Short Report – Birth Weight is Not Associated With Cataracts or Pseudophakia – Results from the Gutenberg Health Study by Fieß A, Gißler S, Grabitz S, Wild PS, Lackner KJ, Beutel ME, Urschitz MS, Tüscher O, Münzel T, Schattenberg JM, Konstantinides SV, Pfeiffer N, Schuster AK

“…Achim Fieß,1,* Sandra Gißler,1,* Stephanie Grabitz,1 Philipp S Wild,2– 5 Karl J Lackner,6 Manfred E Beutel,7 Michael S Urschitz,8 Oliver Tüscher,5,9,10 Thomas Münzel,11 Jörn M Schattenberg,12,13 Stavros V Konstantinides,2,14 Norbert Pfeiffer,1 Alexander K Schuster1 1Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 2Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany; 3German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; 4Preventive Cardiology and Preventive Medicine-Department of Cardiology, University Medical Center Mainz, Mainz, Germany; 5Institute of Molecular Biology (IMB), Mainz, Germany; 6Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; 7Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 8Division of Pediatric Epidemiology, Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 9Clinic for Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; 10Leibniz Institute for Resilience Research, Mainz, Germany; 11Center for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; 12Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany; 13Department of Internal Medicine I, University Medical Center, Mainz, Germany; 14Department of Cardiology, Democritus University of Thrace, Alexandroupolis, 68100, Greece*These authors contributed equally to this workCorrespondence: Achim Fieß, Department of Ophthalmology, Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr 1, Mainz, 55131, Germany, Tel +49-(0)6131-17-5150, Fax +49-(0)6131-17-8495, Email achim.fiess@gmail.comAbstract: This study investigates the association between self-reported birth weight (BW) and the frequency of cataract and pseudophakia in a large population-based cohort in Germany, as part of the Gutenberg Health Study (GHS). …”
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Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation by Guang Yang, Minghui Wang, Mulan Qahar, Jinqing He, Zhiwei Lai, Sanmu Li, Dehua He, Xuefei Yan, Zuying Xiong, Zibo Xiong, Thu H. Le

“…Furthermore, polarized M1 macrophages led to increased MPC5 podocyte death. …”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…Pyruvate kinase isoform M2 (PKM2) is a multifunctional enzyme capable of transitioning between monomeric, dimeric, and tetrameric states, with its oligomeric equilibrium playing a pivotal role in tumour progression and survival. …”
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Safety and feasibility evaluation of a novel robotic surgical system in gynecological surgery application by Yuanbo Tao, Jun Wang, ShiChao Han, Jing Na, Ya Li

“…The average surgical time was (134.15 ​± ​82.44) min, the average intraoperative blood loss was (29.16 ​± ​29.35) mL, the average time for postoperative bowel motility recovery was (27.0 ​± ​11.5) h, and the average hospital stay after surgery was (3.1 ​± ​1.3) d. …”
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Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer’s disease diagnosis and therapeutic targets by Letian Huang, Mingyue Liu, Ze Li, Bing Li, Jiahe Wang, Ke Zhang

“…In cerebrospinal fluid, the levels of triggering receptor expressed on myeloid cells 2 and ubiquitin C-terminal hydrolase L1 are altered, whereas the levels of TREM2, CD40, CD40L, CD14, CD22, cathepsin D, cystatin C, and α2 M in peripheral blood differ. Notably, TREM2 and cathepsin D showed changes in both brain (SMD = 0.31, 95% CI: 0.16–0.47, P < 0.001, I2 = 78.4%; SMD = 1.24, 95% CI: 0.01–2.48, P = 0.048, I2 = 90.1%) and peripheral blood (SMD = 1.01, 95% CI: 0.35–1.66, P = 0.003, I2 = 96.5%; SMD = 7.55, 95% CI: 3.92–11.18, P < 0.001, I2 = 98.2%) samples. …”
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Serum adropin levels as a potential biomarker for predicting diabetic kidney disease progression by I-Wen Chen, I-Wen Chen, Cheng-Wei Lin, Cheng-Wei Lin, Cheng-Wei Lin, Chia-Ni Lin, Chia-Ni Lin, Szu-Tah Chen, Szu-Tah Chen, Szu-Tah Chen

“…Among T2D patients, subjects experienced CKD progression had higher adropin levels than those without (7520.15 ± 843.21 vs. 6151.16 ± 1661.61 pg/mL, P =0.003). Thus, adropin predicts CKD progression in T2D patients with 86% sensitivity and 70% specificity at 6872.24 pg/ml cutoff value. …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

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Genome-wide association study analysis of single nucleotide variants in L. infantum associated with IL-6 inflammatory response in visceral leishmaniasis by Amanda Miranda da Silva, Kátia Silene Sousa Carvalho, Caio Andrey Bezerra Januário, Raquel Gomes de Sena Carneiro Caldas, Bianka Lopes da Silva Paulino, Débora Cavalcante Braz, Dorcas Lamounier Costa, Gabriel da Luz Wallau, Wilson Jose da Silva Junior, Carlos Henrique Nery Costa

“…The analysis revealed that the relationship between IL-6 levels and clinical outcomes (survival vs mortality) had an area under the curve (AUC) of 0.67 (95% CI 0.52–0.81). A cut-off of 391.7 pg mL−1 for IL-6 was established to conduct a logistic regression analysis. …”
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Emergency Airway Management: A Systematic Review on the Effectiveness of Cognitive Aids in Improving Outcomes and Provider Performance by Raisa Chowdhury, Ostap Orishchak, Marco A. Mascarella, Bshair Aldriweesh, Mohammed K. Alnoury, Guillaume Bousquet-Dion, Jeffrey Yeung, Lily Ha-Nam P. Nguyen

