Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma by Yunping Lu, Yajun Shen, Lingyu Li, Min Zhang, Min Wang, Lihua Ge, Jing Yang, Xiaofei Tang

“…By the analysis of Bioinformation Databases, there was a significant interaction of FOXO4 down expression to clinical tumor stages and pathological grades in the patients with HNSCC. Reduced mRNA and protein expression of FOXO4 were found to be significantly correlated with the poor overall survival (OS) of HNSCC patients. …”
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Effects of olive leaf extract on exercise performance and muscle mitochondrial response in young healthy adults by Clément Lanfranchi, Nadège Zanou, Jérôme Feige, Umberto DeMarchi, Aurélie Hermant, Ornella Cominetti, Eugenia Migliavacca, Alba Moreno-Asso, Astrid Hostrman, Sara Mistro, Nicolas Place

“…Nature Communications, 12(1), 7219. https://doi.org/10.1038/s41467-021-27422-1 Gherardi, C., Rossi, L., Bianchi, M., & Ferri, P. (2024). Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance. …”
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TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders by Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

“…After immunization with Spike/CpG-motifs, mRNA vaccination or SARS-CoV-2 infection, CORSET8 T cells strongly proliferated and showed signs of T cell activation. …”
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48例原因不明矮身材儿童临床特征和致病基因分析 by 侯乐乐, 林少汾, 李晓娟, 刘祖霖, 欧辉, 张丽娜, 孟哲, 梁立阳

“…结果纳入患儿48例（男性30例，女性18例），年龄（7.73±3.97）岁，身高标准差分值为-3.63±1.67；临床表现：特殊面容33例（68.8%），体型或骨骼系统异常31例（64.6%），围产期异常26例（54.2%，其中61.5%为小于胎龄儿），内分泌系统异常24例（50.0%，其中87.5%生长激素（GH）峰值低于正常），矮身材家族史21例（43.8%）；实验室检查：GH激发试验峰值（9.72±7.25）ng/mL，IGF-1 标准差分值为-0.82±1.42，骨龄与年龄差值（-0.93±1.39）岁；WES共发现相关基因变异者25例，其中14例（56.0%）为致病变异，6例（24.0%）为可能致病变异，5例（20.0%）为意义未明变异；评价为致病及可能致病变异的基因共14个，其中影响细胞内信号通路10个（<italic>PTPN11、RAF1、RIT1、ARID1B、ANKRD11、CSNK2A1、SRCAP、CUL7、SMAD4</italic>和<italic>FAM111A</italic>），影响细胞外基质（ECM）4个（<italic>ACAN、FBN1、COL10A1</italic>和<italic>COMP</italic>）。…”
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State-of-the-art of loading and unloading tests for glaucoma: potentialities and informative value by O.S. Myakonkaya, A.S. Sarkisyan, A.V. Seleznev, A.V. Kuroyedov, I.R. Gazizova

“…Unloading tests include glyceryl ascorbate test, test with acetazolamide, and instillations of IOP-lowering medications (e.g., M-cholinomimetic or prostaglandin analog). Visual changes accompanying loading and unloading tests are recorded by visual acuity measurement, IOP measurement (tono metry and tonography, visual field testing (campimetry, angioscotometry), adaptometry, retinal tomography, and electrophysiology (visually evoked potentials). …”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Sienna Goren,1,* Nermeen Kidwai,1,* Wilbert S Aronow,2 Gregg M Lanier2 1New York Medical College, Valhalla, NY, USA; 2Departments of Medicine and Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USA*These authors contributed equally to this workCorrespondence: Wilbert S Aronow, Department of Cardiology, Westchester Medical Center, and Professor of Medicine, New York Medical College, Macy Pavilion, Room 141, Valhalla, NY, 10595, USA, Tel +1 914 493 5311, Fax +1 914 235 6274, Email Wilbert.Aronow@wmchealth.orgAbstract: Pulmonary arterial hypertension (PAH) is a rare and potentially fatal condition characterized by progressive increases in blood pressure in the arteries of the lungs. …”
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Mechanistic insights into HPV-positivity in non-smokers and HPV-negativity in smokers with head and neck cancer by Markus Hoffmann, Markus Hoffmann, Susanne Hille, Susanne Hille, Susanne Hille, Asita Fazel, Martin Laudien, Martin Laudien, Susanne Wiegand, Susanne Wiegand, Martin Müller, Oliver J. Müller, Oliver J. Müller, Oliver J. Müller, Elgar Susanne Quabius, Elgar Susanne Quabius

“…Protein isolation, SLPI- and AnxA2-quantification, LDH cytotoxicity assessment, HPV16-PsV-uptake measurement, mRNA-isolation, cDNA-synthesis and RT-qPCR were performed.ResultsIn vitro transfection experiments with HPV16 pseudovirions (PsVs) showed that PsVs entered cells significantly better when SLPI was downregulated and significantly less when AnxA2 was downregulated. …”
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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…Real-time polymerase chain reaction (PCR), Western blot (WB), and immunofluorescence were used to find the expressions of related mRNAs and proteins in the lung tissue or A549 cells. …”
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Peculiar Dust Emission within the Orion Molecular Cloud by Parisa Nozari, Sarah Sadavoy, Edwige Chapillon, Brian Mason, Rachel Friesen, Ian Lowe, Thomas Stanke, James Di Francesco, Thomas Henning, Qizhou Zhang, Amelia Stutz

