Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Patients are to receive nab-paclitaxel (100 mg/m2 weekly, with a 1-week rest after 3 consecutive weeks), ramucirumab (8 mg/kg every 2 weeks), and nivolumab (240 mg/body every 2 weeks). …”
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Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model by Meijiao Yu, Meijiao Yu, Yu Chen, Yu Chen, Sishi Dong, Sishi Dong, Zhongxin Chen, Zhongxin Chen, Xuelian Jiang, Xuelian Jiang, Yufei Wang, Yufei Wang, Linglin Zhang, Linglin Zhang

“…The minimum inhibitory concentration (MIC) against S. mutans was determined at 256 μg/mL. The growth of S. mutans and the biofilm formation were inhibited by SFN in a dose-dependent manner through suppressing the synthesis of extracellular polysaccharide (EPS) and acid production, as well as decreasing the acid tolerance. …”
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Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer by Pragya Gupta, Tamas Heffter, Muhammad Zubair, I-Chow Hsu, E. Clif Burdette, Chris J. Diederich

“…Results: For generic prostate tissue, 360 treatment schemes were simulated based on the number of transducers (1-4), applied power (8-20 W/cm2), heating time (5, 7.5, 10 min), and blood perfusion (0, 2.5, 5 kg/m3/s) using forward treatment modelling. …”
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Application of The Fackler and Full Preliminary Term Methods In Calculating n-Year Term Life Insurance Premium Reserves by Seftina Diyah Miasary, Jihan Ramadhani Ar-Raafi’ Ulna, Emy Siswanah

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Characterization and simulation of AlGaN barrier structure effects in normally-off recessed gate AlGaN/GaN MISHEMTs by An-Chen Liu, Hsin-Chu Chen, Po-Tsung Tu, Yan-Lin Chen, Yan-Chieh Chen, Po-Chun Yeh, Chih-I Wu, Shu-Tong Chang, Tsung-Sheng Kao, Hao-Chung Kuo

“…The device with a 5 nm AlGaN remaining thickness exhibited excellent performance, with an I _D,max current of 347 mA mm ^−1 , a V _TH of +2.6 V, and a breakdown voltage (BV) of 830 V, compared to the AlGaN barrier with remaining thicknesses of 3 nm and 2 nm, which only reached 120 V and 75 V, respectively. …”
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The Monocyte-to-Lymphocyte Ratio at Hospital Admission Is a Novel Predictor for Acute Traumatic Intraparenchymal Hemorrhage Expansion after Cerebral Contusion by Jiangtao Sheng, Tian Li, Dongzhou Zhuang, Shirong Cai, Jinhua Yang, Faxiu Ding, Xiaoxuan Chen, Fei Tian, Mindong Huang, Lianjie Li, Kangsheng Li, Weiqiang Chen

“…Semiautomated software assessed tICH expansion (defined as ≥33% or 5 mL absolute growth). MLR was acquired from routine blood tests upon admission. …”
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hMSC成骨分化相关lncRNA的筛选和初步鉴定 by 罗嘉全

“…钙结节染色显示hMSC成骨诱导分化2周后胞外开始出现少量钙结节,随着诱导时间延长钙结节数量逐渐增加,成骨诱导至第3周钙结节最多,定量测定钙质量浓度达(716 ± 49)mg/mL?RT-qPCR结果显示绝大部分lncRNA在hMSC成骨分化过程中表达均下调,其中2个与Smurf-1相关lncRNA (AK096529和uc003ups)与成骨诱导前相比,存在显著性下调?…”
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Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review by Yaoguang Guo, Sihan Hu, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng, Fang Zeng, Fang Zeng

“…Improvements were also noted in neurological deficit scores [MD = −0.59, 95%CI (−0.92, −0.27), p < 0.05] and modified Neurological Severity Scores (mNSS) [MD = -5.68, 95%CI (−7.41, −3.95), p < 0.05], highlighting functional recovery. …”
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High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism by Lei Yao, Xuefei Zhou, Xianqi Jiang, Hao Chen, Yuanliang Li, Xiao Xiong, Yan Tang, Haogang Zhang, Pengfei Qiao

“…Expression levels of Fxr, Shp and Fgf15 mRNA and protein were detected by quantitative reverse transcription polymerase chain reaction and western blot, respectively.ResultsOur data indicated that high fat diet (HFD) was linked with higher prevalence of GDM, and HFD was positively associated with poor prognosis in GDM patients. …”
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Rectal temperature and heat transfer dynamics in the eye, face, and breast of broiler chickens exposed to moderate heat stress by Moustafa Yehia, Amani Askri, Ahlem Achour, Jean-Michel Allard Prus, Véronique Ouellet, Nabeel Alnahhas

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Global vaccine research and application hotspots and trends: a systematic bibliometric analysis based on SCIE highly cited papers by Liming Liang, Xinyu Wang, Yue Zhu, Xu Xia, Runfeng Shi, Huilin Cao, Meixin He, Yuyu Wang, Caizhen You

