Development and feasibility testing of a new device for home-based leg heat therapy in patients with lower extremity peripheral artery disease by Bohyun Ro, MSc, John P. Spence, BBA, Paul A. Spence, MD, Christian Buckley, BS, Raghu L. Motaganahalli, MD, Bruno T. Roseguini, PhD

“…The 6-minute walk distance improved by an average of 32 m, coupled with increased calf muscle strength and reduced time for the sit-to-stand test. …”
Get full text

Periodontal pathogens and obesity in the context of cardiovascular risks across age groups by Georgy Leonov, Yurgita Varaeva, Elena Livantsova, Andrey Vasilyev, Andrey Vasilyev, Olga Vladimirskaya, Tatyana Korotkova, Dmitry Nikityuk, Antonina Starodubova, Antonina Starodubova

Get full text

Emulsifying Properties of Dried Soy-Whey, Dried Tofu-Whey, and Their Isolated Proteins by Sobral Pablo A., Ossa J. Sebastian Henao, Palazolo Gonzalo G., Wagner Jorge R.

“…Oil-in-water emulsions were prepared at equivalent protein concentration (0.1, 0.5 and 1.0 g/100 mL), using sunflower oil as lipid phase (oil mass fraction = 0.33). …”
Get full text

Using capacity assessments and tailored technical assistance to advance trauma informed care integration at the organizational level by Lindsay Senter, Sabrina R. Baumgartner, Allyson Crinklaw, Emily Rebella, Beth Hurley, Kelly McCauley, Lindsay Bryant, Brita Loeb, Paige Cervantes, Stephanie Bogdewic, Sarah Horwitz, Barbara Cicatelli

Get full text

Study on the Influence of Introducing Al Transition Layer on Deuterium Resistance of Al2O3 Coating by Weijing Wang, Qinghe Yu, Xiaopeng Liu, Lei Hao, Jing Mi, Shijie Li, Shuai Li, Zheng Lu, Shanshan Li, Hao Liu

“…Under the combined action of permeation temperature and pressure of 873 K and 80 kPa, the deuterium permeability of Al/Al2O3 coating is 6.35×10−14 mol·m-1·s-1·Pa-0.5, which shows that the Al/Al2O3 coating has excellent deuterium permeation resistance. …”
Get full text

Adrenomedullin 2 attenuates anxiety-like behaviors by increasing IGF-II in amygdala and re-establishing blood–brain barrier by Denian Wang, Zhi Yang, Pengfei Wu, Qingyan Li, Chunyan Yu, Ying Yang, Yuefan Du, Mengwei Jiang, Junpeng Ma

“…Based on transcriptome analysis and biochemical analyses, we found that ADM2 facilitates the expression of insulin-like growth factor 2 (IGF-II), which then triggers the activation of the AKT-GSK3β-mTOR signaling pathway via the IGF-II receptor (IGF-IIR), rather than the IGF-I receptor (IGF-IR). …”
Get full text

Nutrition and Antioxidant Potential of Three Cauliflower (Brassica oleracea L. Var. Botrytis) Cultivars Cultivated in Southern Part of Bangladesh by Mousumi Jahan Sumi, Sharmin Akter Serity, Tusar Kanti Roy, Keya Akter, Shishir Rasul, Mostofa Jaman Depro, Md. Masum Abdullah, Md. Nesar Uddin

“…DPPH assays indicated that Valentena showed the most effective antioxidant (IC50 = 43.65±3.56 mg/mL FW), followed by Carotena and Snow White. Hierarchical clustering and pricipal component analysis (PCA) revealed distinct biochemical profiles: Valentena and Carotena shared similarities in carotenoids and antioxidant activity, whereas Snow White differed significantly. …”
Get full text

Dietary supplementation with 15% tomato pomace (Solanum lycopersicum L.) improves sperm production and antioxidant status in aged male broiler breeders by Amir Mosayyeb Zadeh, Seyyed Ali Mirghelenj, Mohsen Daneshyar, Mohsen Eslami, Mohammad Amir Karimi Torshizi, Mahdi Zhandi, Touba Nadri, John Patrick Kastelic, Peyman Hasanloo, Mehdi Nabiloo

“…The T-15 and L-10 groups had higher mRNA expressions of AKT1 and Nrf2 (P<0.05). In conclusion, in aged male broiler breeders, up to 15% TP supplementation is recommended to improve reproductive performance by enhancing testes histology and antioxidant status.…”
Get full text

CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study by Jiang N, Wang Q, Hu Z, Tian X

“…In vitro experiments demonstrated that overexpression of CLEC11A in nucleus pulposus cells significantly enhanced mRNA and protein expression of IVDD-related inflammatory markers; conversely, silencing CLEC11A markedly reduced these expressions. …”
Get full text

Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trio... by Sedigheh Khedmat, Seyyed Ali Abaee, Hadi Assadian, Antonio Signore, Stefano Benedicenti

