Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells by Angela P. Bastidas-Coral, Astrid D. Bakker, Behrouz Zandieh-Doulabi, Cornelis J. Kleverlaan, Nathalie Bravenboer, Tim Forouzanfar, Jenneke Klein-Nulend

“…Here, we investigated the effect of the proinflammatory cytokines TNF-α, IL-6, IL-8, and IL-17F and the anti-inflammatory cytokine IL-4 on proliferation and osteogenic differentiation of human adipose stem cells (hASCs). hASCs were treated with TNF-α, IL-6, IL-8, IL-17F, or IL-4 (10 ng/mL) for 72 h mimicking bone repair. TNF-α reduced collagen type I gene expression but increased hASC proliferation and ALP activity. …”
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MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology by Jin Wang, Jinyong Jiang, Haoliang Hu, Linxi Chen

“…They regulate processes, such as mitochondrial Ca2+ (mCa2+) uptake, mitochondrial adenosine triphosphate (ATP) production, calcium dynamics, oxidative stress (OS), and cell death. …”
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Reduction on Proinflammatory Cytokines after Application of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients with a Breast Cancer: A Nonrandomized, Open, and Single-A... by Tábata Cristina do Carmo Almeida, Simone Meneghette Zatta, Laércio da Silva Paiva, Luís Eduardo Werneck de Carvalho, Jean Schoueri, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami

“…All patients will be submitted to TENS intervention (Ibramed, Model Neurodyn III, parameters: VIF—turn on, frequency—2-247 Hz, pulse size—50-500 μs, and intensity (mA)—maximum tolerated by the patient), and the data will be analyzed in the pre- and postintervention of each patient. …”
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A Lightweight YOLO Model for Rice Panicle Detection in Fields Based on UAV Aerial Images by Zixuan Song, Songtao Ban, Dong Hu, Mengyuan Xu, Tao Yuan, Xiuguo Zheng, Huifeng Sun, Sheng Zhou, Minglu Tian, Linyi Li

“…The results demonstrate that the YOLO-Rice model achieved an object detection accuracy of 93.5% and a mean Average Precision (mAP) of 95.9%, with model parameters reduced to 32.6% of the original YOLOv8n model. …”
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D型肉毒毒素灭鼠剂对棕背雪雀危害机理的试验研究 by 李生庆, 李淑萍, 胡国元, 雷萌桐, 韩生义, 刘成录, 王林业

“…结果显示:棕背雪雀对D型肉毒毒素的敏感性介于高原鼢鼠与青海田鼠之间,LD₅₀为2.71万～3.16万MLD/kg(95%可信限为1.69万～4.88万MLD/kg); 大白鼠胃肠内容物对D型肉毒毒素的破坏强度明显高于高原鼠兔及棕背雪雀; 在基因编码区序列推导的氨基酸序列水平上,棕背雪雀体内的VAMP1氨基酸序列(GenBank No.GQ905710)与昆明系小鼠完全相同,VAMP1氨基酸序列在第48号氨基酸位点(为48M型,而非48Ⅰ型)属于D型肉毒毒素敏感型氨基酸,表明棕背雪雀对D型肉毒毒素具有一定的敏感性,在现地鼠害防治中应精准控制鼠药投放剂量,建议采取药物警戒色趋避鸟类食毒饵。…”
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A mediation analysis of meteorological factors on the association between ambient carbon monoxide and tuberculosis outpatients visits by Tianfeng He, Tianfeng He, Xujun Qian, Jing Huang, Guoxing Li, Xinbiao Guo

“…This study aims to investigate the short-term association between low-level CO exposure and PTB outpatient visits in a developing region.MethodsWe conducted a time-series study utilizing a distributed lag non-linear model (DLNM) combined with mediating effect analysis, based on daily CO and PTB cases from 2011 to 2020 in Ningbo, China.ResultsAmong all patients with PTB, a 0.1 mg/m3 increase in CO concentration was associated with an increased risk of PTB outpatient visits in the single-pollutant model, particularly at lag days 2–6. …”
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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

“…Strikingly, modulation of the mTOR/AMPK-dependent metabolic pathways and/or the MCT1 lactate transporter rescue cDC2s and cDC1s from skewing by tumor-derived glycans, Sialyl-Tn antigen and Fucose, and restore anti-tumor T-cell fitness. …”
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Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials by Yang Fang, Yang Fang, Bai Xiaoling, Li Huan, Li Huan, Guan Yaping, Zhang Binying, Wang Man, Wu Juan, Liu Xinyu

“…The mean age of the patients ranged from 33.2 to 70 years, and the average body mass index (BMI) fluctuated between 23.3 and 28.81 kg/m2. Males accounted for a relatively larger proportion of the participants. …”
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Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…As a result, dFONs made from PPDs that combine unprecedented brightness (up to 108 M-1·cm-1 and 106 GM), remarkable colloidal stability and absence of toxicity, have been elaborated, providing superior substitutes to Quantum Dots. …”
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Dual-frequency ultrasonic-assisted enzymolysis for synthesis of microstructure regulated biomass-derived porous carbon for high-performance supercapacitors by Zhaocai Teng, Kuihua Han, Meimei Wang, Jianhui Qi, Jiangwei Liu, Yingjie Li

