Increasing Access to Mental Health Supports for 18- to 25-Year-Old Indigenous Youth With the JoyPop Mobile Mental Health App: Study Protocol for a Randomized Controlled Trial by Angela MacIsaac, Teagan Neufeld, Ishaq Malik, Elaine Toombs, Janine V Olthuis, Fred Schmidt, Crystal Dunning, Kristine Stasiuk, Tina Bobinski, Arto Ohinmaa, Sherry H Stewart, Amanda S Newton, Aislin R Mushquash

“… BackgroundTransitional-aged youth have a high burden of mental health difficulties in Canada, with Indigenous youth, in particular, experiencing additional circumstances that challenge their well-being. Mobile health (mHealth) approaches hold promise for supporting individuals in areas with less access to services such as Northern Ontario. …”
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The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“…As an independent variable, the distance between the direct opponent and the participant was systematically varied (10, 15 and 20 m; the distance at which the pass occurs). Decision accuracy and fixation characteristics were examined. …”
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Response of Hard-Bottom Macro-Zoobenthos to the Transition of a Mediterranean Mariculture Fish Plant (Mar Grande of Taranto, Ionian Sea) into an Integrated Multi-Trophic Aquacultur... by Roberta Trani, Cataldo Pierri, Antonella Schiavo, Tamara Lazic, Maria Mercurio, Isabella Coccia, Adriana Giangrande, Caterina Longo

“…This study was conducted from 2018 to 2021 in the semi-enclosed Mar Grande basin of Taranto (northern Ionian Sea), on a facility located 600 m off the coastline, with a production capacity of 100 tons per year of seabass (<i>Dicentrarchus labrax</i>) and seabream (<i>Sparus aurata</i>). …”
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Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…We find that overexpression of USP14 in clock cells reduces PER protein levels without altering its mRNA levels whereas USP14 knockdown increases PER protein levels, suggesting that USP14 regulates PER post-translationally. …”
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MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data by Katarzyna Arturi, Eliza J. Harris, Lilian Gasser, Beate I. Escher, Georg Braun, Robin Bosshard, Juliane Hollender

“…Scientific Contribution: In contrast to the classical ML-based approaches for toxicity prediction, MLinvitroTox predicts bioactivity for HRMS features (i.e., distinct m/z signals) based on MS2 fragmentation spectra rather than the chemical structures from the identified features. …”
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Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3 by Jian Zhou, Jia Fan, Zhiqiang Hu, Jia Li, Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Haoyang Xin, Chubin Luo, Shaolai Zhou

“…TANs and TAMs produced higher levels of oncostatin M and interleukin-11, respectively, in co-culture than in monoculture. …”
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Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular n... by Liu Chang, Yu Hao, Xia Hongyi, Wang Ziwei, Li Bolin, Xue Hongmei, Jin Sheng, Xiao Lin, Wu Yuming, Guo Qi

“…Microglia polarized to the M2 phenotype and inflammation are markedly attenuated in the PVN of HF model rats after NaB administration. …”
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Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets by Desmond Asamoah Bruce Otu, Frederick William Akuffo Owusu, Mariam El Boakye-Gyasi, Raphael Johnson, Prince George Jnr Acquah, Yayra Edzor-Agbo, Marcel Tunkumgnen Bayor, Mary-Ann Archer

“…This study aimed to evaluate pectin from two popular plantain varieties, Apem (M) and Apantu (T) at different ripening stages, for pharmaceutical use as a binding agent in immediate-release tablets. …”
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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…Irrespective of dose, the blockade of the LPS-LBP interaction was associated with low systemic cytokine levels and delayed increases in hepatic TNF-α and IL-6 mRNA expression. The delayed increase in cytokines was associated with the phosphorylation of STAT3 and AKT. …”
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Pharmacognostic analysis and antimalarial evaluation of quercetin in Ilex umbellulata bark using HPTLC, in vitro screening, molecular docking, and network pharmacology by James H. Zothantluanga, Dipak Chetia, Yasangam Umbon, T. C. Lalhriatpuii, Dhritiman Roy, Nidahun Lamare, Salem Lalvenhimi

“…JazQSAR web tool previously developed by us predicts the IC50 of quercetin against Plasmodium falciparum as 3.88 ± 0.35 µM, which was not far from the practically observed value for quercetin. …”
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Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes by Ambre Bertrand, Andrew Lewis, Julia Camps, Vicente Grau, Blanca Rodriguez

“…Results Participants with T2DM had a higher resting heart rate (66 vs. 61 beats per minute, p < 0.001), longer QTc interval (424 vs. 420ms, p < 0.001), reduced T wave amplitude (0.33 vs. 0.37mV, p < 0.001), lower stroke volume (72 vs. 78ml, p < 0.001) and thicker left ventricular wall (6.1 vs. 5.9mm, p < 0.001) despite a decreased Sokolow-Lyon index (19.1 vs. 20.2mm, p < 0.001). …”
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Phenotypic Identification of Blood Groups in Blood Donors: A Peruvian Multicenter Analysis by Yovera-Ancajima CDP, Calderon Cumpa LY, Lezama-Cotrina ID, Walttuoni-Picón E, Cárdenas-Mendoza WW, Culqui-García JE, Retuerto-Salazar WR, Céspedes Poma RC

