Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B by Chun Wang, Ruiling Fu, Zhenhua Chen, Kun Tan, Lingxia Chen, Xindong Teng, Jia Lu, Chunwei Shi, Xionglin Fan

“…In this study, three rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis were constructed, respectively. rBCG strains showed higher level of overexpression of Ag85A and/or Ag85B proteins than BCG containing empty vector pMV261(rBCG::261), which had low levels of endogenous expression of both proteins as expected. rBCG::AB strain could provide the strongest short-term and long-term protection in the lung against intravenous infection with virulent M. tuberculosis than rBCG::261 control and other two rBCG strains overexpressing single antigen. …”
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酷似急性心肌梗死的主动脉夹层临床特征分析 by 刘君, 何咏聪, 张晓雪, 陈佳, 冷梅芳, 杜作义

“…实验室心肌酶学均阳性，D-二聚体(18.95±1.83)μg/mL；3例行冠脉造影未发现冠脉开口；经胸心脏超声及胸部CTA明确夹层的识别率为100%。其中3例行外科手术，1例术后24h内死亡，2例存活。…”
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Estimation of daily groundwater evapotranspiration from diurnal variations of lysimeter experiments data in an arid zone by Peng Yao, Fengzhi Shi, Yuehui Wang, Ningze Dai, Chengyi Zhao

“…Using an automatic water level-compensating lysimeter, ETg was monitored hourly for P euphratica, T ramosissima, and bare land at groundwater depths of 0.7, 1.1, and 1.5 m in August 2023. Variations at hourly and daily scales were analyzed, and a modified White method was applied to estimate ETg. …”
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Pain Reduction in Patellofemoral Knee Patients During 3-Month Intervention with Biomechanical and Sensorimotor Foot Orthoses: A Randomized Controlled Clinical Study by Steven Simon, Andreas Heine, Jonas Dully, Carlo Dindorf, Oliver Ludwig, Michael Fröhlich, Stephan Becker

“…<b>Results:</b> Statistical analysis revealed no statistically significant interaction between ToMs and treatment groups but a significant main effect on Kujala anterior knee pain scores (M_Diff = 10.189; <i>p</i> = 0.014) and 12-week VAS (<i>p</i> = 0.001). …”
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<i>In Silico</i> Investigation of γ-Sitosterol Isolated from the Ethanol Extract of <i>Artocarpus camansi</i> Leaves as a Sunscreen Agent by Rosnani Nasution, Rafna Azura, Muhammad Bahi, Nur Balqis Maulydia, Reza Akbar Bastian, Michelia Mutiara Hilda, Marianne Marianne

“…The pure compound is thought to be γ-sitosterol by analysis of its molecular weight similarity and positive ion fragment m/z with a melting point of 147 °C. From the molecular docking, it is known that γ-sitosterol has the highest binding affinity value of −7.4 and −8.2 kcal/mol to human neutrophile collagenase (PDB ID: 1BZS) and fibroblast collagenase-1 (PDB ID: 966C), respectively. …”
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Outcomes of Living Kidney Donor Candidates and Living Kidney Recipient Candidates with JC Polyomavirus and BK Polyomavirus Viruria by Sara Querido, Carolina Ormonde, Teresa Adragão, Inês Costa, Maria Ana Pessanha, Perpétua Gomes, André Weigert

“…In a multivariate analysis, LKD candidates with JCV viruria had a lower risk of proteinuria of >200 mg/24 hours (p=0.009, OR: 0.342, 95% CI: 0.153–0.764), in a model adjusted for age, gender, presence of hypertension, and eGFR <80 mL/min. Prevalence of JCV viruria was higher in LKD candidates when compared with LKR candidates (40.0% vs 1.7%, p<0.001). …”
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Optimising subsurface integrity and surface quality in mild steel turning: A multi-objective approach to tool wear and machining parameters by Muhammad Imran, Suo Shuangfu, Bai Yuzhu, Wang Yuming, Naveed Raheel

“…The optimal machining parameters, determined as Vc = 125.6 m/min, f = 0.35 mm/rev, and ap = 0.7 mm, demonstrate the efficacy of the optimization techniques in achieving enhanced surface quality and making a significant contribution to the field of machining and manufacturing.…”
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Immunological Aspects of Fulminant Type 1 Diabetes in Chinese by Zhen Wang, Ying Zheng, Yiting Tu, Zhijie Dai, Jian Lin, Zhiguang Zhou

“…And peripheral T cell responses to GAD65, insulin B9–23 peptide, or C peptide were determined in 10 FT1D patients and 10 healthy controls. The mRNA levels of several related cytokines and molecules, such as IFN-γ, IL-4, RORC, and IL-17 in PBMCs from FT1D patients were analyzed by qRT-PCR. …”
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Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo by Yancui Liang, Qian Zhong, Runhui Ma, Zhijing Ni, Kiran Thakur, Jianguo Zhang, Zhaojun Wei

“…On the other hand, apigenin could promote autophagy via up-regulating Beclin 1, ULK1, ATG5, ATG13, and LC3B and down-regulating AMPK, mTOR, P70S6K, and ATG4. Furthermore, apigenin could inhibit tumor tissue proliferation and restrict tumor growth via ferroptosis in vivo.…”
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DPD-YOLO: dense pineapple fruit target detection algorithm in complex environments based on YOLOv8 combined with attention mechanism by Cong Lin, Wencheng Jiang, Weiye Zhao, Lilan Zou, Zhong Xue

