Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity by Yang Wang, Jianguo Xu, Wanchun You, Haitao Shen, Xiang Li, Zhengquan Yu, Haiying Li, Gang Chen

“…In experiment one, we found that the protein level of Rufy3 decreased and neuronal axon injury in the injured neurons but was rectified by LV-Rufy3 treatment. In experiment two, mRNA and protein levels of Rufy3 were downregulated in brain tissue and reached the lowest level at 24 h after SAH. …”
Get full text

Haploinsufficiency of PDE2A causes in mice increased exploratory behavior associated with upregulation of neural nitric oxide synthase in the striatum by Ana Gabriela de Oliveira do Rêgo, Francesca D'Amico, Vincenza D’Angelo, Silvia Cardarelli, Debora Cutuli, Davide Decandia, Eugenia Landolfo, Laura Petrosini, Manuela Pellegrini, Marcello D’Amelio, Nicola Biagio Mercuri, Mauro Giorgi, Giuseppe Sancesario

“…HET mice exhibited greater tendency to explore novel environments in comparison to WT mice, but spatial working memory, anxiety, and sociability were similar in adult HET and WT mice.In HET mice, PDE2A mRNA, PDE2A protein expression, and cGMP hydrolyzing enzymatic activity were consistently reduced by about 50 %. …”
Get full text

Antimicrobial Resistance and Biofilm-Forming Ability in ESBL-Producing and Non-ESBL-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Isolated from Canine Urinary... by Alessia Facchin, Joel Filipe, Irene Mauri, Filippo Tagliasacchi, Guido Grilli, Tiziana Vitiello, Gabriele Ratti, Laura Musa, Martina Penati, Paola Scarpa, Stefania Lauzi

“…Four (11.8%) were ESBL-producing bacteria, all supported by <i>bla</i>_CTX-M gene belonging to group 1. The <i>K. pneumoniae</i> isolates were significantly associated with ESBL production (<i>p</i> < 0.05). …”
Get full text

Health and tuberculosis systems resilience, the role of the private sector and pandemic preparedness: insights from a cross-country qualitative study with policy-makers in India, I... by Madhukar Pai, Poshan Thapa, Charity Oga-Omenka, Angelina Sassi, Vijayashree Yellappa, Petra Heitkamp, Bony Wiem Lestari, Surbhi Sheokand, Nathaly Aguilera Vasquez, Laura Jane Brubacher, Bolanle Olusola-Faleye, Joel Shyam Klinton

“…Data were analysed thematically using a hybrid inductive-deductive approach, informed by Haldane et al’s Determinants of Health Systems Resilience Framework.Results Policy-makers highlighted the crucial role of intersectoral collaboration, effective governance, innovative financing strategies, health workforce reallocation and technological advancements such as virtual consultations and mHealth in strengthening TB service delivery amid the COVID-19 pandemic. …”
Get full text

Characterization of patients with clonal mast cells in the bone marrow with clinical significance not otherwise specifiedResearch in context by Thomas Ballul, Vito Sabato, Peter Valent, Olivier Hermine, Olivier Lortholary, Julien Rossignol, Thomas Ballul, Vito Sabato, Cristina Bulai Livideanu, Antoine Neuraz, Julie Agopian, Fabienne Brenet, Patrice Dubreuil, Didier G. Ebo, Michiel Beyens, Richard Lemal, Olivier Tournilhac, Louis Terriou, David Launay, Laurence Bouillet, Catharina Chatain, Clément Gourguechon, Gandhi Damaj, Stéphane Durupt, Celine Greco, Laurent Frenzel, Christine Bodemer-Skandalis, Laura Polivka, Marine Madrange, Cécile Meni, Hassiba Bouktit, Anne Florence Bellais, Jean-Marc Durand, Marie Gousseff, Edwige Le Mouel, Mohamed Hamidou, Antoine Neel, Dana Ranta, Mathilde Niault, Aurélie Schiffmann, Stéphane Barete, Michel Arock, Danielle Canioni, Thierry Jo Molina, Julie Bruneau, Mélanie Vaes, Violaine Havelange, Hassan Faour, Nicolas Garcelon, Rose-Marie Javier, Fabien Pelletier, Florence Castelain, Denis Vincent, Frédérique Retornaz, Quentin Cabrera, Patricia Zunic, Philippe Guilpain, Marie Pierre Gourin, Ewa Wierzbicka–Hainaut, Jean François Viallard, Christian Lavigne, Cyrille Hoarau, Ludovic Lhermitte, Maël Heiblig, Roland Jaussaud, Peter Valent, Olivier Hermine, Olivier Lortholary, Julien Rossignol

