Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review by Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis

“…Large amounts of osteoclast-related mRNA (cathepsin K, tartrate-resistant acid phosphatase, and matrix metalloproteinase9) in GCTs (<i>p</i> < 0.05) are associated with the grade of bone resorption. …”
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Agronomic and Nutritional Evaluation of INIA 910—Kumymarca Ryegrass (<i>Lolium multiflorum</i> Lam.): An Alternative for Sustainable Forage Production in Department of Amazonas (NW... by Héctor V. Vásquez, Leandro Valqui, Leidy G. Bobadilla, Enrique Meseth, Milton J. Trigoso, Luis H. Zagaceta, Lamberto Valqui-Valqui, David Saravia-Navarro, Elgar Barboza, Jorge L. Maicelo

“…The results showed that applying 180 kg/ha of nitrogen with a 45-day cutting interval provided the highest dry matter yield (460 kg/m²) and superior agronomic traits, including plant height (96.73 cm), number of tillers, and stem diameter. …”
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Socioeconomic indicators related to the global burden of breast cancer in women in 2020: an analysis of WHO data by Tingting XU, Ruoyu YANG, Jingjing LI, Yiying FANG

“…The mean values of the 10 selected indicators representing national socioeconomic development were as follows: 2 138.06 ± 7 465.03 million for total female population, 26.58 ± 17.12 μg/m3 for mean annual urban particulate matter concentration; 63.97 ± 57.32 per 10 000 population for density of physicians, 4.01 ± 4.11 per 10 000 population for density of pharmacists, 4.11 ± 4.32 US dollars for net official development assistance received by the medical research and basic health sector per capita, 63.65 ± 20.31 for average of 13 International Health Regulations Core Capacity Scores, 10. 41 ± 5.17% for the percentage of government health expenditure, 68.00 ± 28.65% for the percentage of the population using safely managed sanitation services, 66.05 ± 95.28 million US dollars in official development assistance (ODA) provided through government-coordinated expenditure plans specifically for water and sanitation, and 0.587 ± 0.190 for the inequality-adjusted Human Development Index (HDI). …”
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Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple‐Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1‐Regulated Cholesterol Metabolism by Yilan Yang, Jiatao Liao, Zhe Pan, Jin Meng, Li Zhang, Wei Shi, Xiaofang Wang, Xiaomeng Zhang, Zhirui Zhou, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Yi‐Zhou Jiang, Zhi‐Min Shao, Fei Xavier Chen, Xiaoli Yu, Xiaomao Guo

“…This effect is achieved through reduced activity of the transcription factor forkhead box M1 (FOXM1), which normally increases cholesterol production by inducing SREBF1 expression. …”
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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

“…TMT-MS experiments reveal a select group of off-targets, including PCNA clamp-associated factor PCLAF and ribonucleoside-diphosphate reductase subunit M2 (RRM2), that are similarly depleted by XL44 treatment. …”
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Deregulated methylation and expression of PCDHGB7 in patients with non-small cell lung cancer: a novel prognostic and immunological biomarker by Yue Yuan, Yue Yuan, Xin Nie, Jiayi Gao, Jiayi Gao, Yumeng Tian, Yumeng Tian, Liuer He, Liuer He, Xue Wang, Ping Zhang, Junling Ma, Lin Li, Lin Li

“…The methylation level of PCDHGB7 was upregulated in tumor tissue and negatively correlated with PCDHGB7 mRNA level. In immunotherapy cohort studies, patients with higher PCDHGB7 tissue expression showed worse prognosis. …”
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Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis by Min Hu, Xinyu Meng, Tong Wang, Yifan Wang, Xiaodong Chen, Dongliang Xu, Wei He, Hongjia Zhang, Wenzheng Guo, Bo Jing, Siwei Zhang, Jianhua Xu, Beibei Sun, Xueqian Sun, Tingting Liu, Na Ni, Tongtong Zhang, Wenwen Cui, Xiaoyu Wu, Liping Xia, Feng Yao, Fang Zhang, Jing Du, Jiong Deng