Get full text

Chemical Composition and Antioxidant and Antimicrobial Activities of Wormwood (Artemisia absinthium L.) Essential Oils and Phenolics by Kamel Msaada, Nidhal Salem, Olfa Bachrouch, Slim Bousselmi, Sonia Tammar, Abdulkhaleg Alfaify, Khaldoun Al Sane, Wided Ben Ammar, Sana Azeiz, Adel Haj Brahim, Majdi Hammami, Sawsen Selmi, Ferid Limam, Brahim Marzouk

“…Antiradical activity was region-dependant and the methanolic extract of Bou Salem region has the strongest activity (CI50=9.38±0.82 µg/mL). Concerning the reducing power, the methanolic extract of Bou Salem, Jérissa, and Boukornine regions was more active than the positive control. …”
Get full text

Assessment of borehole water quality in Nwadzekudzeku village, Giyani, Limpopo Province, South Africa: Implication for potential human health risks by Tsakane Patience Maluleke, Sifelani Dube, Emmanuel Daanoba Sunkari, Abayneh Ataro Ambushe

“…Results and Discussion: The results showed that borehole water had a pH ranging from 6.96 - 7.76, an electrical conductivity (EC) of 132 - 2740 µS.cm−1, total dissolved solids (TDS) of 381 - 1336 mg.L−1, resistivity in the range of 62 - 1030 Ω, salinity from 0.32 - 1.34 ppt and an oxidation–reduction potential (ORP) of 9.20 - 233 mV. Most borehole water samples were found to have all physicochemical parameters above the maximum permissible levels (MPLs) set by the World Health Organization (WHO) and South African National Standards (SANS) except for pH and temperature. …”
Get full text

Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…The majority of participants (77%) had a body mass index&gt;25 kg/m2 and none was underweight. Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.Conclusions To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.Trial registration number ISRCTN52345929; Post-results.…”
Get full text

Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity by Parichehr Amiri, Seyed Ahmad Hosseini, Maryam Saghafi-Asl, Amin Akbari-Naserkiadeh, Seyedeh Asal Jenani Zavieh, Sara Arefhosseini, Samira Asghari, Neda Roshanravan

“…At the end of the trial, the mRNA expression levels of adiponectin receptor-1, adiponectin receptor-2 and uncoupling protein-3, significantly increased in NaBu group to almost two-fold higher levels, compared with placebo group (p = 0.030, p = 0.030 and p = 0.010, respectively). …”
Get full text

Paul'Ün Kutsadığı Tanrısal Bağ Olarak Gnostik Kutsal Evlilik - The Gnostic Holy Marriage as The Divine Tie was Blessed by Paul by Kürşat Akalın

“…Suyla yıkanma tek kelimeyle bedenselleri tanrısal evliliğe hazırlayarak b&uuml;t&uuml;nl&uuml;ğ&uuml; ve m&uuml;kemmelliği sağlayacaktır. Bu yolla, se&ccedil;ilmişler suyla yaptıkları banyoyla, demiurgik ruhluların bedenleriyle de ilgilenmektedirler. …”
Get full text

Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Flow cytometry and luciferase reporter assays were employed for mutation screening. BALB/c mice and M-NSG mice were used to evaluate the inflammatory response and efficacy of LCG CAR-T in vivo, with TIL grouping detected via immunohistochemistry.ResultsIn this study, we modified the newly discovered Passer (JL) transposon to construct a low-CpG content transposon for CAR-T cell (LCG CAR-T cell) preparation. …”
Get full text

Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…Drug sensitivity analysis found that most sensitive drugs target the phosphatidylinositol 3-kinase/ mechanistic target of rapamycin (PI3K/mTOR) signaling pathway. Further research revealed the expression of STC2 in the endothelial cells (ECs), particularly plasmalemma vesicle associated protein (PLVAP) + ECs, and may regulate the reprogramming and function of macrophages. …”
Get full text

Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications by Guillermo P. Lopez, Guillermo P. Lopez, Leyanet Barberia Roque, Katerine Igal, Katerine Igal, Erasmo Gámez Espinosa, Erasmo Gámez Espinosa, Natalia Bellotti, Natalia Bellotti

“…For bacterial strains, Dt*QC achieved a minimum inhibitory concentration (MIC) of 0.15 mg/mL against Staphylococcus aureus and demonstrated over 99.9% bacterial reduction, even at lower concentrations. …”
Get full text

Rare and syndromic tumours in South African children: A novel report from Sub-Saharan Africa by Alessia Pisapia, Guy Shemesh, Derek Harrison

“…Tumours were classified according to criteria described by international literature. (Ethics: M190920) Results: One hundred and eighty-six tumours were identified, with an average incidence of 10 %. …”
Get full text

In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats by Will J. Costain, Arsalan S. Haqqani, Greg Hussack, Henk van Faassen, Etienne Lessard, Binbing Ling, Eric Brunette, Dao Ly, Hung Fang, Jennyfer Bultinck, Steven Geysens, Gwenda Pynaert, Kathleen Piens, Stefan Ryckaert, Franck Fudalej, Wouter Vervecken, Danica Stanimirovic

“…IDS and IGF1R3H5-IDS exhibited very short (< 10 min) serum half-life (t1/2α), while constructs containing either HSA or anti-serum albumin sdAbs (R28 or M79) showed 8–11 fold increases in the area under the curve (AUC) in serum. …”
Get full text