“…The median baseline serum tryptase level was lower in MMCS compared with ISM or BMM (13 vs 26 vs 23 ng/mL, respectively; p < 0.001). Hereditary alpha-tryptasemia was similarly represented in MMCS and BMM (14.3% vs 19.7% respectively, p = ns). …”
Get full text

Intramural pregnancy after intrauterine insemination in a nulligravid patient without previous uterine trauma, complicated by idiopathic thrombocytopenic purpura: A case report by Koyo Yamamoto, Tsuyoshi Takiuchi, Kengo Kiso, Saki Ishii, Satoshi Nakagawa, Yasuto Kinose, Michiko Kodama, Yutaka Ueda, Kenjiro Sawada, Takahiro Tsuboyama, Tadashi Kimura

“…The blood loss was 320 mL. The patient's postoperative recovery was uneventful, and histopathological examination confirmed the diagnosis of IMP. …”
Get full text

单中心1 041例膀胱癌根治尿流改道患者手术疗效和并发症 by 刘振华, 李向东, 刘泽赋, 秦自科, 尧凯, 韩辉, 周芳坚, 刘卓炜

“…本研究采用独立样本<italic>t</italic>检验、卡方检验、线性回归、K-M生存曲线等统计方法描述患者并发症及预后情况，Logistic回归分析RC术后并发症的影响因素。…”
Get full text

MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…Results: In our study, MPMs were successfully extracted and infected with C. albicans at optimum conditions of 1.5 × 107 CFU/mL for 36 h. Through miRNA gene chips analysis, 40 differential genes were screened. mmu-miR-146b-5p could directly and negatively regulate the expression and translocation of HMGB1, inhibit the expression of inflammatory mediators, and might participate in the NF-κB signaling pathway in a HMGB1-dependent manner under C. albicans infection. …”
Get full text

Epigenetic modifications and emerging therapeutic targets in cardiovascular aging and diseases by Yurou Qiu, Qing Xu, Peichen Xie, Chenshuang He, Qiuchan Li, Xin Yao, Yang Mao, Xiaoqian Wu, Tiejun Zhang

“…The emerging role of RNA methylation, particularly N6-methyladenosine (m6A), in cardiovascular pathogenesis is also discussed. …”
Get full text

LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis by Ma C, Chen Q, Wei YF, Chen SW, Liu H, Xin F, Ren YX

“…Cell viability, proliferation, and apoptosis rates, along with the mRNA and protein levels of apoptosis-related markers (cleaved Caspase 3, cleaved Caspase 9, Bcl-2, Bax), ECM metabolism markers (MMP-3, MMP-13, aggrecan, collagen II), and inflammation-related markers (IL-1β, IL-6, TNF-α) were evaluated using Cell Counting Kit-8, Toluidine Blue staining, Alcian Blue staining, flow cytometry, qRT-PCR, immunofluorescence, and Western Blot. …”
Get full text

Associations between Prospective Memory, Executive Function and Physical Activity in Schoolchildren by Anouk Irina Glättli, Markus Gerber, Sebastian Ludyga

“…Medicine & Science in Sports & Exercise, 48(6), 1197–1222. https://doi.org/10.1249/MSS.0000000000000901 Loprinzi, P. D., Edwards, M. K., & Frith, E. (2018). Exercise and prospective memory. …”
Get full text

A suitability modeling based on geographic information system for potential micro hydropower dam site by O. Setiawan, H.Y.S.H. Nugroho, N. Wahyuningrum, D. Auliyani, K.S. Hardjo

“…A total of 635 potential dam locations were identified with high and very high suitability indexes, located on first or second stream orders, within a 4,000 m radius of roads and settlements, outside conservation forest areas, and with a potential hydraulic head greater than 20 meter.CONCLUSION: Integrating a dam suitability index map and restriction factors into a geographic information system framework, enabled a robust analysis for identifying potential sites of micro-hydropower dams. …”
Get full text

Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains by Xia-Li Lyu, Ting-Ting Lin, Jing-Tao Gao, Hong-Yan Jia, Chuan-Zhi Zhu, Zi-Hui Li, Jing Dong, Qi Sun, Wei Shu, Sai-Sai Wang, Li-Ping Pan, Hai-Rong Huang, Zong-De Zhang, Qi Li

“…Bedaquiline (Bdq) exerts bactericidal effects against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, including multidrug-resistant M. tuberculosis strains (MDR-MTBs). However, few reported investigations exist regarding Bdq effects on MDR-MTBs-infected macrophages activities and cytokine secretion. …”
Get full text

