A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates by Takahiro Jomori, Nanami Higa, Shogo Hokama, Trianda Ayuning Tyas, Natsuki Matsuura, Yudai Ueda, Ryo Kimura, Sei Arizono, Nicole Joy de Voogd, Yasuhiro Hayashi, Mina Yasumoto-Hirose, Junichi Tanaka, Kanami Mori-Yasumoto

“…The sesterterpenoids with a γ-butenolide group exhibited leishmanicidal activity against <i>Leishmania major</i> promastigotes, with IC₅₀ values ranging from 0.69 to 53 μM. The structure–activity relationship and molecular docking simulation suggest that γ-lactone is a key functional group for leishmanicidal activity. …”
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Investigating resting-state functional connectivity changes within procedural memory network across neuropsychiatric disorders using fMRI by Mahdi Mohammadkhanloo, Mohammad Pooyan, Hamid Sharini, Mitra Yousefpour

“…Multivariate region of interest to region of interest connectivity (mRRC) was used to analyze the rs-FC between the defined network regions. …”
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Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire by Soro Kountele Gona, Mahassadi Kouamé Alassan, Koffi Gnangoran Marcellin, Kissi Ya Henriette, Coulibaly Adama, Assohoun Toussaint, Ehua Adjoba Manuela, Seu Gagon Sylvain, Afum-Adjei Awuah Anthony, Ehua Somian Francis

“…In multivariate analysis, risk factors of postoperative complications or mortality were comorbidities (HR = 2.1, P=0.03), tachycardia (pulse rate > 100/minutes) (HR = 2.4, P=0.02), purulent intra-abdominal fluid collection (HR = 2.1, P=0.04), hyponatremia (median value ≤ 134 mEq/L) (HR = 2.3, P=0.01), delayed time of hospital admission > 72 hours (HR = 2.6, P<0.0001), and delayed time of surgical intervention between 24 and 48 hours (HR = 3.8, P<0.0001). …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Conducted Co-IP and ubiquitination experiments for mechanism elucidation. Quantified IgM and IgG using ELISA and FC. Explored public databases for potential correlation molecules. …”
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Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway by Chen Feng, Wei Mao, Chenyang Yuan, Pin Dong, Yuying Liu

“…Knockdown of CHRNA5 can reduce cell migration, invasion, and proliferation, whereas nicotine exposure can reverse this trend. Additionally, the mRNA and protein expression of CES1 decreases with the knockdown of CHRNA5, indicating a regulatory relationship between the two. …”
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Application of solid-phase extraction and gas chromatography-mass spectrometry (SPE-GC-MS) in resolution of metabolism pattern of higher alcohols in rat plasma by Yufei Liu, Xiaonian Cao, Zhilei Zhou, Qingxi Ren, Zhongwei Ji, Min Gong, Yuezheng Xu, Weibiao Zhou, Shuguang Chen, Jian Mao

“…A strategy combining solid-phase extraction and gas chromatography-mass spectrometry (SPE-GC-MS) was established to analyze the metabolism pattern of higher alcohols in rat plasma after gavage of 4 common alcoholic beverages including huangjiu, baijiu, wine and brandy.7 mL of dichloromethane was determined as the optimal extraction condition, and 8 higher alcohols were precisely quantified with detection limits of 1.82−11.65 μg/L, recoveries of 89.07%−110.89% and fine repeatability. …”
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Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction by Yize Sun, Yize Sun, Haibin Zhao, Zheyi Wang

“…The optimal dosage for lavage with the PCF solution in rats was determined to be 1 mL/100 g/day for a duration of 5 days. We also detected the PCF components migrating to blood in the control and model rats. …”
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Quantification of Soil–Water Erosion Using the RUSLE Method in the Mékrou Watershed (Middle Niger River) by Rachid Abdourahamane Attoubounou, Hamidou Diawara, Ralf Ludwig, Julien Adounkpe

“…High-resolution digital elevation models (30 m) provided detailed topographic information, crucial for calculating slope length and steepness factors. …”
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Studies on the alleviating effect of Bifidobacterium lactis V9 on dextran sodium sulfate-induced colitis in mice by Xiaoyan Duan, Xiaoyan Duan, Xiaoyan Duan, Xiaoyan Duan, Rilige Wu, Jianbo Li, Jianbo Li, Zeya Li, Yanqi Liu, Ping Chen, Bangmao Wang, Bangmao Wang, Bangmao Wang

“…RT-qPCR and Western blotting were used to detect mRNA and protein expression of target genes. The fecal microbiota was analyzed by 16S rRNA sequencing. …”
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Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin^−/−/Utrophin^−/− Double-Knockout Mice by Xueqin Gao, Yan Cui, Greg Zhang, Joseph J. Ruzbarsky, Bing Wang, Jonathan E. Layne, Xiang Xiao, Johnny Huard

“…We found that Ep2, Ep4, Cox-2, 15-Pgdh mRNA, and PGE2 were significantly increased in DKO-Hom mice compared to wild-type (WT) mice. …”
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Healthy Eating Index-2015 and Dietary Total Antioxidant Capacity as Predictors of Prediabetes: A Case-Control Study by Jamal Rahmani, Karim Parastouei, Maryam Taghdir, Heitor O. Santos, Farinaz Hosseini Balam, Mohsen Saberi Isfeedvajani

