A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Methods RNA sequencing was performed to examine the mRNA expression of known deubiquitinating enzymes in CRC tissues from patients with alternate response to chemotherapy. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…Inhibition of the IL-6 receptor by tocilizumab in these cells led to a reduction in cellular senescence, accompanied by decreased of the cell cycle regulatory proteins P53 and P21 in mRNA and protein levels, while alleviating cell cycle arrest. …”
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Timber and carbon sequestration potential of Chinese forests under different forest management scenarios by Hui-Ling Tian, Jian-Hua Zhu, Xiang-Dong Lei, Xin-Yun Chen, Li-Xiong Zeng, Zun-Ji Jian, Fu-Hua Li, Wen-Fa Xiao

“…However, under the MPS, BCS in China's forests is projected to increase and be maintained at 322 TgC per year or above by 2060, with wood production reaching 4.71 × 108 m3 per year. China's forests are predicted to experience an increase in biomass carbon stock in the future and play a role as a carbon sink. …”
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Research Note: Reduction of Salmonella load in Brazilian commercial chicken farms using INSPEKTOR®: a bacteriophage-based product by Michael Pino, Karen Mujica, Paola Mora-Uribe, Héctor Garcias-Papayani, Braulio Paillavil, Camilo Avendaño, Diego Flores-Crisosto, Rodrigo Norambuena, Victoria Rojas-Martínez, Matías Aguilera, Nicolás Cifuentes Muñoz, Pablo Cifuentes, Hans Pieringer, Soledad Ulloa

“…Salmonella load was quantified (DNA copies/mL) by real-time PCR using the invA marker for Salmonella spp., together with serovars Minnesota and Heidelberg, which are relevant to the industry in Brazil. …”
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Estudio y medición experimental del coeficiente de arrastre del casco de un dron submarino por medio de un túnel de viento by Jesús Eduardo Rivera López, José Luis Arciniega Martínez, Guadalupe Juliana Gutiérrez Paredes, César Francisco Rodríguez Hibert, Cristian Ariel Martínez Cabrera, Carlos Alfonso Juárez Navarro

“…Utilizando el  se determinó las velocidades de la prueba en airede 8, 10, 12, 14 y 16 m/s, de las corridas experimentales se midió la fuerza de arrastre ; del ajuste de  se estimó que el error de sesgo es menor al 6 %, por lo que se puede decir que el error en las mediciones es aceptable y se puede realizar el escalamiento de los resultados. …”
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Comparison of Finasteride and Dutasteride on Risk of Prostate Cancer in Patients with Benign Prostatic Hyperplasia: A Pooled Analysis of 15 Real-world Databases by Dae Yul Yang, Won-Woo Seo, Rae Woong Park, Sang Youl Rhee, Jae Myung Cha, Yoon Soo Hah, Chang Won Jeong, Kyung-Jin Kim, Hyeon-Jong Yang, Do Kyung Kim, Ji Yong Ha

“…We excluded patients with a history of prostate cancer or a prostate-specific antigen level ≥ 4 ng/mL before the study drug prescription. Cox regression analysis was performed to examine the hazard ratio (HR) for prostate cancer after propensity score (PS) matching. …”

Assessment of various etiological factors for oral squamous cell carcinoma in non-habit patients- a cross sectional case control study by Mudiyayirakkani Muthusamy, Pratibha Ramani, Paramasivam Arumugam, Parthiban Rudrapathy, Boopathi Kangusamy, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman, Balachander Kannan, Anitha Pandi

“…Results Firstly, we found 3 novel pathogenic mutations c.16C > A/p.L6M (missense mutation), c.359 T > C/p.L120P (point mutation), c.382C > T/p.R128W (missense mutation) of HRAS gene in NHOSCC samples by genetic analysis. …”
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Immunosuppressive therapy and nutritional diseases of patients after kidney transplantation: a systematic review by Aleksandra Anna Kajdas, Marcin Kleibert, Anne Katrine Normann, Krzysztof Krasuski, Ditte Søndergaard Linde, Dorota Szostak-Węgierek

