FAK抑制剂对肝癌HCC-LM3细胞骨架重排和侵袭的作用机制 by 姚红兵, 肖芳, 郭威, 吴嘉兴, 文雪霖, 蒋建晖, 华赟鹏

“…方法HCC-LM3细胞分为Control组、CT-707低剂量（1.5 μmol/L）组、CT-707中剂量（3 μmol/L）组、CT-707高剂量（6 μmol/L）组，采用Transwell小室实验、细胞划痕、MTT实验分别测定细胞侵袭、迁移能力及细胞活力；采用RT-qPCR和Western blot分别检测Palladin、Vimentin、MMP2和MMP9 mRNA及蛋白的表达；Western blot检测p-FAK、FAK、p-PI3K、PI3K、p-Akt及Akt蛋白的表达。…”
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High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation by Dariusz Szukiewicz, Michal Pyzlak, Grzegorz Szewczyk, Aleksandra Stangret, Seweryn Trojanowski, Michal Bachanek, Wojciech Braksator, Jaroslaw Wejman

“…Resveratrol (50 and 100 μM; subgroups B and C) administered into the perfusion fluid lowered the production of both CX3CL1 and TNF-α. …”
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بررسی سرعت و جهت باد بیشینه در ایستگاه‌های همدیدی شرق دریاچه ارومیه by پویا اللهویردی پور, محمدتقی ستاری

“…فراوانی بادهای شدید در همه ایستگاه‌ها زیاد بوده و بیش از %50 از بادهای بیشینه در همه ایستگاه‌ها سرعتی بیش از m/s 11/11 دارند. اگرچه نتایج این تحقیق لزوم توجه به آسیب‌پذیری مناطق شرقی دریاچه ارومیه از نظر مخاطرات محیطی را نشان می‌دهد، ولی از دیدگاه انرژی، نشانگر پتانسیل مناسب این منطقه برای تولید انرژی بادی است.…”
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Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Results Of 4362 patients (Poland, N = 759; North America, N = 1243; Other countries, N = 2360), more patients from North America versus Poland/Other countries had CV risk factors such as body mass index ≥ 30 kg/m2 and history of diabetes/hypertension; however, more patients from Poland versus other regions were ever smokers and more patients from Poland/North America versus Other countries had history of coronary artery disease. …”
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Resposta da Vegetação Campos de Altitude às Mudanças Climáticas na Faixa Altitudinal Acima de 400 Metros na Serra do Amolar e Morraria do Urucum, Pantanal Brasileiro by Dhonatan Diego Pessi, Normandes Matos da Silva, Camila Leonardo Mioto, Alfredo Marcelo Grigio, Francisco das Chagas Oliveira, Vinicius de Oliveira Ribeiro, Fábio Veríssimo Gonçalves, Marco Antonio Diodato, Roberto Macedo Gamarra, Felipe Siqueira Pacheco, Antonio Conceição Paranhos Filho

“…This study aims to examine the driving effects of climate change on the spatial distribution of altitude grassland vegetation along an altitudinal range above 400 m in Serra do Amolar and Morraria do Urucum, both inserted in the Pantanal wetlands located in the State of Mato Grosso do Sul, Brazil. …”
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B/C基因型的乙型肝炎病毒在不同ALT状态下对乙型肝炎相关性肾炎的差异性影响

“…而在ALT≥2倍上限组中，C型基因型较B型基因型的乙型肝炎相关性肾小球肾炎患者中，血肌酐、血尿素氮、24h尿蛋白定量、尿NAG、尿β2M明显增高（P<0.05），而肾小球滤过率GFR明显下降（P<0.05），差异有统计学意义。在ALT正常组中B/C型的乙型肝炎病毒对慢性肾脏病分期差异无统计学意义（P>0.05）。…”
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Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome by Manjula Nandakumar, Priya Das, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin

“…In BMI-matched (overweight/obese, BMI ≥ 26 kg/m²) subset analysis, six CVRPs were common to the whole set: ANGPT1 and IL-1Ra were upregulated; and sRAGE, BMP6, GDF2, and Mn-SOD were downregulated. …”
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Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions by Hasan AM, Cavalu S, Kira AY, Hamad RS, Abdel-Reheim MA, Elmorsy EA, El-kott AF, Morsy K, AlSheri AS, Negm S, Saber S

