Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study by François-Clément Bidard, Lisa Belin, Suzette Delaloge, Florence Lerebours, Charlotte Ngo, Fabien Reyal, Séverine Alran, Sylvie Giacchetti, Michel Marty, Ronald Lebofsky, Jean-Yves Pierga

“…After a median follow-up of 70 months, detection of ≥1 CTC/7.5 mL before chemotherapy (N=95) was significantly associated with DMFS (P=0.04) and OS (P=0.03), whereas postchemotherapy CTC detection (N=85) had no significant impact. …”
Get full text

Effects of Soil Disinfection Using Chlorine Dioxide on Soil Fungal Communities in Apple Replant Fields and the Growth of <i>Malus hupehensis</i> Rehd. Seedlings by Gongshuai Wang, Yuxin Xie, Jinhui Lv, Susu Zhang, Chengmiao Yin, Yusong Liu, Zhiquan Mao

“…In summary, disinfection of replant soil using 600 mg·L⁻¹ chlorine dioxide can enhance the growth of <i>M. hupehensis</i> Rehd. seedlings, inhibit the growth and reproduction of pathogenic <i>Fusarium</i> fungi, improve the soil environment, and effectively prevent and control ARD.…”
Get full text

Intensification of future subsurface marine heatwaves in an eddy-resolving model by Xiuwen Guo, Yang Gao, Shaoqing Zhang, Wenju Cai, Deliang Chen, L. Ruby Leung, Jakob Zscheischler, Luanne Thompson, Kristen Davis, Binglin Qu, Huiwang Gao, Lixin Wu

“…Historically, maximum MHW intensity occurs around 100 m depth, which shifts to the faster-warming surface under greenhouse warming. …”
Get full text

Microstructural characteristics, electrical conductivity and mechanical properties of Cu matrix composites reinforced with dual-phase borides by Bo Li, Yimin Gao, Cong Li, Zhen Cao, Xingjuan Yao, Da Wu, Pucun Bai, Zhong Chen

“…The effect of boride content on the microstructure, electrical conductivity, and mechanical properties of TiB2-MB2/Cu composites (M = Cr, Mo, and Zr) was systematically investigated. …”
Get full text

Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…Subsequent miRNA sequencing reveals that ML-EVs exert their effects by delivering miR-27b-3p, which targets ROR1 mRNA in chondrocytes and suppresses downstream NF-κB pathways. …”
Get full text

Structural Characterization and Antioxidant Activity in Vivo of Polysaccharides from the Leaves of Hippophae rhamnoides L. by Niannian SONG, Yuxin YI, Xiaoping ZHANG, Bo YANG, Mangsier SAINAWAER, Abuduwaili AYITUXUN

“…HRLP were extracted by water extraction and alcohol precipitation method, and homogeneous polysaccharide (HRLP-2) was obtained through DEAE-650M anion exchange column chromatography. The structure of HRLP-2 was identified based on the analysis of liquid chromatography, gas chromatography, UV, infrared spectroscopy, circular dichroism, Congo red experiment, as well as partial acid hydrolysis, periodate oxidation, and Smith degradation methods. …”
Get full text

The feasibility study of natural pigments as food colorants and seasonings pigments safety on dried tofu coloring by Wei-Sheng Lin, Pei Hua He, Chi-Fai Chau, Bo-Kang Liou, Shiming Li, Min-Hsiung Pan

“…Furthermore, the results from the PC12 cell suggested that dietary exposure of methylglyoxal (<50 μM) in soy sauce did not affect neuron cellular morphology and cell cycle significantly. …”
Get full text

Heads-Up 3D Surgery under Low Light Intensity Conditions: New High-Sensitivity HD Camera for Ophthalmological Microscopes by Celso Soiti Matsumoto, Masayuki Shibuya, Jun Makita, Takuhei Shoji, Hisato Ohno, Kei Shinoda, Harue Matsumoto

“…The illuminance from the surgical microscope was set to be dimmer (Leica M822F40 main light 2%; otto-flex 6%) than the usual setting to minimize the discomfort and glare for the patient. …”
Get full text

Energy intake insufficiency due to underestimated energy requirement by common predictive formulas can be identified by urinary amino acid levels in advanced heart failure by Yoko Sakamoto, Tomohito Ohtani, Kei Nakamoto, Fusako Sera, Shungo Hikoso, Yasushi Sakata

“…The mean REEBW was 25 kcal/kg/day, while that for the underweight (&lt;18.5 kg/m2) was 28 kcal/kg/day. We found a significant negative correlation between REEBW and body mass index (BMI), but no significant correlation between REEBW and HF-related parameters. …”
Get full text

Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil by Mohamed Bouhrim, Nour Elhouda Daoudi, Hayat Ouassou, Amina Benoutman, El Hassania Loukili, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham

“…ODSO had the highest total phenolic content (518.18 ± 14.36 mg EAC/kg) and DPPH scavenging activity (IC50 = 0.38 ± 0.08 mg/mL). Furthermore, ODSO showed a significant antidiabetogenic effect by reducing bodyweight loss, blood sugar level rise, and mortality rate caused by alloxan in albino mice. …”
Get full text

Model-Based Optimization of a Sliding Vane Rotary Pump for Micro-Organic Rankine Cycle by Fabio Fatigati, Giammarco Di Giovine, Roberto Cipollone

“…The best configuration was that involving four blades, the adoption of graphite and a clearance gap between the rotor face and casing of 10 μm. These design solutions improved efficiency by up to 25%, with a maximum value equal to 0.50, which is close to double with respect to the usual values. …”
Get full text

