漆黄素通过调节Apaf-1,ERK和COX-2信号通路诱导人宫颈癌细胞凋亡

“…滋mol/L时)显著诱导细胞凋亡; 使Caspase-3和Caspase-9的蛋白酶活性分别增加20% ~ 50%和22% ~ 38%;促进Apaf1蛋白的表达;能有效诱导Cytochrome-C的释放;降低 ERK/MAPK信号通路中ERK1/2蛋白的磷酸化水平;与ERK抑制剂或siRNA联合使用可抑制60% ~ 70%细胞增殖;减少COX-2蛋白的表达;明显减少PGE2的产生,仅1800 ~ 2600 pg/mL;减少p300?NF-κB? p50?p65与COX-2启动子的结合,与对照组比较,差异有统计学意义(P < 0.05)?…”
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Impulsivity, Sensation Seeking, and Risk-Taking Behaviors among HIV-Positive and HIV-Negative Heroin Dependent Persons by Koosha Paydary, Somayeh Mahin Torabi, SeyedAhmad SeyedAlinaghi, Mehri Noori, Alireza Noroozi, Sara Ameri, Hamed Ekhtiari

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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…We have previously shown that sulfonylurea receptor 1-transient receptor potential M4 (SUR1-TRPM4) mediates microglial NLRP3-related inflammation following global brain ischemia. …”
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Short-term predictive value of sST2 in patients with STEMI following primary PCI: a prospective observational study by Shan Huang, Lu-Jiao Yu, Guang-Feng Sun, Zi-Xin Zhang

“…Results sST2 ranged from 20.57 to 98.96 ng/mL. High sST2 group had higher MACEs rate compared to low sST2 group (28.8% vs. 8.0%, P = 0.001). sST2 was positively correlated with age (r = 0.181, P = 0.027), SYNTAX score (r = 0.257, P = 0.002), high-sensitive C-reactive protein (hs-CRP) (r = 0.225, P = 0.006), B-type natriuretic peptide (BNP) (r = 0.225, P = 0.006) and negatively with left ventricle ejection fraction (LVEF) (r = -0.197, P = 0.016). …”
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The Accuracy of the NSQIP Universal Surgical Risk Calculator Compared to Operation-Specific Calculators by Mark E. Cohen, PhD, Yaoming Liu, PhD, Bruce L. Hall, MD, PhD, MBA, FACS, Clifford Y. Ko, MD, MS, MSHS, FACS

“…Operation-specific risk calculators (OS-RC) and OS-RCs with operation-specific predictors (OSP-RC) were independently developed for each of 6 operative groups (colectomy, whipple pancreatectomy, thyroidectomy, abdominal aortic aneurysm (open), hysterectomy/myomectomy, and total knee arthroplasty) and 14 outcomes using the same 80%/20% rule applied to the appropriate subsets of the 5M records. Predictive accuracy was evaluated using the area under the receiver operating characteristic curve (AUROC), the area under the precision-recall curve (AUPRC), and Hosmer-Lemeshow (H-L) P values, for 13 binary outcomes, and mean squared error for the length of stay outcome. …”
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Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity by Spike Murphy Müller, Nina Nelson, Manfred Jücker

“…To determine the contribution of the individual domains to catalytic activity, the full-length protein was compared with truncated constructs lacking one or more domain(s), regarding the substrate turnover (k_cat) and catalytic efficiency (k_cat/K_m) towards ci8-PtdIns(3,4,5)P₃. …”
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EL EFECTO DE LA SOBRECARGA CON CREATINA EN EL RENDIMIENTO FÍSICO EN SPRINT DE ATLETISMO, POSTERIOR A UN PROTOCOLO DE EJERCICIO INTERMITENTE Y PROLONGADO by Óscar Pablo Gutiérrez Sancho, José Moncada Jiménez, Wálter Salazar Rojas

“…El estudio examina el efecto de la sobrecarga con Creatina (Cr) sobre el rendimiento en 6 sprints (200m) de atletismo realizados a máxima intensidad, después de haber ocasionado la fatiga (+ 1hr) con ejercicio de carrera submáximo (60-85% de FC_máx). …”
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Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition by Jaison Jeevanandam, Mara Gonçalves, Rita Castro, Juan Gallo, Manuel Bañobre-López, João Rodrigues

“…The smaller size (∼11–72 nm), surface charge (ca. 17–24 mV), crystallite size ranging from 9.07 nm (Zn-doped MgO) to 17.44 nm (Ag-doped MgO), and distinct shapes have led to enhanced stabilization via G5 dendrimer. …”
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Observation-driven model for calculating water-harvesting potential from advective fog in (semi-)arid coastal regions by F. Lobos-Roco, F. Lobos-Roco, J. Vilà-Guerau de Arellano, C. del Río, C. del Río

“…When combined with <span class="inline-formula"><i>r</i>_l</span>, this coefficient facilitates the estimation of fog-harvesting volumes (L m<span class="inline-formula">⁻²</span>). …”
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Reference Intervals of Central Aortic Blood Pressure and Augmentation Index Assessed with an Oscillometric Device in Healthy Children, Adolescents, and Young Adults from Argentina by Alejandro Diaz, Yanina Zócalo, Daniel Bia, Edmundo Cabrera Fischer