“…Alexandru Madalin Hasan,1 Simona Cavalu,1 Ahmed Y Kira,2 Rabab S Hamad,3 Mustafa Ahmed Abdel-Reheim,4 Elsayed A Elmorsy,5 Attalla F El-kott,6,7 Kareem Morsy,6,8 Ali S AlSheri,6 Sally Negm,9 Sameh Saber10 1Department of Preclinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, 410087, Romania; 2Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt; 3Biological Sciences Department, College of Science, King Faisal University, Al Ahsa, 31982, Saudi Arabia; 4Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia; 5Department of Pharmacology and Therapeutics, College of Medicine, Qassim University, Buraidah, 51452, Saudi Arabia; 6Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia; 7Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt; 8Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt; 9Department of Life Sciences, College of Science and Art, Mahyel Aseer, King Khalid University, Abha, 62529, Saudi Arabia; 10Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, EgyptCorrespondence: Ahmed Y Kira, Department of Pharmaceutics, Faculty of Pharmacy, ‎Delta University for Science and Technology, Gamasa, Egypt, +11152, Tel +2 01026462867, Fax +2 0502770140, Email ahmed.kira@deltauniv.edu.eg Mustafa Ahmed Abdel-Reheim, Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia, Email m.ahmed@su.edu.saAbstract: Different types of cancers affect the gastrointestinal tract (GIT), starting from the oral cavity and extending to the colon. …”
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Breeding results for Echinacea purpurea (L.) Moench in Moscow Province by I. N. Korotkikh, E. Yu. Babaeva, A. E. Burova

“…Seeds were sown into plots (total area of 9.6 m2 ) with a 4-fold replication. The yield of crude herbal materials (above-ground part) was registered at the beginning of the flowering phase (the first 10 days of August), and fresh and dry mass of the accessions were measured (after 48-hour ventilated drying at 45°C). …”
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A Pilot Study on the Age-Dependent, Biomechanical Properties of Longitudinal Ligaments in the Human Cervical Spine by Narendra Singh, Ana Trajkovski, Jovan Trajkovski, Robert Kunc, Jose Felix Rodriguez Matas

“…The investigation concentrated on the effects of age on four mechanical parameters of the uniaxial stress–stretch curve: initial tangent stiffness (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>E</mi></mrow><mrow><mn>0</mn></mrow></msub></mrow></semantics></math></inline-formula>), maximum tangent stiffness (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>E</mi></mrow><mrow><mi>m</mi></mrow></msub></mrow></semantics></math></inline-formula>), ultimate stress (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>P</mi></mrow><mrow><mi>u</mi></mrow></msub></mrow></semantics></math></inline-formula>) and ultimate stretch (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>λ</mi></mrow><mrow><mi>u</mi></mrow></msub></mrow></semantics></math></inline-formula>). …”
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Analysis of the sensitization activity of Moringa oleifera leaves protein by Juan Lu, Juan Lu, Xiaoxue Liu, Xiaoxue Liu, Wenjie Li, Wenjie Li, Chuyu Xi, Chuyu Xi, Dan Feng, Dan Feng, Shuang Song, Shuang Song

“…Moringa oleifera leaves protein exhibits hemolytic activity at a concentration of at least 20 mg/mL, and α-methyl-mannoside, galactoside, raffinose and Al3+ can inhibit the hemolysis of Moringa oleifera leaves protein. …”
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Improvement of soil quality through biochar in rice under wastewater irrigated soil: Effects on heavy metals reduction by Sayon Mukherjee, Satish Kumar Singh, Raimundo Jiménez Ballesta, Abhik Patra, Surendra Singh Jatav