“…The results indicate that, compared to existing mainstream target detection models, the proposed DPD-YOLO demonstrated superior detection performance for pineapples in situations where the background is complex and the targets are occluded. The mAP@0.5 reached 62.0%, representing an improvement of 6.6% over the original YOLOv8 algorithm, Precision increased by 2.7%, Recall improved by 13%, and F1-score rose by 10.3%.…”
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History and dynamics of Fennoscandian Ice Sheet retreat, contemporary ice-dammed lake evolution, and faulting in the Torneträsk area, northwestern Sweden by K. Ploeg, K. Ploeg, K. Ploeg, A. P. Stroeven, A. P. Stroeven

“…The recent release of a 1 <span class="inline-formula">m</span> lidar-derived national elevation model reveals an unprecedented record of the glacial geomorphology in Sweden. …”
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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. by Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe

“…Two of these were of the predicted DC11 type (one showing the dual rosetting/IgM-Fc-binding phenotype), whereas two contained DC15 (DBLα1.2-CIDRα1.5b) a PfEMP1 type not previously associated with rosetting. …”
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Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…Secretion levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), NF-κB nuclear translocation, NF-κB activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein levels, as well as the cell proliferation ability were measured at the end of the treatment and after 24 hours of recovery. …”
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腺样体肥大治疗的前瞻性随机对照研究

“…【结果】 治疗前两组患儿的腺样体大小无统计学差异,治疗后两组腺样体大小有统计学差异(P=0.038),两组患儿治疗后的腺样体大小分别同治疗前比较有统计学差异(P=0.000,两组治疗前及治疗后3月血清中IgA、IgG、IgM变化经t检验统计学比较均无差异(P>0.05),两组分泌性中耳炎、儿童慢性鼻窦炎、儿童阻塞性睡眠呼吸暂停低通气综合征疗效对比无统计学差异(P值分别为0.822?…”
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Preparation and In Vivo Expression of CS-PEI/pCGRP Complex for Promoting Fracture Healing by Chun-Liang Li, Feng Qin, Rong-rong Li, Jia Zhuan, Hai-Yong Zhu, Yu Wang, Kai Wang

“…Moreover, CS-PEI/pCGRP significantly enhanced the mRNA and protein levels of downstream RUNX2 and ALP. …”
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Supplementation with Complex Phytonutrients Enhances Rumen Barrier Function and Growth Performance of Lambs by Regulating Rumen Microbiome and Metabolome by Juan Du, Yuan Wang, Shaohui Su, Wenwen Wang, Tao Guo, Yuchao Hu, Na Yin, Xiaoping An, Jingwei Qi, Xuan Xu

“…Our findings suggest that adding CPS to lambs’ diets has widespread positive impacts, including improved growth performance, reduced inflammation and mRNA relative expression of apoptosis-related genes, enhanced barrier function, and beneficial changes in the rumen microbiome and metabolite profiles.…”
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Impact of Wall Material Composition (Maltodextrin vs. Inulin vs. Nutriose) and Emulsion Preparation System (Nano- vs. Microemulsion) on Properties of Spray-Dried Linseed Oil by Dorota Ogrodowska, Iwona Zofia Konopka, Grzegorz Dąbrowski, Beata Piłat, Józef Warechowski, Fabian Dajnowiec, Małgorzata Tańska

“…All emulsions demonstrated Newtonian-like behavior, with viscosity values ranging from 29.07 to 48.26 mPa·s. The addition of nutriose induced the most significant variation in this parameter, with nanoemulsification leading to a 1.6-fold increase in viscosity compared to microemulsification. …”
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Isolation, screening and in-vitro characterization of plant growth-promoting Bradyrhizobium isolates from the nodules of Bambara groundnut (Vigna subterranean) for potential use as... by Osman Abdulai Seidu, Stephen Mwangi Githiri, John Mwibanda Wesonga, Victoria Wambui Ngumi

“…Further, isolates P4A17, P4A18, P4A16, P4A6 and C2 produced IAA concentrations of 54.97 ± 3.21–108 ± 12.10 μg/mL. However, none of the isolates could produce HCN. …”
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Lentinan Attenuates Damage of the Small Intestinal Mucosa, Liver, and Lung in Mice with Gut-Origin Sepsis by Zhongshen Kuang, Tingting Jin, ChangYi Wu, Yanan Zong, Panpan Yin, WangYu Dong, Xue Lin, WeiYan You, Chenlong Zhang, Lijie Wang, Yongying Liu, Shan Ren, Jiangwen Yin, Hang Xu

“…The mice were randomly divided into six groups: sham operation group (sham), gut-origin sepsis model group (CLP), ulinastatin-positive drug control group (UTI), lentinan low concentration group (LTN-L, 5 mg/kg), lentinan medium concentration group (LTN-M, 10 mg/kg), and lentinan high concentration group (LTN-H, 20 mg/kg). …”
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An Experimental Investigation on the Relationship between MS Frequency Response and Coal and Gas Outburst by Quanjie Zhu, Qingsong Li, Yu Feng, Xianwei Heng, Shaoquan Li, Tao Yang

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