Bacteraemia in a Nigerian hospital: Implementing antimicrobial resistance surveillance by Adewale A. Amupitan, Adeyemi T. Adeyemo, Adefunke O. Amupitan, Temitope O. Obadare, Aaron O. Aboderin

“…Sixteen (30.2%) of 53 Gram-negative isolates were extended-spectrum beta-lactamase producers, predominantly harbouring blaCTX-M, three (5.7%) were AmpC beta-lactamase producers, and 20 (37.7%) were carbapenem-resistant, predominantly harbouring blaKPC. …”
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Preferences and Attitudes Towards Digital Communication and Symptom Reporting Methods in Clinical Trials by McDowell B, Dumais KM, Gary ST, de Gooijer I, Ward T

“…Bryan McDowell,1 Kelly M Dumais,2 Sarah Tressel Gary,2 Ingeborg de Gooijer,2 Tomás Ward3 1eCOA Science, Clario, Geneva, Switzerland; 2eCOA Science, Clario, Philadelphia, PA, USA; 3Insight Science Foundation Ireland Research Centre for Data Analytics, Dublin City University, Dublin, IrelandCorrespondence: Bryan McDowell, eCOA Science, Clario, Chemin Louis-Hubert 2, Petit-Lancy, Geneva, 1213, Switzerland, Tel +41 22 879 91 00, Fax +41 22 879 91 01, Email bryan.mcdowell@clario.comPurpose: With the growing use of digital health technologies (DHT) in clinical trials, the opportunity to use technology to promote greater patient centricity and inclusivity has emerged. …”
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GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…Methods Bioinformatics analysis was conducted to evaluate the mRNA/protein expression and prognostic significance of G protein–coupled receptor kinase 6 (GRK6) in BC subtypes. …”
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Prevalence of Hyper virulence and Multidrug resistance Klebsiella pneumoniae isolates from UTI patients by Manar Abdul karim, Zainab Mohammed Alzubaidy, Khazal Dabua Wadi

“…Serial dilutions were generated, and the resulting MIC values were found to be 512 and 1024µg/mL, respectively. The production of extended-spectrum beta-lactamases (ESBLs) was assessed through the utilisation of the double disc synergy test. …”
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The active roles of Rhodotorula mucilaginosa ZTHY2 in regulating antioxidant capacity and immune function of Leizhou black ducks by Jiang Wu, Yingxin Hu, Namula Zhao, Wei Yang, Zhibao Chen, Zhibao Chen

“…Moreover, ZTHY2 modulated the mRNA expression profiles of these cytokines in the thymus, spleen, and bursa, thereby sustaining the balance of immune dynamics. …”
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High Stability Single-Port Dual Band Microwave Sensor Based on Interdigital Capacitor Structure With Asymmetry Branch Feedline by Syah Alam, Indra Surjati, Lydia Sari, Raden Deiny Mardian, Teguh Firmansyah, Muhammad Iqbal, Slamet Widodo, Mudrik Alaydrus, Zahriladha Zakaria

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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Results RT-qPCR results showed that PTEN expression was significantly increased in RCC tumor tissues compared to normal tissues (p < 0.01). However, PTEN mRNA levels were significantly reduced in 786-O cells compared to HK-2 cells (p < 0.01). …”
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TSH Levels in Subclinical Hypothyroidism in the 97.5th Percentile of the Population by Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Gabriel Mayoral-Andrade, Eduardo Pérez-Campos Mayoral, Edgar Zenteno, Ruth Martínez-Cruz, Héctor Martínez Ruíz, Margarito Martínez Cruz, Alma Dolores Pérez Santiago, Eduardo Pérez-Campos

“…Generally, two different groups are identified for treatment by levels of 10 and 20 mIU/L. Nevertheless, the question remains, “what cutoff point should be chosen?” …”
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Pendekatan Onto-Semiotik Berbasis Problem Solving untuk Memperbaiki Pengetahuan Tanda “Sama Dengan” by Ahmad Hassan Nurdien, Mohammad Faizal Amir

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Exploring the Cardioprotective Mechanisms of Ligusticum wallichii in Myocardial Infarction Through Network Pharmacology and Experimental Validation by Yang H, Cao J, Zhou L, Chen J, Tang J, Chen J, Yin L, Xie L, Li J, Luo J

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Plasma S100A8/A9 level predicts response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer by Tadahiro Kuribayashi, Rie Kinoshita, Kiichiro Ninomiya, Go Makimoto, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura, Shinichi Toyooka, Masakiyo Sakaguchi, Kadoaki Ohashi

“…The TTF and OS were worse in patients with high plasma S100A8/A9 levels (≥ 2.475 µg/mL) (median TTF: 4.3 vs. 8.5 months, p = 0.009; median OS: 15.4 vs. 38.0 months, p = 0.001). …”
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مدى وعى أعضاء هیئة التدریس بجامعة المنوفیة بالانتحال العلمى : دراسة استکشافیة by د. السید رجب الأسرج

