Pathogenic and therapeutic role of bile acids at reflux-gastritis by T. L. Lapina, I. M. Kartavenko, V. T. Ivashkin

“…They can increase endocellular concentration of calcium which is responsible for toxic effects of bile acids as a secondary messenger. Increase of endocellular calcium stimulates secretion of pepsinogen and acid production in the stomach,  that in the case of decreased cytoprotective factors by DGR can cause changes mucosal injury. …”
Get full text

Overexpression of MiR-183/96/182 Triggers Retina-Like Fate in Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMSCs) in Culture by Mohammad-Reza Mahmoudian-Sani, Fatemeh Forouzanfar, Samira Asgharzade, Nilufar Ghorbani

“…Ectopic overexpression of the miR-183 cluster could further increase the expression of CRX and RHO at the messenger RNA (mRNA) and protein levels. Furthermore, the data indicated that the miR-183 cluster could serve as a crucial function in photoreceptor cell differentiation. …”
Get full text

Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome by Chenxi Yang, Yi Chen, Guangfeng Tang, Tongtong Shen, Li Li

“…Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to evaluate the messenger RNA levels of JUN and FOSB in the peripheral blood of healthy volunteers (lean and obese) and patients with MetS (lean and obese), along with that in the adipose tissue and peripheral blood of obese mouse model. …”
Get full text

Identification of the Role of Mume fructus in Treating Nocturnal Asthma Based on Network Pharmacology and In vitro Investigation by Ling-Ling Tang, Yan-Qiu Xu, Ying Yang, Xian-Hong Sun, Bo-Han Wang, Xiao-Lu Shi, Li Liu

“…Data provided included analyses of cell viability detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, cell proliferation and apoptosis detected by 5-ethynyl-2’-deoxyuridine and Hoechst 33342, messenger ribonucleic acid (mRNA) levels obtained by real-time polymerase chain reaction, and protein expression detected by Western blotting. …”
Get full text

Genotype-dependent resilience mediated by melatonin in sweet corn by Tahoora Batool Zargar, Mawia Sobh, Oqba Basal, Szilvia Veres

“…This study aimed to enhance water deficit resilience in sweet corn by applying foliar melatonin to four genotypes-Messenger, Dessert, Royalty, and Tyson under two levels of water deprivation induced by polyethylene glycol at 8% and 12% concentrations in a hydroponic, controlled environment. …”
Get full text

ВИКОРИСТАННЯ МЕСЕНДЖЕРА TELEGRAM ЯК ЗАСОБУ ПІДТРИМКИ ОСВІТНЬОГО ПРОЦЕСУ В УМОВАХ КАРАНТИННИХ ОБМЕЖЕНЬ... by Олександр Володимирович Носенко, Юлія Григорівна Носенко, Роман Миколайович Шевчук

“…Проаналізовано сучасні месенджери, зокрема Telegram, Viber, Facebook Messenger, WhatsApp, за визначеними критеріями (комерційність, функціональність, архітектура, безпека) та показниками. …”
Get full text

mRNA vaccines as cancer therapies by Shaoxiong Huang, Haiying Que, Manni Wang, Xiawei Wei, Yanjie Yin

“…This review provides an in-depth analysis of messenger RNA (mRNA) vaccines as a therapeutic approach for cancer immunotherapy, focusing on their molecular biology, classification, mechanisms, and clinical studies. …”
Get full text

Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data by Jie Ma, Chuanxi Chen, Andreas S. Barth, Chris Cheadle, Xiangdong Guan, Li Gao

“…We identified 6 cohorts consisting of 450 individuals (sepsis = 323, control = 127) providing genome-wide messenger RNA (mRNA) expression data. Through meta-analysis we found the “Lysosome” and “Cytoskeleton” pathways were upregulated in human sepsis patients relative to controls, in addition to previously known signaling pathways (including MAPK, TLR). …”
Get full text

Assessment of Allometry in Environmental DNA and RNA Production From Ayu (Plecoglossus altivelis) in an Experimental Condition Using Mitochondrial and Nuclear Gene Markers by Toshiaki S. Jo, Yusuke Ozaki, Nao Matsuda, Hiroki Yamanaka

