Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5 by You Ning, Jianhua Huang, Bill Kalionis, Qin Bian, Jingcheng Dong, Junzhen Wu, Xiantao Tai, Shijin Xia, Ziyin Shen

“…We found OA significantly inhibited neurosphere formation in a dose-dependent manner and achieved a maximum effect at 10 nM. OA also reduced 5-ethynyl-2′-deoxyuridine (EdU) incorporation into NSCs, which was indicative of inhibited NSC proliferation. …”
Get full text

De l’observation des écroulements aux solutions opérationnelles : près de deux décennies d’études sur les risques cryo-gravitaires dans le massif du Mont-Blanc by Florence Magnin, Ludovic Ravanel, Matan Ben-Asher, Josué Bock, Maëva Cathala, Pierre-Allain Duvillard, Pierrick Jean, Jean-Yves Josnin, Suvrat Kaushik, André Revil, Philip Deline

“…L’augmentation de la fréquence des écroulements rocheux (V > 100 m3), d’abord observée dans les Alpes européennes depuis les années 2000, a impulsé des études sur les parois de haute altitude et le permafrost de paroi. …”
Get full text

The association between ambient air pollution and the risk of incident nasopharyngeal carcinoma in Hangzhou, China by Zesheng Chen, Zongxue Cheng, Yaoyao Wu, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu

“…We discovered that the risk of incident NPC was increased by 0.75% (95% CI: 0.01–1.58), 0.36% (95% CI: 0.03–0.69), and 0.14% (95% CI: 0.01–0.28) for every 1 μg/m3 increase in the concentration of SO2, NO2, and PM10, respectively. …”
Get full text

Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy by Francesca Lombardi, Simone Belmonti, Alessia Sanfilippo, Alberto Borghetti, Valentina Iannone, Pierluigi Francesco Salvo, Massimiliano Fabbiani, Elena Visconti, Simona Di Giambenedetto

“…Results We enrolled 299 experienced PLWH with virological suppression (HIV-RNA < 50cps/mL). The mean of the d-ROMs levels was 409 UCARR (95%CI 394–422), whereas the mean of the BAP levels was 1.809 µmol/L (95%CI 1706–1851). …”
Get full text

General medical comorbidities in psychotic disorders in the Finnish SUPER study by Johan Ahti, Tuula Kieseppä, Willehard Haaki, Jaana Suvisaari, Solja Niemelä, Kimmo Suokas, Minna Holm, Asko Wegelius, Olli Kampman, Markku Lähteenvuo, Tiina Paunio, Jari Tiihonen, Jarmo Hietala, Erkki Isometsä

“…Regardless of diagnostic category, participants had high BMI (average 30.3 kg/m2), and current smoking was common (42.4%). Diabetes and COPD were more common in SZ than in other diagnostic categories. …”
Get full text

Integration of machine learning and experimental validation to identify the prognostic signature related to diverse programmed cell deaths in breast cancer by Longpeng Li, Longpeng Li, Jinfeng Zhao, Yaxin Wang, Zhibin Zhang, Wanquan Chen, Jirui Wang, Yue Cai

“…Clofibrate and imatinib could serve as potential small-molecule complexes targeting SLC7A5 and BCL2A1, respectively. The mRNA expression levels of seven genes were upregulated in clinical cancer tissues.ConclusionPCDRS can be used as a biomarker to assess the prognosis and treatment response of BRCA patients, which offers novel insights for prognostic monitoring and treatment personalization of BRCA patients.…”
Get full text

Exosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury by Xutong Li, Ye Zhang, Yong Wang, Dan Zhao, Chengcheng Sun, Shaoting Zhou, Dongsheng Xu, Jing Zhao

“…Compared with the control groups, the ExoCXCR4 group showed a significantly lower mNSS score at 7 d, 14 d, and 21 d after ischemia/reperfusion (P<0.05). …”
Get full text

River-groundwater transformation and ecological effects in the Tuwei River watershed by Jinxuan WANG, Yi WANG, Fan GAO, Xuanming ZHANG, Zhitong MA, Fan YANG

“…Maintaining hydrological connectivity, enhancing the intensity of three-water transformation, and ensuring the groundwater level in the desert area within the range of 1.5～5 m are crucial to the health of the ecosystem in the area. …”
Get full text

USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer by Zhongdong Xie, Hanbin Lin, Yuecheng Wu, Yanan Yu, Xintong Liu, Yating Zheng, Xiaojie Wang, Jiashu Wu, Meifang Xu, Yuting Han, Qiongying Zhang, Yu Deng, Lin Lin, Yan Linzhu, Li Qingyun, Xinjian Lin, Ying Huang, Pan Chi

“…Examination of clinical samples confirmed that USP4 expression positively correlates with CENPF protein expression, but not mRNA transcript levels. Taken together, this study describes a novel USP4-CENPF signaling axis which is crucial for CRC metastasis, potentially serving as a therapeutic target and a promising prognostic biomarker for CRC.…”
Get full text

Feasibility analysis of non-electrocardiogram-triggered chest low-dose computed tomography using a kV-independent reconstruction algorithm for predicting cardiovascular disease ris... by Xiangming Wang, Ao Liu, Yan Zhao, Xianbo Yu, Yushuo Cao, Min Li, Jing Liu, Yu Du, Li Yang

“…The effective radiation doses of standard CACS and non-ECG-triggered chest LDCT scannings were 1.34 ± 0.74 and 1.04 ± 0.35 mSv, respectively. Conclusions The non-ECG-triggered, automated tube voltage selection, high-pitch chest LDCT protocol with a kV-independent reconstruction algorithm can obtain chest scans and ASs simultaneously and significantly reduce patients’ radiation exposure.…”
Get full text