“…Which candestroy the entire course of scientific research, and then had a clear impact onthe delay in the classification of Arab universities among the lists of the bestuniversities in the world.In view of the seriousness of this phenomenon, which clarified the extentof ignorance of some researchers about what they do, whether intentionally orunintentionally, the researcher tried in the folds of this study to define what isscientific plagiarism and the difference between it and scientific quotation, as wellas the definition of the program applied to detect scientific plagiarism at MenoufiaUniversity, and the methods and means used for advertising and advertising Theprogram for detecting scientific plagiarism, and how to avoid falling into scientificplagiarism, as well as the difficulties that researchers face when examining theirintellectual production to reveal and determine the percentage of scientificcitation, this researcher has prepared a questionnaire for researchers of all   disciplines M. In Menoufia University, as well as through personal interviews anddirect observation, and the questionnaire was distributed to the study sample andrepresentative of all scientific disciplines for all job categories (graduate student,teaching assistant, assistant teacher, teacher, assistant professor, professor),which numbered about (100) researchers, The study reached a set of results, themost important of which is that more than two-thirds of the study sample reportedtheir knowledge of the difference between quotation and plagiarism, and thestudy also demonstrated the presence of statistically significant differences in thescale of knowledge of the difference between plagiarism and quotation inavoiding plagiarism in scientific research with a different degree, as reported (76)Researcher) proportions Its percentage (76%) of the total sample size is that theyare fully aware of the permissible percentage in the process of scientificquotation. …”
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Coupling mechanism of seepage and coal and rock mass destruction during coal and gas outburst by Shiling ZHANG, Junfei CUI, Shudong HE

“…The seepage force does not act uniformly in the coal wall, but concentrated in the thin layer less than 0.1 m near the exposed face of the coal wall. This action feature of seepage force makes the stress in the mining direction of coal body sharply reduce or even become negative to form tensile stress, which leads to the tensile failure and instability of the thin layer and the formation of spall. …”
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Synthesis of Nanocrystalline Mn-Doped Bi₂Te₃ Thin Films via Magnetron Sputtering by Joshua Bibby, Angadjit Singh, Emily Heppell, Jack Bollard, Barat Achinuq, Sarah J. Haigh, Gerrit van der Laan, Thorsten Hesjedal

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Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…After 14 days, and for another 4 weeks, MET (100 mg/kg per day) was added to half of each group’s drinking source, thus C (water), F (fructose), M (MET) and FM (fructose + MET). Serum and adipose tissue were collected. …”
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Self‐Healing Hyaluronic Acid‐based Hydrogel with miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach by Wei Zhu, Han Wang, Bin Feng, Guangli Liu, Yixin Bian, Tianhao Zhao, Qi Wang, Xisheng Weng

“…These findings demonstrate that this novel hydrogel (miR140‐5p‐CaP@mSF‐HA‐NB) effectively encapsulates and releases miR140‐5p, exhibits excellent biocompatibility, and promotes enhanced cartilage regeneration in both in vitro and in vivo models. …”
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The morphological, clinical, and prognostic factors in the management of giant anterior communicating artery aneurysms: A systematic review of cases by Roua Nasir, Midhat e Zahra Naqvi, Salaar Ahmed, Maarij ul Hassan, Rabeet Tariq, Saad Akhter Khan, Pia Koeskemeier, Rajiv K. Khajuria, Mohammad Hamza Bajwa, Sajjad Muhammad

“…The mean age was 52 years with an overall male preponderance (3:1). 73% presented with symptoms; mostly visual impairment/loss and subarachnoid hemorrhage. 82% had favorable outcomes (mRS 0–2). 56% had a mean maximum diameter between 25 and 30 mm. …”
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Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health by Yan Zuo, Zhilan Bai, Kaixuan Yang, Ziyuan Lin, Xiaolin Hu, Huaqin Sun

“…To elucidate the molecular mechanisms underlying these effects, we employed transcriptomics, metabolomics, and epigenomics (m6A-MeRIP-seq). KEGG enrichment analysis revealed significant alterations in arachidonic acid metabolism, axon guidance, and ubiquitin-mediated proteolysis. …”
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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

“…After adjusting for age, sex, dose (mg/m2), infusion duration, HDMTX course, and baseline estimated glomerular filtration rate, it remained significant for AKI with an OR of 1.29 and 95% confidence interval of 1.03–1.65. …”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…VAD diet-driven changes in intestinal microbiota followed the inflammatory response with increased intestinal permeability and higher mRNA expression of intestinal inflammatory cytokines through nuclear factor-κB signaling pathway activation. …”
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