“…The most highly cited paper was ‘Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine’ from the New England Journal of Medicine, which was cited 9435 times in total. …”
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Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study by Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov

“…<b>Results</b>: A total of 146 patients with metastatic colorectal cancer (mCRC) were included in this retrospective two-center study. …”
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Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial by Anxin Wang, Zhengfang Hu, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Yunzhen Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Zihui Zhang

“…Additional safety and efficacy parameters included the 24-hour ΔNIHSS (baseline NIHSS - NIHSS at 24-hour) score, final infarct volume at 72 hours postrandomisation, 90-day Modified Rankin Scale (mRS) score, early neurological deterioration, postoperative pulmonary complications, blood gas parameters, symptomatic intracranial haemorrhage and 90-day mortality.Ethics and dissemination Following a rigorous review process, Oxy-TARGET has received official approval from the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (KY2023-257-02). …”
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FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle by Pengfei Du, Xiangli Zhang, Yao Zhu, Ziyang Wang, Xuemeng Si, Huaiyong Zhang, Yanqun Huang, Wen Chen

“…Insulin regulates FKBP5 expression in pectoral muscles in a time-dependent manner, while pyruvate increases FKBP5 levels and fasting/energy restriction reduces FKBP5 mRNA expression in the pectoral muscles.…”
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Inhibición de Mycosphaerella fijiensis en banano orgánico (Musa AAA L.) con la aplicación de bacterias promotoras del crecimiento vegetal by Iris Esther Marcano, César Antonio Díaz-Alcántara, Ángel Radhamés Pimentel Pujols, Ángel Felipe Vicioso Alcalá, Pedro Antonio Núñez Ramos

“…Se identificó la especie M. fijiensis por PCR con iniciadores específicos. …”
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Effect of fructo-oligosaccharides on growth performance and meat quality in broilers by ZhiHui Yan, XiaoWu Tang, RunTao Wu, Can Yang, YunMiao Jiang, Xuan Wang, QingHai Tang, YongLing Hu, LeLi Wang, Zhi Jiang

“…There was an increasing trend for total antioxidant capacity (T-AOC) activity of thigh muscle in FOS group compared to CON group (P = 0.053). Relative mRNA expression of breast catalase (CAT), superoxide dismutase 1 (SOD1), thioredoxin reductase 1 (TXNRD) were up-regulated by FOS supplementation compared with CON group (P &lt; 0.05). …”
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Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection by Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang

“…Accordingly, the CXCL16 mRNA expression in the liver tissue of CHB‐replication mice was markedly higher than in acute HBV‐replicating and control mice. …”
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L’apport de la géomatique à la connaissance de la partie terminale de l’aqueduc du Gier à Lyon by Éric Leroy

“…Over the entire route, it was calculated to be about 0.11%, or 1.1 m per km, but many “irregularities” –counter-slopes and accelerations– were observed locally. …”
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Quantifying diversity and growth form distribution of scleractinian corals, in Mangrove Bay, El Qoseir, Egypt by Theres Koch, Angelina Ivkić, Lewis Jones, Victor Scharnhorst, Constanze Stix, Antonia Auer, Theda Schöchtner, Gözde Özer, Simon Steinwender, Joseph Wallace Daurella, Martin Zuschin

“…As a result of our 2023 field survey, we identified a total of 68 species across 29 genera and 14 families, spanning six reef habitats — three per study site — at two study locations (sheltered and current-exposed), with depths ranging from 0 to 9.5 m. We found that both scleractinian coral diversity and coral growth forms varied amongst the six habitats. …”
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Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study by Lauren D'Mello-Guyett, Ruwan Ratnayake, Andrew S Azman, Yap Boum, Francesco Checchi, W John Edmunds, Placide Okitayemba Welo, Nicolas Peyraud, Iza Ciglenecki, Etienne Gignoux, Maria Lightowler, Primitive Gakima, Jean Patrick Ouamba, Joseph Amadomon Sagara, Rollin Ndombe, Nana Mimbu, Alexandra Ascorra, Elisabeth Mukamba Musenga, Berthe Miwanda, Francisco Luquero, Klaudia Porten, Flavio Finger, Miriam Alia, Bachir Assao, Catherine Bachy, Rob D'hondt, Karl Njuwa Fai, Caroline Henry-Ostian, Abdoul-Moumouni Issa-Soumana, Danish Malik, Herbert Mutubuki, Rodrigue Ntone, Isabella Panunzi, Issaka Soumana, Oumar Touré, Mamady Traore

“…CATI aims to deliver synergistic interventions (eg, water, sanitation, and hygiene interventions, vaccination, and antibiotic chemoprophylaxis) to households in a 100—250 m ‘ring’ around primary outbreak cases.Methods and analysis We report on a protocol for a prospective observational study of the effectiveness of CATI. …”
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