“…To address the knowledge gaps, we conducted a long‐term rearing experiment using ayu (Plecoglossus altivelis) to monitor the production of their eDNA and messenger and ribosomal eRNA in their growth from larvae to adults. …”
Get full text

Impact of Myo-Inositol-Chiro Inositol Combination on the improvement of Polycystic Ovary Syndrome Condition by Zuhair Assi Hussein, Maysaa Jalal Majeed, Lubna Amer Al-Anbari

“…It plays a role as a second messenger of insulin in several insulin-dependent processes, including polycystic ovarian syndrome (PCOS) and metabolic syndrome. …”
Get full text

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance by Xiaoyan Zhang, Huaijun Tu, Yazhi Yang, Lijun Fang, Qiong Wu, Jian Li

“…Different studies have reported that MSC-EVs may exert various effects on the growth, metastasis, and drug response of different tumor cells by transferring proteins, messenger RNA, and microRNA to recipient cells. In the present review, we summarize the components of MSC-EVs and discuss the roles of MSC-EVs in different malignant diseases, including the related mechanisms that may account for their therapeutic potential. …”
Get full text

The Effect of High Levels Carbohydrate on Intestinal Microbiota, Metabolites, and Health of Common Carp (Cyprinus carpio L.) by Jinrui Xiong, Liping Yang, Luming Wang, Shaoyang Zhi, Mengjuan Zhao, Chunchu Xu, Leya Qu, Xiaorui Guo, Xiao Yan, Chaobin Qin, Guoxing Nie

“…Specifically, the RT-qPCR results revealed that HCD treatment significantly upregulated il1β, il6, and il8 transcript levels. Whereas, the il10 messenger RNA (mRNA) was markedly reduced in comparison to the LCD group. …”
Get full text

The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole. by Marie Seveno, Manon N Loubens, Laurence Berry, Arnault Graindorge, Maryse Lebrun, Catherine Lavazec, Mauld H Lamarque

“…First, we provide further evidence that PP1 controls the homeostasis of the second messenger cGMP by modulating the basal activity of guanylyl cyclase alpha and consequently the PKG-dependent downstream Ca2+ signaling. …”
Get full text

Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy by Saber Imani, Xiaoyan Li, Keyi Chen, Mazaher Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Mehrdad Hashemi, Saloomeh Khoushab, Saloomeh Khoushab, Xiaoping Li

“…Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. …”
Get full text

lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke by Lin Ma, Yu-Hua Liu, Chun Liu, Shu-Qi Wang, Jun Ma, Xiao-Qing Li, Min Ren, Ting-Ting Yang, Guang-Zhi Liu

“…Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM). …”
Get full text

Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…The application of messenger RNA (mRNA) technology in antigen-based immuno-oncology therapies represents a significant advancement in cancer treatment. …”
Get full text

Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing by Xianglin Cao, Han Cui, Xinyu Ji, Baohua Li, Ronghua Lu, Yuru Zhang, Jianjun Chen

“…Additionally, the regulatory network between miRNA and messenger RNA (mRNA) in the modulation of the role of BCAAs on skeletal muscle growth in fish has not been studied. …”
Get full text

Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model by Tao Cheng, Yaochao Zhao, Bin Li, Mengqi Cheng, Jiaxing Wang, Xianlong Zhang

“…Furthermore, CUR downregulated the osteoclast-specific gene expression and reversed the receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin messenger RNA and protein ratio in PMMA particle-stimulated mice. …”
Get full text

Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer by Naomi Yoshuantari, Didik Setyo Heriyanto, Susanna Hilda Hutajulu, Johan Kurnianda, Ahmad Ghozali

“…The quantitative expressions of CXCL12 and CXCR4 messenger RNA (mRNA) were evaluated in 32 patients with adenocarcinoma-type CRC. …”
Get full text

APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression by Nora Hase, Danny Misiak, Helge Taubert, Stefan Hüttelmaier, Michael Gekle, Marcel Köhn

“…Furthermore, we identified that A3C binds and potentially stabilizes messenger RNAs (mRNAs) encoding positive regulators of the NF‐κB pathway. …”
Get full text