Striatal-cortical dysconnectivity underlies somatosensory deficits in Parkinson's disease: Insights from rhythmic auditory-motor training by Cheng-Wei Huang, Hsin-Yun Tsai, Yi-Hsuan Lin, Wen-Wei Lin, Chin-Hsien Lin, Ming-Tsung Tseng

Get full text

Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival by Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng, Wei Huang

“…Overexpression of HDAC11 and the use of the autophagy activator rapamycin further validated that the HDAC11/IL10 axis regulates mitophagy via the mTOR pathway, which is essential for supporting S. aureus intracellular survival. …”
Get full text

ＥＮＨ 蛋白与病理性疼痛相关性研究

“…ＥＮＨ与正常对照组相比，ＳＮＩ组术后手术侧痛敏、ＥＮＨ蛋白及ｍＲＮＡ有一过性增高继而恢复正常，并随时间推移而逐渐再次增高（ｎ＝ ５／组）。【结论】 ＥＮＨ蛋白在大鼠慢性病理性疼痛模型中有表达，且其改变与痛敏的进程一致。…”
Get full text

Development of Safe and Non-Self-Immunogenic Mucosal Adjuvant by Recombinant Fusion of Cholera Toxin A1 Subunit with Protein Transduction Domain by Byoung-Shik Shim, In Su Cheon, Eugene Lee, Sung-Moo Park, Youngjoo Choi, Dae-Im Jung, Eunji Yang, Jung-ah Choi, June Young Chun, Jae-Ouk Kim, Cheol-Heui Yun, Cecil Czerkinsky, Man Ki Song

“…In addition, coadministration of influenza M2 protein with TCTA1T conferred near complete protection against lethal influenza virus challenge. …”
Get full text

经食道-胸壁电刺激建立兔心脏骤停模型

“…方法：经食道插入食道调搏电极至心脏水平，在心前区心搏最明显处皮下插入针灸针形成电流回路，用恒定35mA交流电诱发心脏骤停，无干预观察5min后进行心肺复苏。分别记录15只新西兰大白兔达到心脏骤停标准的时间、停止刺激时的心律、复苏开始前的心律、心肺复苏时间、除颤次数、给药次数、自主循环恢复率、自主循环恢复后机械通气时间、自主循环恢复后生存时间及72h生存率。…”
Get full text

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study by Wenhao Cheng, Yinghui Li, Wei Yang, Siyang Wu, Mengmeng Wei, Yang Gao, Chen Kang, Shuofeng Zhang, Yingfei Li

“…The lower limit of quantitation of the analytes was 0.1–1 ng/mL. The intrabatch and interbatch accuracies were 87.1–109%, and the precision was within the acceptable limits. …”
Get full text

Sleep-Aiding Effect of Casein-Derived Peptide TPTLN and Its Underlying Mechanism by DENG Shijie, LIU Ling, HUANG Ju, FENG Fengqin, ZHAO Minjie, DU Juan

“…Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of 5-hydroxytryptamine (5-HT), γ-aminobutyric acid (GABA), 5-hydroxyindoleacetic acid (5-HIAA), glutamate (Glu), β-endorphin (β-EP), cortisol, norepinephrine (NE) in the serum and brain tissue, and the GABA/Glu ratio was evaluated. real-time quantitative polymerase chain reaction (qPCR) was used to detect the effect of TPTLN on the mRNA relative expression levels of γ-aminobutyric acid A receptor α1 (GABAA-α1) and 5-hydroxytryptamine receptor 1A (5-HT1A) in the hypothalamus. …”
Get full text

Effects of helium irradiation damage on deuterium plasma-driven permeation through tungsten coated RAFM steel by Yue Xu, Xiao-Ping Tian, Hong-Yan Tan, Hai-Ying Fu, Jun-Jie Ni, Lai-Ma Luo, Yu-Cheng Wu

“…After He irradiation with a fluence of 6.0 × 10 ^24 He m ^−2 , the D-PDP flux was found to decrease with increasing incident ion energy despite the fact that the sample temperature was gradually increasing. …”
Get full text

Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators by Tong Lin, Shanshan Huang, Fen Zhou, Xingkai Shen, Haiyan Mao

“…RCS analysis showed a nonlinear protective effect of vitamin D, with risk stabilizing at levels above 50 nmol/mL. Mediation analysis highlighted bilirubin as a positive mediator (ACME = −4.11 × 10−5, p < 0.001), while TyG demonstrated a suppressive mediation effect (ACME = 2.68 × 10−5, p < 0.001). …”
Get full text

A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…For this study, we first found the PPAR pathway-related genes on the gene set enrichment analysis (GSEA) website and found the KIRC mRNA expression data and clinical data through TCGA database. …”
Get full text

Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study by Shuhei Suzuki, Hiromitsu Negoro, Masashi Kubota, Takayuki Sumiyoshi, Ryoichi Saito, Tomoya Okuno, Takehiko Segawa, Shigeki Fukuzawa, Hiroyuki Onishi, Kodai Hattahara, Kanji Nagahama, Yuya Sekine, Ryoma Kurahashi, Kimihiro Shimatani, Atsuro Sawada, Shusuke Akamatsu, Hiroyuki Nishiyama, Takayuki Goto, Takashi Kobayashi