“…The lymphocytes from lymph nodes and tumor tissues exhibited greatly enhanced activities of Th1 cells and M1 macrophages. Conclusion Immunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.…”
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LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…Results Genetic editing of CD38 universal CAR-T cells, including CD38, T cell receptor alpha constant (TRAC), beta-2-microglobulin (B2M), and class II major histocompatibility complex transactivator (CIITA) knockdowns, was successfully achieved. …”
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Technological dental sealants: in vitro evaluation of material properties and antibiofilm potential by Witalo Pereira de Jesus, Luiza de Almeida Queiroz Ferreira, Washington Henrique Themoteo da Silva, Fernanda Vieira Belém, Ana Paula Turrioni, Cláudia Silami de Magalhães, Mila Fernandes Moreira Madeira, Ivana Márcia Alves Diniz, Marco Aurelio Benini Paschoal

“…For the MBS test, specimens were made in bovine enamel with the addition of the experimental group FluroShield® (Dentsply) + Single Bond Universal® adhesive (3 M)(G5) and measured in a universal testing machine. …”
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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…Lactylation, for example, activates genes such as Arg1, which is a hallmark of the M2 macrophage phenotype implicated in immunosuppression and tumor growth. …”
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Eco-friendly sustainable farming: Enhancing summer tomato (Lycopersicon esculentum mill.) yield with jute non-woven agro textile Mulch by Nilimesh Mridha, Dipak Nayak, Ashok Yadav, Tilak Mondal, Rakesh Kr Ghosh, Manik Bhowmick, Atul Singha, D.P. Ray, B.S. Manjunatha, Avijit Das, D.B. Shakyawar, Sourav Paul, Amit Das, Santanu Mukherjee, Ravinder Kumar

“…Jute non-woven mulch with 100 % jute (100:0) of 250, 450, and 650 g per square meter (GSM), the blend non-woven of pure jute with caddis (50:50) of 250, 450, and 650 GSM, plastic (50 μm) and rice straw mulch were evaluated on summer tomato crop at the ICAR-CISH regional station in Malda, West Bengal, India. …”
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Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm by Jingting Wei, Jingting Wei, Kunhong Xiao, Qingyuan Cai, Qingyuan Cai, Shenghua Lin, Xiangjie Lin, Yujie Wang, Yujie Wang, Jiawen Lin, Kunfeng Lai, Yunxi Ye, Yuhan Liu, Li Li

“…Infrared meibography was performed using the non-contact mode of the Keratograph 5M. MG images were analyzed using a deep learning-based a quantitative analysis algorithm to evaluate gland length, area, dropout ratio, and deformation. …”
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Mechanical response characteristics and damage mechanism of water-containing mudstone under low strain rate dynamic loading by Guichen LI, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO

“…Higher dynamic loading rates and strength tests show a high correlation between loading strain and plastic strain during disturbance, and the plastic strain is always greater than the elastic strain. ④ The percentage of shear damage in the whole loading process of mudstone increases with the increase of water content, in which the dynamic loading stage increases significantly from 6.94% in dry to 33.95% in saturated, and the macroscopic shear damage characteristics are gradually obvious. ⑤ Dissolution and subduction of water in saturated mudstone, fracture of cementation under higher-rate dynamic loading, and wide-scale displacement of particle cementation under higher-intensity dynamic loading are the fundamental causes of the deterioration of mudstone mechanical properties. ⑥ A mudstone damage model considering lateral stress and cyclic dynamic loading was constructed and verified using the stress-strain relationship between loading and unloading during the cyclic dynamic loading stage of specimens with different water contents, and the model parameter F0 has a more significant effect on the strength of mudstone specimens compared with the parameter m. The model is based on the model of mudstone damage, and the model has a more significant effect on the strength of mudstone specimens. …”
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Facilitating free travel in the Schengen area—A position paper by the European Association for Biometrics by Christoph Busch, Farzin Deravi, Dinusha Frings, Els Kindt, Ralph Lessmann, Alexander Nouak, Jean Salomon, Mateus Achcar, Fernando Alonso‐Fernandez, Daniel Bachenheimer, David Bethell, Josef Bigun, Matthew Brawley, Guido Brockmann, Enrique Cabello, Patrizio Campisi, Aleksandrs Cepilovs, Miles Clee, Mickey Cohen, Christian Croll, Andrzej Czyżewski, Bernadette Dorizzi, Martin Drahansky, Pawel Drozdowski, Catherine Fankhauser, Julian Fierrez, Marta Gomez‐Barrero, Georg Hasse, Richard Guest, Ekaterina Komleva, Sebastien Marcel, Gian Luca Marcialis, Laurent Mercier, Emilio Mordini, Stefance Mouille, Pavlina Navratilova, Javier Ortega‐Garcia, Dijana Petrovska, Norman Poh, Istvan Racz, Ramachandra Raghavendra, Christian Rathgeb, Christophe Remillet, Uwe Seidel, Luuk Spreeuwers, Brage Strand, Sirra Toivonen, Andreas Uhl