Anomalous photovoltaics in Janus MoSSe monolayers by Chang Liu, Tianyu Liang, Xin Sui, Lena Du, Quanlin Guo, Guodong Xue, Chen Huang, Yilong You, Guangjie Yao, Mengze Zhao, Jianbo Yin, Zhipei Sun, Hao Hong, Enge Wang, Kaihui Liu

“…A photoresponsivity up to 3 mA/W, with ~ 1% external quantum efficiency and ultrafast photoresponse (~50 ps) were observed in the MoSSe device. …”
Get full text

Effectiveness of sacral neuromodulation with 3D-printing and ultrasound localization for treating neurogenic bladder in patients with pelvic structural anomalies by Runze Liu, Yuxuan Zhou, Qiang Hao, Yaoguang Zhang, Peng Zhang, Guoqing Chen, Yong Zhang

“…X-ray exposure was eliminated in the study group, in contrast to 11.51 ± 4.62 mAs in the control group(P < 0.01). The phase two implantation rates were 67.8 % for the study group and 57.1 % for the control group(P = 0.04). …”
Get full text

Identification of natural and anthropogenic factors in the spatial pattern of Pb in the surface soil of the Nanliu River Basin by Xu Liu, Zhongfang Yang, Huading Shi, Tiansheng Wu, Tao Yu, Bo Li, Lei Wang, Yuxiang Shao, Zexin He, Minghui Xie, Chenning Deng

“…When the distance band of the Local Moran's I is set at 8000 m, the most reasonable spatial partitioning characteristics are exhibited. …”
Get full text

<i>CCND1</i> and <i>PTEN</i> genes as markers of progression in vulvar cancer by A. V. Busarova, N. A. Petrusenko, P. A. Kruze, N. V. Porhanova

“…The relative copy number of genes (RCQ) was assessed using the RT-qPCR method: MYC, PTEN, CCND1, PIK3CA, TP53, CDKN2A, MDM2, MCL1, NFKBIA, MTAP, BIRC2, KMT2C and reference genes: GAPDH and B2M. Raw RT-qPCR data were analyzed using Bio-Rad CFX Manager software (ver. 2.1). …”
Get full text

Balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: short- and long-term results from a cohort in Brazil by Fabio Solano de Freitas Souza, Marcelo Gottschald Ferreira, Iury Andrade Melo, Marta Ferreira Leite de Sá, Camila Melo Coelho Loureiro, Rosalvo Abreu, Paulo Henrique Alves de Carvalho, Mateus dos Santos Viana, Valdemar Oliveira Jr, Luiz Eduardo Fonteles Ritt

“…Results: After a mean of 5.6 ± 1.3 sessions and 11 ± 2.8 treated segments/patient (at a mean of 6.7 ± 2.9 months post-BPA), there was a 26% decrease in mean pulmonary artery pressure (51 ± 11 vs. 38 ± 11 mmHg; p < 0.0001), a 43% decrease in pulmonary vascular resistance (10 ± 3.7 vs. 5.7 ± 3.3 WU; p < 0.0001), and a 22.5% increase in the cardiac index (2.38 ± 0.6 vs. 2.95 ± 0.6 L/min/m2; p < 0.0001). There was an increase in the six-minute walk distance and an improvement in functional class. …”
Get full text

Inhalation of patchouli essential oil alleviates airway inflammation in cigarette smoke-induced COPD mice by Yan Zhang, Rui Cao, Duo Wang, Qiulin Yue, Le Su, Kunlun Li, Baojun Li, Lin Zhao, Song Zhang

“…Furthermore, PEO treatment reduced the levels of inflammatory factors IL-6, IL-1β, and TNF-α, and reversed the CS-induced elevation of mRNA levels of these factors. Additionally, PEO treatment significantly countered cigarette smoke-induced COPD via the NF-κB signaling pathway in mice; Our result has shown that inhalation of PEO can substantially alleviate the increase in inflammatory factors, mitigate lung function impairment, and reduce airway remodeling in cigarette smoke-induced COPD mice.…”
Get full text

Defining the sensitivity of cosmic ray muons to groundwater storage changes by Tramontini, Matías, Rosas-Carbajal, Marina, Zyserman, Fabio Iván,  Longuevergne, Laurent, Nussbaum, Christophe, Marteau, Jacques

“…In this work we employ for the first time, the muography method to investigate groundwater variations at the scale of 100 m. We study a mountainous karstic aquifer in the Mont Terri Underground Rock Laboratory (URL), Switzerland. …”
Get full text

Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery by Karolina Kaźmierczak, Joanna Stafiej, Joanna Stachura, Paweł Żuchowski, Grażyna Malukiewicz

“…Generally, the functional outcomes were better in eyes with short-time duration of the MH, when a smaller diameter (<400 μm) of the hole was measured and a V-shaped closure of the MH and the restoration of the ELM line on OCT were present. …”
Get full text

自发性高血压大鼠TGFβ1/ Smad7通路与心室纤维化的关系 by 高修仁, 翟原生, 彭龙云, 何旭瑜, 郭小刚, 朱莺莺

“…与SHR14周龄组相比，SHR22周龄组的心室质量指数、心肌羟脯氨酸的含量、Ⅰ型和Ⅲ型胶原均明显增加（P<0.01）；在mRNA 水平或蛋白水平，心肌中的TGFβ1的表达上调，smad7的表达下调。[结论]在一定的时间窗内，自发性高血压大鼠血压的升高及心肌纤维化随着病程的进展而发展，同时伴随着TGFβ1的表达上调，smad7的表达下调。…”
Get full text