Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis by Yunzhi Xu, Qi Zhu, Jinglve Song, Hongli Liu, Yutong Miao, Fan Yang, Feiyan Wang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He, Guangjie Chen

“…Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay. mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR. …”
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Long-term results of treatment of right-sided colon cancer with mesocolic excision and D3-lymph node dissection by S. K. Efetov, I. A. Tulina, A. Yu. Kravchenko, D. N. Fedorov, S. V. Efetov, P. V. Tsarkov

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The adaptation process of a safety planning intervention to promote connectedness and reduce distress in Diné adolescents and adults during the COVID-19 pandemic by Joshuaa Dominic Allison-Burbank, Vanessa Begaye, Kyann Dedman-Cisco, Lisa Jim, Shannon Archuleta, Renae Begay, Lacey Howe, Emily E. Haroz

“…By using an Indigenous approach that restores connectedness, and reminds participants of their belonging, +CiM researchers were able to develop enhanced versions of safety plans to use in their pilot randomized controlled trial.…”
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Myxedema Psychosis: Neuropsychiatric Manifestations and Rhabdomyolysis Unmasking Hypothyroidism by Sundus Sardar, Mhd-Baraa Habib, Aseel Sukik, Bashar Tanous, Sara Mohamed, Raad Tahtouh, Abdelrahman Hamad, Mouhand F. H. Mohamed

“…Additional investigations revealed a high thyroid-stimulating hormone (TSH) of 56.6 mIU/L, low free T4<0.5 pmol/L, elevated creatine kinase of 3601 U/L, and urine dipstick positive for blood, suggestive of myoglobinuria. …”
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New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease by Ting Fang, Qiaoyan Liu, Xinxin Huangfu, Hongkai Zhu, Hongwen Sun, Liming Chen

“…The study also detected mRNA expression of core targets molecularly docked with TPHP and DPHP using real-time-PCR. …”
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High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing by Yuqiao Zheng, Jiacheng Sun, Yaqing Ma, Hongyong Zhang, Zhen Cui, Giannis G. Paschos, Xixi Song, Ying Tao, Pavlos Savvidis, Wei Kong, Liaoyong Wen, Sumin Bian, Mohamad Sawan

“…Moreover, the metacavity biosensor achieves high surface sensitivity, together with a detection‐limit of 119 viral copies mL−1 for label‐free severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pseudovirus sensing, revealing remarkable performance in both bulk and surface sensing.…”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Furthermore, it increased phosphatase and tensin homolog (PTEN) expression and inactivated the serine/threonine kinase (AKT)/mechanistic target of the rapamycin kinase (mTOR) signaling pathway. Interference with forkhead box O1 (FOXO1) inhibited MAF1 expression and activated the RIG-I/IRF3 signaling pathway, while MAF1 overexpression promoted PTEN expression, decreased cell apoptosis, and normalized autophagy. …”
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Dietary insulin load and index in relation to incident gestational diabetes mellitus: a prospective cohort study by Azadeh Aminianfar, Hamid Zolfaghari, Sanaz Soltani, Hossein Hajianfar, Leila Azadbakht, Zahra Shahshahan, Ahmad Esmaillzadeh

“…Mean ± SD of age and BMI of study participants was 29.4 ± 4.84 y and 25.14 ± 4.08 kg/m2, respectively at study baseline. Mean ± SD of DIL was 80,629 ± 29,328 and mean ± SD of DII was 40.23 ± 4.93. …”
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Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts by Rhowell Navarro Tiozon, Rhowell Navarro Tiozon, Erstelle Pasion-Uy, Saleh Alseekh, Saleh Alseekh, Kristel June D. Sartagoda, Shem Gempesaw, Joel H. G. Tolentino, Alisdair R. Fernie, Alisdair R. Fernie, Nese Sreenivasulu

“…This superior MTA combination exhibited potent inhibitory activity against HCT116 and A549 cell lines, with average 1/IC50 values of 0.03 and 0.02 (mL/μg), respectively, compared to the inferior MTAs.DiscussionCollectively, our findings demonstrate that MTAs linked to selected GDSL esterase/lipase (GELP) genes, OsACP1, and lecithin-cholesterol acyltransferase significantly enhance antioxidant and anti-cancer properties, potentially through the mobilization of unsaturated lipids and carotenoids during germination. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…The renal tissue SGLT2 mRNA amounts and the number of renal proximal tubules with overexpressed SGLT2 in the lumen were more in the Fn-LPS-administered-diabetic mice than in diabetic mice. …”
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Temporal Trends in the Utilization and Survival Outcomes of Lobar, Segmental, and Wedge Resection for Early-Stage NSCLC, 2004 to 2020 by Eden Z. Deng, BS, Xiaofei Wang, PhD, Jianrong Zhang, MD, MPH, Thomas E. Stinchcombe, MD, Chi-Fu (Jeffrey) Yang, MD, Nasser Altorki, MD

“…Methods: To examine the trends over time in the utilization, quality, and overall survival (OS) differences of lobectomy, segmentectomy, and wedge resection, we performed an observational, population-level study of 76,466 patients with T1 or T2 N0M0 NSCLC tumors 2 cm or less in size in the National Cancer Database, from 2004 to 2020. …”
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酪氨酸羟化酶缺乏症导致多巴反应性肌张力不全患儿临床及遗传特点 by 朱海霞, 李小晶, 梁惠慈, 吴汶霖, 侯池, 陈连凤, 田杨, 陈文雄

