knowledge augmented mask fusion approach
Published 2025-01-01Subjects: “…MGMT methylation…”
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Validating a clinically based MS-MLPA threshold through comparison with Sanger sequencing in glioblastoma patients
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Expression of O6-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients
Published 2010-01-01“…These observations suggest that, overall, MGMT levels are increased during human bladder carcinogenesis and that MGMT downregulation is not a common feature of bladder cancers. …”
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褪黑激素促进水貂冬皮早熟的研究
Published 1995-01-01“…水貂用MT植入物处理后,表现食欲旺盛,死亡率降低。成年水貂在6月15日用含5mgMT植入物处理,冬皮在10月4日成熟.比正常对照组提早2个月。当年产幼水貂在7月15日用含5mgMT或6mgMT植入物处理,或在7月20日用含6mgMT的植入物处理,冬皮分别在10月20日和10月15日成熟,其提前天数分别为40d和52d。…”
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Development and Validation of a Prognostic Molecular Phenotype and Clinical Characterization in Grade III Diffuse Gliomas Treatment with Radio-Chemotherapy
Published 2025-01-01“…IDH-1 mutation and 1p/19q co-deletion patients had the best prognosis than other molecular types. Also, the MGMT methylation and IDH-1 mutation or 1p/19q co-deletion group had a longer mPFS and mOS than the MGMT unmethylation and IDH-1 wildtype or 1p/19q non-codeletion of grade III patients. …”
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Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy
Published 2012-01-01“…Drug-resistant mutation of the MGMT protein has been shown to render chemoprotection against TMZ. …”
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Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment.
Published 2025-01-01“…We observed that activation of NF-κB was positively correlated with the levels of O-6-methylguanine-DNA methyltransferase (MGMT) protein, a direct DNA repair enzyme leading to TMZ resistance, regardless of MGMT promoter methylation status, further supporting the clinical potential for inhibition of NF-kB signaling in GBM treatment. …”
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Unraveling the heterogeneity of WHO grade 4 gliomas: insights from clinical, imaging, and molecular characterization
Published 2025-02-01“…A4 tumors were associated with younger age, higher MGMT promoter methylation, lower rates of TERT mutations, and distinct radiological features, such as cortical non-enhancing tumor infiltration (CnCE). …”
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Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets: A Case Study of Glioblastoma
Published 2025-01-01“…O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is the only biomarker for TMZ responsiveness but has shown limited predictive power. …”
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