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Perbandingan Model Generalized Ammi (Gammi) dengan Row Column Interaction Model pada Interaksi Genotipe dan Lingkungan by Kurnia Ahadiyah, Ardiana Fatma Dewi

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Effect of carbon quantum dots on the anticorrosive action of the tin coatings by Taiane Fíngolo Duarte, Victor Magno Paiva, Braulio Soares Archanjo, Clara Muniz da Silva de Almeida, Natasha Midori Suguihiro, Rodrigo José Corrêa, Emerson Schwingel Ribeiro, Eliane D'Elia

“…Mild steel plates were used as substrate using electrodeposition in galvanostatic mode with j = 6.25 mA cm−2. The performance of the coatings was evaluated by electrochemical measurements such as open circuit potential, electrochemical impedance, and potentiodynamic polarization curve. …”
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Childhood overweight and obesity and back pain risk: a cohort study of 466 997 children by Daniel Prieto-Alhambra, Andrew J Carr, Antony J Palmer, Talita Duarte-Salles, Jose Luis Poveda, Daniel Martinez-Laguna, Carlen Reyes, Jeroen de Bont, Alan Silman

“…Models were adjusted for age, sex, socioeconomic status and nationality.Participants Children seen at age 4 years at paediatric primary care clinics between 1 January 2006 and 31 December 2013 and followed up until 31 December 2016 or age 15 years.Outcome measures Incident back pain registered by paediatricians at primary care using the International Statistical Classification of Diseases and Health Related Problems, 10th Edition code M54.Results 466 997 children were followed for a median 5.0 years (IQR 5.1). …”
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Investigation of 3D iris morphology early alteration after implantable collamer lens implantation by using SS-OCT by Zhengwei Zhang, Shuimiao Chang, Kaiwen Li, Jinhan Yao, Zhao Wang, Jiewei Liu, Lin Jiang, Feiyan Chai, Xiaogang Wang

“…The mean ICL vault values were 537.92 ± 161.69 μm, which positively and significantly correlated with the pre- (r = 0.333, P = 0.024) and postoperative (r = 0.351, P = 0.017) anterior chamber depth (ACD). …”
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Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells by Hyun-Jae Jang, Kang-Hoon Kim, Eun-Jae Park, Jeong A. Kang, Bong-Sik Yun, Seung-Jae Lee, Chan Sun Park, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho

“…Among compounds 1–17, deoxynimbidiol (1) and new trinorditerpenoid (3) showed the most potent inhibitory effects (IC50: 4.9 and 12.6 μM, respectively) on lipopolysaccharide- (LPS-) stimulated NO releases as well as proinflammatory mediators, such as inducible nitric oxide (iNOS), cyclooxygenase- (COX-) 2, interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-) α. …”
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Predictive value of the perivascular fat attenuation index for MACE in young people suspected of CAD by Yani Yu, Dongkai Shan, Xi Wang, Zinuan Liu, Guanhua Dou, Junjie Yang, Yuqi Liu, Yundai Chen

“…The perivascular FAI at the proximal segment of the right coronary artery (RCA) was measured and grouped into high FAI and low FAI according to the optimal cut-off value, and the association between a high FAI and major adverse cardiac events (MACE) was evaluated by Cox hazard regression. K‒M survival analysis was conducted to assess the prognostic value of the perivascular FAI and improvement over traditional risk factor prediction methods. …”
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Correlates of and Body Composition Measures Associated with Metabolically Healthy Obesity Phenotype in Hispanic/Latino Women and Men: The Hispanic Community Health Study/Study of L... by Mayra L. Estrella, Amber Pirzada, Ramon A. Durazo-Arvizu, Jianwen Cai, Aida L. Giachello, Rebeca Espinoza Gacinto, Anna Maria Siega-Riz, Martha L. Daviglus

“…Data from the Hispanic Community Health Study/Study of Latinos (2008–2011) were used to estimate the age-adjusted distribution of obesity phenotypes among 5,426 women and men (aged 20–74 years) with obesity (BMI ≥ 30 kg/m2) and to compare characteristics between individuals with MHO and MAO phenotypes. …”
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Reaction kinetics and molecular characterization of the compounds formed by photosensitized degradation of the plastic additive bisphenol A in the atmospheric aqueous phase by Yiting Wang, Qingxin Deng, Yiqun Wang, Pan Li, Biao Jin, Jiangping Liu, Peng Cheng, Marcello Brigante, Dario D’Antuono, Luca Carena, Hui Chen, Davide Vione, Sasho Gligorovski

“…Bromide levels as per seawater conditions have the potential to slow down BPA photodegradation, a phenomenon that could not be offset by reaction of BPA with Br2 •− (second-order reaction rate constant of (2.54 ± 0.09) × 108 M−1 s−1). Ultra-high resolution mass spectrometry revealed that the presence of inorganic salts (NaCl and NaBr) markedly increased the complexity of the observed CHO product compounds formed upon photosensitized degradation of BPA. …”
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