Nécropoles multipolaires et élaboration d’un nouveau modèle socio-politique au premier âge du Fer : réflexions à partir des sites du Camp de l’Église Sud à Flaujac-Poujols (Lot) et... by Antoine Dumas

“…In this particular sector, the anthropological data indicates that the dimensional variations of the stone circles (from 1 to 3 m in diameter) are related to variations in age of the deceased: the largest structures correspond to adult graves, while the smallest correspond to those of small children. …”
Get full text

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a... by Xiaoting Gu, Xiaohe Li, Weixue Tian, Chaoyue Zheng, Chaoyue Zheng, Yutian Cai, Yutian Cai, Xiang Xu, Xiang Xu, Conglu Zhao, Conglu Zhao, Hongting Liu, Hongting Liu, Yao Sun, Yao Sun, Zhilin Luo, Zhilin Luo, Shuwen Zhu, Shuwen Zhu, Honggang Zhou, Honggang Zhou, Xiaoyu Ai, Cheng Yang, Cheng Yang

“…A HLM inhibition reaction system was established to evaluate the inhibitory effect of Deg-AZM on CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. The mRNA expression of human primary hepatocytes incubated with Deg-AZM or not was evaluate the induction of Deg-AZM on CYP1A2, CYP2B6, and CYP3A4.Results44 metabolites of Deg-AZM were identified in rat urine, feces, bile, and plasma, the metabolic pathways included demethylation, monohydroxylation, dihydroxylation, dehydroxidation, hydroreduction, hydrolysis, methylation, glucuronidation and the combination of different metabolic pathways. …”
Get full text

CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…Furthermore, CREB3L1-induced TAM polarization toward an M2 phenotype and reduced the infiltration of CD8+ T cells. …”
Get full text

The burden of acute respiratory infection attributable to fine particulate matter brought by dust storms among children under 5 years of age in low- and middle-income countries by Hong Lu, Mingkun Tong, Ruohan Wang, Ning Kang, Xueqiu Ni, Jianyu Deng, Jiajianghui Li, Pengfei Li, Tianjia Guan, Tong Zhu, Tao Xue

“…Results: The analysis of 1,223,118 children showed that a 10 μg/m3 increase in dust PM2.5 was associated with a 7.43% (95% confidence interval [CI]: 4.77–10.15%) increase in the odds of U5-ARI. …”
Get full text

Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…Methods: This population-based cohort study used Swedish and Danish registry data for over 5.1 M individuals born between 1958 and 1993/1996. …”
Get full text

Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…The diverse composition of bEVs, including their proteins, mRNAs, metabolites, and lipids, makes them useful for investigating diseases such as cancer. …”
Get full text

Risk factors associated with in-hospital mortality during yellow fever outbreak in Brazil by Max McClure, Izabela Maurício de Rezende, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Jordana Rodrigues Barbosa Fradico, Rodrigo Macedo, Marcelle Cardoso Marçal, Lívia Soares Coelho Fonte Boa, Alexandre Maurício Castro Bragato, Flávio Augusto de Almeida Faria, Livia Pamplona, Rodrigo Fabiano do Carmo Said, Carlos Eduardo Calzavara-Silva, Dario Brock Ramalho, Cintia Lopes de Brito Magalhães, Pedro Augusto Alves, Thaysa Drummond Palmeira Gama, Gláucia Fernandes Cota, Thomas P. Monath, Olindo Assis Martins-Filho, Marcelo Antônio Pascoal-Xavier, Andrea Teixeira-Carvalho, Betânia Paiva Drumond, A. Desiree LaBeaud, Yellow Fever Collaborative Group, Argus Leão Araújo, Barbara Lenoir, Bruno Dala Vedova Gomes Beato, Carolina Lins Rodrigues Vieira, Daniel Vitor de Vasconcelos Santos, Flavia Mansur Starling, Gabriela Miana de Mattos Paixão, Indiara Penido, Izabela Aparecida Coelho, Leandro Henrique Malta Cunha, Letícia Menezes, Livia Frota Rabelo, Letícia Lemos Jardim, Lívia Fulgêncio da Cunha Melo, Lívia Zignago Moreira dos Santos, Ludmila de Paula, Luísa Lages de Abre Paladino, Natalia Soares Albuquerque, Simone Lopes Oliveira Lemos, Tayrine Araújo