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Structural basis of FpGalNase and its combination with FpGalNAcDeAc for efficient A-to-O blood group conversion by Meiling Zhou, Kaishan Luo, Chao Su, Yan Sun, Zuyan Huang, Shuo Ma, Xun Gao, Jiwei Wang, Chen Zhang, Pengcheng Han, Guoqiu Wu

“…We optimized treatment conditions, achieving over 99% conversion in just five minutes using phosphate buffer saline and a 16 nM enzyme concentration. Additionally, we engineered two fusion proteins, FpGalNAcDeAc-FpGalNase and FpGalNase-FpGalNAcDeAc, which showed a 28-fold increase in catalytic efficiency compared to the enzyme mixture. …”
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Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…We here aim to comprehensively analyze the mRNA expression of FNDC1, FNDC3A, FNDC3B, FNDC4, FNDC5, and GPR116 in nonaffected and affected mucosal samples of patients with IBD or colorectal cancer (CRC). …”
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Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…For instance, in 2021, 22.3% of women were over 35 years old, 17.7% were born outside of France, 11.3% had a body mass index (BMI) of 30 kg/m2 or higher, and 39.9% were primiparous. Episiotomy and OASI (third- and fourth-degree tears) were identified from medical records. …”
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage by Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang

“…The present study was designed to determine whether FAM134B is expressed in SGNs of C57BL/6 mice and, if so, to explore the potential function of FAM134B in Cis-induced SGN damage in vitro.MethodsMiddle turns of neonatal murine cochleae were cultured and treated with 30 μM Cis in vitro. The distribution of FAM134B, morphological changes of SGNs, and the colocalization of ER segments with lysosomes were measured by immunofluorescence (IF). …”
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Ecologie alimentaire des bonobos en mosaïque forêt-savane : aliments de base et aliments de réserve by Victor Narat, Flora Pennec, Jean Christophe Bokika Ngawolo, Sabrina Krief

“…Le suivi phénologique mensuel de 204 individus de 26 espèces différentes (24 arbres et 2 lianes), associé à un recensement de végétation sur 45 parcelles (20x50m) réparties de manière aléatoire stratifiée sur le site d’étude a permis d’estimer les densités des espèces alimentaires ainsi que les variations temporelles de la disponibilité en fruits (catégorisés en fruits à pulpe molle, fibreuse, arille, et graines). …”
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Inhalation d'aérosols liquides ou solides chez les Primates Non Humains by Jérôme Montharu, Chrystophe Aubert, Georges Roseau, Laurent Vecellio, Antoine Guillon, Michèle de Monte

“…Nous présentons la procédure d'administration d'un aérosol liquide tracé au Technétium 99m à partir d’un aérosol-doseur muni d'une chambre d'inhalation reliée à un masque facial chez un PNH vigile, et les images obtenues à l'aide d'une gamma caméra. 2. …”
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