“…Finally, mammalian target of rapamycin (mTOR) inhibitors was associated with bone status and mycophenolate mofetil was linked to Vitamin B12 deficiencies. …”
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Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation by Kabita Pradhan, Balram Neupane, Paul Niehues, Martin Kirschner, Fabian Beier, Chao‐Chung Kuo, Erika Anneliese Hilbold, Christian Bär, Oana‐Maria Thoma, Maximilian Waldner, Margherita Vieri, Tim H. Brümmendorf, Vithurithra Tharmapalan, Wolfgang Wagner, Michael Kleines, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich

“…TL was quantified and correlated to low voltage areas. 3′ mRNA sequencing was performed for gene expression profiling. …”
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Physicochemical and functional optimization of probiotic yogurt with encapsulated Lacticaseibacillus paracasei E1 enriched with green tea using Box–Behnken design by Muhaimin Rifa'i, Mochammad Fitri Atho'illah, Siti Nur Arifah, Aditya Ragil Suharto, Aghnia Nuri Fadhilla, Nur Alfi Maghfirotus Sa'adah, Esha Ardiansyah, Rahmi Izati, Belinda Nabiila Al Faizah, Dawama Nur Fadlilah, Septhyanti Aprilia Kavitarna, Shinta Oktya Wardhani, Wisnu Barlianto, Hideo Tsuboi, Yoga Dwi Jatmiko

“…The titratable acidity and viability were 1.39 % and 9.55 log CFU/mL, respectively. A 4 % GT addition reduced the acceptance rate of GT yogurt (GTY) than plain yogurt (PY). …”
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Universal antibacterial and anti-inflammatory treatment using chitosan-prussian blue nanozyme by Jian Wang, Jiayi Wang, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia, Xueliang Liu, Yu Yang

“…Moreover, these nanozymes exhibited potent antioxidant and anti-inflammatory properties, promoting macrophage polarization toward the M2-like phenotype, reducing oxidative stress, and alleviating inflammation. …”
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Computing the time-dependent activity rate using non-declustered and declustered catalogues – a first step towards time-dependent seismic hazard calculations for operational earthq... by D. Montiel-López, S. Molina, S. Molina, J. J. Galiana-Merino, J. J. Galiana-Merino, I. Gómez, I. Gómez, A. Kharazian, J. L. Soler-Llorens, J. A. Huesca-Tortosa, A. Guardiola-Villora, G. Ortuño-Sáez

“…The first one is located in Central Italy, where the L'Aquila earthquake happened, while the other is in south-eastern Spain, where several earthquakes with a moment magnitude (<span class="inline-formula"><i>M</i>_w</span>) greater than 4.0 have taken place over the last 30 years, including two earthquakes with magnitude greater than or equal to 5.0. …”
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The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken by Yachao Wang, Yilei Liang, Yan Huang, Wei wang, Xiaoyan Long, Li Jiang, Tingting Cheng, Jinfeng Du, Xuegang Luo

“…Intestinal findings indicated that TTO treatment enhanced villus height, reduced crypt depth, and upregulated the expression of Claudin 1, Occludin, and ZO-1 mRNA in the jejunum (P < 0.05). After TTO treatment, H2S-induced oxidative stress injury and apoptosis protein expression in spleen were improved (P < 0.05). …”
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Programmable Macrophage Vesicle Based Bionic Self‐Adjuvanting Vaccine for Immunization against Monkeypox Virus by Weiqiang Lin, Chenguang Shen, Mengjun Li, Shengchao Ma, Chenxin Liu, Jialin Huang, Zuning Ren, Yuechao Yang, Minghai Zhao, Qiulin Xie, Shuang Guo, Wei Wang, Kaiyuan Wang, Qiang Ma, Yideng Jiang, Judun Zheng, Yuhui Liao

