长短效GnRHa降调节方案与卵泡发育同步化

“…A组Gn使用时间(d)长(9.78 ± 1.51 ;10.81 ± 1.93;11.16 ± 1.98;11.4 ± 2.12),获卵数(10.38 ± 4.68;12.17 ± 5.29;12.97 ± 5.29;13.59 ± 5.41)?MⅡ卵子数(8.91 ± 4.1;10.25 ± 4.58;11.36 ± 4.92;11.95 ± 5.02)和利用胚胎数(5.7 ± 3.05;5.97 ± 3.47;7.35 ± 4.12;7.89 ± 4.0)在A组中均较少(P < 0.05)?…”
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Comparative study of robotic-assisted vs. laparoscopic surgery for colorectal cancer: a single-center experience by Wenpeng Wang, Jia Liu, Jiefu Wang, Li Li, Dalu Kong, Junfeng Wang

“…Statistical significance was set at p &lt; 0.05.ResultsRACS was associated with longer surgery durations (median: 218.5 vs. 165 minutes) and greater blood loss (median: 100 vs. 50 mL) compared to LCS (p &lt; 0.001 for both). Additionally, the median hospitalization cost was notably higher for RACS at 117,822 RMB compared to 78,174 RMB for LCS (p &lt; 0.0001). …”
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The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus by Zhang Mengjuan, Lin Guanglan, Pan Xiaohua, Song Weitao, Tan Can, Chen Xuan, Yang Yanling, Zhuang Zhenhong

“…Bioinformatics analysis showed Cti6 is conservative in Aspergillus spp., and mCherry mediated subcellular localization showed that most Cti6 accumulated in the nuclei, which reflected that Cti6 performed its important biological function in the nuclei in Aspergillus spp.. …”
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iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma by Liu T, Liang X, Liu W, Yang S, Cui T, Yan F, Li Z

“…Targeting efficiency of iRGD-sGVs was evaluated using flow cytometry and confocal microscopy on endothelial and K7M2 osteosarcoma cells. In vivo contrast-enhanced ultrasound imaging of iRGD-sGVs was performed in osteosarcoma-bearing mice, and the expression of avβ3 in osteosarcoma was detected through immunofluorescence staining assay. …”
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Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation by Lana Wang, Zhenyu Yang, Zhenyu Yang, Dominic LaBella, Zachary Reitman, John Ginn, Jingtong Zhao, Justus Adamson, Kyle Lafata, Kyle Lafata, Kyle Lafata, Evan Calabrese, John Kirkpatrick, Chunhao Wang

“…Regarding segmentation performance, SPU-Net demonstrated comparable results to a traditional U-Net in sensitivity (0.758 vs. 0.746), Dice similarity coefficient (0.760 vs. 0.742), reduced mean Hausdorff distance (mHD) (0.612 cm vs 0.744 cm), and reduced 95% Hausdorff distance (HD95) (2.682 cm vs 2.912 cm). …”
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Habitat radiomics based on CT images to predict survival and immune status in hepatocellular carcinoma, a multi-cohort validation study by Kun Chen, Chunxiao Sui, Ziyang Wang, Zifan Liu, Lisha Qi, Xiaofeng Li

“…Ultimately, an immune status profiling was conducted based on bioinformatic analyses and multiplex immunohistochemistry (mIHC) assays to reveal the potential mechanisms. …”
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A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer by Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Ali Darehkordi, Alireza Najafi, Milad Karimi, Majid Khoshmirsafa, Gholamhossein Hassanshahi, Elaheh Safari, Reza Falak

“…A1 effectively inhibited the proliferation of CT-26 cells, significantly reduced tumor cell migration, attenuated Treg infiltration, and suppressed IL-10 and TGF-β expression at both mRNA and protein levels in vivo. Notably, A1 outperformed AMD3100 in reducing tumor size and increasing survival rate in treated animals, with minimal side effects. …”
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AI for IMPACTS Framework for Evaluating the Long-Term Real-World Impacts of AI-Powered Clinician Tools: Systematic Review and Narrative Synthesis by Christine Jacob, Noé Brasier, Emanuele Laurenzi, Sabina Heuss, Stavroula-Georgia Mougiakakou, Arzu Cöltekin, Marc K Peter