Determination of antibiotics in bean sprouts by UHPLC-MS/ MS-internal standard method by ZHANG Xiaoyi, ZHENG Sanyan, ZHANG Xiuyao, LI Ruifen, YANG Shuran

“…ObjectiveTo establish an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-internal standard method for the simultaneous determination of 59 antibiotics, including quinolones, sulfonamides, tetracyclines, macrolides and nitroimidazole in bean sprouts.MethodsThe internal standard compounds and 5.0 mL of acetonitrile containing 0.1% formic acid were added into 5.0 g of the sample, and then extracted by ultrasonication. …”
Get full text

Evaluation of Machine Learning Models for Stress Symptom Classification of Cucumber Seedlings Grown in a Controlled Environment by Kyu-Ho Lee, Samsuzzaman, Md Nasim Reza, Sumaiya Islam, Shahriar Ahmed, Yeon Jin Cho, Dong Hee Noh, Sun-Ok Chung

“…In a controlled plant factory setup, two-week-old cucumber seedlings were subjected to varied environmental conditions across five chambers with differing temperatures (15, 20, 25, and 30 °C), light intensities (50, 250, and 450 µmol m⁻² s⁻¹), and day-night cycles (8/16, 10/14, and 16/8 h). …”
Get full text

Meta-analysis to evaluate the comparative effectiveness of enzalutamide and abiraterone acetate for first-line treatment of metastatic castration-resistant prostate cancer in real-... by Armen Aprikian, Amit Bahl, Aurelius Omlin, Giulia Baciarello, Abhiroop Chakravarty, Prashanth Kondaparthi, Georgia Gourgioti, Thomas McLean, Alexis Serikoff, Andrew Chilelli

“…IntroductionAndrogen-receptor pathway inhibitors such as abiraterone and enzalutamide have demonstrated clinical benefit in patients with metastatic castration-resistant prostate cancer (mCRPC). The aim of this study was to conduct a meta-analysis of published real-world evidence studies comparing outcomes among patients treated with enzalutamide or abiraterone in the first-line setting.MethodsWe conducted a systematic literature review to identify eligible studies. …”
Get full text

Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies by Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Viktor Sinkunas, Cristiano Jesus Correia, Raphael dos Santos Coutinho e Silva, Fernando Luiz Zanoni, Vera Demarchi Aiello, Martin Conrad Harmsen, Luiz Felipe Pinho Moreira

“…The volume of intrapericardial injection was 2 ml/kg, the ASC density was 20 million/mL, while the hydrogel contained 100-fold concentrated CMed. …”
Get full text

Wind and rainfall erosion energy in large sediment generating and coarse sediment class areas of the middle Yellow river by Tao Yang, Jianzhi Niu, Dengxing Fan, Di Wang, Yubo Miao, Miao Wang, Chunguang Zhao, Linus Zhang, Xiongwen Chen, Ronny Berndtsson

Get full text

Effectiveness of multimethod, community-based educational interventions on the knowledge and attitude to birth preparedness and complications readiness among women in southwest Nig... by Bosede B Afolabi, Ifeoma P Okafor, Mobolanle R Balogun, Adekemi O Sekoni, Duro C Dolapo, Claudia A Hawkins

“…Intervention was delivered using multiple educational methods: health education sessions, information, education, and communication materials, and mHealth. A total of 2600 women were recruited by multistage sampling. …”
Get full text

Manifestações Patológicas em Sistemas Construtivos de Paredes de Concreto – Estudo de Caso em Obras de Interesse Social by Felipe Dias de Abreu Coutinho, Laísa do Rosário Souza Carneiro, Janaíne Conceição Santos, Flávia Spitale Jacques Poggiali

“…É importante ater-se às seguintes recomendações: dosagem adequada do concreto usinado, garantia do bom funcionamento da bomba lança, concretagem integral de uma parede antes de prosseguir para a concretagem de outros elementos e posicionamento do mangote a uma altura inferior a 2m durante a concretagem. Destaca-se, ainda, o posicionamento adequado da armadura de reforço nos cantos das janelas e portas e a preparação do substrato para aplicação de revestimento cerâmico, a partir da lavagem com detergente e escova de aço. …”
Get full text

Response to Statin Therapy in Obstructive Sleep Apnea Syndrome: A Multicenter Randomized Controlled Trial by Marie Joyeux-Faure, Renaud Tamisier, Jean-Philippe Baguet, Sonia Dias-Domingos, Stephen Perrig, Georges Leftheriotis, Jean-Paul Janssens, Wojciech Trzepizur, Sandrine H. Launois, Françoise Stanke-Labesque, Patrick A. Lévy, Frédéric Gagnadoux, Jean-Louis Pepin

“…Key demographics for the study population were age 54 ± 11 years, 21.6% female, and BMI 28.5 ± 4.5 kg/m2. In intention to treat analysis, mean PAT difference between atorvastatin and placebo groups was 0.008 (−0.29; 0.28), P=0.979. …”
Get full text

Long noncoding RNA Gm4419 promotes mesangial cell proliferation and extracellular matrix accumulation via the miR-455-3p/histone deacetylase 2 axis by Yang Wen, Hua Gan, Qing Zhong, Ying Gong

“…In this study, a potential diabetic nephropathy-related long noncoding-microRNA-mRNA axis, Gm4419-miR-455-3p-Hdac2, was predicted using bioinformatics methods. …”
Get full text

RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…Our findings show elevated levels of RIPK1 mRNA levels across various forms of tauopathies, in both mouse models and human tissue samples associated with primary and secondary TAU-related disorders. …”
Get full text