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Corporate Governance and Corporate Sustainability Performance: A Systematic Literature Review
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Current Trends in Targeted Therapies for Glioblastoma Multiforme
Published 2012-01-01“…To date, many studies report several determinants of resistance to this aggressive therapy: (1) O6-methylguanine-DNA methyltransferase (MGMT), (2) the complexity of several altered signaling pathways in GBM, (3) the existence of glioma stem-like cells (GSCs), and (4) the blood-brain barrier. …”
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Does Regime-Dependent Volatility Drive Dynamism in Investor Herding?
Published 2024-06-01Get full text
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Testing the Adaptive Market Hypothesis and Time-Varying Efficiency in the Indian Equity Market
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Temozolomide Therapy for Aggressive Pituitary Tumors: Results in a Small Series of Patients from Argentina
Published 2015-01-01“…In all the patients tested O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression in surgical specimens was absent. …”
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Identification of an Inflammatory Response-Related Gene Signature to Predict Survival and Immune Status in Glioma Patients
Published 2022-01-01“…Furthermore, the high-risk group was significantly correlated with several risk factors, including older age, higher tumor grade, IDH wild type, 1p19q noncodel, and MGMT unmethylation. The nomogram was constructed by integrating the risk scores and other independent clinical characteristics. …”
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Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer
Published 2014-01-01“…Promoter methylation of p14ARF, hMLH1, p16INK4a, MGMT, and MINT1 was determined by methylation specific polymerase chain reaction (MSP). …”
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[18F]FDG PET-Based Radiomics and Machine Learning for the Assessment of Gliomas and Glioblastomas: A Systematic Review
Published 2025-01-01“…Signatures, including radiomics analysis and ML, generally demonstrated a possible diagnostic value to assess different characteristics of gliomas and GBMs, such as the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter, the isocitrate dehydrogenase (IDH) genotype, alpha thalassemia/mental retardation X-linked (ATRX) mutation status, proliferative activity, differential diagnosis with solitary brain metastases or primary central nervous system lymphoma, and prognosis of these patients. …”
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Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development
Published 2006-01-01“…Methods: In a series of 47 nonprogressed adenomas, 41 progressed adenomas (malignant polyps), 38 colorectal carcinomas and 18 paired normal tissues, we evaluated promoter methylation status of hMLH1, O6MGMT, APC, p14ARF, p16INK4A, RASSF1A, GATA-4, GATA-5, and CHFR using methylation-specific PCR. …”
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A Case of Nonfunctioning Pituitary Carcinoma That Responded to Temozolomide Treatment
Published 2012-01-01“…There was an apparent antitumor response seen in MRI. MGMT, an enzyme antagonized by TMZ, was negative in the tumor. …”
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Epigenetic alterations in salivary gland neoplasms and the impact of these alterations in tumor progression and prognosis: A systematic review and meta-analysis
Published 2024-03-01“…A meta-analysis was conducted for methylation regarding the genes MGMT and RASSF1A and found that both genes methylation is related to higher stages of the SGTs but did not show an association with grade of tumors. …”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023)
Published 2025-02-01“…The research focus has shifted from traditional topics such as the “MGMT gene” to emerging areas including the “tumor microenvironment,” “immune infiltration,” and “nanoparticles.” …”
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