“…Mean age and body mass index of participants were 47.42 ± 15.98 years and 27.90 ± 4.96 kg/m2. Patients with prediabetes had lower DTAC scores when compared to controls (11.86 ± 5.77 and 17.81 ± 12.08, P = 0.01). …”
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Composites Based on Poly(ortho-toluidine) and WS₂ Sheets for Applications in the Supercapacitor Field by Teodora Burlanescu, Ion Smaranda, Andreea Androne, Cristina Stefania Florica, Madalina Cercel, Mirela Paraschiv, Adelina Udrescu, Adam Lőrinczi, Petru Palade, Andrei Galatanu, Catalin Negrila, Elena Matei, Monica Dinescu, Radu Cercel, Mihaela Baibarac

“…Capacitances equal to 123.5, 465.76, and 751.6 mF cm⁻² in the cases of POT-ES/WS₂ composites, synthesized by SSI, ICP, and ECP, respectively, were reported.…”
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Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis by Prabhakar Yellanur Konda, Vijayakumar Poondla, Krishna Kumar Jaiswal, Sreenivasulu Dasari, Reddemma Uyyala, Venkata Prasad Surtineni, Janardhan Yadav Egi, Anthony Johnson Antony Masilamani, Lakshmi Bestha, Sreenath Konanki, Muthukumaran Muthulingam, Lakshman Kumar Lingamgunta, Bindu Prasuna Aloor, Sridevi Tirumalaraju, Ankanna Sade, Venkata Ratnam Kamsala, Sreeharsha Nagaraja, Ranjani Ramakrishnan, Vijayakumar Natesan

“…The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease (p < 0.05) in body weight (380 ± 0.34), total fat (72 ± 0.8), fat percentage (17 ± 0.07) and fat free mass (165 ± 0.02). …”
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Ablation mechanisms of bulk Nb4AlC3 ceramics at 1600–2200 °C in nitrogen plasma flame by Ye Yu, Hao Zhang, Zhen Teng, Yiwang Bao, Man Jiang, Longsheng Chu, Qingguo Feng, Chunfeng Hu

“…As the ablation temperature increased from 1600 °C to 2200 °C, the linear ablation rate increased from 4.17 to 12.8 μm/s, while the mass ablation rate increased from −4.12 to 22 mg/s. …”
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Association between normal weight obesity and comorbidities and events of cardiovascular diseases among adults in South China. by Miaomiao Ma, Deliang Lv, Xiaobing Wu, Yuqing Chen, Shimiao Dai, Yutian Luo, Hui Yang, Wei Xie, Fengzhu Xie, Qinggang Shang, Ziyang Zhang, Zhiguang Zhao, Ji-Chang Zhou

“…NWO was defined as a condition with the highest tertile of body fat percentage (BF%) among the normal body mass index (BMI) range (18.5-23.9 kg/m2). Continuous data were reported as mean [standard deviation (SD)] and categorical data as percentages (%). …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…The upstream 13 miRNAs, 4 lncRNA, and 42 circRNAs were detected and used to construct a lncRNA/circRNA-miRNA-mRNA-pathway regulatory network.ConclusionThis study identified candidate genes and the regulatory networks underlying the therapeutic effects of GA on CC using GA data mining methods, thus establishing a theoretical basis for targeted therapy of CC.…”
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Geographic disparities in physical and mental health comorbidities and socioeconomic status of residence among Medicaid beneficiaries in Utah by Roberta Z. Horth, Roberta Z. Horth, Roberta Z. Horth, Srimoyee Bose, Srimoyee Bose, Carl Grafe, Carl Grafe, Navina Forsythe, Angela Dunn

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Mn-doped ZnO thin films as a platform for reagentless uric acid biosensor by Bilasini Devi Naorem, Jatinder Pal Singh, Babita Sharma, Satyam Garg, Athira C, Hashima Sherin, Mahima Momaliya, Muskan, Shubhi Sahu, Arijit Chowdhuri, Mallika Verma, Monika Tomar, Neha Batra

“…The fabricated biosensor exhibits excellent performance in terms of sensitivity (40 µAmM-1cm-2), selectivity with <5 % deviation found in presence of other known markers present in human sera, and shelf life >12 weeks, enabling precise and sensitive uric acid detection. …”
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Yoruba Epistemology, Art, Language and the Universe of Meanings: A Meta-Analysis by Michael O. Afolayan

“…The paper reminds one of the title of the memoir of Ellen DeGeneres, the famous American comedian, titled Seriously . . . I’m Kid[1]ding. Even as a non-apologist of Ellen DeGeneres, or of any other American comedian for that matter, one would find profound meaning to that title, and embrace it as very deep and philosophical. …”
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High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells by Hong Feng, Junling Gu, Fang Gou, Wei Huang, Chenlin Gao, Guo Chen, Yang Long, Xueqin Zhou, Maojun Yang, Shuang Liu, Shishi Lü, Qiaoyan Luo, Yong Xu

“…We found that the expression of thioredoxin-interacting protein (TXNIP), NLRP3, and IL-1β was observed by immunohistochemistry in vivo. Simultaneously, the mRNA and protein levels of TXNIP, NLRP3, procaspase-1, and IL-1β were significantly induced by high glucose concentration and lipopolysaccharide in a dose-dependent and time-dependent manner in vitro. …”
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