Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC by Chenxuan Li, En-di Zhang, Rui Yu, Bo Yuan, Yunxin Yang, Zhong Zeng, Hanfei Huang

“…Methods: Explored CDC6 mRNA and protein expression in normal human tissues and tumors using TCGA, GTEx, and HPA. …”
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MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis by Junwei Zou, Xiuhua Shi, Zhaoying Wu, Siyuan Zuo, Xiaolei Tang, Hailang Zhou, Yong Huang

“…LINC02159 expression is regulated by METTL14, with METTL14 knockdown decreasing m6A methylation of LINC02159, leading to its increased expression in CRC cells. …”
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Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis by Zikun Huang, Qing Luo, Cuifen Xiong, Haiyan Zhu, Chao Yu, Jianqing Xu, Yiping Peng, Junming Li, Aiping Le

“…Levels of tsRNA-Gly-CCC-2, tsRNA-Gly-GCC-1, and tsRNA-Lys-CTT-2-M2 were significantly elevated in the serum of TB patients compared to non-TB individuals, showing a correlation with lung injury severity and acid-fast bacilli grades in TB patients. …”
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Synergistic evolution of dual-precipitation and reverted austenite on mechanical properties in 2.4 GPa ultrahigh strength steel by Aijun Li, Yangxin Wang, Xinyu Jin, Jiaxin Liu, Chundong Hu, Han Dong

“…Furthermore, NiAl not only precipitates uniformly in the matrix of martensite but also facilitates the highly uniform distribution of M2C in the matrix. The growth of reverted austenite at boundaries of martensite reduces the amount of precipitations at the same position. …”
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Successful Treatment of Myeloid Sarcoma in an Elderly Patient with Myelodysplastic Syndrome with Reduced-Dose Azacitidine by Kazuya Sato, Nodoka Tsukada, Junki Inamura, Shigetsuna Komatsu, Keisuke Sato, Masayo Yamamoto, Motohiro Shindo, Kentaro Moriichi, Yusuke Mizukami, Mikihiro Fujiya, Yoshihiro Torimoto, Toshikatsu Okumura

“…Monotherapy with reduced-dose AZA (37.5 mg/m2 for 7 days, every 4–6 weeks) was restarted, and the MS quickly disappeared. …”
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一种简易的促排卵周期挽救性卵子体外成熟培养技术

“…【目的】 探讨人类成熟卵丘细胞在未成熟卵母细胞体外成熟培养中的作用,并建立一种简易的实施技术65377;【方法】 在控制性促排卵周期有未成熟卵母细胞时,将同周期成熟卵丘复合体切出部分卵丘细胞,用1 mL注射器抽打分散细胞,贴壁培养65377;113个治疗周期中,298枚生发泡期卵母细胞经3种不同培养液(A65380;B65380;C)体外成熟培养(同一病人的生发泡期卵被随机分到某同一组中):第1组28个周期中73枚(A液):基础培养液+卵泡液;第2组40个周期中115枚(B液):A液 + 分散贴壁的卵丘细胞;第3组45个周期中110枚(C液):A液 + 分散贴壁的卵丘细胞 + 促卵泡生成激素 + 表皮生长因子65377;观察其成熟率65380;受精率及可用胚胎获得率等65377;【结果】 24 h成熟率:组间比较有显著性差异(A: 45.2%, B: 61.7%, C: 78.2%, P < 0.05); 25 ~ 48 h无显著意义65377;成熟卵的正常受精率在59% ~ 67%之间,组间比较无显著差异;与第1组(54.5%,11.0%)相比,第2组(83.3%,25.2%)65380;第3组(90.7%,37.3%)的卵裂率和挽救率均有显著性差异(P < 0.05),可用胚胎获得率组间比较依次呈现上升趋势(66.7%,82.9%,83.7%)65377; 【结论】 来自控制性促排卵周期的成熟卵丘细胞经简易吹打分散后贴壁培养,可能能协同卵泡液中或外加的生长因子,促进未成熟卵母细胞的体外成熟,而本研究技术简易有效,可用于挽救促排卵周期的未成熟卵65377;…”
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Anxiolytic, Antidepressant, and Anticholinesterase Effects of Essential Oil from <i>Myrcia sylvatica</i> (G.Mey.) DC by Antônio Quaresma da Silva Júnior, Mariana Maciel Garcia, Wanderson da Silva Farias, Deise Juliane dos Anjos de Sousa, Adenilson de Sousa Barroso, Pablo Luis Baia Figueiredo, Gabriela B. dos Santos, Ricardo Bezerra de Oliveira, Rosa Helena Veras Mourão

“…Moreover, MsEO inhibited acetylcholinesterase with an IC₅₀ of 0.47 μg/mL. These findings suggest that MsEO has potential therapeutic applications for anxiety and depression disorders, with additional anticholinesterase activity warranting further investigation in cognitive-related conditions.…”
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Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy by Yonghua Cai, Heng Xiao, Shuaishuai Xue, Peng Li, Zhengming Zhan, Jie Lin, Zibin Song, Jun Liu, Wei Xu, Qixiong Zhou, Songtao Qi, Xi’an Zhang, Ziyi Luo

“…Cinobufagin effectively induced PANoptosis, leading to increased immunogenic cell death, facilitated tumor-associated microglia/macrophages (TAMs) polarization towards an M1-like phenotype while augmenting CD4+/CD8 + T cell infiltration and activation. …”
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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