“…First, we evaluated if RIs for males and females were necessary using correlation and covariate analysis. Second, mean (M) and standard deviation (SD) age-related equations were obtained for cSBP and cAIx, using parametric regression methods based on fractional polynomials. …”
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From ecological menace to roadside attraction: 28 years of evidence support successful biocontrol of purple loosestrife by Bernd Blossey, Victoria Nuzzo, Stacy B. Endriss

“…We used a standardized monitoring protocol to record insect abundance and L. salicaria stem densities and heights in 1‐m2 permanent quadrats at 33 different wetlands and followed sites for up to 28 years. …”
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Perceived coercion amongst healthcare workers during the COVID-19 pandemic by Andrea S. Stoltenberg, Veronica Ranieri, Hege Kristine N. Dahlen, Eleni Nastouli, SAFER Investigators, Roger Almvik, Sarah J. L. Edwards, Sunjeev K. Kamboj

“…On average, across the three PPCS-HCW scale factors, HCWs showed low levels of perceived coercion (M = 0.22 (95% CI [0.11, 0.33] on a − 3 to + 3 scale). …”
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Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…These compounds have demonstrated effective dose 50 values within the sub-micromolar range, i.e., 0.4–0.58 µM. Normal mode analysis investigations provided additional confirmation regarding the stability of the conformational interactions between the HslV protease and the active compounds. …”
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Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…Effects of vernolactone on the expression of autophagy-related genes (LC3, Beclin 1, PI3K, Akt, and mTOR) were evaluated using real-time PCR. 2,2-Diphenyl-1-2,2-diphenyl-picrylhydrazyl (DPPH) radical scavenging assay, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, and ferric reducing antioxidant power (FRAP) assays were also carried out to evaluate the antioxidant activity of vernolactone. …”
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A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study by Nathan R. Weeldreyer, Mindy L. McEntee, Matthew P. Martin, Chong D. Lee, Farshad Fani Marvasti, Glenn A. Gaesser, Rodger Kessler, Siddhartha S. Angadi

“…Modest reductions were observed for waist circumference (115.5 ± 12.6 vs. 112.5 ± 15.2 cm; p = 0.014, 95% CI: −5.66 to −0.26), body weight (97.7 ± 21.9 vs. 95.6 ± 23.9 kg; p = 0.016. 95% CI: −3.84 to −0.31), and BMI (33.7 ± 7.2 vs. 32.8 ± 7.5 kg/m2; p = 0.028, 95% CI: −1.29 to −0.12). This 90‐day, patient choice‐intervention was successful at lowering HbA1c in patients with T2D. …”
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Optimization of the Solid-state Fermentation Process for Morchella esculenta Fermented Wheat and Analysis of Its Nutritional Components, Physicochemical Properties and Antioxidant... by Dandan GU, Xue DONG, Jinxiu ZHANG, Xiaoru WANG, Zongshuo ZHAO, Li'an WANG

“…The results showed that the optimal fermentation conditions were a material to liquid ratio of 1:0.9 (g:mL), an initial substrate pH of 7.0, an inoculum amount of 5 inoculum blocks (each with a diameter of 0.8 cm), and a fermentation duration of 10 days. …”
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Effectiveness and safety of human placenta hydrolysate injection into subacromial space in patients with shoulder impingement syndrome: a single-blind, randomized trial by Du Hwan Kim, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Don-Kyu Kim, Chul-Hyun Cho, Ye-Ji Kim

“…All patients received three ultrasound-guided subacromial space injections of 4 mL hPH or normal saline every week. Outcome measurements included the Visual Analog Scale (VAS) score during daily activity, Shoulder Pain and Disability Index (SPADI), and EuroQoL 5-Dimension 5-Level (EQ-5D-5L) utility index. …”
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End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle by Xiaoyan Hu, Jingqi Zeng, Lijuan Ma, Xiaomeng Wang, Jing Du, Lu Yao, Zhisheng Wu

“…Furthermore, a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey, the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered (KD < 1 × 10−8 M), and the abnormal batches of B2, B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm. …”
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Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia by Allan George, Eric McConathey, Amy Vogel-Eyny, Elizabeth Galletta, Giuseppina Pilloni, Leigh Charvet

“…During the first 30-min, participants received tDCS over the left inferior frontal gyrus (anode F7, cathode O1) at 2.0 mA. Language measures were remotely administered at baseline and intervention end.ResultsWe enrolled 10 patients (age: 70 ± 7 years; 60% male) with confirmed logopenic variant (n = 2), semantic variant (n = 2), or unspecified (n = 6) PPA. …”
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Using a region-specific ice-nucleating particle parameterization improves the representation of Arctic clouds in a global climate model by A. B. Gjelsvik, R. O. David, T. Carlsen, F. Hellmuth, S. Hofer, Z. McGraw, Z. McGraw, H. Sodemann, H. Sodemann, T. Storelvmo, T. Storelvmo

“…The change in CLWP in boreal autumn and winter is found to likely be the dominant contributor to the annual average increase in net surface CRE of 2 W m<span class="inline-formula">⁻²</span>. …”
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