Showing 21 - 40 results of 43 for search '"MGMT"', query time: 0.04s Refine Results
  1. 21
  2. 22
  3. 23
  4. 24
  5. 25
  6. 26
  7. 27
  8. 28
  9. 29

    Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

    Published 2012-01-01
    “…To date, many studies report several determinants of resistance to this aggressive therapy: (1) O6-methylguanine-DNA methyltransferase (MGMT), (2) the complexity of several altered signaling pathways in GBM, (3) the existence of glioma stem-like cells (GSCs), and (4) the blood-brain barrier. …”
    Get full text
    Article
  10. 30
  11. 31
  12. 32
  13. 33

    Temozolomide Therapy for Aggressive Pituitary Tumors: Results in a Small Series of Patients from Argentina by Oscar D. Bruno, Lea Juárez-Allen, Silvia B. Christiansen, Marcos Manavela, Karina Danilowicz, Carlos Vigovich, Reynaldo M. Gómez

    Published 2015-01-01
    “…In all the patients tested O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical specimens was absent. …”
    Get full text
    Article
  14. 34

    Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients by Zhaoyue Yan, Yushuai Gao, Jinliang Yu, Zhiyuan Shen, Xingyao Bu

    Published 2022-01-01
    “…Furthermore, the high-risk group was significantly correlated with several risk factors, including older age, higher tumor grade, IDH wild type, 1p19q noncodel, and MGMT unmethylation. The nomogram was constructed by integrating the risk scores and other independent clinical characteristics. …”
    Get full text
    Article
  15. 35

    Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer by Yuwei Wang, Yadong Long, Ye Xu, Zuqing Guan, Peng Lian, Junjie Peng, Sanjun Cai, Guoxiang Cai

    Published 2014-01-01
    “…Promoter methylation of p14ARF, hMLH1, p16INK4a, MGMT, and MINT1 was determined by methylation specific polymerase chain reaction (MSP). …”
    Get full text
    Article
  16. 36

    [18F]FDG PET-Based Radiomics and Machine Learning for the Assessment of Gliomas and Glioblastomas: A Systematic Review by Francesco Dondi, Roberto Gatta, Maria Gazzilli, Pietro Bellini, Gian Luca Viganò, Cristina Ferrari, Antonio Rosario Pisani, Giuseppe Rubini, Francesco Bertagna

    Published 2025-01-01
    “…Signatures, including radiomics analysis and ML, generally demonstrated a possible diagnostic value to assess different characteristics of gliomas and GBMs, such as the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter, the isocitrate dehydrogenase (IDH) genotype, alpha thalassemia/mental retardation X-linked (ATRX) mutation status, proliferative activity, differential diagnosis with solitary brain metastases or primary central nervous system lymphoma, and prognosis of these patients. …”
    Get full text
    Article
  17. 37

    Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development by Sarah Derks, Cindy Postma, Peter T. M. Moerkerk, Sandra M. van den Bosch, Beatriz Carvalho, Mario A. J. A. Hermsen, Walter Giaretti, James G. Herman, Matty P. Weijenberg, Adriaan P. de Bruïne, Gerrit A. Meijer, Manon van Engeland

    Published 2006-01-01
    “…Methods: In a series of 47 nonprogressed adenomas, 41 progressed adenomas (malignant polyps), 38 colorectal carcinomas and 18 paired normal tissues, we evaluated promoter methylation status of hMLH1, O6MGMT, APC, p14ARF, p16INK4A, RASSF1A, GATA-4, GATA-5, and CHFR using methylation-specific PCR. …”
    Get full text
    Article
  18. 38

    A Case of Nonfunctioning Pituitary Carcinoma That Responded to Temozolomide Treatment by Haruko Morokuma, Takao Ando, Takuya Hayashida, Ichiro Horie, Naoko Inoshita, Fumi Murata, Ikuko Ueki, Kan Nakamura, Misa Imaizumi, Toshiro Usa, Atsushi Kawakami

    Published 2012-01-01
    “…There was an apparent antitumor response seen in MRI. MGMT, an enzyme antagonized by TMZ, was negative in the tumor. …”
    Get full text
    Article
  19. 39

    Epigenetic alterations in salivary gland neoplasms and the impact of these alterations in tumor progression and prognosis: A systematic review and meta-analysis by Karolina Skarlet Silva Viana, Mariana Saturnino de Noronha, Cristiane Squarize, Lucas Guimarães Abreu, Maria Cássia Ferreira Aguiar, Vanessa Fátima Bernardes

    Published 2024-03-01
    “…A meta-analysis was conducted for methylation regarding the genes MGMT and RASSF1A and found that both genes methylation is related to higher stages of the SGTs but did not show an association with grade of tumors. …”
    Get full text
    Article
  20. 40

    Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

    Published 2025-02-01
    “…The research focus has shifted from traditional topics such as the “MGMT gene” to emerging areas including the “tumor microenvironment,” “immune infiltration,” and “nanoparticles.” …”
    Get full text
    Article