Assessing gut barrier integrity and reproductive performance following pre-mating oral administration of solid-lipid-nanoparticles designed for drug delivery by Valentina Lacconi, Valentina Lacconi, Micol Massimiani, Micol Massimiani, Giulia Antonello, Paolo Gasco, Roberta Bernardini, Cristiana Ferrari, Lorenzo Ippoliti, Gina La Sala, Antonio Pietroiusti, Ivana Fenoglio, Chiara Riganti, Luisa Campagnolo

“…Although recently several studies have shown the possibility to administer SLNs during pregnancy to vehicle mRNA to the placenta, data about the effect of premating exposure to SLNs on pregnancy outcome are scant. …”
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Dexmedetomidine versus Dexamethasone as an Adjuvant to Ropivacaine in Transversus Abdominis Plane Block in Infraumbilical Surgeries for Postoperative Analgesia: A Randomised Clinic... by Anupama Kumari, Aarjvi Patel, Payal Berawala, Sara Mary Thomas

“…The total volume was made up to 50 mL with normal saline. Postoperative pain was assessed using VAS scores. …”
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Study on optimization of extraction and purification processes for total flavonoids from Lycopi herba roots and their anti-proliferative effects on fibrous synoviocytes in human rh... by Jie Chen, Chunyang Jiang, Zhenyu Liu, Panpan Wang, Qiang Ma, Nong Zhou

“…By utilizing ultrasound-assisted extraction combined with response surface methodology (RSM), we optimized the extraction conditions, achieving a total flavonoid content of 90.484 ± 0.974 mg/g under the optimal settings: a liquid–solid ratio of 48:1 mL/g, 13 min of ultrasound treatment, 70 % ethanol, and an extraction temperature of 43°C. …”
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Loss of histone H3K27me3 up-regulates SLC7A11 in diffuse gastric cancer cells by REN Yuanfeng, LIU Wenkang, CHU Zhaole

“…Among them， 56 genes displayed the most significant up-regulation （fold change in signal intensity ≥2， P<0.05）， with notable enrichment in the mammalian target of rapamycin complex 1 （mTORC1） signaling pathway. Specifically， the methionine transporter SLC7A5 and the cystine transporter SLC7A11 were found to have the highest expression levels in gastric cancer tissues. …”
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Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses by Hongyu Yu, Shaoyuan Cui, Yan Mei, Qinggang Li, Lingling Wu, Shuwei Duan, Guangyan Cai, Hanyu Zhu, Bo Fu, Li Zhang, Zhe Feng, Xiangmei Chen

“…Polarization of naïve CD4+ T cells (Th0 cells) towards the Th1 phenotype was induced by coculture with activated mesangial cells, and the resulting Th1 cells showed increased mRNA and protein expression of inflammation-associated genes. …”
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Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis by Huanxia Xie, Jiang Ji, Zhichen Liu, Ning Lu, Yuqian Wei, Aina Zhou, Jisheng Liu, Qingqing Jiao, Qingqing Jiao

“…Gαi1/3 were required for IL-5-induced Akt-mTOR and Erk activation in MEFs. In EoL-1 cells, Gαi1/3 was associated with IL-5-activated IL-5Rα, promoting IL-5Rα endocytosis and transducing downstream signaling. …”
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Effect of Aerobic Treadmill Exercise Regulating Glucose Transporter 9 on Renal Function in Hyperuricemia Rats by LIANG Jiarong, YANG Huan, CUN Yongdan, WANG Lihuan, LI Yijie, YE Bin

“…The Exercise group was given intragastric administration as same as the Model group, and was given aerobic treadmill training simultaneously, the speed was 12 m/min, 20 minutes a time, once a day, continuous training for six days and rest for one day, continuous training for three weeks. …”
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Production and metabolic responses of Montbéliarde and Holstein cows during the periparturient period and a sequential feed-restriction challenge by J.A.A. Pires, A. De La Torre, L. Barreto-Mendes, I. Cassar-Malek, I. Ortigues-Marty, F. Blanc

“…During early lactation, energy balance was lower (5 vs. 16 MJ/d) and plasma NEFA (270 vs. 163 µM) were greater for HOLS than MONT, respectively. …”
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Evaluación del potencial genético de germoplasma exótico de soja para incrementar el contenido de aceite en el grano by S. B. Bologna, D. O. Soldini, J. J. Carreras

“…Se utilizó un diseño experimental de bloques completos al azar con 3 repeticiones y parcelas de 12 plantas a 0,50 x 0,50 m. Se evaluó: número de días a floración (NDF) y a madurez (NDM), período reproductivo (PR), productividad de granos (PG), peso de 100 semillas (PS) y porcentaje de aceite (OL). …”
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Evaluation of CellerateRX Surgical Powder utility in reducing groin complications after femoral exposure by Vy C. Dang, BS, Eric K. Peden, MD, Trisha Roy, MD, PhD, Alan B. Lumsden, MD, Linda Le, MD, Charudatta S. Bavare, MD, Sohaib K. Mhaidi, MD, Maham Rahimi, MD, PhD

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A Digital Tool (Technology-Assisted Problem Management Plus) for Lay Health Workers to Address Common Mental Health Disorders: Co-production and Usability Study in Pakistan by Maham Saleem, Shamsa Zafar, Thomas Klein, Markus Koesters, Adnan Bashir, Daniela C Fuhr, Siham Sikander, Hajo Zeeb