“…Gentle and effective sonobiocatalysis facilitates microstructural regulation and composition management of the precursor, granting DUGPC an impressive specific surface area (SSA, 3006 m2/g), improved pore distribution, low metal impurity content (less than 100 ppm) and high wettability. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Also, VWF and ITGB2 were significantly related to the clinical features, including age, serum creatinine level, and GFR (MDRD). Besides, mRNA and protein expression levels of ITGB2 in HG-treated HK-2 cells were remarkably elevated. …”
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Deer Browsing Increases Stem Slenderness and Crown Irregularity and Modifies the Effects of Light Gradients on Architecture of Forest Tree Saplings by Cecilia Cacciatori, Anna Gazda, Jan Bodziarczyk, Kacper Foremnik, Aklilu B. Madalcho, Zbigniew Maciejewski, Remigiusz Pielech, Andrzej Tomski, Antoni Zięba, Tomasz Zwijacz‐Kozica, Jerzy Szwagrzyk

“…BI was weakly but negatively correlated with sapling height, indicating that even tall saplings (> 2 m) experience browsing, particularly in the lower crown. …”
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New acorane-sesequiterpenes and anti-retinoblastoma constituents from the marine algicolous fungus Trichoderma harzianum NTU2180 guided by molecular networking strategy by Andrea Gu, Fan-Li Lin, Chung-Kuang Lu, Tz-Wei Yeh, Yih-Fung Chen, Ho-Cheng Wu, Tzong-Huei Lee

“…In addition, compound 11 displayed cytotoxicity against Y79 retinoblastoma cells with IC50 value of 35.3 ± 6.9 µM. Conclusions The current study utilizes FBMN concept with OSMAC approach to accelerate the exploration of potential metabolites of the fungus Trichoderma harzianum NTU2180. …”
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Distribution Characteristics and Coupling Relationship Between Soil Erosion and Hydrologic and Sediment Connectivity in Changchong River Basin by LI Jianing, ZHANG Hongli, TIAN Changyuan, ZHANG Yi, ZHA Tonggang

“…Among the hydrological and sediment connectivity grades, the proportion of 5° ~ 10° and 10° ~ 15° slope, 90.30 ~ 131.96 and 131.96 ~ 175.34 m elevation area is higher. The higher the grade, the higher the proportion of sunny slope area is. (4) Soil erosion has a significant positive correlation with hydrologic and sediment connectivity, mainly reflected in slope, slope direction, land use and elevation. …”
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PDMS microspheres as rheological additives for PDMS-based DIW inks by Utkarsh Ramesh, Jonathan Miller, Bryce Stottelmire, James Beach, Steven Patterson, Laura Cumming, Sabrina Wells Torres, Dakota Even, Petar Dvornic, Cory Berkland

“…We utilize a facile oil-in-water emulsion method to reproducibly obtain small (∼5 μm) PDMS microspheres, which are then incorporated into PDMS-based inks. …”
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Selective suppression of influenza A/H5N1 virus replication <i>in vitro</i> using nanocomplexes consisting of siRNA and aminopropylsilanol nanoparticles by Marina N. Repkova, Asya S. Levina, Oleg Yu. Mazurkov, Elena V. Makarevich, Ekaterina I. Filippova, Natalya A. Mazurkova, Valentina F. Zarytova

“…The most effective nanocomplex that contained siRNA targeted at the chosen region of mRNA segment 5 of the viral genome reduced virus replication in the culture by a factor of 630. …”
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FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer by Shun Zhang, Dongyi Yan, Qi Sun, Tao Du, Dongliang Cao, Yao Yang, Biao Yuan, Haiqiang Li, Xiaohua Jiang, Chun Song

“…Patients aged 18–75 years with gastric adenocarcinoma (stage cT3–4 and/or N + M0) underwent neoadjuvant FLOT therapy (four preoperative and four postoperative 2-week cycles) at Shanghai East Hospital. …”
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Ações de prevenção e controle de diabetes na atenção primária no Amazonas by Elisa Brosina de Leon, Lucas Santos Fernandes, Hércules Lázaro Morais Campos, Fabio Araujo Almeida

“…Estratégias adotadas em ações de PM foram descritas pelas 5 dimensões: (R) Alcance, (E) Efetividade, (A) Adoção, (I) Implementação e (M) Manutenção. Dados foram coletados em Unidades Básicas de Saúde em 6 cidades do Amazonas, Brasil. …”
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Livogrit mitigates ANIT-induced cholestasis-like symptoms in an in vivo model by curbing hepatic inflammation and regulating BAX, TGF-β, MMP-9 and α-SMA gene expression by Acharya Balkrishna, Ritu Paliwal, Surjeet Singh, Rani Singh, Vivek Gohel, Rishabh Dev, Kunal Bhattacharya, Sandeep Sinha, Anurag Varshney

“…At molecular level, Livogrit inhibited up-regulation of BAX, TGF-β, α-SMA, and MMP-9 mRNA expressions, associated with the liver damages. …”
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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis by Xiang F, Zhang Z, Nie Y, Cao X, Li Y, Chen X, Gong S, Zou J, Teng J, Ding X, Shen B

“…Animal models demonstrated reduced CD73 mRNA transcript and adenosine receptor levels, along with decreased serum adenosine levels in CKD. …”
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