“…<italic>TH</italic>基因共检测到7个突变，包括5个已知突变c.698G&gt;A（p.R233H）、c.1145T&gt;C（p.I382T）、c.739G&gt;A（p.G247S）、c.1481C&gt;T（p.T494M）、c.880G&gt;C（p.G294R），以及2个新突变： c.1279A＞G（p.Y427H）和 c.1128_1138del（p.Q377GfsTer12）。…”
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Identification of Candidate Genes for Green Rind Color in Watermelon by Wei Zhou, Licong Yi, Yunqiang Wang, Hongsheng Wang, Qingke Li, Na Wu, Zhaoyi Dai

“…In this study, a mapping population of 505 F₂ plants, derived from a cross between green (CG058) and light-green (CG265) rinds, along with a high-density genetic linkage (average 0.9 cM distance between bin markers), was used to map and identify possible candidate genes. …”
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Concordancia de la clasificación VI-RAD S® y la patología en espécimen de cistectomía en un centro oncológico colombiano by Estefanía Celis-Reyes, Juan C. Londoño-Cano, Andrés Gómez-Hoyos, David Ruiz, Rodolfo Varela, Efraín Betancourt-López

“…Objetivo: El objetivo principal de este estudio es evaluar la concordancia del reporte de la clasificaci&oacute;n Vesical Imaging-Reporting and Data System (VI-RADS&reg;) en resonancia magn&eacute;tica (RM) y el reporte de patolog&iacute;a del esp&eacute;cimen de cistectom&iacute;a y definir si este estudio puede considerarse un est&aacute;ndar en el proceso de estadificaci&oacute;n en el paciente con diagn&oacute;stico cl&iacute;nico de c&aacute;ncer de vejiga. M&eacute;todo: Estudio anal&iacute;tico retrospectivo de corte transversal, se incluyeron 34 pacientes llevados a cistectom&iacute;a radical o parcial a quienes se realiz&oacute; RM multiparam&eacute;trica prequir&uacute;rgica y se realiz&oacute; un estudio de concordancia entre la clasificaci&oacute;n VI-RADS&reg; y el resultado de patolog&iacute;a. …”
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Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscl... by Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade de Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto

“…The athletes presented an average of body fat (8.6 ± 2.0%), maximal oxygen consumption (53.3 ± 2.4 mL. (kg.min)-1), 2km row time (07:00 ± 00:21 mm:ss), 1-Repetition maximum in power clean (125.2 ± 21.2 kg) and Tibana test performance (281.0 ± 35.9 repetitions). …”
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Exploring the taste presentation and receptor perception mechanism of salty peptides from Stropharia rugosoannulata based on molecular dynamics and thermodynamics simulation by Wen Li, Shuai Sun, Wanchao Chen, Haile Ma, Tingzhao Li, Zhong Zhang, Di Wu, Mengqiu Yan, Yan Yang

“…The taste intensity of the salty peptide positively correlates with its concentration within a specific concentration range (0.25–1.0 mg/mL). The receptor more easily recognizes the first amino acid residue at the N-terminal of salty peptides and the aspartic acid residue in the peptides. …”
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Characterization of Avocado (<i>Persea americana</i> Mill) Seed Extract from the Variety Semil 34 Cultivated in the Dominican Republic by Ramon Sanchez-Rosario, Luis Castillo, Alejandra Féliz-Jiménez, Sebastián Vargas, Ramón Pérez-Romero, Mónica Aquino, Maha T. Abutokaikah

“…The hydroalcoholic extract of the Semil 34 seeds exhibited an antioxidant capacity of 1743.3 ± 52.3 µM Trolox/g extract, total phenolic content of 25.86 ± 2.17 mg gallic acid equivalents/g extract, and total flavonoid content of 2.09 ± 0.10 mg quercetin equivalents/g extract. …”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

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Remote-sensing detectability of airborne Arctic dust by N. T. O'Neill, K. Ranjbar, L. Ivănescu, Y. Blanchard, S. A. Sayedain, Y. AboEl-Fetouh

“…While there is little dispute about the presence of both Asian and local dust across the Arctic, the direct RS detectability of airborne dust, as ascribed to satellite (MODIS and AVHRR) measurements of significantly negative brightness temperature differences at 11 and 12 <span class="inline-formula">µ</span>m (BTD<span class="inline-formula">_11–12)</span>, has been misrepresented in certain cases. …”
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Transplant oncology and anti-cancer immunosuppressants by Dejun Kong, Jinliang Duan, Shaofeng Chen, Zhenglu Wang, Zhenglu Wang, Jiashu Ren, Jianing Lu, Tao Chen, Zhuolun Song, Di Wu, Yuan Chang, Zhongqian Yin, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen, Hong Zheng, Hong Zheng, Hong Zheng, Hong Zheng

“…Therefore, it is of substantial clinical significance to develop immunosuppressants that possess both immunosuppressive and anti-tumor properties. For instance, mTOR inhibitors demonstrate anti-tumor effects among antimetabolite immunosuppressive drugs, and recent studies indicate that capecitabine, an antimetabolite chemotherapeutic, may also exhibit immunosuppressive activity in the clinic for liver transplants suffering from hepatocellular carcinoma. …”
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