“…A database search identified patients who underwent RARP for pT2-3N0M0 disease at any of 25 centers between 2011 and 2022, categorized into aspirin (n = 350) and control groups (n = 5857). …”
Get full text

Evaluation of throwing ability after coracoid transfer in non-overhead athletes by Ryota Yokoi, DP, Takayuki Kawasaki, MD, PhD, Yuuki Hirai, DP, Hiroki Tanabe, MD, Tomohiko Tateishi, MD, PhD, Nobukazu Maki, DP, Daichi Morikawa, MD, PhD, Muneaki Ishijima, MD, PhD

“…Results: In the primary analysis, mean maximum ball velocity and long-throw distance in the BL and C groups were 83.5 and 87.9 km/h versus 44.8 and 54.7 m, respectively, demonstrating no significant differences between the groups. …”
Get full text

Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 He... by S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart

“…The pharmacokinetics of one intranasal puff of fentanyl formulation (47 μg, 140 mL per puff), one short intravenous infusion of 50 μg fentanyl, and one lozenge with an integrated applicator (200 μg fentanyl) were studied, and bioavailability was calculated. …”
Get full text

MiRNA-138抑制JNK/p38MAPK通路保护新生大鼠心肌细胞凋亡 by 郭伟伟, 张晓鹏, 李霞, 刘平洋

“…采用qRT-PCR检测全血和心肌组织中miRNA-138、Bcl2及Bax mRNA的表达，电生理记录仪检测大鼠血流动力学指标水平，HE染色观察大鼠心肌组织病理损伤，免疫组法化检测心肌组织中Casapse-3的表达，TUNEL染色观察大鼠心肌组织细胞的凋亡情况，ELISA法检测心肌组织活性氧（ROS）的含量，Western blotting检测JNK/p38MAPK通路蛋白的表达。…”
Get full text

Actividad física en la población urbana costarricense y su relación con patrones sociodemográficos y antropométricos by Georgina Gómez, Elvira Salas Hidalgo, Amed Sheik Oreamuno, Gerson Ferrari de Morais

“…La circunferencia de cintura fue significativamente menor entre las personas activas (90.6 vs 94.1 cm, p < .011) y, los hombres activos también mostraron una menor circunferencia de cuello (38.2 vs 39.6 cm, p < .001), menor peso (75.7 vs 79.3 kg, p = .025) y menor índice de masa corporal (26.1 vs 27.9 kg/m2, p = .004). Estos resultados podrían usarse para concientizar sobre la necesidad de mejoras en la implementación de políticas y prácticas globales que promuevan la actividad física.…”
Get full text

珠三角地区变应性鼻炎和/或支气管哮喘患者皮下特异性免疫治疗依从性的真实世界研究 by 江育蔺, 王心悦, 唐隽, 鲍燕敏, 王桂兰, 白珺, 廖振鹏, 黎雅婷

“…结果纳入1 244例接受SCIT的患者，中止治疗427例（脱落率为34.3%）；儿童、已婚、过敏家族史阳性、总IgE （tIgE）&gt;200 U/mL的患者表现出相对良好的SCIT依从性（<italic>P</italic>值均&lt;0.05），而单纯AR患者依从性较AR合并BA组低（<italic>P</italic>&lt;0.05），治疗前症状评分和药物评分高的患者脱落率低（<italic>P</italic>值均&lt;0.001）。…”
Get full text

Effect of Forest Management Types on Soil Carbon Stocks in Montane Forests: A Case Study of Eastern Mau Forest in Kenya by George K. Tarus, Stanley W. Nadir

“…A nested experimental design was used in data collection, where thirty-two sample plots were nested into four blocks each measuring 100 m2 delineated by forest management types (disturbed by fire, natural forest, undisturbed natural forest, plantation, and glades). …”
Get full text

Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro by Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang

“…In addition, naringenin (25−75 µg/mL) decrease TG and TC levels in 3T3 mature adipocytes. …”
Get full text

miRNA Expression Profile and Effect of Wenxin Granule in Rats with Ligation-Induced Myocardial Infarction by Aiming Wu, Lixia Lou, Jianying Zhai, Dongmei Zhang, Limin Chai, Bo Nie, Haiyan Zhu, Yonghong Gao, Hongcai Shang, Mingjing Zhao

“…And, WXKL increased the expressions of miR-1 and miR-133, while also increased the mRNA levels of Cx43 and Cx45, and, especially, recovered the Cx43/Cx45 ratio near to normal level. …”
Get full text

Contribution of dust emissions from farmland to particulate matter concentrations in North China Plain: Integration of WRF-Chem and WEPS model by Haopeng Zhang, Feng Wang, Shenghui Zhou, Tianning Zhang, Minghui Qi, Hongquan Song

“…Wind erosion from farmland is a significant contributor to atmospheric particulate matter, particularly PM10 (atmospheric particulate matter with an aerodynamic diameter ≤ 10 μm), in regions with intensive agricultural activities such as the North China Plain (NCP). …”
Get full text