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Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects by Feng Cheng, Tao Shen, Fucheng Zhang, Chenghao Lei, Ye Zhu, GuoJun Luo, Dawei Xiao

“…The subjects were administered 1 mg (2 mL:0.5 mg,plastic ampoules) of generic fluticasone propionate nebuliser suspension as a test formulation or Flixotide Nebules® as reference formulation and cross administration after sufficient washout period (5 days) for the second period study. …”
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GAIRAH BERAGAMA MASYARAKAT MUSLIM by Hafidz Hafidz, Akhmad Munir

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Effects of milk extracellular vesicles from Holstein Friesian and Brown Swiss heat-stressed dairy cows on bovine mammary epithelial cells by S. Castellani, L. Basiricò, A. Maggiolino, C. Lecchi, P. De Palo, U. Bernabucci

“…Cell viability and apoptosis assay, reactive oxygen species production, and mRNA expression of heat shock proteins and antioxidant genes by reverse transcription and real time PCR were determined. …”
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Narrow Linewidth All-Optical Microwave Oscillator Based on Torsional Radial Acoustic Modes of Single-Mode Fiber by Wen Wang, Wenjun He, Xinyue Fang, Yi Liu, Yajun You, Mingxing Li, Lei Yu, Qing Yan, Yafei Hou, Jian He, Xiujian Chou

“…A Hz level narrow linewidth all-optical microwave oscillator based on the torsional radial acoustic modes (TR_2,m) of a single-mode fiber (SMF) is proposed and validated. …”
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舒洛地特对高糖诱导的人视网膜微血管内皮细胞功能紊乱的作用及其机制

“…【方法】 将体外培养的HREC分为以下4组:对照组(普通内皮细胞培养基,含5. 5 mmol/L葡萄糖),甘露醇组 (24. 5 mmol/L甘露醇+5. 5 mmol/L葡萄糖),高糖组(30 mmol/L葡萄糖),舒洛地特干预组(0.25?0.5?1.0 LRU/mL舒洛地特+30 mmol/L葡萄糖)?采用Western blot法检测各组CTPR3?TNF-α?…”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…These sensors were tested for the detection of a SARS-CoV-2 RNA sequence and showed a linear response in the range of 10−7 - 102 ng μL−1 with an estimated limit of detection of 10 fM. This work is an important milestone in the development of the next generation of point-of-care RNA sensors.…”
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Effects of Yanghe Decoction on IL-1 and TNF-α of Papain in Rabbit Knee Osteoarthritis by Zhenqiang HONG, Hongjian GAO, Junjun HE, Zeling HUANG

“…The rabbit knee joint was slightly bend, insert the needle through the middle or both sides of the joint, and 0.5 mL 1.6%Papain saline solution was injected into the knee joint cavity through the superior patellar ligament, all were injected every three days, three consecutive times. …”
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Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting by Frederik Rastfeld, Marco Hoffmann, Sylvie Krüger, Patrick Bohn, Anne-Sophie Gribling-Burrer, Laura Wagner, Nils Hersch, Carina Stegmayr, Lukas Lövenich, Sven Gerlach, Daniel Köninger, Christina Hoffmann, Helene L. Walter, Dirk Wiedermann, Hajaani Manoharan, Gereon R. Fink, Rudolf Merkel, Heribert Bohlen, Redmond P. Smyth, Maria A. Rueger, Bernd Hoffmann

“…The specific combination of the molecular properties of antisense technology and mRNA therapy with functional RNA secondary structures allowed us to develop selectively expressed RNA molecules for medical applications. …”
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Serum levels of oxidative stress, IL-8, and pepsinogen I/II ratio in Helicobacter pylori and gastric cancer patients: potential diagnostic biomarkers by Marwa Nasier-Hussain, Jaleel Najah Samanje, Khatere Mokhtari, Mohsen Nabi-Afjadi, Zeinab Fathi, Asieh Hoseini, Elham Bahreini

“…Results Individuals with H. pylori infection exhibited elevated levels of IL-8 (940.5 ± 249.7 vs. 603.4 ± 89.1 pg/ml, P < 0.0001) and oxidative species (5.47 ± 0.7 vs. 1.64 ± 0.7 nM, P < 0.05) compared to gastric cancer patients, who, despite having lower levels of IL-8 and oxidative species, showed higher levels of MDA. …”
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吴茱萸次碱通过Sirt1改善血管平滑肌细胞钙化 by 邵静, 陈安, 张秀丽, 杨平珍

“…另外，高磷高钙可下调血管平滑肌细胞Sirt1的表达水平，qRT-PCR和Western blot结果证实吴茱萸次碱可明显地上调Sirt1 mRNA（0.35±0.06、0.75±0.11；0.22±0.08、0.87±0.13；P<0.05）和Sirt1的蛋白（0.38±0.09、0.71±0.13；P<0.05）的表达水平。…”
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Application of response surface methodology (RSM) for experimental optimization in biogenic silica extraction from rice husk and straw ash by Yigezu Temesgen Zewide, Temesgen Atnafu Yemata, Adane Adugna Ayalew, Hawi Jihad Kedir, Asab Alemneh Tadesse, Asmarech Yeshaneh Fekad, Alemayehu Keflu Shibesh, Fentahun Adamu Getie, Tegen Dagnew Tessema, Tessera Alemneh Wubieneh, Wondmagegn Wonago Kululo, Muluken Tilahun Mihiret

“…The effects of three independent ash digestion process factors like sodium hydroxide concentration (1–3 M), temperature (60–120 °C) and time (1–3 h), for silica production from the mixture of rice husk (RH) and rice straw (RS) were studied. …”
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