“…The criteria are organized into seven key clusters, each corresponding to a letter in the acronym: (1) I—integration, interoperability, and workflow; (2) M—monitoring, governance, and accountability; (3) P—performance and quality metrics; (4) A—acceptability, trust, and training; (5) C—cost and economic evaluation; (6) T—technological safety and transparency; and (7) S—scalability and impact. …”
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Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway by Weijuan Li, Zhi Li, Yaoqi Chen, Songhai Li, Yuanyuan Lv, Wenping Zhou, Mengyang Liao, Feng Zhu, Zihua Zhou, Xiang Cheng, Qiutang Zeng, Yuhua Liao, Yumiao Wei

“…Interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemotactic protein-1 (MCP-1) expression were improved at both mRNA and protein levels in HEC, while NF-κB in the DNA level was improved detected by electrophoretic mobility shift assays (EMSA). …”
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Elevation-dependent shift of landslide activity in mountain permafrost regions of the Qilian Mountains by Jie Chen, Jing Zhang, Tong-Hua Wu, Lin Liu, Fan-Yu Zhang, Jun-Ming Hao, Ling-Cao Huang, Xiao-Dong Wu, Peng-Ling Wang, Zhuo-Xuan Xia, Xiao-Fan Zhu, Pei-Qing Lou

“…Notably, we observed an upward shift in the elevation of landslide occurrences, with an average increase of approximately 130 m over the ten-year period. Analysis of annual permafrost distribution maps indicates that this shift coincides with the rising lower altitudinal limit of mountain permafrost in the study area, likely driven by increased temperatures and precipitation. …”
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Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity by Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann, Amelia K. Linnemann

“…Previously, we discovered that β-cell autophagy is impaired prior to the onset of T1D, implicating this pathway in T1D pathogenesis.AimsTo assess the role of autophagy in β-cell health and survival, and whether defects in autophagy render islets more immunogenic.MethodsWe knocked out the critical autophagy enzyme, ATG7, in the β-cells of mice (ATG7Δβ-cell) then monitored blood glucose, performed glucose tolerance tests, and evaluated bulk islet mRNA and protein. We also assessed MHC-I expression and presence of CD45+ immune cells in ATG7Δβ-cell islets and evaluated how impaired autophagy affects EndoC-βH1 HLA-I expression under basal and IFNα stimulated conditions. …”
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Two‐Step Design Rule for Simultaneously High Conductivity and Seebeck Coefficient in Conjugated Polymer‐Based Thermoelectrics by Zelong Li, Wei Fu, Dorothea Scheunemann, Xiaoran Wei, Maximilian Litterst, Priya Mariam Viji, Yong Cui, Jianhui Hou, Junhui Tang, Ziqi Liang, Zehua Qu, Martijn Kemerink, Ruiqian Guo, Guangzheng Zuo

“…A maximum power factor (PF) over 155 (142.7 ± 12.7) µW m−1 K−2, coupled with S ≈202 (194.6 ± 7.6) µV K−1 is achieved, leading to up to 32‐fold enhancement of the PF compared to the initial non‐planar and non‐fluorinated polymer. …”
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小鼠脂肪间充质肝细胞的分离培养及生物学特性分析

“…【方法】 体外分离、纯化BALB/C小鼠ADSC,进行细胞形态、表面标志、成脂及成骨分化潜能鉴定、克隆形成能力、生长动力学等方面的研究,并通过淋巴细胞增殖抑制试验研究其免疫调节特性:用终浓度为20 μg/mL 的ConA作用于T淋巴细胞(1 × 105个),以不同数量的ADSC分别与活化T淋巴细胞作用,根据ADSC数量不同实验分为A 组(ConA+T细胞)、B 组(ADSC 1 × 103/孔+ ConA+T细胞)、C 组(ADSC 1 × 104/孔+ ConA + T细胞)、D 组(ADSC 2 × 104/孔+ ConA + T细胞),同时E组(单纯T细胞)作为阴性对照组,F组(ADSC 1 × 103/孔)、G组(ADSC 1 × 104/孔)、H组(ADSC 2 × 104/孔)作为参照组,用CCK-8法检测作用前后T 细胞功能。…”
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Effects of Long-Term Serum Starvation on Autophagy, Metabolism, and Differentiation of Porcine Skeletal Muscle Satellite Cells by Yi Wang, Juan Gao, Bojun Fan, Yuemin Hu, Yuefei Yang, Yajie Wu, Jiaqiao Zhu, Junwei Li, Feng Li, Huiming Ju