“…Results V̇O2max, LF/HF ratio, and LFnu increased while HFnu decreased in the training group (before and after training mean [SD] values: V̇O2max 134 [12.8]‐146 [16.5] mL/[kg min]; P < .001; LF/HF ratio 0.51 [0.2]‐0.91 [0.3] [P = .02]; LFnu 37.5 [10.1]‐46.8 [7.8] [P = .02]; HFnu 76.2 [7.9]‐53.2 [7.7] [P < .001]). …”
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Genetic Variability, Character Association, Path Coefficient, and Diversity Analysis of Rice (Oryza sativa L.) Genotypes Based on Agro-Morphological Traits by Shubh Pravat Singh Yadav, Sujan Bhandari, Netra Prasad Ghimire, Dipesh Kumar Mehata, Soni Kumari Majhi, Susmita Bhattarai, Samaz Shrestha, Bishnu Yadav, Pratima Chaudhary, Sangita Bhujel

“…According to the correlation analysis, selection based on days to maturity (DM), TW, HI, tiller per m2 (TM), and effective tiller per hill (ETH) will be beneficial for raising rice GY. …”
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Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism by Waleed Aldamarany, Huang Taocui, Deng Liling, Yang Wanfu, Geng Zhong

“…It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and (IL)-1beta (IL-1β), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). …”
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Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report by Amedeo Minichino, Francesco Saverio Bersani, Francesco Spagnoli, Alessandra Corrado, Francesco De Michele, Wanda Katharina Calò, Martina Primavera, Baoran Yang, Laura Bernabei, Francesco Macrì, Lucilla Vergnani, Massimo Biondi, Roberto Delle Chiaie

“…Methods. 25 euthymic outpatients with a diagnosis of BD Type I or II have been enrolled in the study. tDCS montage was as follows: cathode on the right cerebellar cortex and anode over the left dorsolateral prefrontal cortex (DLPFC); the intensity of stimulation was set at 2 mA and delivered for 20 min/die for 3 consecutive weeks. …”
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Palmitic Acid Methyl Ester Enhances Adipogenic Differentiation in Rat Adipose Tissue-Derived Mesenchymal Stem Cells through a G Protein-Coupled Receptor-Mediated Pathway by Jian-Hong Lin, Huan-Hsin Chang, Wen-Sen Lee, Pei-Ching Ting, Yu-Po Luo, Kun-Ta Yang

“…Moreover, PAME significantly increased phosphorylation of extracellular signal-regulated kinases (ERK), but not AKT and mTOR. Cotreatment with PAME and a GPR40/120 antagonist together inhibited the PAME-enhanced ERK phosphorylation and adipogenic differentiation. …”
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Epigenome-wide association study of Chinese monozygotic twins identifies DNA methylation loci associated with estimated glomerular filtration rate by Xueting Qi, Jingjing Wang, Tong Wang, Weijing Wang, Dongfeng Zhang

“…Gene expression profiling sequencing was employed to measure mRNA expression levels, and the GEE model was used to investigate the association between gene expression and eGFR. …”
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Identification of Immune-Related lncRNA Pairs and Construction and Validation of a New Prognostic Signature of Colon Cancer by Minxian Xu, Qing Li, Jianfang Zhang, Hui Xie

“…We downloaded the expression matrix of mRNA and lncRNA of patients with colon cancer and their clinical information from the public TCGA database. …”
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Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases by Alexander Desuki, Frank Staib, Ines Gockel, Markus Moehler, Hauke Lang, Stefan Biesterfeld, Annett Maderer, Peter R. Galle, Martin R. Berger, Carl C. Schimanski

“…Loss of LLGL1 expression was associated with the diffuse type of gastric cancer (P=0.029) with peritoneal carcinomatosis (M1; P=0.006) and with female gender (P=0.017). …”
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Deficit Irrigation and an IoT-Based System for Improving Yield and Water Use Efficiency of Winter Wheat Grown Under Semi-Arid Conditions by Salah Belkher, Basma Latrech, Wifak Bekri, Felix Markwordt, Mohamed Abdur Rahim, Corentin Dupont, Mohamed Ali Ben Abdallah, Hedi Daghari, Mourad Rezig

“…Across all growing seasons and treatments, WUE_TDM values ranged between 4.11 and 6.32 Kg m⁻³. The highest values were achieved under rainfed treatment. …”
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The Feasibility of Using CT-Guided ROI for Semiquantifying Striatal Dopamine Transporter Availability in a Hybrid SPECT/CT System by Chien-Chin Hsu, Yen-Hsiang Chang, Wei-Che Lin, Shu-Wen Tang, Pei-Wen Wang, Yung-Cheng Huang, Nan-Tsing Chiu

“…We enrolled twenty-eight patients who underwent Tc-99m TRODAT-1 brain SPECT/CT and brain MRI. ROIs of the striatal, caudate, putamen, and occipital cortex were manually delineated on the SPECT, CT, and MRI. …”
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Exploring the role of epileptic focus lateralization on facial emotion recognition in the spectrum of mesial temporal lobe epilepsy by Fabio Iannaccone, Chiara Pizzanelli, Francesca Lorenzini, Francesco Turco, Chiara Milano, Claudia Scarpitta, Luca Tommasini, Gloria Tognoni, Riccardo Morganti, Enrica Bonanni, Gabriele Siciliano

“…This study explores FER in both mild (mMTLE) and refractory forms, examining the influence of epileptic focus lateralization on FER.Methods50 MTLE patients, categorized by epilepsy severity and focus lateralization, were compared with healthy controls. …”
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The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response by Bush NJ, Cushnie AK, Boissoneault J, Aghabeigi S, Alexander C, Staud R, Robinson ME

“…However, despite robust research characterizing these effects, individual differences in predicting placebo analgesic responses are not well understood.Methods: Fifty-four healthy pain-free adults over 18 (M=22.8, SD=7.82) were recruited (66.7% women). …”
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