“…In round 1 conducted in laboratory settings, 6 LHWs participated in role plays and completed the 15-item mHealth Usability App Questionnaire (MUAQ) (score range 0-7). …”
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A novel arterial coupler with non-return snap-fit connection approach optimized arterial end-to-end anastomotic technique: An experimental study by Hong-Bo Guo, Mo-Fei Wang, Ren-Qi Yin, Kang-Kang Zhi

“…The results of electromagnetic flowmeter, vascular Doppler ultrasound, and pathological examination showed that QAC-assisted anastomotic arteries were superior to hand-sewn arteries in terms of postoperative blood flow (16.86 ± 3.93 vs. 10.36 ± 0.92 mL/min) and vascular patency in 6 weeks after surgery. …”
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Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…In the GRAND PLAN, we documented sustained virological response post-treatment Week12 (SVR12) in 108/117 (92.3 %) individuals (108/111 (mITT) or 97.3 % of those reaching the SVR12 timepoint) receiving an 8-week course of glecaprevir/pibrentasvir (G/P), with almost all using fentanyl and over half being unstably housed. …”
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Genetic Landscape and Clinical Manifestations of Multiple Endocrine Neoplasia Type 1 in a Korean Cohort: A Multicenter Retrospective Analysis by Boram Kim, Seung Hun Lee, Chang Ho Ahn, Han Na Jang, Sung Im Cho, Jee-Soo Lee, Yu-Mi Lee, Su-Jin Kim, Tae-Yon Sung, Kyu Eun Lee, Woochang Lee, Jung-Min Koh, Moon-Woo Seong, Jung Hee Kim

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Empirical estimation of saturated soil-paste electrical conductivity in the EU using pedotransfer functions and Quantile Regression Forests: A mapping approach based on LUCAS topso... by Calogero Schillaci, Simone Scarpa, Felipe Yunta, Aldo Lipani, Fernando Visconti, Gábor Szatmári, Kitti Balog, Triven Koganti, Mogens Greve, Giulia Bondi, Georgios Kargas, Paraskevi Londra, Fuat Kaya, Giuseppe Lo Papa, Panos Panagos, Luca Montanarella, Arwyn Jones

“…The final model resulted in an R2 of 0.302 with an RMSE of 0.265 dS m−1 for soil samples not used for model calibration. …”
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Assessment approach for conservation effectiveness and gaps for endangered species based on habitat suitability: A case study of alpine musk deer in western China by Feng Jiang, Pengfei Song, Jingjie Zhang, Dongwu Wang, Renhong Li, Chengbo Liang, Tongzuo Zhang

“…Results indicated that altitude, annual mean temperature, and temperature annual range were the primary environmental factors influencing the distribution of suitable habitats, which were concentrated in areas with altitudes of 3,000–5,000 m, annual mean temperatures of 0–5 °C, and temperature annual ranges of 30–40 °C. …”
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Research on ion cyclotron emission driven by deuterium–deuterium fusion-produced tritium ions on the Experimental Advanced Superconducting Tokamak by Huapeng Zhang, Lunan Liu, Wei Zhang, Xuan Sun, Xinjun Zhang, Zhengshuyan Wang, Zelin Xu, Jiadong Zhang, Weijian Qin, Liuxin Li, Yuhao Jiang, Sichun Qiu, Chengming Qin, Guanghui Zhu, Yongxin Zhu, Kai Zhang, Tao Jin, Zhiping Li

“…The excitation position of ICE is approximately R = 2.29 m on EAST, and we find that ICE is easier to excite below a certain threshold of plasma radiation. …”
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CHANGES IN THE QUALITY OF LIFE AND SEXUAL FUNCTION IN WOMEN WITH PELVIC PROLAPSE AFTER LIGATION OF COLPOPEXY WITH POLYPROPYLENE MESH by A. D. Kaprin, A. A. Kostin, V. B. Filimonov, R. V. Vasin, I. V. Vasina

“…The patients were divided into two groups according to the method of vaginal ligation of colpopexy: in group 1 (n = 50) included patients who underwent the surgery perforated polypropylene implant "Cineplex" (LINTEX, Russia) according to the developed method (patent RF № 2538796); 2 (n = 43) group included patients who had an operation using standard kits with polypropylene mesh (ProliftTM, Prolift™ + M, ProsimaTM ETHICON Women's Health &amp; Urology" Johnson &amp; Johnson Company, USA). …”
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Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early r... by Bong-Ki Hong, Sungyong You, Jung Gon Kim, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju, Wan-Uk Kim, Wan-Uk Kim, Ho-Youn Kim

“…Specifically, the expression of these genes was elevated in IL1B+ proinflammatory monocytes (likely M1 monocytes), correlating with serum IFN-γ levels.DiscussionCompared to ACPA- eRA, ACPA+ eRA showed higher serum IFN-γ and IL-12 levels, upregulated IFN-γ response genes, and enhanced IFN-γ-driven monocyte-T cell interactions. …”
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Characterization of dynamic stall of a wind turbine airfoil with a high Reynolds number by H. R. Kim, J. A. Printezis, J. D. Ahrens, J. R. Seume, L. Wein

“…<p>This study shows an extensive analysis of dynamic stall on wind turbine airfoils, preparing for the development of a reduced-order model applicable to thick airfoils (<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><mi>t</mi><mo>/</mo><mi>c</mi><mo>&gt;</mo><mn mathvariant="normal">0.21</mn></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="53pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="aa10b0f7589f34c39cbb1ba9f034335d"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="wes-10-161-2025-ie00001.svg" width="53pt" height="14pt" src="wes-10-161-2025-ie00001.png"/></svg:svg></span></span>) in the future. …”
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