Treatment outcomes and associated factors among patients with multidrug-resistant tuberculosis in Ashanti Region, Ghana: a retrospective, cross-sectional study by Peter Agyei-Baffour, Victoria Panford, Emmanuel Kumah, Collins Kokuro, Prince Owusu Adoma, Michael Afari Baidoo, Adam Fusheini, Samuel Egyakwa Ankomah, Samuel Kofi Agyei

“…Patients who were female (adjusted OR (AOR)=1.27, 95% CI: 1.18 to 1.39, p=0.023), younger (AOR=0.53, 95% CI: 0.19 to 2.11, p=0.012), had a higher level of education (AOR=1.12, 95% CI: 0.65 to 1.90, p=0.034), had a baseline body mass index of 18.5 kg/m2 or above (AOR=1.57, 95% CI: 1.23 to 2.47, p=0.011) and those who did not have a history of TB (AOR=0.47, 95% CI: 0.10 to 0.75, p=0.028) were more likely to have successful MDR-TB treatment outcomes.Conclusions Favourable treatment outcomes for patients with MDR-TB can be achieved in a resource-limited country. …”
Get full text

New evidence on the nephrotoxicity of fine particulate matter: Potential toxic components from different emission sources by Fu-Jen Cheng, Chien-Er Huang, Pei-Shih Chen, Yu-Lun Tseng, Chung-Shin Yuan, Ching-Shu Lai

“…Exposure to PM2.5 water extract increased the mRNA levels of tumor necrosis factor-α, interleukin-6, and nitrite production in RAW264.7 macrophages. …”
Get full text

Phenotypic and genotypic characterization of clinical carbapenem-resistant Acinetobacter species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China by Qingye Xu, Xinli Mu, Jintao He, Haiyang Liu, Xiaochen Liu, Yanfei Wang, Xiaoting Hua, Yunsong Yu

“…A207 and A1014 were susceptible to cefiderocol, and only blaIMP-8-carrying A1014 had low MIC value (4/2 µg/mL) toward cefoperazone/sulbactam. In conclusion, we characterized the phenotypic and genotypic features of one IMP-8-producing and four NDM-1-producing plasmids recovered from Acinetobacter spp. strains isolated in 2010, contributing to the understanding of the dissemination and evolution of these enzymes.IMPORTANCEGiven the low prevalence of IMP among A. baumannii and the limited sequencing technology in earlier years, research on blaIMP in A. baumannii is scarce, and genetic information on blaNDM-1-producing Acinetobacter spp. strains isolated in earlier years is limited. …”
Get full text

Partial Stereotactic Ablative Radiotherapy Boost Before Conventional Radiotherapy (P‐SABR) for Large (> 5 cm) Unresectable Stage III Nonsmall Cell Lung Cancer by Yun Bai, Xianshu Gao, Shangbin Qin, Shanshi Li, Mingwei Ma, Xi Cao, Feng Lyu, Jiayan Chen, Xin Qi, Siwei Liu, Yan Gao, Hongzhen Li, Xiaomei Li, Xiaoying Li, Xueying Ren, Lei Huang

“…Methods From April 2014 to January 2024, 44 patients with > 5 cm unresectable T3‐4N0‐3M0 stage III NSCLC were analyzed. The median diameter was 9 cm (5.2–22.7 cm). …”
Get full text

Estilos de encuadre en el discurso político español progresista: la oratoria de Pedro Sánchez y Yolanda Díaz by Beatriz Gallardo Paúls

“…Con este planteamiento general como punto de partida se seleccionaron datos pertenecientes a los dos líderes, y procedentes de tres ámbitos de uso: discurso parlamentario emitido en el Congreso de los diputados (corpus P), mítines preelectorales (corpus M) y mensajes publicados en los perfiles de la red social Twitter (corpus T). …”
Get full text

Multi-channel AlN/GaN Schottky barrier diodes by Hanchao Li, Yue Wang, Qingyun Xie, Hanlin Xie, Hui Teng Tan, Pradip Dalapati, Siyu Liu, Kumud Ranjan, Siewchuen Foo, Subramaniam Arulkumaran, Chee Lip Gan, Geok Ing Ng

“…The SBDs exhibit a low on voltage of 0.5 V, a small forward voltage of 1.1 V, and high current of 1050 mA mm ^−1 . Temperature-dependent I–V characteristics of the proposed device revealed that both thermionic emission and tunneling contributed to the current transport. …”
Get full text

Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction by Aric A. Prather, PhD, Ying Gao, MS, Legna Betancourt, BS, Rose C. Kordahl, BS, Anya Sriram, BS, Chiung-Yu Huang, PhD, Steven R. Hays, MD, Jasleen Kukreja, MD, Daniel R. Calabrese, MD, Aida Venado, MD, Bhavya Kapse, PhD, John R. Greenland, MD, PhD, Jonathan P. Singer, MD, MS

Get full text