Showing 1 - 20 results of 43 for search '"MGMT"', query time: 0.05s Refine Results
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6

    胰腺神经内分泌肿瘤CT征象与SSTR2、VEGFR2及MGMT表达的关系 by 李璐杰, 宋晨宇, 周小琦, 罗宴吉, 冯仕庭, 彭振鹏

    Published 2021-11-01
    “…目的探讨胰腺神经内分泌肿瘤(pNENs)的CT征象与生长抑素2型受体(SSTR2)、血管内皮生长因子2型受体(VEGFR2)及O<sup>6</sup>-甲基鸟嘌呤-DNA甲基转移酶(O<sup>6</sup>-methylguanine-DNA-methyltransferse,MGMT)表达的关系。方法收集2010年1月至2020年11月本机构经术后病理证实为pNENs 86例,所有患者术前均行增强CT检查,术后行SSTR2、VEGFR2、MGMT免疫组化检查。…”
    Get full text
    Article
  7. 7
  8. 8
  9. 9
  10. 10
  11. 11

    Expression of O6-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients by Abir A. Saad, Heba Sh. Kassem, Andrew C. Povey, Geoffrey P. Margison

    Published 2010-01-01
    “…These observations suggest that, overall, MGMT levels are increased during human bladder carcinogenesis and that MGMT downregulation is not a common feature of bladder cancers. …”
    Get full text
    Article
  12. 12

    褪黑激素促进水貂冬皮早熟的研究 by 孔庆松, 刘志平, 景松岩, 张伟, 叶春艳

    Published 1995-01-01
    “…水貂用MT植入物处理后,表现食欲旺盛,死亡率降低。成年水貂在6月15日用含5mgMT植入物处理,冬皮在10月4日成熟.比正常对照组提早2个月。当年产幼水貂在7月15日用含5mgMT或6mgMT植入物处理,或在7月20日用含6mgMT的植入物处理,冬皮分别在10月20日和10月15日成熟,其提前天数分别为40d和52d。…”
    Get full text
    Article
  13. 13

    Development and Validation of a Prognostic Molecular Phenotype and Clinical Characterization in Grade III Diffuse Gliomas Treatment with Radio-Chemotherapy by Gu W, Tang J, Liu P, Gan J, Lai J, Xu J, Deng J, Liu C, Wang Y, Zhang G, Yu F, Shi C, Fang K, Qiu F

    Published 2025-01-01
    “…IDH-1 mutation and 1p/19q co-deletion patients had the best prognosis than other molecular types. Also, the MGMT methylation and IDH-1 mutation or 1p/19q co-deletion group had a longer mPFS and mOS than the MGMT unmethylation and IDH-1 wildtype or 1p/19q non-codeletion of grade III patients. …”
    Get full text
    Article
  14. 14

    Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy by Sadhak Sengupta, Jaclyn Marrinan, Caroline Frishman, Prakash Sampath

    Published 2012-01-01
    “…Drug-resistant mutation of the MGMT protein has been shown to render chemoprotection against TMZ. …”
    Get full text
    Article
  15. 15
  16. 16

    Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment. by Artem Berezovsky, Oluwademilade Nuga, Indrani Datta, Kimberly Bergman, Thais Sabedot, Katherine Gurdziel, Susan Irtenkauf, Laura Hasselbach, Yuling Meng, Claudius Mueller, Emanuel F Petricoin, Stephen Brown, Neeraja Purandare, Sidhesh Aras, Tom Mikkelsen, Laila Poisson, Houtan Noushmehr, Douglas Ruden, Ana C deCarvalho

    Published 2025-01-01
    “…We observed that activation of NF-κB was positively correlated with the levels of O-6-methylguanine-DNA methyltransferase (MGMT) protein, a direct DNA repair enzyme leading to TMZ resistance, regardless of MGMT promoter methylation status, further supporting the clinical potential for inhibition of NF-kB signaling in GBM treatment. …”
    Get full text
    Article
  17. 17
  18. 18

    Unraveling the heterogeneity of WHO grade 4 gliomas: insights from clinical, imaging, and molecular characterization by Haihui Jiang, Xijie Wang, Xiaodong Chen, Shouzan Zhang, Qingsen Ren, Mingxiao Li, Ming Li, Xiaohui Ren, Song Lin, Yong Cui

    Published 2025-02-01
    “…A4 tumors were associated with younger age, higher MGMT promoter methylation, lower rates of TERT mutations, and distinct radiological features, such as cortical non-enhancing tumor infiltration (CnCE). …”
    Get full text
    Article
  19. 19

    Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets: A Case Study of Glioblastoma by Jie Ju, Ioannis Ntafoulis, Michelle Klein, Marcel JT Reinders, Martine Lamfers, Andrew P Stubbs, Yunlei Li

    Published 2025-01-01
    “…O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is the only biomarker for TMZ responsiveness but has shown limited predictive power. …”
    Get full text
    Article
  20. 20