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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…The biomimetic ECM NGCs comprising a 3D interconnected porous network in a 10-mm sciatic nerve defect rat model sustain IGF-1 delivery, promoting early infiltration of macrophages and polarisation towards M2-type macrophages. Furthermore, observations at 12 weeks post-implantation revealed improvements in electrophysiological performance, alleviation of gastrocnemius muscle atrophy, increased peripheral nerve regeneration, and motor function restoration. …”
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Integrated hepatic transcriptomics and metabolomics identify Pck1 as a key factor in the broad dysregulation induced by vehicle pollutants by Gajalakshmi Ramanathan, Yuqi Zhao, Rajat Gupta, Siri Langmo, May Bhetraratana, Fen Yin, Will Driscoll, Jerry Ricks, Allen Louie, James A. Stewart, Timothy R. Gould, Timothy V. Larson, Joel Kaufman, Michael E. Rosenfeld, Xia Yang, Jesus A. Araujo

“…As an example, while gene network analysis of DE livers identified phosphoenolpyruvate carboxykinase 1 (Pck1) as a key driver gene of DE response, DEP treatment of HepG2 cells resulted in increased mRNA expression of Pck1 and glucose production, the latter replicated in mouse primary hepatocytes. …”
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Lattice Stabilized and Emission Tunable Pure‐Bromide Quasi‐2D Perovskite for Air‐Processed Blue Light‐Emitting Diodes by Yangyang Guo, Penghui Yang, Fan Dong, Huixin Li, Jialiang Gao, Zeyi Cheng, Jiandong Wu, Yadong Xu, Hongyue Wang, Hongqiang Wang

“…The champion deep blue PeLED shows maximum external quantum efficiency (EQE) of 2.05% and luminance of 246.56 cd m−2, which are comparable to the state‐of‐the‐art of similar devices fabricated in glovebox. …”
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Coordination Chemistry of Mixed-Donor Pyridine-Containing Macrocyclic Ligands: From Optical to Redox Chemosensors for Heavy Metal Ions by Alessandra Garau, Alexander J. Blake, Maria Carla Aragoni, Massimiliano Arca, Claudia Caltagirone, Francesco Demartin, Vito Lippolis, Giacomo Picci, Enrico Podda

“…The maximum anodic shift of the ferrocene oxidation wave is observed in the presence of Pb²⁺ (230 mV), to which corresponds a reaction coupling efficiency (RCE) value as large as 7.9 × 10³. …”
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New Dihydro OO'Bis(Salicylidene) 2,2' Aminobenzothiazolyl Borate Complexes: Kinetic and Voltammetric Studies of Dimethyltin Copper Complex with Guanine, Adenine, and Calf Thymus DN...

“…The kinetic data were obtained from the rate constants, <mml:math alttext="$k_{ m {obs}}$"> <mml:msub> <mml:mi>k</mml:mi> <mml:mrow> <mml:mtext>obs</mml:mtext> </mml:mrow> </mml:msub> </mml:math>, values under pseudo-first-order conditions. …”
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Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat by Tamara Zenz, Robert Jenke, Denys Oliinyk, Sandra Noske, René Thieme, Tim Kahl, Ines Gockel, Florian Meier-Rosar, Achim Aigner, Thomas RH Büch

“…Methods: We investigated entinostat effects on EGFR and amphiregulin (AREG) expression in various cell line- and primary patient tumor-based in vitro, ex vivo and in vivo models, on the mRNA and protein level. Based on these results, a combined entinostat plus EGFR inhibitor erlotinib treatment in vitro and in vivo was studied. …”
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Teacher performance analysis using analytic network process method by Zuraidah, Nurul Hudha Purnomo

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Effects of brown alga, Stoechospermum marginatum extract on growth performance, body chemical compositions and some serum biochemical parameters in grey mullet, Mugil cephalus (Lin... by Nazanin Kiani, Paria Akbary

“…Also, in order to determine the biochemical parameters, blood was taken from the heart using a syringe, and poured into a 2 mL- micro tube. Then, it was centrifuged at 3000 rpm for 10 min and serum was separated and stored at -70°C. …”
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Efficacy of Intramuscular versus Intravenous Dexmedetomidine on Attenuation of Haemodynamic Responses to Laryngoscopy and Endotracheal Intubation: A Randomised Clinical Trial by Anupama Kumari, Paras Anand, Jigisha Mehta, Sara Mary Thomas

“…Dexmedetomidine 1 μg/kg intravenously as infusion in 100 mL Normal Saline (NS) over 10 minutes 45 minutes prior to induction. …”
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Effects of exogenous selenium application on quality characteristics, selenium speciation, and in vitro bioaccessibility of rice pancakes by Feiran An, Kun Zhuang, Lingling Shangguan, Lan Yao, Jun Dai

“…When sodium selenite was added at 3.3 μg/mL, the maximum values of SeCys2 and MeSeCys were 328.35 ± 33.43 and 311.11 ± 49.48 μg/kg, respectively. …”
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Relationship between muscle power, muscle volume and limb length in healthy male and female adolescents by Souhail Bchini, Nadhir Hammami, Dhouha Moussaoui, Taoufik Selmi, Najla Mhimdi, Anissa Bouassida, Abderraouf Ben Abderrahman, Ismail Laher, Juan Del Coso, Hassane Zouhal, Hassane Zouhal

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