“…Based on MPV‐related antigen‐stimulated macrophage‐derived vesicles, the nanovaccine is constructed by loading the mature virion (MV)‐related intracellular protein (A29L/M1R) and simultaneously modifying with the enveloped virion (EV) antigen (B6R), enabling them to effectively promote antigen presentation and enhance adaptive immune through self‐adjuvant strategy. …”
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Hubungan Konsumsi Makanan Fungsional Sumber Antioksidan dengan Fungsi Kognitif dan Kadar 4-Hydroxynonenal (4-HNE) Plasma Lansia by Widia Rahmawati, Nur Indrawati Lipoeto, Yuliarni Syafrit Syafrita

“…</em><em>Functional foods sources of antioxidant consumption </em><em>were </em><em>obtained </em><em>by</em><em> Foos Frequency Questionnaires and cognitive function was measured by Moca-INA method,  where as the levels of 4-HNE plasma checked in Bio</em><em>m</em><em>edic laboratory  of Unversitas Andalas.   …”
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A qualitative study exploring the acceptability of the TEXTPAD telehealth and virtual supervised exercise intervention and trial for patients with peripheral arterial disease livin... by Maddey Patterson, MPH, Letitia Sermin-Reed, MSc, James Prentis, MBBS, Arathi Radhakrishnan, MBBS, Eileen Kaner, PhD, Sandip Nandhra, MBBS, Maisie Rowland, BSc, Gabriel Cucato, PhD, Mackenzie Fong, PhD

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Efectos de la co-inoculación de Bioformulados (PGPR´s) sobre el porcentaje de germinación y promover el crecimiento en plántula de papaya (Carica papaya L.) by Cristhian Macías Holguín, Hayron Fabricio Canchignia Martínez, Angel Virgilio Cedeño Moreira, Vicenta Dayana Delgado-Basurto, Fernando Patricio Paucar-Nieto, Ketty Vanessa Arellano Ibarra

“…En rizotrones se exhibieron mayor aumento de pelos absorbentes de 5,67 mm y área de raicillas 0,86 mm2 por BIOIMPULSE comparable al tratamiento expuesto con AIA (25 mg/mL). En plántulas son altamente efectivas para mejorar la morfología de las raíces y altura emendando 5 g/L fosforo se observó dimensiones Ø del hipocótilo entre (5,12 a 4,62 mm) y hojas funcionales (9,75 a 11,75). …”
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MLL4 regulates postnatal palate growth and midpalatal suture development by Jung-Mi Lee, Hunmin Jung, Bruno de Paula Machado Pasqua, Yungki Park, Qinghuang Tang, Shin Jeon, Shin Jeon, Soo-Kyung Lee, Jae W. Lee, Hyuk-Jae Edward Kwon

“…Whole-mount and histological staining at perinatal stages identified that the midline defects in the Mll4-cKO mice emerged as early as 1 day prior to birth, presenting as a widened midpalatal suture, accompanied by increased cell apoptosis in the suture mesenchyme. Genome-wide mRNA expression analysis of the midpalatal suture tissue revealed that MLL4 is essential for the timely expression of major cartilage development genes, such as Col2a1 and Acan, at birth. …”
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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

“…In vitro and in vivo studies demonstrated radiotracer stability in human serum (> 97% after 24 h evaluated by radio-HPLC), adequate affinity by the PDL1 protein (IC50 = 4.21 nM), and specific detection for PD-L1 assessed in 4T1, HCT116, and AR42J cancer cells, in which PD-L1 expression was verified by immunofluorescence and Western Blot assays. …”
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Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

“…Methods: The prevalence of Bbsl-specific antibodies in the English population was estimated in a cross-sectional cohort, selected from an archive of residual NHS blood donor plasma samples (age range 17 - 84, collected between 2021 - 2022). 10,000 samples were randomly selected proportionate to the population size of each of the nine English administrative regions. 9,994 samples were tested using a standard two-tiered testing strategy, with an IgG/IgM ELISA followed by an IgG immunoblot (array) test for any sera with positive or indeterminate reactivity in the ELISA. …”
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