“…Method: The investigation consists of ten treatments in completely randomized design with three replications using simple and concentrated H3PO4 and 1 M FeCl3 modified biochar at graded dose and one biochar untreated control. …”
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Hospital in-reach family-centred social prescribing pilot for children with neurodisability: mixed methods evaluation with social return on investment analysis by Laura Gordon, Megan Hastry, Angela Bate, Katie Gordon, Emily Greaves, Simoni Dimitriadou, Tim Rapley, Anna Purna Basu

“…Results Of 48 families supported by the service, 25 were recruited to the evaluation (26 children, aged 10 m-15y; 4 siblings; 36 parents). Baseline quality of life and wellbeing indices averaged below population norms. …”
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Macro-environment oscillation notably up risk of water quality degradation: A case study in Shanxi Reservoir, China by Wangwei Cai, Jihong Xia, Zewen Liu, Jiayi Zu, Shuyi Ji, Yue Wang, Qihua Wang

“…Shanxi Reservoir in Zhejiang, China, a large reservoir with a total storage capacity of 1.82 billion m3 was used as the study area to test this hypothesis. …”
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Levels of Cytokines (IL-1β, IL-2, IL-6, IL-8, TNF-α) and Trace Elements (Zn, Cu) in Breast Milk From Mothers of Preterm and Term Infants by Bilal Ustundag, Erdal Yilmaz, Yasar Dogan, Saadet Akarsu, Halit Canatan, Ihsan Halifeoglu, Gurkan Cikim, A. Denizmen Aygun

“…Milk was collected from total of 40 mothers (group M: mothers of mature infants, n=20; group PM: mothers of premature infants, n=20) from four lactation stages: colostrum (0–7 days), transitional (7–14 days), mature milk (21 days), and mature milk (2nd month). …”
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Comparative Evaluation of AI-Based Multi-Spectral Imaging and PCR-Based Assays for Early Detection of <i>Botrytis cinerea</i> Infection on Pepper Plants by Dimitrios Kapetas, Eleni Kalogeropoulou, Panagiotis Christakakis, Christos Klaridopoulos, Eleftheria Maria Pechlivani

“…At an Intersection over Union with a 0.5 threshold, the Mean Average Precision (mAP50) achieved by the leaf-segmentation solution YOLOv11-Small was 86.4%. …”
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A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of do... by Thatchaya Prathum, Thanwarat Chantanachai, Oranich Vimolratana, Chotica Laksanaphuk, Irin Apiworajirawit, Benchaporn Aneksan, Kanthika Latthirun, Cheng-Ta Yang, Wanalee Klomjai

“…Significant effects were observed when tDCS was used alone (SMD = 0.39, p = 0.04), at current densities $$\le$$ ≤ 0.06 mA/cm2 (SMD = 0.25, p = 0.04), session durations exceeding 20 min (SMD = 0.89, p = 0.01), up to 15 sessions (SMD = 0.28, p = 0.009), and when an active electrode was placed over the temporal area (SMD = 0.33, p = 0.02). …”
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Associations of the levels of adipokines and cytokines in individual follicles with in vitro fertilization outcomes in women with different ovarian reserves by Xuelan Li, Chujun Li, Jie Yang, Min Lin, Xianli Zhou, Ziyang Su, Yuting Zhang, Xinning Li, Xin Chen

“…Patients diagnosed with DOR, defined as a basal antral follicle count < 5 or an anti-Mullerian hormone concentration < 1.1 ng/mL, were assigned to the DOR group, while patients with a normal ovarian reserve (NOR) were assigned to the NOR group. …”
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Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases by Xing Li, Mingyu Liao, Rufei Shen, Linlin Zhang, Hua Hu, Jun Wu, Xiuli Wang, Hua Qu, Shaodong Guo, Min Long, Hongting Zheng

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ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1 by Živa Frangež, Deborah Gérard, Zhaoyue He, Marios Gavriil, Yuniel Fernández-Marrero, Yuniel Fernández-Marrero, S. Morteza Seyed Jafari, Robert E. Hunger, Philippe Lucarelli, Shida Yousefi, Thomas Sauter, Lasse Sinkkonen, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon

“…We then show that nuclear respiratory factor 1 (NRF1) stimulates the production of mRNA and protein as well as the promoter activity of ATG5 and ATG7. …”
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