“…The results showed that long-term serum starvation induced autophagy through the AMPK/mTOR signaling pathway, accelerated cell metabolism and apoptosis, exacerbated reactive oxygen species accumulation, and inhibited myogenic and adipogenic differentiation of SMSCs. …”
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Lymphatic leaks – success of intranodal lymphangiogram first strategy by Alan Campbell, Diana Velazquez-Pimentel, Matthew Seager, Richard Hesketh, Julian Hague, Jowad Raja, Jocelyn Brookes, An Ngo, Miles Walkden, Anthie Papadopoulou, Daron Smith, Borzoueh Mohammadi, Ravi Barod, Mohammed Rashid Akhtar, Jimmy Kyaw Tun, Deborah Elise Low, Ian Daniel Renfrew, Tim Fotheringham, Conrad von Stempel

“…Clinical success was defined as reduction in drain output to less than 20 mL per 24 h, or no further insensible lymph leak. …”
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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…Results Our results revealed that mRNA expression levels of ELOVL2, ELOVL4 and ELOVL6 and protein expression levels of ELOVL5 and ELOVL6 were elevated in LUAD tissues compared to normal subjects. …”
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First validation of the novel Freiburg Neurointerventional Score purposely designed for use by emergency medical dispatchers for detecting anterior circulation large-vessel occlusi... by Erik Farin-Glattacker, Christian A Taschner, Hans-Jörg Busch, Wolf-Dirk Niesen, Matthias L Herrmann, Florian F Schuchardt, Clara Franck, Simone Meier, Max Henningsen, Friederike S Brohl, Christoph Sonntag, Nicole Wimmesberger, Jochen Brich

“…The FRENS had the highest sensitivity and negative predictive values for an aLVO stroke and the highest sensitivity value for M2 occlusions. The FRENS provided results after two and all four steps, in 71% and &lt;3% of cases, respectively.Conclusions The FRENS enabled the rapid, sensitive detection of an aLVO in patients with suspected acute stroke. …”
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Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System by Izabelly Bianca da Silva Santos, Bruno Santos dos Santos, João Ricardhis Saturnino de Oliveira, Wêndeo Kennedy Costa, Adrielle Zagmignan, Luís Cláudio Nascimento da Silva, Magda Rhayanny Assunção Ferreira, Vilmar Luiz Lermen, Maria Silvanete Benedito de Sousa Lermen, Alexandre Gomes da Silva, Rafael Matos Ximenes, Luiz Alberto Lira Soares, Patrícia Maria Guedes Paiva, Vera Lúcia de Menezes Lima, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva

“…Taken together, these data support the use of M. floribunda fruit peels for development of functional foods and nutraceutics.…”
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Evaluation of Serum Leucine-Rich Alpha-2 Glycoprotein as a New Inflammatory Biomarker of Inflammatory Bowel Disease by Tetsuhiro Yoshimura, Keiichi Mitsuyama, Ryosuke Sakemi, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Shuhei Fukunaga, Toshihiro Araki, Masaru Morita, Kozo Tsuruta, Hiroshi Yamasaki, Takuji Torimura

“…UC and CD showed comparable areas under the curve (AUC) values for determining clinical remission and differentiating between endoscopic remission associated with LRG and CRP. The levels of LRG mRNA were also increased in PBMCs from patients with UC and CD and reflected disease activity. …”
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Characterization and Spatial Distribution of Sand Group Architecture and Channel Types in Tight Gas Reservoirs: A Case Study From the Jurassic Shaximiao Formation of the Jinqiu Gas... by Guian Guo, Deyu Zhu, Xiaojuan Wang, Mingqiu Li, Xu Guan, Xiaoju Zhang, Changjiang Wu, Shaomin Zhang, Li Hu, Juan Zhao, Nan Li, Huiqiang Wang, Bohan Duan

“…There is a high content of natural gas in Types A and B of sandstones, with a daily gas production of 29.16×104–47.6×104 m3/day and pressure coefficients of 0.72–1.08. …”
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