“…Initial viral load above the cutoff of 4.45 log10 copies/mL was significantly associated with death prior to discharge (OR 12.2; CI 2.83, 92.3). …”
Get full text

Severe obesity, high inflammation, insulin resistance with risks of all-cause mortality and all-site cancers, and potential modification by healthy lifestyles by Qianyun Jin, Siwen Liu, Yunmeng Zhang, Yuting Ji, Jie Wu, Hongyuan Duan, Xiaomin Liu, Jingjing Li, Yacong Zhang, Zhangyan Lyu, Fangfang Song, Fengju Song, Hua Li, Yubei Huang

“…The independent and joint associations of severe obesity (body mass index ≥ 35 m/kg2), inflammation (C-reactive protein > 10 mg/L and systemic inflammation markers > 9th decile), and IR surrogates with the risks of all-cause mortality and all-site cancers, were evaluated in 163,008 participants from the UK Biobank cohort. …”
Get full text

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape by Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen

“…We aassembled the sequences of IgM and IgD repertoire from 130 people to investigate the genetic variations in the population. …”
Get full text

Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group by Laura Massaro, Annamaria Iagnocco, Florenzo Iannone, Corrado Campochiaro, Maria De Santis, Ilaria Cavazzana, Piero Ruscitti, Roberto Giacomelli, Rosario Foti, Lorenzo Dagna, Giovanna Cuomo, Giacomo De Luca, Francesco Caso, Ilenia Di Cola, Clodoveo Ferri, Vincenzo Raimondo, Francesco Ursini, Veronica Brusi, Giuseppe Varcasia, Roberta Pellegrini, Domenico Olivo, Giuseppe Murdaca, Carlo Selmi, Olga Addimanda, Erika Pigatto, Francesca Francioso, Rossella De Angelis, Jacopo Ciaffi, Luana Mancarella, Marcella Visentini, Francesca Motta, Virginia Caira, Alberto Lo Gullo, Caterina Naclerio, Elena Marchetti, Sebastiano Lorusso, Jessica Luppino, Roberta Foti, Massimo Reta

Get full text

Microbial metabolites and immune modulation by Hassan Ghasemi

“…Propionate, another SCFA, has been linked to the inhibition of histone deacetylases, which are involved in gene regulation, further supporting anti-inflammatory pathways.3,4 These metabolites also modulate macrophage function by promoting a shift toward an anti-inflammatory M2 phenotype, a process essential for resolving inflammation and facilitating tissue repair.5 Additionally, they enhance gut barrier integrity by upregulating proteins involved in epithelial tight junctions, reducing the translocation of harmful microbial components into systemic circulation and thereby mitigating systemic inflammation.6 Secondary bile acids, produced through the microbial biotransformation of primary bile acids synthesized in the liver, exhibit immunomodulatory properties. …”
Get full text

Dacostaite, K(Mg₂Al)[Mg(H₂O)₆]₂(AsO₄)₂F₆  ⋅  2H₂O, a new fluoride–arsenate mi... by C. Biagioni, C. Biagioni, D. Mauro, D. Mauro, J. Sejkora, Z. Dolníček, A. Dini, R. Škoda

“…Dacostaite is monoclinic, with a space group of <span class="inline-formula"><i>C</i></span>2/<span class="inline-formula"><i>m</i></span> and <span class="inline-formula"><i>a</i>=12.474(5)</span>, <span class="inline-formula"><i>b</i>=7.198(3)</span>, <span class="inline-formula"><i>c</i>=13.724(6)</span> Å, <span class="inline-formula"><i>β</i>=99.518(13)</span>°, and <span class="inline-formula"><i>V</i>=1215.3(8)</span> Å<span class="inline-formula">³</span>. …”
Get full text

Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Genome-wide association studies (GWAS) identified multiple single-nucleotide polymorphisms (SNPs) associated with plasma apolipoproteins (P < 5.00E-08), including APOE-rs7412 for ApoE, LPA-rs56393506 for Apo(a), APOM-rs707921 for ApoM, ABCC4-rs117797426 for ApoJ, THSD7B-rs575613 for ApoA-II, and LOC102724443-rs140433245 for ApoA-IV. …”
Get full text

Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation by Renate Oberhoffer, Peter Ewert, Harald Kaemmerer, Nicole Nagdyman, Oliver Dewald, Frank Klawonn, Michael Huntgeburth, Andreas Eicken, Christian Meierhofer, Sebastian Freilinger, Martin Middeke, Pinar Bambul Heck, Annika Freiberger, Frank Harig, Manuel Lösch, Fritz Mellert, Fabian von Scheidt, Elsa Ury, Nicole Wolfrum, Ann-Sophie Kaemmerer-Suleiman, Mathieu N. Suleiman

“…Pulse wave velocity, indicative of aortic stiffness, averaged 9.1 m/s, with higher values in 13 patients (27.7%), including 4 after end–end anastomosis, 2 after graft interposition and 7 after stent placement/angioplasty as the most recent procedure. …”
Get full text

Influence of Investors' Sentiment on Bitcoin Returns by Mahdieh Rezagholizadeh, Mohammad Abdi Seyyedkolaee, Zahra Mohseni Kolagar

Get full text

A Conversation with Toyin Falola on the future of Yoruba Language by Oyesina Fadare

“…Oun ti ̀ wọn ́ f ń kọ́ aẁ ọn ọmọ Yorùbá tó jẹ́ akẹẹ́ ̀kọ́ ni ́ẹ̀kọ; ò un ni w ̀ ọn ́ f ńṣe etò ̀ of̀ n, oun na ̀ á ̀ sìni wọn ́ f ṣe etò ̀ kará ̀katá . È yí tu ́ ḿ ọ̀ si ́ wipé ́ẹnikẹni to ́ ́ bá fẹ́ rí ọwọ́ mun nigba ́ ̀ naa gbọdọ le sọ e ̀dè Gẹẹ̀ si. …”
Get full text

İMKB’ye Kayıtlı Seçilmiş İşletmelere Yönelik Etkinlik Ölçümü ve Performans Değerlendirmesi: Veri Zarflama Analizi ve Topsis Uygulaması by Mustafa Soba, Fatma Akcanlı, Işıl Erem

“…. • Metal eşya, makine ve gereç yapım sektöründe 2008 yılında F-M İzmit Piston işletmesi 25 işletme arasında en yüksek performans derecesine sahip olmuşve diğer iki yılda da performans derecesine düşürmesine rağmen birincilik konumunu korumayıbaşarmıştır. …”
Get full text

Steady-state mixing state of black carbon aerosols from a particle-resolved model by Z. Zhang, Z. Zhang, J. Wang, J. Wang, J. Wang, J. Wang, N. Riemer, C. Liu, C. Liu, Y. Jin, Y. Jin, Z. Tian, Z. Tian, J. Cai, J. Cai, Y. Cheng, Y. Cheng, G. Chen, G. Chen, B. Wang, B. Wang, S. Wang, A. Ding, A. Ding

“…In the model simulation, the mean CT, equivalent to the <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M2" display="inline" overflow="scroll" dspmath="mathml"><mrow><mn mathvariant="normal">1</mn><mo>/</mo><mi>k</mi></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="20pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="bbb65cad56c0d284439060f0b57b1898"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="acp-25-1869-2025-ie00001.svg" width="20pt" height="14pt" src="acp-25-1869-2025-ie00001.png"/></svg:svg></span></span>, is 62 nm, which is consistent with the statistical results indicating a mean CT of 63 nm. …”
Get full text

Analyzing the Influence of Company's Business Strategy and Its Components as a Factor of Information Risk on Excess Stock Returns by Alireza Rahrovi Dastjerdi, Daryoosh Forooghi, Zahra Moradi

Get full text

Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials by Jingyun Yang, Weiqi Hong, Huashan Shi, Cai He, Hong Lei, Yanan Zhou, Hao Yang, Aqu Alu, Zimin Chen, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Jiong Li, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhaoming Su, Yuquan Wei, Qiangming Sun, Shuaiyao Lu, Zhenling Wang, Youchun Wang, Guangwen Lu, Weimin Li, Xiawei Wei

“…Tri-Vac also serves as a candidate booster for enhancing immunity after three doses of inactivated virus or mRNA vaccines. A phase 1 investigator-initiated trial was initiated to assess safety and immunogenicity in humans, focusing on the primary endpoint of adverse reactions within 7 days and key secondary endpoints including the geometric mean titers (GMTs) of serum neutralizing antibodies within 30 days and 6 months post-vaccination, as well as adverse events within 30 days and serious adverse events within 6 months post-vaccination. …”
Get full text